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1.
Artigo em Inglês | MEDLINE | ID: mdl-32543825

RESUMO

Highly dense hexagonal Fe(II)-based coordination nanosheets (CONASHs) were designed by dual-branching, at the metal-coordination moieties and the tritopic ligands, which successfully obtained a liquid/liquid interface by the complexation of Fe(II) ions and the tritopic bidentate ligands. The 1:1 complexation was confirmed by titration. The obtained Fe(II)-based nanosheets were fully characterized by small-angle X-ray scattering (SAXS), atomic force microscopy (AFM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS). A monolayer of the sheets was obtained, employing the Langmuir-Blodgett (LB) method, and the determined thickness was ∼2.5 nm. The polymer nanosheets exhibited red-to-colorless electrochromism because the electrochemical redox transformation between Fe(II) and Fe (III) ions controlled the appearance/disappearance of the metal (ion)-to-ligand charge-transfer (MLCT) absorption. The poor π-conjugation in the tritopic ligands contributed to the highly colorless electrochromic state. A solid-state device, with the robust polymer film, exhibited excellent electrochromic (EC) properties, with high optical contrast (ΔT > 65%) and high durability after repeated color changes for >15 000 cycles, upon applying low-operating voltages (+1.5/0 V).

2.
Adv Mater ; : e1905657, 2020 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-32191374

RESUMO

Exploration of molecular functions and material properties based on the control of chirality would be a scientifically elegant approach. Here, the fabrication and function of chiral-featured materials from both chiral and achiral components using a supramolecular nanoarchitectonics concept are discussed. The contents are classified in to three topics: i) chiral nanoarchitectonics of rather general molecular assemblies; ii) chiral nanoarchitectonics of metal-organic frameworks (MOFs); iii) chiral nanoarchitectonics in liquid crystals. MOF structures are based on nanoscopically well-defined coordinations, while mesoscopic orientations of liquid-crystalline phases are often flexibly altered. Discussion on the effects and features in these representative materials systems with totally different natures reveals the universal importance of supramolecular chiral nanoarchitectonics. Amplification of chiral molecular information from molecules to materials-level structures and the creation of chirality from achiral components upon temporal statistic fluctuations are universal, regardless of the nature of the assemblies. These features are thus surely advantageous characteristics for a wide range of applications.

3.
Chemistry ; 26(29): 6461-6472, 2020 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-32159246

RESUMO

Soft and flexible two-dimensional (2D) systems, such as liquid interfaces, would have much more potentials in dynamic regulation on nano-macro connected functions. In this Minireview article, we focus especially on dynamic motional functions at liquid dynamic interfaces as 2D material systems. Several recent examples are selected to be explained for overviewing features and importance of dynamic soft interfaces in a wide range of action systems. The exemplified research systems are mainly classified into three categories: (i) control of microobjects with motional regulations; (ii) control of molecular machines with functions of target discrimination and optical outputs; (iii) control of living cells including molecular machine functions at cell membranes and cell/biomolecular behaviors at liquid interface. Sciences on soft 2D media with motional freedom and their nanoarchitectonics constructions will have increased importance in future technology in addition to popular rigid solid 2D materials.

4.
Macromol Rapid Commun ; 41(5): e1900585, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32009277

RESUMO

3D liquid crystal elastomer (3D-LCE) foams are used to support long-term neuronal cultures for over 60 days. Sequential imaging shows that cell density remains relatively constant throughout the culture period while the number of cells per observational area increases. In a subset of samples, retinoic acid is used to stimulate extensive neuritic outgrowth and maturation of proliferated neurons within the LCEs, inducing a threefold increase in length with cells displaying morphologies indicative of mature neurons. Designed LCEs' micro-channels have a similar diameter to endogenous parenchymal arterioles, ensuring that neurons throughout the construct have constant access to growth media during extended experiments. Here it is shown that 3D-LCEs provide a unique environment and simple method to longitudinally study spatial neuronal function, not possible in conventional culture environments, with simplistic integration into existing methodological pipelines.


