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1.
Adv Exp Med Biol ; 1232: 193-199, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31893410

RESUMO

Measurement of oxyhemoglobin (O2Hb) changes in the cerebral cortex using near-infrared spectroscopy (NIRS) shows that its levels increase during moderate-intensity exercise and persists after exercise. However, the effects of exercise duration on O2Hb persistence in the premotor cortex (PMC) are unknown. We aimed to determine the effects of exercise duration on the persistence of O2Hb changes after moderate-intensity cycling as exercise. Healthy young volunteers were recruited to participate in this study. After a 3-min rest period, the exercise was initiated at a workload corresponding to 50% VO2peak. The exercise continued for 10 min and 20 min, followed by 15 min of rest. The O2Hb levels in the right (R-PMC) and left premotor cortices (L-PMC) were measured using an NIRS system. The O2Hb values during the 15-min post-exercise rest period in the R-PMC were 0.010 ± 0.011 mM·cm after the 10-min exercise and 0.035 ± 0.010 mM·cm after the 20-min exercise, without significant differences (p = 0.104). The O2Hb value in the L-PMC during post-exercise rest (0.055 ± 0.010 mM·cm) after the 20-min exercise was significantly higher than that after the 10-min exercise (0.023 ± 0.007 mM·cm; p = 0.014). Thus, the effects of exercise duration on O2Hb persistence have laterality in the PMC.


Assuntos
Exercício , Córtex Motor , Consumo de Oxigênio , Oxiemoglobinas , Espectroscopia de Luz Próxima ao Infravermelho , Adulto , Feminino , Humanos , Masculino , Córtex Motor/metabolismo , Oxiemoglobinas/metabolismo , Fatores de Tempo , Adulto Jovem
2.
Adv Exp Med Biol ; 1232: 201-207, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31893411

RESUMO

Our previous research confirmed that patients with malignant hematopoietic disease already had a low hemoglobin level before allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, no study has determined whether a correlation exists between exercise load, hemoglobin level, and muscle oxygen saturation (SmO2), during exercise. Therefore, the purpose of this study was to investigate whether near-infrared spectroscopy (NIRS)-derived SmO2 is associated with exercise load, as determined by a dynamometer, before allo-HSCT. This study included 19 male patients who received allo-HSCT in Hyogo College of Medicine Hospital (Japan) between November 2009 and October 2012. Patients performed isometric repeated dorsiflexion at 50% maximum voluntary contraction for 180 s to determine exercise load, and SmO2 was evaluated during exercise at the same time using NIRS (BOM-L1TRW, Omega Wave, Inc., Japan). The hemoglobin level was also evaluated before allo-HSCT. Patients with hematopoietic disease before allo-HSCT already had a low hemoglobin level. There was a significant correlation between exercise load and ∆SmO2; however, the hemoglobin level was not correlated with exercise load. In these patients, exercise load might be affected by muscle oxygen consumption rather than by the hemoglobin level. This finding shows that NIRS can used to assess fatigue in patients with malignant hematopoietic disease.


Assuntos
Exercício , Doenças Hematológicas , Neoplasias Hematológicas , Hemoglobinas , Músculo Esquelético , Consumo de Oxigênio , Doenças Hematológicas/metabolismo , Doenças Hematológicas/fisiopatologia , Neoplasias Hematológicas/metabolismo , Neoplasias Hematológicas/fisiopatologia , Hemoglobinas/metabolismo , Humanos , Japão , Masculino , Músculo Esquelético/metabolismo , Oxigênio/metabolismo
3.
Adv Exp Med Biol ; 1232: 209-214, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31893412

