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1.
Adv Exp Med Biol ; 1232: 113-119, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31893402

##### RESUMO

The prefrontal cortex (PFC) is sensitive to the stress exposure and involved in stress coping. And the effects of gum chewing on the stress have been studied using NIRS. However, when measuring NIRS on PFC during gum chewing, blood flows in shallow tissues (scalp, skin, muscle) might be affected. A NIRS used in the present study first, which has a short distance (1 cm) and the usual (3 cm) source-detector (S-D) regression, can allow eliminating shallow tissues effect of gum chewing. The aim of this study was to investigate the hypothesis that gum chewing activates the right prefrontal cortex (PFC) in stress coping against negative sounds (NS) from the International Affective Digitized Sounds-2 (IADS) as a mental stress task. NS showed activation in the right PFC. There was a significant difference between NS, and NS with Gum, where NS with Gum showed an increased PFC activity, increased alpha wave appearance rate, a higher value in heart rate level, and a higher VAS score indicating 'pleasant'. Gum chewing activated right PFC activity while exposed to negative sounds from IADS as a mental stress task.

##### Assuntos
Goma de Mascar , Mastigação , Som , Estresse Psicológico , Adaptação Psicológica , Adulto , Feminino , Humanos , Masculino , Córtex Pré-Frontal/fisiologia , Córtex Pré-Frontal/efeitos da radiação , Som/efeitos adversos , Estresse Psicológico/terapia , Adulto Jovem
2.
J Comp Pathol ; 173: 30-40, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31812171

##### RESUMO

The aim of this study was to investigate the expression of tumour endothelial marker 8 (TEM8) in canine mammary gland tumours (MGTs) by immunohistochemistry and to evaluate the association between tumour cell TEM8 expression and tumour histological features, histological grades and expression of luminal and basal/myoepithelial cell markers. TEM8 expression was detected in >60 % of neoplastic epithelial cells in all simple adenomas (n = 25), simple carcinomas (n = 43) and invasive micropapillary carcinomas (n = 5) studied. Six of the 18 solid carcinomas studied showed TEM8 expression in >60% of carcinoma cells present in solid structures and in 12 of the 18 solid carcinomas, <30% of the luminal structure-forming carcinoma cells showed TEM8 expression. TEM8 expression in the neoplastic cells was not associated with histological malignancy in canine MGTs. TEM8+ tumour cells frequently showed the luminal-like phenotype cytokeratin (CK)19+/p63-/α-smooth muscle actin (SMA)-, while most TEM8- tumour cells exhibited the basal-like phenotype CK19-/p63+/αSMA-. These findings indicate that TEM8 may be involved in maintaining the characteristics of luminal cells in canine MGTs and that TEM8 would be useful in identifying the type of neoplastic epithelial cell in MGTs.

3.
Osteoporos Int ; 2019 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-31814062

##### RESUMO

We compared the bone strength measured via quantitative computed tomography-based finite element method (QCT/FEM) between healthy adults with and without ossification of the posterior longitudinal ligament (OPLL). No statistically significant difference was observed in the bone strength between healthy adults with and without OPLL. Hyperostosis of the posterior longitudinal ligament in OPLL may not be associated with the systemic bone strength. INTRODUCTION: Although patients with OPLL have been reportedly associated with increased level of bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA), little is known about the bone strength in OPLL subjects. The aim of this study is to investigate the bone strength measured via QCT/FEM in healthy subjects with OPLL using the medical check-up data, including whole-body CT scans. METHODS: We examined 796 participants (529 men and 267 women) who underwent CT scans in a single health center between January 2008 and May 2009. We identified OPLL in whole spine and divided the subjects into two groups: non-OPLL and OPLL groups. We calculated the predicted bone strength (PBS) of the proximal femur using QCT/FEM and examined the bone mineral status of the calcaneus using quantitative ultrasound (QUS). We compared the PBS and the QUS parameters between the non-OPLL and OPLL groups. RESULTS: Seventy-four subjects (9.3%; 57 men and 17 women) were diagnosed with OPLL in the whole spine. The OPLL group was significantly older than the non-OPLL group. No statistically significant difference was observed in the PBS and the QUS parameters between the non-OPLL and OPLL groups in both sexes. Furthermore, no statistically significant difference was noted in the PBS and the QUS parameters between two groups in age- and gender-matched analysis. CONCLUSIONS: Our results suggest that hyperostosis of the posterior longitudinal ligament in OPLL may not be associated with bone strength and bone mineral status at the extremities.

