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1.
Rev Esp Anestesiol Reanim ; 67 Suppl 1: 33-38, 2020 May.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-32178910

RESUMO

Postoperative hypertension (HT) is defined as a significant rise in blood pressure (BP) during the immediate postoperative period that can lead to serious neurological, cardiovascular or surgical complications requiring urgent management. In non-cardiac surgery, HT is common and leads to an increase in adverse events, including stroke, injury and myocardial infarction, and bleeding. In certain procedures, such as carotid endarterectomy, aortic aneurysm surgery or intracranial surgery, postoperative HT has specific considerations not present in other surgeries and may be associated with worse neurological outcomes. Among the risk factors for its occurrence is the history of hypertension prior to surgery, although not all episodes of postoperative hypertension correspond to chronic hypertensive patients. In the first hours after surgery, pain, agitation, hypoxemia or bladder distension, among other factors, may contribute to the appearance of hypertension. Although there is no clear consensus on the thresholds and goals of antihypertensive therapy, it is usually initiated when the systolic BP is >180mmHg or the diastolic BP is >110mmHg, especially if it persists after treating possible underlying causes. The use of oral medication in the postoperative period may be limited by the circumstances of the surgery, but also by the slow onset of action of the drugs and the difficulty of controlling the degree of pressure drop. If oral administration of medication is not feasible, we recommend the use of short-acting intravenous drugs. The choice of antihypertensive drug will depend on the clinical situation and conditions of the patient, and should take into account the pharmacokinetic and pharmacodynamic parameters of the different agents available.

2.
Buenos Aires; GCBA. Gerencia Operativa de Epidemiología; 15 nov. 2019. a) f: 13 l:18 p. graf.(Boletín Epidemiológico Semanal: Ciudad Autónoma de Buenos Aires, 4, 169).
Monografia em Espanhol | LILACS, InstitutionalDB, BINACIS, UNISALUD | ID: biblio-1102775

RESUMO

Hasta la Semana Epidemiológica 36 de 2018 se notificaron en la Ciudad de Buenos Aires 104 casos de Chagas congénito, de los cuales se confirmaron 6 (5,8%), se descartaron 6 y el 88% restante aún no cuenta con el cierre de caso. Las comunas del sur de la Ciudad acumulan el 56% de los casos. Durante el primer semestre de 2018 se diagnosticaron en la Maternidad Sardá 67 mujeres con Chagas en el embarazo, de un total de 2972 partos realizados en la institución en ese periodo, lo que representa una prevalencia de 22,54 por cada mil embarazadas En este informe se busca describir la situación de la transmisión vertical de la enfermedad de Chagas en el primer semestre de 2018, entre SE 1 y 26; describir la modalidad de notificación de los casos por la Unidad de Promoción y Protección de la Salud (P y P); y reforzar la importancia de la notificación de Enfermedades de Notificación Obligatoria debido a su relevancia en la Salud Pública. Se presentan los casos de Chagas en embarazo por grupo etario, y según provincia de residencia, y se detallan propuestas para la optimización de resultados.


Assuntos
Doença de Chagas/congênito , Doença de Chagas/transmissão , Doença de Chagas/epidemiologia , Transmissão Vertical de Doença Infecciosa/estatística & dados numéricos , Notificação de Doenças/métodos , Notificação de Doenças/estatística & dados numéricos , Maternidades
5.
Med. intensiva (Madr., Ed. impr.) ; 42(8): 463-472, nov. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-180518