RESUMO

Cognitive function is reported to improve by moderate aerobic exercise. However, the effects of intermittent exercise with rest between the moderate-intensity exercise are unclear. Therefore, this study aimed to compare the effects of continuous and intermittent exercise on cerebral oxygenation and cognitive function. This study included 18 healthy adults. For the continuous exercise protocol, 5 min of rest was followed by 30 min of exercise; 5 min of rest was allowed after each exercise. For the intermittent exercise protocol, 3 sets of 10 min of exercise were completed, with 5 min of rest between the sets. Exercise intensity was 50% of maximum oxygen uptake. Oxyhemoglobin (O2Hb) in the prefrontal cortex (PFC) was measured during each protocol, and cognitive tasks (Stroop test) were performed before and after exercise. O2Hb levels for the left and right PFCs were significantly higher post-exercise than pre-exercise for both exercise protocols (p < 0.01). The average reaction time in the Stroop test was significantly shorter post-exercise than pre-exercise for both protocols (p < 0.01). There was no significant difference in the error rate pre- and post-exercise for both protocols (continuous p = 0.22; intermittent p = 0.44). There was no significant difference between both protocols in all measurement results (O2Hb: p = 0.67; average reaction time p = 0.50; error rate p = 0.24). O2Hb was higher and average reaction time was shorter after exercise than before exercise for both exercise protocols. Intermittent and continuous exercise may improve cognitive function to the same degree after exercise.


Assuntos
Cérebro , Cognição , Exercício , Oxigênio , Espectroscopia de Luz Próxima ao Infravermelho , Adulto , Cérebro/metabolismo , Cognição/fisiologia , Humanos , Oxigênio/metabolismo , Consumo de Oxigênio
4.
Adv Exp Med Biol ; 1232: 215-221, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31893413

RESUMO

Patients with hematological malignancy might already have decreased muscle oxygen saturation at rest and exercise capacity before undergoing hematopoietic stem cell transplantation (HSCT). However, to date, no studies have investigated the relationship between exercise capacity and muscle oxygen saturation at rest in these patients. Therefore, purpose of this study was to investigate the relationship between exercise capacity and muscle oxygen-hemoglobin (O2Hb) saturation (SmO2) at rest and patients' hemoglobin level before undergoing HSCT. METHODS: This study included 60 men with hematologic disease who underwent allo-HSCT. Patients performed a 6-minute walk test (6MWT) to determine exercise capacity, and muscle O2Hb saturation at rest was evaluatabed using near-infrared spectroscopy (BOM-L1TRW, Omegawave Inc., Japan); hemoglobin levels in hematological malignancy patients before undergoing HSCT were also evaluated. RESULTS: There was a significant correlation between the 6MWT and muscle O2Hb saturation at rest in hematological malignancy patients (p < 0.05). Additionally, the 6MWT was significantly correlated to the hemoglobin level (p < 0.05). Furthermore, muscle O2Hb saturation at rest was significantly related to hemoglobin level (p < 0.05). CONCLUSION: In patients with hematological malignancy, a relationship exists between exercise capacity, muscle O2Hb saturation, and hemoglobin level before they undergo HSCT. Therefore, rehabilitation staff, nurses, and physicians should recognize these relationships in patients who undergo allo-HSCT. Moreover, physiotherapists may need to promote muscle oxidative metabolism through exercise to increase exercise capacity in these patients.


Assuntos
Tolerância ao Exercício , Transplante de Células-Tronco Hematopoéticas , Hemoglobinas , Músculo Esquelético , Adolescente , Adulto , Hemoglobinas/metabolismo , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/metabolismo , Adulto Jovem
5.
Adv Exp Med Biol ; 1232: 231-237, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31893415