Assuntos
Materiais Biocompatíveis/química , Elastômeros/química , Cristais Líquidos/química , Neurônios/citologia , Tecidos Suporte/química , Proliferação de Células/efeitos dos fármacos , Células Cultivadas , Cristais Líquidos/ultraestrutura , Porosidade , Tretinoína/farmacologia
5.
Chem Asian J ; 15(3): 406-414, 2020 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-31922659

RESUMO

Molecular functions depend on conformations and motions of the corresponding molecular species. An air-water interface is a suitable asymmetric field for the control of molecular conformations and motions under a small applied force. In this work, double-paddled binuclear PtII complexes containing pyrazole rings linked by alkyl spacers were synthesized and their orientations and emission properties dynamically manipulated at the air-water interface. The complexes emerge from water with concurrent variation of interface orientation of the planes of the PtII complexes from perpendicular to parallel during mechanical compression suggesting a unique 'submarine emission'. Phosphorescence of the complexes is quenched at the air-water interface prior to monolayer formation with intensities subsequently rapidly increasing during monolayer compression. These results indicate that asymmetric reactions and motions might be controlled by applying mechanical force at the air-water interface.

6.
Hepatol Res ; 50(4): 466-477, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31808236

RESUMO

AIM: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of liver disease worldwide. Because liver fibrosis is associated with the long-term prognosis of patients with NAFLD, there is an urgent need for non-invasive markers of liver fibrosis. Sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7) is an immunomodulatory molecule expressed on various immune cells, including macrophages, which plays a key role in liver inflammation and fibrosis in NAFLD. We aimed to determine whether serum levels of soluble Siglec-7 (sSiglec-7) could have utility at a marker of fibrosis in this patient population. METHODS: We examined serum samples from 93 NAFLD patients and 19 healthy donors for macrophage-associated protein, including sSiglec-7, soluble CD163, and YKL-40, and examined their correlation with liver fibrosis scores, tissue elastography, and histological findings. Independent factors associated with advanced fibrosis were analyzed using a logistic regression model and a decision tree. To clarify the source of sSiglec-7, we examined its expression in liver tissue-derived macrophages and cultured monocyte-derived macrophages. RESULTS: Serum sSiglec-7 levels were significantly higher in NAFLD patients compared with healthy donors, and correlated positively with sCD163 and YKL-40 levels. Serum sSiglec-7 was an independent diagnostic marker with high specificity (96.3%) for advanced fibrosis (F3 and F4) in NAFLD patients. Siglec-7 was mainly expressed on CCR2+ macrophages in the liver, and sSiglec-7 production by monocyte-derived macrophages in vitro was increased after stimulation by pro-inflammatory factors. CONCLUSIONS: Elevated serum sSiglec-7 could serve as an independent marker with high specificity for advanced liver fibrosis in patients with NAFLD.

7.
Sci Rep ; 9(1): 15788, 2019 10 31.
Artigo em Inglês | MEDLINE | ID: mdl-31673081

RESUMO

Current serum hepatocellular carcinoma (HCC) biomarkers are insufficient for early diagnosis. We aimed to clarify whether serum MFG-E8 can serve as a diagnostic or prognostic biomarker of HCC. Serum MFG-E8 levels of 282 HCC patients, who underwent primary hepatectomy, were examined by ELISA. We also quantified serum MFG-E8 levels in patients with chronic hepatitis (CH), liver cirrhosis (LC), as well as in healthy volunteers (HVs). Serum MFG-E8 levels were significantly lower in HCC patients than in HVs regardless of the etiology of liver disease (3.6 ± 0.1 vs 5.8 ± 0.2 ng/mL, p < 0.0001), and recovered after treatment of HCC. Serum MFG-E8 levels in CH and LC patients were comparable to those in HVs. Serum MFG-E8 could detect HCCs, even α-fetoprotein (AFP)-negative or des-γ-carboxy prothrombin (DCP)-negative HCCs, in CH and LC patients. Our new HCC prediction model using MFG-E8 and DCP (Logit(p) = 2.619 - 0.809 × serum MFG-E8 + 0.0226 × serum DCP) distinguished HCC patients from CH and LC patients with an area under the curve of 0.923, a sensitivity of 81.1%, and a specificity of 89.8%. Futhermore, low preoperative serum MFG-E8 was an independent predictor of poor overall survival. Thus, serum MFG-E8 could serve as a feasible diagnostic and prognostic biomarker for HCC.