RESUMO

OBJECTIVE: To assess whether patient age is independently associated to Intensive Care Unit (ICU) admission after non-cardiac surgery. DESIGN: An observational cohort study of the Spanish subset of the European Surgical Outcome Study (EuSOS) was carried out. SETTING: Hospitals of the public National Health Care System and private hospitals in Spain. Intervention: None. PATIENTS AND METHODS: All patients over 16 years of age undergoing inpatient non-cardiac surgery in the participating hospitals during a 7-day period in the month of April 2011 were consecutively included. Main variables of interest: ICU admission rate, factors associated with ICU admission and hospital mortality were assessed using logistic regression analysis and fractional polynomial regression. RESULTS: Out of 5412 patients, 677 (12.5%) were admitted to the ICU after surgery. The adjusted odds ratio (95% confidence interval [CI]) for ICU admission was 1.1 (0.8-1.4) for patients aged 65-74 years, 0.7 (0.5-1) for patients aged 75-85 years, and 0.4 (0.2-0.8) for patients over 85 years, respectively. Age, ASA score, grade of surgery (minor, intermediate, major), urgent surgery, surgical specialty, laparoscopic surgery and metastatic disease were independent factors for ICU admission. Global risk-adjusted mortality was 1.4 (95% CI 0.9-2.2). The ASA score, urgent surgery, surgical specialty and diabetes were predictors of hospital mortality. CONCLUSIONS: Elderly patients (over 80 years) appear less likely to be admitted to ICU after non-cardiac surgery in Spanish hospitals. There was no significant association between age and postoperative mortality in this cohort


OBJETIVO: Evaluar si la edad del paciente se asociaba independientemente con el ingreso en la unidad de cuidados intensivos (UCI) tras cirugía no cardiaca. DISEÑO: Estudio observacional de cohortes del subgrupo español del European Surgical Outcome Study (EuSOS). Ámbito: Hospitales públicos y privados en España. Intervención: Ninguna. PACIENTES Y MÉTODOS: Pacientes consecutivos mayores de 16 años sometidos a cirugía no cardiaca con ingreso durante un periodo de 7 días del mes de abril de 2011. Variables de interés principal: Tasa de ingreso en la UCI, factores asociados con ingreso en la UCI y mortalidad hospitalaria, analizadas mediante regresión logística y regresión fraccional polinómica. RESULTADOS: De 5.412 pacientes, 677 (12,5%) fueron ingresados en la UCI tras la cirugía. La odds ratio ajustada (intervalo de confianza [IC] del 95%) de ingreso en la UCI fue de 1,1 (0,8-1,4) para 65-74 años, 0,7 (0,5-1) para 75-85 años y de 0,4 (0,2-0,8) para más de 85 años, respectivamente. La edad, el grado ASA, el grado de la cirugía (menor, intermedia, mayor), la cirugía urgente, la especialidad quirúrgica, la cirugía laparoscópica y la enfermedad metastásica fueron factores independientes de ingreso en la UCI. El riesgo global ajustado de mortalidad fue de 1,4 (IC 95%: 0,9-2,2). El grado ASA, cirugía urgente, especialidad quirúrgica y diabetes fueron predictores de mortalidad hospitalaria. CONCLUSIONES: En los hospitales españoles, los pacientes ancianos (más de 80 años) son menos propensos a ser ingresados en la UCI tras cirugía no cardiaca. En esta cohorte, la edad y la mortalidad hospitalaria no se asociaron significativamente


Assuntos
Humanos , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Fatores Etários , Mortalidade Hospitalar , Unidades de Terapia Intensiva/estatística & dados numéricos , Admissão do Paciente/estatística & dados numéricos , Complicações Pós-Operatórias/epidemiologia , Arritmias Cardíacas/epidemiologia , Hospitais Privados/estatística & dados numéricos , Hospitais Públicos/estatística & dados numéricos , Hospitais Universitários/estatística & dados numéricos , Inquéritos e Questionários
6.
Environ Res ; 166: 25-34, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-29859370