4.
J Opt Soc Am A Opt Image Sci Vis ; 36(12): 2129-2137, 2019 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-31873389

##### RESUMO

To expand the spectral bandwidths with high diffraction efficiency of volume phase (VP) gratings, it is important to know the influence of a variety of refractive index distributions (RIDs) inside the recording material on the bandwidths. The influence of various graded types of RIDs on the full width at half the maximum of the spectral bandwidth (${\lambda _{\rm FWHM}}$λFWHM) and the angular bandwidth (${\theta _{\rm FWHM}}$Î¸FWHM) is investigated in the Bragg regime. It becomes clear that various graded types of RIDs influence their bandwidths and the characteristics, and the combination of the RIDs and refractive index modulation (${{ n}_m}$nm) is the most important factor for obtaining the large bandwidths of VP gratings. Theoretically, the ${\lambda _{\rm FWHM}}$λFWHM are obtained as the values of 149.7 nm and 257.6 nm (${{ n}_m} = {0.045}$nm=0.045) for the wavelengths of 900 nm and 1550 nm, respectively. Furthermore, I have succeeded in developing the expression for ${\lambda _{\rm FWHM}}$λFWHM and ${\theta _{\rm FWHM}}$Î¸FWHM, using the proportional characteristics of VP gratings investigated in this work. The correlative coupling-length coefficients "G-factors" devised as a variety of RID functions in the previous paper are introduced into them. It is apparent that the derived equations of the bandwidths can be adapted to any graded type of RID that changes continuously from a triangular type to a rectangular type of VP grating, which has not been reported yet. The equations have made it easy to design ${\lambda _{\rm FWHM}}$λFWHM and ${\theta _{\rm FWHM}}$Î¸FWHM of VP gratings.

5.
J Opt Soc Am A Opt Image Sci Vis ; 36(11): 1861-1870, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31873697

##### RESUMO

The equations for the coupling coefficient and the grating thickness of volume phase gratings are derived from Maxwell's equations in this work. The equations cover all graded types of refractive index distributions (RIDs) which change continuously from a triangular type to a rectangular type. The functions expressed as various graded types of RIDs, which are proposed in this work, are used among them. Furthermore, the new idea, which is the correlative coupling-length coefficient, is devised for the first time as a variety of RID function, "G-factor." The results based on the coupled mode theory in this work show a very close agreement under 0.2% with the results of the rigorous coupled-wave analysis method. The values of the grating thickness and the G-factor are confirmed with validity. By means of this new method, not only can the grating thickness of any graded type of VP grating which is under the Bragg condition be obtained very easily, but the spectral bandwidths and the angular bandwidths which are not under the Bragg condition can be controlled very easily and the configurations of RIDs can be estimated as well.

6.
Phys Rev Lett ; 122(21): 217003, 2019 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-31283313

##### RESUMO

We report neutron scattering measurements of single-crystalline YFe_{2}Ge_{2} in the normal state, which has the same crystal structure as the 122 family of iron pnictide superconductors. YFe_{2}Ge_{2} does not exhibit long-range magnetic order but exhibits strong spin fluctuations. Like the iron pnictides, YFe_{2}Ge_{2} displays anisotropic stripe-type antiferromagnetic spin fluctuations at (π, 0, π). More interesting, however, is the observation of strong spin fluctuations at the in-plane ferromagnetic wave vector (0, 0, π). These ferromagnetic spin fluctuations are isotropic in the (H, K) plane, whose intensity exceeds that of stripe spin fluctuations. Both the ferromagnetic and stripe spin fluctuations remain gapless down to the lowest measured energies. Our results naturally explain the absence of magnetic order in YFe_{2}Ge_{2} and also imply that the ferromagnetic correlations may be a key ingredient for iron-based materials.

7.
Phys Med Biol ; 64(7): 07LT01, 2019 03 29.
Artigo em Inglês | MEDLINE | ID: mdl-30870825

##### RESUMO

Radiation detectors dedicated to time-of-flight positron emission tomography (PET) have been developed, and coincidence time resolution (CTR) of sub-100 ps full width at half maximum (FWHM) has been achieved by carefully optimizing scintillators and photodetectors. Achieving a CTR of 30 ps FWHM by using a pair of annihilation Î³-rays would allow us to directly localize the annihilation point within an accuracy of 4.5 mm. Such direct localization can potentially eliminate the requirement of image reconstruction processes in clinical PET systems, which would have a huge impact on clinical protocols and molecular imaging. To obtain such a high CTR, researchers have investigated the use of prompt emissions such as Cherenkov radiation and hot-intra band luminescence. Although it is still challenging to achieve a CTR of 30 ps FWHM even with a Cherenkov-based detector, the experimentally measured CTR is approaching the goal. In this work, we developed a Cherenkov-radiator-integrated micro-channel plate photomultiplier tube (CRI-MCP-PMT), where there are no optical boundaries between the radiator and photocathode, and its timing performance was investigated. By removing the optical boundaries, reflections are eliminated and transmission to the photocathode is improved, resulting in high timing capability. As a result, a CTR of 30.1 ± 2.4 ps FWHM, which is equivalent to a position resolution of 4.5 ± 0.3 mm along a line of response (LOR), was obtained by using a pair of CRI-MCP-PMTs.