8.
Beilstein J Nanotechnol ; 10: 2014-2030, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31667049

RESUMO

Many recent advances in sensor technology have been possible due to nanotechnological advancements together with contributions from other research fields. Such interdisciplinary collaborations fit well with the emerging concept of nanoarchitectonics, which is a novel conceptual methodology to engineer functional materials and systems from nanoscale units through the fusion of nanotechnology with other research fields, including organic chemistry, supramolecular chemistry, materials science and biology. In this review article, we discuss recent advancements in sensor devices and sensor materials that take advantage of advanced nanoarchitectonics concepts for improved performance. In the first part, recent progress on sensor systems are roughly classified according to the sensor targets, such as chemical substances, physical conditions, and biological phenomena. In the following sections, advancements in various nanoarchitectonic motifs, including nanoporous structures, ultrathin films, and interfacial effects for improved sensor function are discussed to realize the importance of nanoarchitectonic structures. Many of these examples show that advancements in sensor technology are no longer limited by progress in microfabrication and nanofabrication of device structures - opening a new avenue for highly engineered, high performing sensor systems through the application of nanoarchitectonics concepts.

9.
ACS Nano ; 13(9): 10312-10326, 2019 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-31424907

RESUMO

The creation and transmission of chirality in molecular systems is a well-known, widely applied notion. Our understanding of how the chirality of nanomaterials can be controlled, measured, transmitted through space, and applied is less well understood. Dynamic assemblies for chiral sensing or metamaterials engineered from chiral nanomaterials require exact methods to determine transmission and amplification of nanomaterial chirality through space. We report the synthesis of a series of gold nanorods (GNRs) with a constant aspect ratio of ∼4.3 capped with C2-symmetric, axially chiral binaphthyl thiols, preparation of dispersions in the nematic liquid crystal 5CB, measurements of the helical pitch, and the determination of the helical twisting power as well as the average distance between the chiral nanomaterial additives. By comparison to the neat organic chiral derivatives, we demonstrate how the amplification of chirality facilitated by GNRs decorated with chiral molecules can be used to clearly distinguish the chiral induction strength of a homologous series of binaphthyl derivatives, differing only in the length of the nontethered aliphatic chain, in the induced chiral nematic liquid crystal phase. Considering systematic errors in sample preparation and optical measurements, these chiral molecules would otherwise be deemed identical with respect to chiral induction. Notably, we find some of the highest ever-reported values of the helical twisting power. We further support our experimentally derived arguments of a more comprehensive understanding of chirality transfer by calculations of a suitable pseudoscalar chirality indicator.

10.
Beilstein J Nanotechnol ; 10: 1559-1587, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31467820

RESUMO

Much attention has been paid to the synthesis of low-dimensional materials from small units such as functional molecules. Bottom-up approaches to create new low-dimensional materials with various functional units can be realized with the emerging concept of nanoarchitectonics. In this review article, we overview recent research progresses on materials nanoarchitectonics at two-dimensional liquid interfaces, which are dimensionally restricted media with some freedoms of molecular motion. Specific characteristics of molecular interactions and functions at liquid interfaces are briefly explained in the first parts. The following sections overview several topics on materials nanoarchitectonics at liquid interfaces, such as the preparation of two-dimensional metal-organic frameworks and covalent organic frameworks, and the fabrication of low-dimensional and specifically structured nanocarbons and their assemblies at liquid-liquid interfaces. Finally, interfacial nanoarchitectonics of biomaterials including the regulation of orientation and differentiation of living cells are explained. In the recent examples described in this review, various materials such as molecular machines, molecular receptors, block-copolymer, DNA origami, nanocarbon, phages, and stem cells were assembled at liquid interfaces by using various useful techniques. This review overviews techniques such as conventional Langmuir-Blodgett method, vortex Langmuir-Blodgett method, liquid-liquid interfacial precipitation, instructed assembly, and layer-by-layer assembly to give low-dimensional materials including nanowires, nanowhiskers, nanosheets, cubic objects, molecular patterns, supramolecular polymers, metal-organic frameworks and covalent organic frameworks. The nanoarchitecture materials can be used for various applications such as molecular recognition, sensors, photodetectors, supercapacitors, supramolecular differentiation, enzyme reactors, cell differentiation control, and hemodialysis.