RESUMO

Bisphenol A (BPA) and Di-(2-ethylhexyl) phthalate (DEHP) are two wide spread chemicals classified as endocrine disruptors (ED). The present study aims to estimate the non-dietary (dermal, non-dietary ingestion and inhalation) exposure to BPA and DEHP for a pregnant women cohort. In addition, to assess the prenatal exposure for the fetus, a physiologically based pharmacokinetic (PBPK) model was used. It was adapted for pregnancy in order to assess the internal dosimetry levels of EDs (BPA and DEHP) in the fetus. Estimates of exposure to BPA and DEHP from all pathways along with their relative importance were provided in order to establish which proportion of the total exposure came from diet and which came from non-dietary exposures. In this study, the different oral dosing scenarios (dietary and non-dietary) were considered keeping inhalation as a continuous exposure case. Total non-dietary mean values were 0.002 µg/kgbw/day (0.000; 0.004 µg/kgbw/day for 5th and 95th percentile, respectively) for BPA and 0.597 µg/kgbw/day (0.116 µg/kgbw/day and 1.506 µg/kgbw/day for 5th and 95th percentile, respectively) for DEHP. Indoor environments and especially dust ingestion were the main non-dietary contributors to the total exposure of BPA and DEHP with 60% and 81%. However, as expected, diet showed the higher contribution to total exposure with > 99.9% for BPA and 63% for DEHP. Although diet was considered the primary source of exposure to BPA and phthalates, it must be taken into account that with non-dietary sources the first-pass metabolism is lacking, so these may be of equal or even higher toxicological relevance than dietary sources. The present study is in the framework of "Health and environmental-wide associations based on large population surveys" (HEALS) project (FP7-603946).


Assuntos
Compostos Benzidrílicos/análise , Exposição Dietética/análise , Dietilexilftalato/análise , Exposição Materna , Fenóis/análise , Feminino , Humanos , Gravidez , Espanha
7.
Med Intensiva ; 42(8): 463-472, 2018 11.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-29502889

RESUMO

OBJECTIVE: To assess whether patient age is independently associated to Intensive Care Unit (ICU) admission after non-cardiac surgery. DESIGN: An observational cohort study of the Spanish subset of the European Surgical Outcome Study (EuSOS) was carried out. SETTING: Hospitals of the public National Health Care System and private hospitals in Spain. INTERVENTION: None. PATIENTS AND METHODS: All patients over 16 years of age undergoing inpatient non-cardiac surgery in the participating hospitals during a 7-day period in the month of April 2011 were consecutively included. MAIN VARIABLES OF INTEREST: ICU admission rate, factors associated with ICU admission and hospital mortality were assessed using logistic regression analysis and fractional polynomial regression. RESULTS: Out of 5412 patients, 677 (12.5%) were admitted to the ICU after surgery. The adjusted odds ratio (95% confidence interval [CI]) for ICU admission was 1.1 (0.8-1.4) for patients aged 65-74 years, 0.7 (0.5-1) for patients aged 75-85 years, and 0.4 (0.2-0.8) for patients over 85 years, respectively. Age, ASA score, grade of surgery (minor, intermediate, major), urgent surgery, surgical specialty, laparoscopic surgery and metastatic disease were independent factors for ICU admission. Global risk-adjusted mortality was 1.4 (95% CI 0.9-2.2). The ASA score, urgent surgery, surgical specialty and diabetes were predictors of hospital mortality. CONCLUSIONS: Elderly patients (over 80 years) appear less likely to be admitted to ICU after non-cardiac surgery in Spanish hospitals. There was no significant association between age and postoperative mortality in this cohort.


Assuntos
Fatores Etários , Mortalidade Hospitalar , Unidades de Terapia Intensiva/estatística & dados numéricos , Admissão do Paciente/estatística & dados numéricos , Complicações Pós-Operatórias/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Arritmias Cardíacas/epidemiologia , Grupos Diagnósticos Relacionados , Hospitais Privados/estatística & dados numéricos , Hospitais Públicos/estatística & dados numéricos , Hospitais Universitários/estatística & dados numéricos , Humanos , Tempo de Internação/estatística & dados numéricos , Pessoa de Meia-Idade , Espanha , Inquéritos e Questionários , Adulto Jovem
8.
J Phys Chem A ; 122(7): 1916-1923, 2018 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-29381071