RESUMO

Near-infrared spectroscopy (NIRS) during cardiopulmonary exercise test (CPX) has shown a correlation between prefrontal cortex (PFC) oxygenated hemoglobin (O2Hb) level and negative affective responses. We hypothesized that O2Hb changes differ between the PFC and motor-related areas. This study investigated changes in hemoglobin levels in the PFC and motor-related areas during CPX. Twelve young healthy adults participated in this study. They performed a CPX after 4 min of rest and 4 min of warming up. Cortical O2Hb, deoxygenated hemoglobin (HHb), and total hemoglobin (THb) levels were measured with NIRS during CPX. Regions of interest (ROI) were the PFC, premotor area (PMA), supplementary motor area (SMA), and primary motor cortex (M1). The anaerobic threshold (AT), respiratory compensation (RC), and peak oxygen uptake (Peak) points were determined. The rest, AT, RC and Peak points of O2Hb, HHb, and THb were averaged over 5 s; hemoglobin slopes, from RC to the Peak points, were calculated to compare functional changes in cortical oxygenation. Average values of O2Hb, HHb, and THb in each ROI were compared among the rest, AT, RC, and Peak points. Average values of hemoglobin slopes, from RC to Peak points, were compared among ROIs using Bonferroni multiple comparisons. The HHb of all ROIs significantly increased at Peak point, compared with at the AT point. THb of the PFC, PMA, and SMA significantly increased at the RC or Peak points, compared with at the rest point. Hemoglobin slopes, from RC to Peak, showed no significant differences among ROIs. Each ROI exhibited similar changes, regardless of cortical function.


Assuntos
Córtex Motor , Oxigênio , Córtex Pré-Frontal , Espectroscopia de Luz Próxima ao Infravermelho , Adulto , Teste de Esforço , Feminino , Humanos , Masculino , Córtex Motor/metabolismo , Oxigênio/metabolismo , Consumo de Oxigênio , Oxiemoglobinas/metabolismo , Córtex Pré-Frontal/metabolismo , Adulto Jovem
6.
J Clin Med Res ; 11(12): 834-841, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31803328

RESUMO

Background: Intensive care unit-acquired weakness (ICU-AW) can be diagnosed using the Medical Research Council (MRC) score. However, such scoring may not be possible in ICU patients who may be sedated or delirious or have encephalopathy. Currently, a quantitative assessment of the cross-sectional area of the muscle is available to assess changes in skeletal muscle mass using computed tomography (CT) images. This assessment calculates the skeletal muscle index (SMI) (cm2/m2) by dividing the cross-sectional area (cm2) of the skeletal muscle at the level of the third lumbar vertebra by the square of the patient's height (m2) on CT. This study assessed the effectiveness of SMI, as measured by abdominal CT scans, in predicting the onset of ICU-AW in patients with sepsis admitted to the ICU. Methods: We examined septic ICU patients admitted to the Niigata University Hospital ICU during 2012 - 2017 under mechanical ventilation. Patients were retrospectively divided into two groups by MRC score at ICU discharge: group AW comprised patients with an MRC score < 48, and group non-AW (NAW) comprised the remaining patients. Clinicopathological factors at ICU admission such as age, gender, underlying disease, body mass index, and SMI were compared between the two groups. Statistical analyses were performed using the Mann-Whitney U test, Fisher's exact test, receiver operator characteristic (ROC) analysis and multivariate analysis. Results: A total of 31 septic patients were examined, and 23 patients met the criteria for ICU-AW. The prevalence of women was significantly higher in group AW (P < 0.05). All clinical factors, except for gender, were not significantly different between the two groups. SMI was significantly lower in group AW than in group NAW (P < 0.05). ROC analysis revealed that the cut-off value of SMI for predicting ICU-AW was 44.1, and the multivariate analysis revealed that only low SMI was a significant factor in predicting ICU-AW (P < 0.05). Conclusions: Our results show that SMI measurement at ICU admission is a valid predictive factor for ICU-AW progression in septic patients.

7.
Respir Physiol Neurobiol ; 274: 103354, 2019 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-31809903

RESUMO

We evaluated the effects of moderate-intensity exercise in improving the decline in cognitive performance induced by a 24-h period of acute sleep deprivation (SD). We hypothesized that the positive effect of exercise is mediated by increased oxygenation (measured using near-infrared spectroscopy) of the dorsolateral prefrontal cortex (DLPFC). Cognitive performance was measured using the reaction time and interference scores of the Stroop colour and word test, in 12 healthy adults (eight males, 21.1 ± 0.3 years-old), at pre- and post-exercise. Cognitive scores were compared under two conditions: rested wakefulness (RW) and 24-h SD. The exercise consisted of 20-min of ergometer cycling at an intensity of 60 % VO2peak. Oxygenation to the DLPFC increased, at 12 min after exercise onset, compared to the baseline and was maintained until the end of the exercise in both RW and SD conditions (P < 0.01). The change in RT correlated with sleepiness (P < 0.05), with no correlation for the interference score and oxygenation. Taken together, moderate-intensity exercise reverses SD-induced cognitive decline.