11.
ACS Appl Mater Interfaces ; 11(12): 11893-11903, 2019 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-30817110

RESUMO

The coordination nanosheets (CONASHs) are emerging as a new class of functional two-dimensional materials, which are one of the most active research areas of chemistry and physics in this decade. Despite the success of various structural and functional CONASHs, the development of a new molecular structure to discover alluring functional CONASHs remains challenging. Herein, we report successful preparation of two novel CONASHs (NBP1 and NBP2) through coordination between one of the unexplored molecular frameworks of bis(2,2'-bipyridine)-based ligands (BP1 and BP2) and Fe2+ ions. Using a liquid-liquid interface as a platform, large-scale thin films of multilayer CONASHs have been prepared without any support, which can be deposited onto any desired substrate. Detailed characterization of the CONASHs using various microscopic and spectroscopic techniques reveals homogeneous and flat morphology of nanometer thickness with the quantitative formation of tris(2,2'-bipyridine)-Fe2+ complex motifs in the nanosheet frameworks. The color of the films has been tuned from blue to magenta by the suitable molecular design of the ligands. Owing to the insolubility of the CONASH films in any solvent and the presence of redox-active Fe2+, we explore the functionality of these nanostructured thin films deposited on indium tin oxide as electrochromic materials. The CONASHs exhibit color-to-colorless and color-to-color electrochromic transitions with attractive response times, switching stabilities, and coloration efficiencies. Finally, we demonstrate solid-state electrochromic devices of the CONASHs operated at a potential range of +2.5 to -2.5 V, which are electrochemically stable for several switching cycles, suggesting that these CONASHs are potential electrochromic materials for next-generation display applications.

12.
Sci Technol Adv Mater ; 20(1): 51-95, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30787960

RESUMO

The development of science and technology of advanced materials using nanoscale units can be conducted by a novel concept involving combination of nanotechnology methodology with various research disciplines, especially supramolecular chemistry. The novel concept is called 'nanoarchitectonics' where self-assembly processes are crucial in many cases involving a wide range of component materials. This review of self-assembly processes re-examines recent progress in materials nanoarchitectonics. It is composed of three main sections: (1) the first short section describes typical examples of self-assembly research to outline the matters discussed in this review; (2) the second section summarizes self-assemblies at interfaces from general viewpoints; and (3) the final section is focused on self-assembly processes at interfaces. The examples presented demonstrate the strikingly wide range of possibilities and future potential of self-assembly processes and their important contribution to materials nanoarchitectonics. The research examples described in this review cover variously structured objects including molecular machines, molecular receptors, molecular pliers, molecular rotors, nanoparticles, nanosheets, nanotubes, nanowires, nanoflakes, nanocubes, nanodisks, nanoring, block copolymers, hyperbranched polymers, supramolecular polymers, supramolecular gels, liquid crystals, Langmuir monolayers, Langmuir-Blodgett films, self-assembled monolayers, thin films, layer-by-layer structures, breath figure motif structures, two-dimensional molecular patterns, fullerene crystals, metal-organic frameworks, coordination polymers, coordination capsules, porous carbon spheres, mesoporous materials, polynuclear catalysts, DNA origamis, transmembrane channels, peptide conjugates, and vesicles, as well as functional materials for sensing, surface-enhanced Raman spectroscopy, photovoltaics, charge transport, excitation energy transfer, light-harvesting, photocatalysts, field effect transistors, logic gates, organic semiconductors, thin-film-based devices, drug delivery, cell culture, supramolecular differentiation, molecular recognition, molecular tuning, and hand-operating (hand-operated) nanotechnology.