RESUMO

The chemical formation process has been studied from relaxation holes, Δh(u), resulting from the difference between the radial intracule density and the nonrelaxed counterpart, which is obtained from atomic radial intracule densities and the pair density constructed from the overlap of the atomic densities. Δh(u) plots show that the internal reorganization of electron pairs prior to bond formation and the covalent bond formation from electrons in separate atoms are completely recognizable processes from the shape of the relaxation hole, Δh(u). The magnitude of Δh(u), the shape of Δh(u) ∀ u < Req, and the distance between the minimum and the maximum in Δh(u) provide further information about the nature of the chemical bond formed. A computational affordable approach to calculate the radial intracule density from approximate pair densities has been also suggested, paving the way to study electron-pair distributions in larger systems.

9.
Oral Dis ; 24(4): 552-560, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29117464

RESUMO

OBJECTIVES: The value of salivary gland scintigraphy in the diagnosis of Sjögren's syndrome remains controversial. The primary aim of this study was to estimate the diagnostic accuracy of salivary gland scintigraphy in the diagnosis of Sjögren's syndrome among 237 patients with xerostomia. METHODS: We retrospectively compared eight scintigraphy parameters between 106 Sjögren patients and 131 non-Sjögren patients. RESULTS: Seven of the eight parameters were significantly decreased in patients with Sjögren; however, their diagnostic accuracy was low, with areas under the curves (AUCs) ranging from 0.58 (95% CI 0.50-0.65) to 0.63 (95% CI: 0.55-0.70). The prestimulatory oral activity index allowed discrimination between primary and secondary Sjögren's syndrome (AUC 0.73, 95% CI: 0.62-0.84), and the secretion velocity for parotid glands allowed discrimination between patients with Sjögren and burning mouth syndrome (AUC 0.71, 95% CI 0.59-0.82). CONCLUSION: The accuracy of scintigraphy parameters for the diagnosis of Sjögren's syndrome among patients with xerostomia was low; however, some functional indices appeared to assist discrimination between primary and secondary SS patients and between subgroups of patients with different causes of xerostomia.


Assuntos
Síndrome da Ardência Bucal/diagnóstico por imagem , Cintilografia , Glândulas Salivares/diagnóstico por imagem , Síndrome de Sjogren/diagnóstico por imagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Área Sob a Curva , Síndrome da Ardência Bucal/complicações , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Curva ROC , Estudos Retrospectivos , Síndrome de Sjogren/complicações , Xerostomia/etiologia , Adulto Jovem
10.
Environ Res ; 158: 566-575, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-28715785

RESUMO

Prenatal exposure to Endocrine disruptors (EDs), such as Bisphenol A (BPA) and di (2-ethylhexyl) phthalate (DEHP), has been associated with obesity and diabetes diseases in childhood, as well as reproductive, behavioral and neurodevelopment problems. The aim of this study was to estimate the prenatal exposure to BPA and DEHP through food consumption for pregnant women living in Tarragona County (Spain). Probabilistic calculations of prenatal exposure were estimated by integrated external and internal dosimetry modelling, physiologically based pharmacokinetic (PBPK) model, using a Monte-Carlo simulation. Physical characteristic data from the cohort, along with food intake information from the questionnaires (concentrations of BPA and DEHP in different food categories and the range of the different food ratios), were used to estimate the value of the total dietary intake for the Tarragona pregnancy cohort. The major contributors to the total dietary intake of BPA were canned fruits and vegetables, followed by canned meat and meat products. In turn, milk and dairy products, followed by ready to eat food (including canned dinners), were the most important contributors to the total dietary intake of DEHP. Despite the dietary variations among the participants, the intakes of both chemicals were considerably lower than their respective current tolerable daily intake (TDI) values established by the European Food Safety Authority (EFSA). Internal dosimetry estimates suggest that the plasma concentrations of free BPA and the most important DEHP metabolite, mono (2-ethylhexyl) phthalate (MEHP), in pregnant women were characterized by transient peaks (associated with meals) and short half-lives (< 2h). In contrast, fetal exposure was characterized by a low and sustained basal BPA and MEHP concentration due to a lack of metabolic activity in the fetus. Therefore, EDs may have a greater effect on developing organs in young children or in the unborn child.