8.
J Phys Ther Sci ; 31(10): 790-794, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31645808

RESUMO

[Purpose] It is important to accurately measure one-repetition maximum to determine the training load and number of repetitions. However, huge and expensive equipment, such as a torque machine and/or dynamometer, is needed to measure one-repetition maximum. Therefore, a more accessible and affordable method has been developed to predict one-repetition maximum. In this study, we aimed to investigate whether one-repetition maximum of the knee extensor could be predicted more accurately with a combination of muscle strength, measured using a handheld dynamometer, muscle thickness, and thigh circumference. [Participants and Methods] Participants were sixty-four non-athletic healthy adult volunteers (33 males and 31 females). Muscle strength of the knee extensor measured using one-repetition maximum, maximal voluntary isometric contraction measured using a handheld dynamometer, muscle thickness of the quadriceps and/or thigh circumference measured on ultrasonography. [Results] The stepwise regression analysis revealed that body mass, gender, muscle thickness at 15 cm above the patella, and maximal voluntary isometric contraction were the significant and independent determinants (R2=0.813). [Conclusion] One-repetition maximum could be predicted more accurately with a combination of maximal voluntary isometric contraction measured using a handheld dynamometer and muscle thickness.

9.
Clin Biomech (Bristol, Avon) ; 69: 28-33, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31288138

RESUMO

BACKGROUND: Cancer survivors experience late and long-term effects of treatment; also, the disease itself might be responsible for persisting functional impairments. The purpose of this study was to investigate muscle strength, balance function using the Mini-Balance Evaluation Systems Test and Timed Up and Go test with single and cognitive dual tasks and body sway in breast cancer survivors and healthy women and non-breast cancer survivors and healthy participants. METHODS: Twenty-six cancer survivors and 19 healthy participants were assessed for grip and knee extension strength with the Mini-Balance Evaluation Systems Test, Timed Up and Go, and body sway test performance. FINDINGS: Breast cancer survivors had significantly lower hand grip strength (p < .05) and Mini-Balance Evaluation Systems Test scores than healthy women (p < .05). Additionally, in breast cancer survivors, hand grip strength had a significant relationship with Mini-Balance Evaluation Systems Test and Timed Up and Go scores (p < .05) but had no relationship with the total center of pressure length. Hand grip strength and Mini-Balance Evaluation Systems Test scores were not significantly different in non-breast cancer survivors and healthy participants. In non-breast cancer survivors, knee extension strength had a significant relationship with the Timed Up and Go scores (p < .05). INTERPRETATION: The relationship between muscle strength and balance function may be characterized by the different diagnoses in cancer survivors. The current findings showed the changes in balance function and muscle strength among cancer survivors.