13.
ACS Nano ; 13(2): 2410-2419, 2019 02 26.
Artigo em Inglês | MEDLINE | ID: mdl-30673207

RESUMO

The intramolecular rotation of 4-farnesyloxyphenyl-4,4-difluoro-4-bora-3a,4a-diaza- s-indacene (BODIPY-ISO) was controlled by tuning its local physical environment within a mixed self-assembled monolayer at an air-water interface. Intramolecular rotation was investigated by considering the twisted intramolecular charge transfer (TICT) fluorescence of BODIPY-ISO, which increases in intensity with increasing viscosity of the medium. In situ fluorescence spectroscopy was performed on mixed monolayers of BODIPY-ISO with several different lipids at the air-water interface during in-plane compression of the monolayers. Depending on the identity of the lipid used, the fluorescence of the mixed monolayers could be enhanced by mechanical compression, indicating that the rotation of BODIPY-ISO can be controlled dynamically in mixtures with lipids dispersed at the air-water interface. Taken together, our findings provide insight into strategies for controlling the dynamic behavior of molecular machines involving mechanical stimuli at interfaces.

14.
Langmuir ; 35(10): 3585-3599, 2019 03 12.
Artigo em Inglês | MEDLINE | ID: mdl-29806980

RESUMO

Methodology to combine nanotechnology and these organization processes has been proposed as a novel concept of nanoarchitectonics, which can fabricate functional materials with nanolevel units. As an instant nanoarchitectonics approach, confining systems within a two-dimensional plane to drastically reduce translational motion freedom can be regarded as one of the rational approaches. Supramolecular chemistry and nanofabrication and their related functions at the air-water interface with the concept of nanoarchitectonics would lead to the creation of a novel methodology of Langmuir nanoarchitectonics. In this feature article, we briefly summarize research efforts related to Langmuir nanoarchitectonics including the basics for anomalies in molecular interactions such as highly enhanced molecular recognition capabilities. It is also extended to frontiers including the fabrication of supramolecular receptors and two-dimensional patterns with subnanometer-scale structural regulation, manual control of molecular machines and receptors by hand-motion-like macroscopic actions, and the regulation of cell fates at nanoarchitected arrays of nanocarbon assemblies and at direct liquid interfaces.

15.
Chem Rec ; 19(9): 1891-1912, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30230688

RESUMO

The challenges of pollution, environmental science, and energy consumption have become global issues of broad societal importance. In order to address these challenges, novel functional systems and advanced materials are needed to achieve high efficiency, low emission, and environmentally friendly performance. A promising approach involves nanostructure-level controls of functional material design through a novel concept, nanoarchitectonics. In this account article, we summarize nanoarchitectonic approaches to create nanoscale platform structures that are potentially useful for environmentally green and bioprocessing applications. The introduced platforms are roughly classified into (i) membrane platforms and (ii) nanostructured platforms. The examples are discussed together with the relevant chemical processes, environmental sensing, bio-related interaction analyses, materials for environmental remediation, non-precious metal catalysts, and facile separation for biomedical uses.


Assuntos
Materiais Biomiméticos/química , Bicamadas Lipídicas/química , Nanopartículas/química , Nanotecnologia/métodos , Catálise , Recuperação e Remediação Ambiental/métodos , Química Verde/métodos
16.
JCI Insight ; 3(20)2018 10 18.
Artigo em Inglês | MEDLINE | ID: mdl-30333304

