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3.
Semin Thorac Cardiovasc Surg ; 30(4): 454-455, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30244139
4.
World J Pediatr Congenit Heart Surg ; 9(4): 412-418, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29945509

RESUMO

BACKGROUND: There are no reliable markers to assess brain injury in neonates following cardiac surgery. We examine ubiquitin C-terminal hydrolase 1 (UCHL1) and phosphorylated axonal neurofilament heavy chain (pNF-H), neuronal-specific biomarkers released following axonal and cortical injury, in neonates undergoing cardiac surgery involving cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA). METHODS: Twenty-six patients younger than three months were prospectively enrolled (CPB only, n = 12 and DHCA, n = 14). Healthy newborns (n = 22) served as the control. Blood samples were collected preoperatively and postoperatively upon intensive care unit admission (hour 0) and subsequently at 12, 24, 36, and 48 hours. Serum was tested for UCHL1 and pNF-H using enzyme-linked immunosorbent assay. Concomitant arterial blood gas, lactate, and cerebral near-infrared spectroscopy (NIRS) monitoring were performed. RESULTS: Ubiquitin C-terminal hydrolase 1 showed a significant rise at 0 hours in the DHCA group compared to baseline (74.9 ± 13.7 pg/mL vs 33.9 ± 37.3 pg/mL, P < .0001). Levels returned to baseline at 12 hours. There was an early rise in UCHL1 at 0 hours in the CPB group, P = .09. Phosphorylated axonal neurofilament heavy chain was decreased at 0 hours in both the CPB and DHCA groups compared to baseline, P = .06. There was no difference between control and baseline levels of UCHL1 ( P = .9) or pNF-H ( P = .77). Decreased NIRS was observed in the DHCA group at 0 hours (57.3 ± 10.5) versus baseline (64.2 ± 12.3), but not significant ( P = .21). There was no correlation between biomarkers and NIRS at 0 hours. CONCLUSION: A rapid rise in UCHL1 levels was observed in the DHCA group, suggesting that it may be a marker for acute brain injury. Follow-up with neurodevelopmental studies is ongoing.


Assuntos
Lesões Encefálicas/diagnóstico , Ponte Cardiopulmonar , Parada Circulatória Induzida por Hipotermia Profunda , Proteínas de Neurofilamentos/sangue , Complicações Pós-Operatórias/diagnóstico , Ubiquitina Tiolesterase/sangue , Biomarcadores/sangue , Lesões Encefálicas/sangue , Lesões Encefálicas/etiologia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Projetos Piloto , Complicações Pós-Operatórias/sangue , Estudos Prospectivos , Espectroscopia de Luz Próxima ao Infravermelho
7.
World J Pediatr Congenit Heart Surg ; 8(2): 189-195, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28329461

RESUMO

BACKGROUND: Repair of complete atrioventricular canal (CAVC) with tetralogy of Fallot (TOF) is a challenging operation increasingly being performed as a complete, primary repair in infancy. Previous studies have focused on perioperative outcomes; however, midterm valve function, ventricular function, and residual obstruction have received little attention. METHODS: We retrospectively reviewed 20 patients who underwent CAVC/TOF repair (January 2005 to December 2014). A two-patch repair was used in all patients to correct the CAVC defect. Tetralogy of Fallot repair included transannular patch in 11 (65%) patients and valve-sparing in 6 (35%) patients. RESULTS: The average age at surgery was 72 ± 122 weeks, 40% were male, and 80% had trisomy 21. Mean echo follow-up was 3.0 ± 3.0 years. There were no in-hospital or late mortalities. The rate of reoperation was 20%. At the latest follow-up, moderate left atrioventricular valve regurgitation was present in three (15%) patients and mild stenosis present in seven (35%) patients. One (5%) patient had moderate right ventricular outflow tract (RVOT) obstruction. The valve-sparing population was smaller at the time of surgery than the non-valve-sparing cohort (body surface area: 0.28 ± 0.04 vs 0.42 ± 0.11, P = .002) and less likely to have had a previous shunt (0% vs 64%, P = .01). Among the valve-sparing patients (six), at the latest follow-up, moderate pulmonary insufficiency was present in two (33%) patients. CONCLUSION: Repair of CAVC concomitant with TOF can be performed with low mortality and acceptable perioperative morbidity. Management of the RVOT remains a challenge for the long term.