Assuntos
Compostos Benzidrílicos/farmacocinética , Dieta , Dietilexilftalato/farmacocinética , Poluentes Ambientais/farmacocinética , Contaminação de Alimentos/análise , Exposição Materna , Fenóis/farmacocinética , Adolescente , Adulto , Disruptores Endócrinos/farmacocinética , Monitoramento Ambiental , Feminino , Humanos , Modelos Biológicos , Gravidez , Espanha , Adulto Jovem
11.
Ann Dermatol Venereol ; 144(5): 356-361, 2017 May.
Artigo em Francês | MEDLINE | ID: mdl-28063594

RESUMO

BACKGROUND: There are no guidelines regarding the management of scabies in infants and recurrence is common at this age. We report the case of an infant with subungual hyperkeratosis and ungual lesions subsequent to classic scabies. PATIENTS AND METHODS: A 7-month-girl, treated 6 weeks earlier with esdepallethrin for scabies, consulted for acquired lesions on 3 toe nails. These nails were thickened and displayed subungual hyperkeratosis. Physical examination of the skin, the finger nails and mucous membranes was otherwise normal. Fungal analyses were negative, but direct microscopic examination revealed numerous larvae of Sarcoptes scabiei as well as ovular debris. The child was treated with urea 40% to obtain chemical avulsion of the nails, and with topical esdepallethrin and a quarter tablet of ivermectin orally; there was no follow-up of the child. DISCUSSION: Ungual scabies has already been reported in crusted scabies and very rarely in classic scabies. Subungual and ungual locations of S. scabiei may constitute a source of reinfestation with scabies in infants. Treatment is not well defined and currently involves chemical avulsion of the nails and the application of topical antiscabies treatment.


Assuntos
Aletrinas/administração & dosagem , Antiparasitários/administração & dosagem , Ivermectina/administração & dosagem , Unhas/efeitos dos fármacos , Butóxido de Piperonila/administração & dosagem , Escabiose/complicações , Escabiose/tratamento farmacológico , Ureia/administração & dosagem , Administração Cutânea , Administração Oral , Feminino , Humanos , Lactente , Unhas/patologia , Escabiose/patologia , Resultado do Tratamento
12.
Environ Pollut ; 214: 517-523, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27131810

RESUMO

For the first time this study reports on the presence of microplastics (1 nm to <5 mm) in the gastrointestinal tracts of small semipelagic fish (Boops boops) in the Balearic Islands (Mediterranean Sea) from March to May 2014. The results show microplastic ingestion in 68% of full stomach samples with an average of 3.75 items per fish. Only filament type microplastics were observed in B. boops full gastrointestinal tracts. The frequency of occurrence of microplastics was high, with values ranging from 42% to 80%, in comparison to the other ingested items. Spatial variability among locations is high, which suggests that this type of contamination is ubiquitously distributed and originates from multiple sources. The results are important and indirectly provide further evidence of the presence of microplastics, which can be ingested by biota, in the marine environment.


Assuntos
Peixes , Plásticos , Poluentes Químicos da Água , Animais , Ingestão de Alimentos , Monitoramento Ambiental , Ilhas , Mar Mediterrâneo
13.
Environ Sci Pollut Res Int ; 23(9): 8175-83, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26452658

RESUMO

Airborne particles are known to cause illness and to influence meteorological phenomena. It is therefore important to monitor their concentrations and to identify them. A challenge is to collect micro and nanoparticles, microorganisms as well as toxic molecules with a device as simple and small as possible to be used easily and everywhere. Electrostatic precipitation is an efficient method to collect all kinds of airborne particles. Furthermore, this method can be miniaturized. A portable, silent, and autonomous air sampler based on this technology is therefore being developed with the final objective to collect very efficiently airborne pathogens such as supermicron bacteria but also submicron viruses. Particles are collected on a dry surface so they may be concentrated afterwards in a small amount of liquid medium to be analyzed. It is shown that nearly 98 % of airborne particles from 10 nm to 3 µm are collected.