10.
PM R ; 2019 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-31222952

RESUMO

OBJECTIVE: Evaluate Functional Independence Measure (FIM) changes and incidence of serious medical complications requiring return to the primary acute care service of acute rehabilitation cancer inpatients with leptomeningeal disease (LMD). DESIGN: Retrospective chart review. SETTING: Tertiary referral based comprehensive cancer center acute inpatient rehabilitation unit. PARTICIPANTS: Thirty cancer patients admitted to acute inpatient rehabilitation between 8 January 2014 and 8 August 2018 with pathology confirmed LMD within 6 months. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: FIM and incidence of return to the primary acute care service. RESULTS: Twenty five of 30 (83.3%) patients were noted to have neurologic impairments and 13/30 (43.3%) were noted to have cognitive impairments. Five of 30 patients (16.7%) received intrathecal chemotherapy and 4/30 (13.3%) received radiation during acute inpatient rehabilitation for LMD treatment. Median days in acute care prior to acute inpatient rehabilitation was 22.5. Median days from acute inpatient rehabilitation admission until death of the 23 deceased patients as of 1 January 2019 was 180.00. Twenty of 30 (66.7%) patients were discharged home, 9/30 (30%) transferred to the primary acute care service, and 1/30 (3.3%) discharged to a skilled nursing facility. Reasons for return to the primary acute care service included additional chemotherapy 3/9 (33%), neurologic decline 2/9 (22%), fever 2/9 (22%), altered mental status 1/9 (11%), and progressive polyarthritis 1/9 (11%). Of the 21 patients who completed acute inpatient rehabilitation without return to the primary acute care service, mean FIM subscore changes from admission to discharge for Activities of Daily Living, Mobility, and Motor were 5.1 (P < .001), 4.8 (P < .001) and 11.7 (P < .001), respectively (Wilcoxon signed rank test, significance P < .05). CONCLUSION: LMD patients who completed acute inpatient rehabilitation made statistically significant improvements on the majority of FIM items. Most patients were discharged home. Our data suggest LMD should not be a reason for exclusion from acute inpatient rehabilitation. LEVEL OF EVIDENCE: III.

11.
J Int Soc Phys Rehabil Med ; 2(1): 54-61, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31131374

RESUMO

Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is increasingly used in the treatment of hematologic cancers such as leukemias, lymphomas, and myeloma, and for other hematologic disorders such as primary immunodeficiency, aplastic anemia, and myelodysplasia. Allo-HSCT entails a conditioning regimen of frequent high-dose chemotherapy in combination with total body irradiation, followed by infusion of donor-harvested bone marrow or peripheral blood stem cells. As an aggressive and demanding medical therapy that profoundly impacts patient quality of life (QOL), allo-HSCT is associated with numerous treatment-related physical, psychological, and psychosocial side effects. The procedure can result in decreased respiratory and balance function, skeletal muscle strength, and exercise capacity. Thus, as physical exercise has been shown to positively effect physical and psychosocial function and QOL in allo-HSCT patients, it is a recommended intervention for improving essential functions and offsetting lost exercise capacity after the procedure. Furthermore, recent evidence has shown that physical exercise can influence survival rate and mortality in allo-HSCT patients. This review provides an overview of the current research on the effectiveness of physical exercise for allo-HSCT patients.

12.
Support Care Cancer ; 27(11): 4107-4113, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30788627

RESUMO

PURPOSE: According to reports, patients with lung cancer have decreased pulmonary function and exercise capacity after surgery. However, to date, physical function and health-related quality of life (HRQOL) after surgery for malignant pleural mesothelioma (MPM) have not been evaluated in detail in the convalescent phase. This study aimed to assess physical function and HRQOL of MPM patients following pleurectomy/decortication (P/D) in the convalescent phase. METHODS: The study included 16 male MPM patients who underwent P/D between September 2014 and August 2016. Physical function was assessed based on handgrip and knee extensor strengths, the six-minute walk distance (6MWD), and pulmonary function, including forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). HRQOL was assessed using the Medical Outcome Study 36-item Short Form Health Survey (SF-36). The assessment was performed preoperatively, postoperatively, and 1-year after surgery. RESULTS: The 6MWD, FVC, and FEV1 values 1-year postoperatively improved significantly compared with baseline (P < 0.05 all). Additionally, the scores of six of the eight SF-36 domains were significantly improved 1 year after P/D: physical functioning, body pain, general health, vitality, social functioning, and mental health (all P < 0.05). 6MWD, FVC, and FEV1 were correlated with vitality, mental health, and physical functioning (P < 0.05 all). CONCLUSIONS: Patients with MPM who underwent P/D showed improved physical function and HRQOL compared with postoperative values in the convalescent phase. Physicians, nurses, and rehabilitation staff should note these findings, which may provide insight into the development of customized rehabilitation strategies in the convalescent phase for such patients.