Assuntos
Procedimentos Cirúrgicos Cardíacos/métodos , Ventrículos do Coração/fisiopatologia , Insuficiência da Valva Mitral/cirurgia , Insuficiência da Valva Pulmonar/cirurgia , Tetralogia de Fallot/cirurgia , Função Ventricular/fisiologia , Pré-Escolar , Ecocardiografia , Feminino , Defeitos dos Septos Cardíacos , Ventrículos do Coração/diagnóstico por imagem , Humanos , Lactente , Masculino , Insuficiência da Valva Mitral/diagnóstico , Insuficiência da Valva Mitral/fisiopatologia , Insuficiência da Valva Pulmonar/diagnóstico , Insuficiência da Valva Pulmonar/fisiopatologia , Estudos Retrospectivos , Tetralogia de Fallot/diagnóstico , Tetralogia de Fallot/fisiopatologia , Fatores de Tempo , Resultado do Tratamento
8.
Echocardiography ; 34(5): 802-804, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28317159

RESUMO

Rapid prototyping may be beneficial in properly selected cases of complex congenital heart disease, providing detailed anatomical understanding that helps to guide potential surgical and cardiac catheterization interventions. We present a case of double-outlet right ventricle, where the decision to obtain a three-dimensional printed model helped for better understanding of the anatomy, with the additional advantage of surgical simulation in planning the surgical approach and type of surgical repair.


Assuntos
Dupla Via de Saída do Ventrículo Direito/patologia , Dupla Via de Saída do Ventrículo Direito/cirurgia , Ventrículos do Coração/anormalidades , Ventrículos do Coração/cirurgia , Modelos Anatômicos , Modelos Cardiovasculares , Impressão Tridimensional , Desenho Assistido por Computador , Dupla Via de Saída do Ventrículo Direito/diagnóstico , Desenho de Equipamento , Ventrículos do Coração/diagnóstico por imagem , Humanos , Imageamento Tridimensional/métodos , Cuidados Pré-Operatórios
9.
J Thorac Cardiovasc Surg ; 153(6): 1501-1502, 2017 06.
Artigo em Inglês | MEDLINE | ID: mdl-28087108
10.
Cardiol Young ; 27(3): 418-426, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27161562

RESUMO

BACKGROUND: It is still thought by some that a common wall is to be found in the normal heart between the attachments of the caval and pulmonary veins, with absence of this wall underscoring the presence of sinus venosus defects. Recent findings using episcopic microscopy in developing mice have shown the deficiencies of this notion. Understanding that the superior rim of the oval fossa is a fold, rather than a true septum, which can be distorted in the presence of partially anomalous pulmonary venous drainage, has provided an alternative explanation for the morphogenesis of sinus venosus defects. METHODS: We reviewed our experience with patients suspected of having a sinus venosus defect from August, 2011, through October, 2015, analysing the findings in light of the current hypotheses used to explain the development of the defects, along with correlations made by inspection of autopsy specimens. RESULTS: We evaluated findings from 16 patients, with a mean age of 7.7 years, ranging from 2.7 to 15 years. Of the group, 13 were ultimately diagnosed with a superior sinus venosus defect, two with an inferior defect, and one with isolated anomalous pulmonary venous connection in the absence of an interatrial communication. Initially, two patients were thought to have oval fossa defects, one from each subtype, but were correctly diagnosed following cardiac magnetic resonance interrogation. Anomalous pulmonary venous connections were present in all cases. CONCLUSION: Appreciation of the changes occurring during normal cardiac development helps in understanding the anatomical substrate underscoring the spectrum of sinus venosus defects. The lesions are veno-venous connections due to partially anomalous pulmonary venous connections, producing interatrial communications outside the confines of the interatrial septum.


Assuntos
Anormalidades Múltiplas , Comunicação Interatrial/diagnóstico , Veias Pulmonares/anormalidades , Malformações Vasculares/diagnóstico , Veia Cava Superior/anormalidades , Adolescente , Criança , Pré-Escolar , Ecocardiografia Transesofagiana , Feminino , Humanos , Masculino , Veias Pulmonares/diagnóstico por imagem , Estudos Retrospectivos , Veia Cava Superior/diagnóstico por imagem
11.
Pediatr Cardiol ; 38(1): 103-114, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27837304

RESUMO

Rapid prototyping facilitates comprehension of complex cardiac anatomy. However, determining when this additional information proves instrumental in patient management remains a challenge. We describe our experience with patient-specific anatomic models created using rapid prototyping from various imaging modalities, suggesting their utility in surgical and interventional planning in congenital heart disease (CHD). Virtual and physical 3-dimensional (3D) models were generated from CT or MRI data, using commercially available software for patients with complex muscular ventricular septal defects (CMVSD) and double-outlet right ventricle (DORV). Six patients with complex anatomy and uncertainty of the optimal management strategy were included in this study. The models were subsequently used to guide management decisions, and the outcomes reviewed. 3D models clearly demonstrated the complex intra-cardiac anatomy in all six patients and were utilized to guide management decisions. In the three patients with CMVSD, one underwent successful endovascular device closure following a prior failed attempt at transcatheter closure, and the other two underwent successful primary surgical closure with the aid of 3D models. In all three cases of DORV, the models provided better anatomic delineation and additional information that altered or confirmed the surgical plan. Patient-specific 3D heart models show promise in accurately defining intra-cardiac anatomy in CHD, specifically CMVSD and DORV. We believe these models improve understanding of the complex anatomical spatial relationships in these defects and provide additional insight for pre/intra-interventional management and surgical planning.