RESUMO

BACKGROUND: The clearance of hepatitis B surface antigen (HBsAg) loss, defined as functional cure, is a clinical target in patients with chronic hepatitis B (CH). To understand the immune responses underlying functional cure, we evaluated cytokine and chemokine expression profiles from patients with resolving and nonresolving acute hepatitis B (AH). METHODS: We cross-sectionally evaluated 41 chemokines and cytokines at the peak of hepatitis in the sera from 41 self-limited AH patients who achieved HBsAg seroconversion, 8 AH patients who failed to clear HBsAg within 1 year after the diagnosis, 8 CH patients with hepatic flare, and 14 healthy volunteers. We longitudinally examined 41 chemokines and cytokines in the sera from 4 self-limited AH patients, 3 chimpanzees inoculated with hepatitis B virus (HBV), and 2 CH patients treated with nucleotide analogs and PEG-IFN-α, one resulting in functional cure. RESULTS: In AH patients and HBV-inoculated chimpanzees with HBsAg loss, CXCL9, CXCL10, CXCL11, CXCL13, and IL-21 were elevated at hepatitis with subsequent decline of HBsAg. Interestingly, IL-21 elevation was observed only in resolving AH patients but not in nonresolvers. CXCL13 and IL-21 elevation was not observed in CH patients who failed to attain HBsAg loss, even at hepatic flare. A concomitant increase of CXCL13 and IL-21 was significant in CH patients who attained HBsAg seroconversion with a sequential therapy. CONCLUSION: Elevation of serum CXCL9, CXCL10, CXCL11, CXCL13, and IL-21 might be a hallmark of functional cure of AH or CH patients.


Assuntos
Antivirais/uso terapêutico , Citocinas/sangue , Antígenos de Superfície da Hepatite B/imunologia , Vírus da Hepatite B/imunologia , Hepatite B/tratamento farmacológico , Adulto , Animais , Antivirais/farmacologia , Estudos Transversais , Citocinas/imunologia , Modelos Animais de Doenças , Feminino , Hepatite B/sangue , Hepatite B/imunologia , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Pan troglodytes , Soroconversão/efeitos dos fármacos , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
17.
Nat Commun ; 9(1): 3908, 2018 09 25.
Artigo em Inglês | MEDLINE | ID: mdl-30254259

RESUMO

Induction, transmission, and manipulation of chirality in molecular systems are well known, widely applied concepts. However, our understanding of how chirality of nanoscale entities can be controlled, measured, and transmitted to the environment is considerably lacking behind. Future discoveries of dynamic assemblies engineered from chiral nanomaterials, with a specific focus on shape and size effects, require exact methods to assess transmission and amplification of nanoscale chirality through space. Here we present a remarkably powerful chirality amplification approach by desymmetrization of plasmonic nanoparticles to nanorods. When bound to gold nanorods, a one order of magnitude lower number of chiral molecules induces a tighter helical distortion in the surrounding liquid crystal-a remarkable amplification of chirality through space. The change in helical distortion is consistent with a quantification of the change in overall chirality of the chiral ligand decorated nanomaterials differing in shape and size as calculated from a suitable pseudoscalar chirality indicator.

18.
Cell Rep ; 24(7): 1830-1841, 2018 08 14.
Artigo em Inglês | MEDLINE | ID: mdl-30110639

RESUMO

Lnk/Sh2b3 is an adaptor protein that negatively regulates cytokine signaling in lymphohematopoiesis. A missense variant within the LNK/SH2B3 gene has been reported to be a risk variant for several autoimmune diseases, including diabetes. We found that glucose tolerance and insulin responses were impaired in Lnk-/- mice. Moreover, immune cells such as group 1 innate lymphoid cells (G1-ILCs), CD8+ T cells, and M1 macrophages accumulated in adipose tissue. When Lnk-/- mice were crossed with Il15-/- mice or depleted of G1-ILCs but not CD8+ T cells, glucose intolerance and adipose inflammation were ameliorated. Lnk-/- G1-ILCs showed activated phenotypes as well as enhanced reactivity for IL-15, and administration of a JAK inhibitor improved glucose tolerance. Accordingly, a high-fat diet greatly worsened glucose intolerance in Lnk-/- mice. Thus, Lnk/Sh2b3 controls homeostasis in adipose tissue and reduces the risk of onset of diabetes by regulating the expansion and activation of IL-15-dependent adipose G1-ILCs.