Assuntos
Monitoramento Ambiental/instrumentação , Eletricidade Estática , Microbiologia do Ar , Bactérias , Monitoramento Ambiental/métodos , Vírus
17.
Ann Dermatol Venereol ; 142(3): 201-5, 2015 Mar.
Artigo em Francês | MEDLINE | ID: mdl-25681031

RESUMO

BACKGROUND: Aquagenic palmar keratoderma is an entity recently described in the literature by English and McCollough in 1996. It is a rare condition affecting young women and is of unknown incidence. It causes a wrinkled and oedematous appearance in the skin of the hands that may be seen a few minutes after immersion in water. This condition may be associated with a heterozygous mutation in CFTR, the gene involved in cystic fibrosis. We report the first case of aquagenic keratoderma associated with a new mutation in the CFTR gene. PATIENTS AND METHODS: An 18-year-old patient with no particular history was referred for a painful rash on both palms occurring whenever she showered, and which had been ongoing for several months. The clinical examination was normal except for an appearance of moderate palmar hyperhidrosis. Following a test in which both hands were immersed in cold water for 5minutes, the patient presented itching, burning and pain localized to the hands. The palms were wrinkled and oedematous with white, translucent and confluent papules. A clinical diagnosis of aquagenic palmar keratoderma was made. Since this condition may be associated with mutations in the CFTR gene, a genetic study was performed for this patient and revealed the presence of a new mutation in the CFTR gene for cystic fibrosis in the heterozygous state inherited from her mother: c.3197G>C or p.Arg1066.Pro and a heterozygous polypyrimidic 5T variant inherited from her father. DISCUSSION: We report a new case of aquagenic palmar keratoderma in a patient heterozygous for a new mutation of the gene involved in cystic fibrosis. Several studies have shown association of aquagenic keratoderma with the CFTR gene for heterozygotes (carriers without cystic fibrosis), for patients with cystic fibrosis and for a patient presenting CFTRopathy with pancreatic insufficiency.


Assuntos
Regulador de Condutância Transmembrana em Fibrose Cística/genética , Heterozigoto , Ceratodermia Palmar e Plantar/genética , Mutação , Adolescente , Feminino , Humanos , Ceratodermia Palmar e Plantar/etiologia , Água/efeitos adversos
18.
Artigo em Espanhol | LILACS | ID: lil-770789

RESUMO

El Instituto Universitario de Ciencias de las Salud ha mostrado un particular compromiso con la formación de sus estudiantes en la estrategia de Atención Primaria de la Salud, con las prácticas asistenciales dedicadas al 1er nivel de atención ambulatoria y a las patologías prevalentes en ese ámbito. Del mismo modo se han desenvuelto las actividades de formación en investigación. Como exponente de esa orientación, la revista Ciencias de la Salud publicó en el Vol. 2, N°1, 2011:4-9, el artículo “Prevalencia de la Enfermedad de Chagas” de Érica G. Morais, que había obtenido el premio “Futuros Líderes”, otorgado por el Curso Anual Internacional de Investigación en Ciencias de la Salud (IUCS-AMA, Prof. Carlos Álvarez Bermúdez). Aquella investigación formaba parte de un proyecto más amplio realizado en el Hospital Teodoro Álvarez entre 2004 y 2012, en el que participaron un conjunto de investigadores, que compartieron la autoría de la actual publicación. El Dr. Jorge Mitelman, Prosecretario de Ciencia y Técnica del IUCS e integrante de ese equipo, preparó además una reseña sobre la jornada del INCOSUR, realizada en abril del presente año, describiendo asimismo el proceso de desarrollo de la Ciudad de Buenos Aires, como área no endémica, para encarar las consecuencias de la enfermedad de Chagas