Assuntos
Neoplasias Pulmonares/psicologia , Mesotelioma/psicologia , Neoplasias Pleurais/psicologia , Qualidade de Vida/psicologia , Adulto , Idoso , Feminino , Humanos , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Masculino , Mesotelioma/patologia , Mesotelioma/cirurgia , Pessoa de Meia-Idade , Neoplasias Pleurais/patologia , Neoplasias Pleurais/cirurgia
13.
Expert Rev Cardiovasc Ther ; 17(2): 135-142, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30569775

RESUMO

INTRODUCTION: The American College of Sports Medicine and American Heart Association recommends resistance training involving 60-70% of 1-repetition maximum (1RM) for 8-12 repetitions on 2 or 3 nonconsecutive days per week for the elderly. The Borg 6-20 scale, Borg category ratio (CR-10) scale, and OMNI scale are used to determine the rating of perceived exertion (RPE) for resistance training. Areas covered: RPE scales for resistance training performed by elderly individuals are described. The RPE has been related to resistance training intensity, and the RPE scale was used to determine the resistance training intensity of elderly or ill individuals. Expert commentary: RPE scales can determine the resistance training intensity of elderly individuals and may be used at home or in nursing homes, if they do not have specific resistance training machines. RPE is simple and useful, and may improve skeletal muscle strength or other health-related issues.


Assuntos
Esforço Físico/fisiologia , Treinamento de Resistência/métodos , Idoso , American Heart Association , Humanos , Percepção , Estados Unidos
14.
Brain Sci ; 8(11)2018 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-30360469

RESUMO

Gazing at objects at a near distance (small eye-object distance) can reduce body sway. However, whether body sway is regulated by movement in the mediolateral or anteroposterior direction remains unclear. Galvanic vestibular stimulation (GVS) can induce body tilting in the mediolateral or anteroposterior direction. This study examined the directionality of the eye-object distance effect, using body-tilting GVS manipulations. Ten healthy subjects (aged 21.1 ± 0.3 years) stood on a force plate covered with a piece of foamed rubber and either closed their eyes or gazed at a marker located 0.5 m, 1.0 m, or 1.5 m in front of them. The GVS polarities were set to evoke rightward, forward, and backward body tilts. To compare the effects of eye-object distance in the mediolateral and anteroposterior directions, the root mean square (RMS) of the center of pressure (COP) without GVS was subtracted from the COP RMS during GVS. For swaying in the mediolateral direction, significant visual condition-related differences were found during rightward and forward GVS (p < 0.05). Thus, reductions in mediolateral body sway are more evident for smaller eye-object distances during rightward GVS. It would be appropriate to use body-tilting GVS to detect the directionality of the eye-object distance effect.

15.
Adv Exp Med Biol ; 1072: 127-131, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30178334

RESUMO

Aerobic exercise produces changes in cerebral oxyhaemoglobin (O2Hb) concentration; however, the effects of exercise on O2Hb during the post-exercise period remain to be established. The aim of the present study was to evaluate O2Hb levels during and after a 20-min bout of moderate-intensity cycling exercise. After a 3-min rest period, 12 healthy volunteers (9 women, 3 men) cycled for 20 min at an intensity corresponding to 50% of their VO2max, after which they were monitored during a 15-min post-exercise rest period. O2Hb levels in the right (R-PFC) and left prefrontal cortices (L-PFC), right (R-PMA) and left premotor areas (L-PMA), supplementary motor area (SMA), and primary motor cortex (M1) were measured using near-infrared spectroscopy. A one-way repeated-measures analysis of variance (ANOVA) was performed to compare mean pre-exercise O2Hb levels with O2Hb levels during the last 5 min of exercise and the last 5 min of the post-exercise rest period. O2Hb levels increased significantly (p < 0.01) between the pre-exercise rest period and the last 5 min of the exercise session for each region of interest (range: 0.040-0.085 mM·cm). O2Hb levels did not return to pre-exercise values during the 15-min post-exercise rest period. O2Hb levels during the last 5 min of the post-exercise rest period were significantly higher than pre-exercise values in the L-PFC, L-PMA, SMA, and M1 (p < 0.01). Our results indicate that cortical oxygenation persists for at least 15 min following a 20-min bout of moderate-intensity cycling, and that aerobic exercise may facilitate neuroplasticity.