Assuntos
Tecido Adiposo/imunologia , Intolerância à Glucose/genética , Peptídeos e Proteínas de Sinalização Intracelular/genética , Linfócitos/imunologia , Obesidade/genética , Adipócitos/efeitos dos fármacos , Adipócitos/imunologia , Adipócitos/patologia , Tecido Adiposo/efeitos dos fármacos , Tecido Adiposo/patologia , Animais , Glicemia/efeitos dos fármacos , Proteínas de Ligação a DNA/deficiência , Proteínas de Ligação a DNA/genética , Proteínas de Ligação a DNA/imunologia , Dieta Hiperlipídica/efeitos adversos , Feminino , Regulação da Expressão Gênica , Intolerância à Glucose/tratamento farmacológico , Intolerância à Glucose/imunologia , Intolerância à Glucose/fisiopatologia , Imunidade Inata , Resistência à Insulina/genética , Interleucina-15/genética , Interleucina-15/imunologia , Peptídeos e Proteínas de Sinalização Intracelular/deficiência , Peptídeos e Proteínas de Sinalização Intracelular/imunologia , Janus Quinase 1/antagonistas & inibidores , Janus Quinase 1/genética , Janus Quinase 1/imunologia , Inibidores de Janus Quinases/farmacologia , Depleção Linfocítica , Linfócitos/efeitos dos fármacos , Linfócitos/patologia , Macrófagos/efeitos dos fármacos , Macrófagos/imunologia , Macrófagos/patologia , Masculino , Proteínas de Membrana , Camundongos , Camundongos Knockout , Obesidade/etiologia , Obesidade/imunologia , Obesidade/patologia , Transdução de Sinais
19.
Chem Asian J ; 13(22): 3366-3377, 2018 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-29959818

RESUMO

In this Focus Review, nanoarchitectonic approaches for mechanical-action-based chemical and biological sensors are briefly discussed. In particular, recent examples of piezoelectric devices, such as quartz crystal microbalances (QCM and QCM-D) and a membrane-type surface stress sensor (MSS), are introduced. Sensors need well-designed nanostructured sensing materials for the sensitive and selective detection of specific targets. Nanoarchitectonic approaches for sensing materials, such as mesoporous materials, 2D materials, fullerene assemblies, supported lipid bilayers, and layer-by-layer assemblies, are highlighted. Based on these sensing approaches, examples of bioanalytical applications are presented for toxic gas detection, cell membrane interactions, label-free biomolecular assays, anticancer drug evaluation, complement activation-related multiprotein membrane attack complexes, and daily biodiagnosis, which are partially supported by data analysis, such as machine learning and principal component analysis.


Assuntos
Técnicas Biossensoriais , Nanoestruturas/química , Técnicas de Microbalança de Cristal de Quartzo , Anti-Infecciosos/química , Anti-Infecciosos/metabolismo , Antineoplásicos/análise , Carbono/química , Gases/análise , Bicamadas Lipídicas/química , Bicamadas Lipídicas/metabolismo , Porosidade
20.
Angew Chem Int Ed Engl ; 57(31): 9679-9683, 2018 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-29917300

RESUMO

Two-dimensional (2D) carbon nanomaterials possessing promising physical and chemical properties find applications in high-performance energy storage devices and catalysts. However, large-scale fabrication of 2D carbon nanostructures is based on a few specific carbon templates or precursors and poses a formidable challenge. Now a new bottom-up method for carbon nanosheet fabrication using a newly designed anisotropic carbon nanoring molecule, CPPhen, is presented. CPPhen was self-assembled at a dynamic air-water interface with a vortex motion to afford molecular nanosheets, which were then carbonized under inert gas flow. Their nanosheet morphologies were retained after carbonization, which has never been seen for low-molecular weight compounds. Furthermore, adding pyridine as a nitrogen dopant in the self-assembly step successfully afforded nitrogen-doped carbon nanosheets containing mainly pyridinic nitrogen species.

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