Assuntos
Doença de Chagas , Doença de Chagas/epidemiologia , Doença de Chagas/patologia , Doença de Chagas/prevenção & controle
19.
Arch. prev. riesgos labor. (Ed. impr.) ; 16(4): 190-191, oct.-dic. 2013.
Artigo em Espanhol | IBECS | ID: ibc-129196

RESUMO

La construcción en Constantí (Condado de Tarragona, Cataluña) de la primera, y hasta ahora la única incineradora de residuos peligrosos (IRP) en España, terminó en 1999. En este estudio medimos las concentraciones de determinadas sustancias orgánicas en la sangre y la orina de los trabajadores de la IRP. Las muestras se recogieron en 2011, perteneciendo a 18 hombres y 9 mujeres trabajadores de la instalación después de aproximadamente 12 años de operaciones regulares en las instalaciones. Los resultados se compararon con valores de referencia obtenidos al inicio de la puesta en marcha de la IRP, así como con los datos disponibles para 2008, 2009 y 2010. Se analizaron los niveles en plasma de hexaclorobenceno (HCB), bifenilos policlorados (PCB 28, 52, 101, 138, 153, y 180), dibenzo-p-dioxinas y dibenzofuranos (PCDD/Fs), y los niveles en orina de 2,4 - y 2,5-diclorofenol (DCP), 2,4,5 - y 2,4,6-triclorofenol (TCP), pentaclorofenol (PCP) y 1-hidroxipireno (HP-1).En plasma, las concentraciones medias fueron las siguientes: 10,8 μg/kg de lípidos para el HCB; 0,8 μg/kg de lípidos paraPCB28; 0,3 μg/kg de lípidos para PCB52; 0,5 μg/kg de lípidos para PCB101; 42,2 μg/kg de lípidos para PCB138; 18,5 μg/kg de lípidos para PCB153 y 51,2 μg/kg de lípidos para PCB180. Para PCDD/Fs, la concentración media fue de 4,6 ng EQT-I/kg lípidos (4,7 ng lípidos EQT-OMS/kg). Estos niveles, así como los que se encontraron en las muestras de orina, son coincidentes con niveles disponibles en los estudios previos realizados en la misma empresa. Los niveles detectados no indican exposiciones laborales en los trabajadores de la IRP a PCDD/Fs ni a las otras sustancias orgánicas evaluadas. Sin embargo, estos resultados deben considerarse con precaución ya que el número de participantes es limitado y no se dispone de datos sobre las concentraciones en el aire de las sustancias químicas consideradas. En consecuencia, no permiten derivar conclusiones para la aplicación de medidas de higiene industrial en otras IRP (AU)


The construction in Constantí (Tarragona County, Catalonia) of the first, and up till now the only hazardous waste incinerator (HWI) in Spain, finished in 1999. In this study, we measured the concentrations of a number of organic substances determined in blood and urine of the HWI workers. Samples of 18 men and 9 women, classified according to the irrespective workplaces, were collected in 2011, after approximately 12 years of regular operations in the facility. The current results were compared with those of the baseline survey, as well as with the most recent surveys performed in 2008, 2009and 2010. Plasma analyses were carried out for hexachlorobenzene (HCB), polychlorinated biphenyls (PCBs 28, 52, 101,138, 153, and 180) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), while the levels of 2,4- and 2,5-dichlorophenol (DCP), 2,4,5- and 2,4,6-trichlorophenol (TCP), pentachlorophenol (PCP) and 1-hydroxypyrene (1-HP)were measured in urine samples. In plasma, the mean concentrations were the following: 10.8 μg/kg lipid for HCB; 0.8 μg/kg lipid for PCB28; 0.3 μg/kg lipid for PCB52; 0.5 μg/kg lipid for PCB101; 42.2 μg/kg lipid for PCB138; 18.5 μg/kg lipid forPCB153, and 51.2 μg/kg lipid for PCB180. For PCDD/Fs, the mean concentration was 4.6 ng I-TEQ/kg lipid (4.7 ng WHOTEQ/kg lipid). These levels, as well as those found in urine samples, are in agreement with the data of previous surveys performed in the same area. The current results in HWI workers do not show any evident sign of occupational exposure to PCDD/Fs and other organic substances. However, these results must be considered only as an indication of potential exposure, as the study presents notable limitations, such as the reduced number of participants and the lack of data relative to the air concentrations of chemicals. Consequently, general conclusions cannot be derived and the results should not be used as a basis for the implementation of industrial hygiene measures in other HWIs (AU)