Assuntos
Encéfalo/irrigação sanguínea , Encéfalo/metabolismo , Exercício/fisiologia , Oxiemoglobinas/metabolismo , Teste de Esforço , Feminino , Voluntários Saudáveis , Humanos , Masculino , Consumo de Oxigênio/fisiologia , Oxiemoglobinas/análise , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Adulto Jovem
16.
Adv Exp Med Biol ; 1072: 133-137, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30178335

RESUMO

The purpose of this study was to compare the prefrontal cortex (PFC) oxyhaemoglobin (HbO2) levels observed during cycling in the upright and supine positions. Twelve healthy volunteers were randomly assigned to either the upright or supine position. After measuring maximal oxygen consumption (VO2max) with a cycle ergometer in the upright position, each subject exercised at an intensity corresponding to 50% of the VO2max for 20 min. HbO2 levels in the right PFC (R-PFC) and left PFC (L-PFC) were measured using near-infrared spectroscopy. The R-PFC HbO2 level measured within the 6-20-min window in the supine position was significantly higher than that in the upright position (0.072 ± 0.015 vs. 0.038 ± 0.013 mM·cm, respectively; p < 0.01). No significant effects were observed in the L-PFC. The laterality index for the supine position was significantly higher than that for the upright position (0.385 ± 0.181 vs. -0.272 ± 0.271, respectively; p < 0.05). Our results suggest that moderate-intensity cycling in the supine position increases R-PFC oxygenation.


Assuntos
Teste de Esforço/métodos , Exercício/fisiologia , Consumo de Oxigênio/fisiologia , Postura/fisiologia , Córtex Pré-Frontal/irrigação sanguínea , Feminino , Humanos , Masculino , Córtex Pré-Frontal/metabolismo , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Decúbito Dorsal , Adulto Jovem
17.
Adv Exp Med Biol ; 1072: 287-291, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30178360

RESUMO

Impaired oxygen utilization in skeletal muscle potentially contributes to muscle weakness in patients with malignant hematopoietic disease and may explain altered hemodynamic responses to exercise in these patients. We investigated whether changes in hemoglobin parameters in the tibialis anterior muscle in patients with malignant hematopoietic diseases were different from those in age-matched healthy controls and whether these results were associated with a decline in muscle strength. Near-infrared spectroscopy was used during and after a repeated isometric contraction task at 50% of maximal voluntary contraction in 16 patients and 21 age- and sex-matched healthy controls. In the healthy control group, there was a correlation between muscle strength and hemoglobin dynamics, (ΔtHbmean: r = 0.42, p < 0.05; ΔtHbmax: r = 0.575, p < 0.01, respectively) but not in patients with malignant hematopoietic disease. The results of this study may suggest that haemoglobin dynamics during and following exercise were different between patients with malignant hematopoietic disease and healthy controls.