Assuntos
Dupla Via de Saída do Ventrículo Direito/diagnóstico por imagem , Comunicação Interventricular/diagnóstico por imagem , Coração/diagnóstico por imagem , Imagem por Ressonância Magnética/métodos , Tomografia Computadorizada por Raios X/métodos , Procedimentos Cirúrgicos Cardíacos/métodos , Criança , Pré-Escolar , Tomada de Decisões , Dupla Via de Saída do Ventrículo Direito/cirurgia , Feminino , Coração/anatomia & histologia , Comunicação Interventricular/cirurgia , Humanos , Imageamento Tridimensional/métodos , Lactente , Masculino , Modelos Anatômicos , Impressão Tridimensional
12.
Cardiol Young ; 27(2): 377-380, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27869052

RESUMO

Rapid prototyping is quickly gaining utility in various complex forms of CHD. In properly selected cases, these printed models provide detailed anatomical understanding that help guide potential surgical and cardiac catheterisation interventions. We present a case of a tunnel-like ventricular septal defect referred for surgical repair, where the decision to obtain a three-dimensional printed model helped in better understanding of the anatomy, leading to delaying, and hopefully avoiding altogether, surgical repair.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Tomada de Decisões , Gerenciamento Clínico , Comunicação Interventricular/diagnóstico , Modelos Anatômicos , Impressão Tridimensional , Cateterismo Cardíaco , Ecocardiografia , Comunicação Interventricular/cirurgia , Humanos , Recém-Nascido , Tomografia Computadorizada por Raios X
14.
Ann Pediatr Cardiol ; 9(2): 115-9, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27212844

RESUMO

BACKGROUND: Bacterial infection (BI) after congenital heart surgery (CHS) is associated with increased morbidity and is difficult to differentiate from systemic inflammatory response syndrome caused by cardiopulmonary bypass (CPB). Procalcitonin (PCT) has emerged as a reliable biomarker of BI in various populations. AIM: To determine the optimal PCT threshold to identify BI among children suspected of having infection following CPB. SETTING AND DESIGN: Single-center retrospective observational study. MATERIALS AND METHODS: Medical records of all the patients admitted between January 2013 and April 2015 were reviewed. Patients in the age range of 0-21 years of age who underwent CHS requiring CPB in whom PCT was drawn between postoperative days 0-8 due to suspicion of infection were included. STATISTICAL ANALYSIS: The Wilcoxon rank-sum test was used for nonparametric variables. The diagnostic performance of PCT was evaluated using a receiver operating characteristic (ROC) curve. RESULTS: Ninety-eight patients were included. The median age was 2 months (25th and 75th interquartile of 0.1-7.5 months). Eleven patients were included in the BI group. The median PCT for the BI group (3.42 ng/mL, 25th and 75th interquartile of 2.34-5.67) was significantly higher than the median PCT for the noninfected group (0.8 ng/mL, 25th and 75th interquartile 0.38-3.39), P = 0.028. The PCT level that yielded the best compromise between the sensitivity (81.8%) and specificity (66.7%) was 2 ng/mL with an area under the ROC curve of 0.742. CONCLUSION: A PCT less than 2 ng/mL makes BI unlikely in children suspected of infection after CHS.

15.
Artigo em Inglês | MEDLINE | ID: mdl-27060040

RESUMO

Anomalous aortic origin of the coronary artery (AAOCA) from the opposite sinus of Valsalva with an interarterial course has become a high-profile lesion as a result of its association with sudden cardiac death in otherwise young and healthy individuals. Despite our incomplete knowledge of its pathophysiology and natural history, surgical intervention is often recommended. Evidence now shows AAOCA to be relatively common, with lower than previously suspected rates of sudden cardiac death. Analysis of this information reveals that AAOCA is not always a surgical disease. Future multi-institutional studies will continue to define those subgroups best served by observation or surgery.


Assuntos
Anomalias dos Vasos Coronários/cirurgia , Seio Aórtico/anormalidades , Anomalias dos Vasos Coronários/complicações , Anomalias dos Vasos Coronários/diagnóstico por imagem , Morte Súbita Cardíaca/etiologia , Morte Súbita Cardíaca/prevenção & controle , Humanos , Seleção de Pacientes , Stents
18.
Catheter Cardiovasc Interv ; 87(7): 1294-1297, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26514545

RESUMO

We report a case of retrograde transcatheter device closure of a complex paravalvular leak (PVL) after bioprosthetic pulmonary valve replacement (PVR) in a 13-year-old patient with congenital pulmonary valve stenosis. There are prior reports of pulmonary PVL closure after PVR in adults (Seery and Slack, Congenit Heart Dis 2014;9:E19-F22), but indications for and technical considerations in PVL closure after bioprosthetic PVR, particularly in children, are not well defined. © 2015 Wiley Periodicals, Inc.

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