Assuntos
Humanos , Carga Corporal (Radioterapia) , Resíduos Perigosos/análise , Exposição Ocupacional/análise , Dioxinas/isolamento & purificação , Eliminação de Resíduos Perigosos , Armazenamento de Resíduos Perigosos , Contêineres de Resíduos Perigosos
20.
Trauma (Majadahonda) ; 24(1): 6-11, ene.-mar. 2013. tab
Artigo em Espanhol | IBECS | ID: ibc-111452

RESUMO

Objetivo: Analizar un programa de ejercicio físico moderado y sus efectos sobre la masa muscular y la tolerancia al esfuerzo en pacientes con cirrosis. Pacientes y métodos: Se estudiaron 17 pacientes con cirrosis hepática compensada divididos aleatoriamente en dos grupos: grupo ejercicio (n=8), que realizó un programa de ejercicio físico moderado durante 12 semanas, y grupo control (n=9). Todos los pacientes recibieron 10 g/día de leucina. Se analizaron cambios antropométricos, tolerancia al ejercicio y calidad de vida; además, se evaluó la seguridad durante el programa. Resultados: En el grupo ejercicio se observó un aumento en el perímetro del m. cuádriceps (p=0,02) y una mejora de la tolerancia al esfuerzo en el test de la marcha (p=0,01) y el test de los escalones (p=0,02). Además, en este grupo mejoró la calidad de vida de forma significativa. No observamos complicaciones de la cirrosis, deterioro hemodinámico o de la función renal en ninguno de los dos grupos durante el estudio. Conclusión: El ejercicio físico moderado en pacientes con cirrosis compensada es seguro, aumenta la masa muscular y mejora la tolerancia al esfuerzo y la calidad de vida (AU)


Objetive: To evaluate the efficacy and safety of an exercise programme to increase muscle mass, effort tolerance and quality of life in cirrhotic patients. Patients and methods: Seventeen compensated cirrhotic patients were randomized into either an exercise group (n=8) or a control group (n=9). The programme of moderate exercise was given for 12 weeks. All patients received oral leucine (10 g/day) during the study. Anthropometric measurements, effort tolerance and quality of life were determined at study start and end. We also analysed the safety during the study. Results: In the exercise group thigh circumference increased (p=0.02) and effort tolerance improved (p=0.01) and 2-min step test (p=0.02). Moreover, quality of life improved significantly in this group. In the control group there were no statistically significant changes in any of the studied parameters. We did not observe complications of cirrhosis in either group. Conclusion: Our results suggest that moderate physical exercise in patients with compensated cirrhosis is safe and improves quality of life, effort tolerance and muscle mass (AU)


Assuntos
Humanos , Masculino , Feminino , Exercício Físico/fisiologia , Leucina/uso terapêutico , Qualidade de Vida , Aminoácidos de Cadeia Ramificada/metabolismo , Aminoácidos de Cadeia Ramificada/uso terapêutico , Cirrose Hepática/tratamento farmacológico , Antropometria/instrumentação , Antropometria/métodos , Cirrose Hepática/cirurgia , Cirrose Hepática/terapia
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