Assuntos
Neoplasias Hematológicas/metabolismo , Hemoglobinas/metabolismo , Músculo Esquelético/metabolismo , Adulto , Humanos , Masculino , Contração Muscular/fisiologia , Força Muscular/fisiologia
18.
Adv Exp Med Biol ; 1072: 293-298, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30178361

RESUMO

The purpose of this study was to compare the differences in fatigue to those in muscle oxygen consumption and blood flow to the skeletal muscles before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study included 25 male patients who had received allo-HSCT between November 2009 and August 2012. Fatigue was assessed by using the Piper fatigue scale. Muscle oxygen consumption, shown by the change in deoxyhemoglobin (ΔHHb), and blood flow to the skeletal muscle, shown by the change in total hemoglobin (ΔtHb), were measured non-invasively in the tibialis anterior muscle during endurance exercise using near-infrared spectroscopy. ΔHHb and ΔtHb were significantly lower following allo-HSCT than before it (p < 0.05). Before allo-HSCT, no relationship was observed between fatigue and either ΔHHb or ΔtHb. However, after allo-HSCT, a significant relationship was found between fatigue and ΔHHb (p < 0.05). Patients experience decreased muscle oxygen consumption and blood flow to skeletal muscles after allo-HSCT. Furthermore, fatigue may have a relationship with decreased muscle oxygen consumption in patients after allo-HSCT. Rehabilitation staff, nurses, and physicians should recognise both decreases in muscle oxygen consumption and blood flow in patients who have undergone allo-HSCT, and physiotherapists may need to promote muscle oxidative metabolism through exercise in order to maintain muscle strength.


Assuntos
Fadiga/etiologia , Neoplasias Hematológicas/terapia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Músculo Esquelético/irrigação sanguínea , Músculo Esquelético/metabolismo , Adulto , Hemoglobinas/análise , Humanos , Masculino , Consumo de Oxigênio/fisiologia , Transplante Homólogo
19.
Integr Cancer Ther ; 17(4): 1144-1149, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30043664

RESUMO

Older adults who have survived cancer experience significantly more falls compared with healthy adults. Adult cancer survivors may also have a lower balance function than healthy adults. We examined muscle strength and balance function among 19 cancer survivors and 14 healthy subjects. The mean age of the cancer survivors was 51.5 ± 11.2 years; 6 men and 13 women. Cancer diagnoses included breast cancer, retroperitoneal sarcoma, acute leukemia, lung cancer, colorectal cancer, thyroid cancer, Ewing's sarcoma, and tongue cancer. The mean age of healthy subjects was 47.4 ± 14 years; 3 men, 11 women. Muscle strength was assessed using hand grip and knee extensor strength tests. Balance function was evaluated using the Timed Up and Go (TUG) test, and body sway was tested using a force platform. No significant differences were found with respect to right and left grip strength or right and left knee extension strength between the 2 groups. A significantly higher TUG time was observed in cancer survivors than in healthy subjects ( P < .05). With eyes open, the area of the center of pressure was significantly larger in cancer survivors than in healthy subjects ( P < .05). Similarly, the length per area was significantly lower both with eyes open and closed for cancer survivors than for healthy subjects ( P < .05). TUG was significantly correlated with muscle strength in both groups ( P < .05). However, no body sway parameters were related to muscle strength in either group. Cancer survivors had lower balance function that might not have been related to muscle strength. Cancer survivors should be evaluated for balance function as there is a potential for impairment. The findings of this study will be relevant for planning the prevention of falls for cancer survivors.


Assuntos
Neoplasias/fisiopatologia , Equilíbrio Postural/fisiologia , Acidentes por Quedas/prevenção & controle , Sobreviventes de Câncer , Feminino , Força da Mão/fisiologia , Voluntários Saudáveis , Humanos , Joelho/fisiopatologia , Masculino , Pessoa de Meia-Idade , Força Muscular/fisiologia , Projetos Piloto , Qualidade de Vida
20.
Curr Phys Med Rehabil Rep ; 6(2): 115-120, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29868247

RESUMO

Neurologic tumors account for over 50% of American acute inpatient rehabilitation facility cancer admissions. WHO Grade IV astrocytoma (also known as glioblastoma multiforme, high grade glioma or GBM) is the most common primary brain tumor in adults and is invariably fatal. The majority of primary brain tumor patients experience neurologic deficits. However, under-referral from oncology to rehabilitation has been reported. This brief narrative review article covers functional, medical and regulatory considerations when rehabilitating brain tumor inpatients.

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