##### Assuntos
Processamento de Imagem Assistida por Computador/métodos , Tomografia por Emissão de Pósitrons/instrumentação , Contagem de Cintilação/instrumentação , Raios gama , Humanos , Tomografia por Emissão de Pósitrons/métodos , Fatores de Tempo
8.
Opt Express ; 26(12): 15211-15220, 2018 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-30114771

##### RESUMO

We propose and experimentally demonstrate a low-loss and low-crosstalk Mach-Zehnder mode/wavelength multi/demultiplexer for WDM/MDM transmission based on a Si-photonics platform. A broadband 3-dB mode divider, which is also newly devised here, makes it possible to compose a Mach-Zehnder filter for "mode" and "wavelength" simultaneously. Transmission characteristics of fabricated 3-dB mode dividers are in excellent agreement with theoretical results. Mach-Zehnder filters using the 3-dB mode divider with a free spectral range (FSR) of 20 and 1 nm are also fabricated and the modal crosstalk is less than -24 dB in the 40-nm wavelength range for the MZ filter with an FSR of 20 nm. The tuning of the peak wavelength position by the TiN heater is also demonstrated.

9.
Dis Esophagus ; 31(7)2018 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-29617733

##### RESUMO

Reflux following an esophagectomy with gastric conduit reconstruction in the posterior mediastinum is a clinically significant problem. In this study, we investigated the frequency and impact of reflux on the quality of life (QOL) among 158 patients who underwent an esophagectomy for esophageal cancer using an original questionnaire and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Version 3.0 (EORTC QLQ-C30). Reflux frequency was assessed using the original questionnaire. The number of patients who complained of reflux every day, two or three times a week, once a week, or less than once a week was 16 (10.1%), 21 (13.3%), 26 (16.5%), and 60 (38.0%), respectively. Out of 35 patients (22.2%) reported no reflux symptoms. Patients were divided into two groups: those with reflux ≥ once/week (63 patients) and those with low frequency of symptoms (95 patients). Time elapsed following surgery was the only factor to influence reflux frequency. Reflux frequency decreased within two years of surgery; however, the frequency plateaued after more than two years. QOL was assessed using the EORTC QLQ-C30. The ≥ once/week reflux group had a significantly lower global health status score than the low-frequency reflux group (59.6 ± 24.2 vs. 70.8 ± 20.7; P = 0.007). In addition, the ≥ once/week reflux group had a significantly lower social functioning score than the low-frequency reflux group (81.6 ± 24.1 vs. 88.4 ± 19.8; P = 0.035). Regarding symptoms, the ≥ once/week reflux group had significantly higher scores for fatigue, nausea, and vomiting, dyspnea and insomnia compared to the low-frequency reflux group (fatigue: 42.4 ± 21.9 vs. 28.9 ± 18.4, P < 0.001; nausea and vomiting: 17.3 ± 17.1 vs. 4.9 ± 10.6, P < 0. 001; dyspnea: 29.2 ± 26.0 vs. 21.7 ± 26.8, P = 0.043; insomnia: 22.2 ± 31.1 vs. 10.5 ± 21.7, P = 0.015). Thus, reflux after an esophagectomy was associated with a lower QOL.

##### Assuntos
Esofagectomia/efeitos adversos , Refluxo Gastroesofágico/psicologia , Complicações Pós-Operatórias/psicologia , Qualidade de Vida/psicologia , Procedimentos Cirúrgicos Reconstrutivos/efeitos adversos , Idoso , Neoplasias Esofágicas/cirurgia , Esofagectomia/métodos , Junção Esofagogástrica/cirurgia , Feminino , Refluxo Gastroesofágico/epidemiologia , Refluxo Gastroesofágico/etiologia , Humanos , Masculino , Mediastino/cirurgia , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Período Pós-Operatório , Procedimentos Cirúrgicos Reconstrutivos/métodos , Inquéritos e Questionários , Resultado do Tratamento
10.
Nat Mater ; 17(3): 226-230, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29335610

##### RESUMO

As a generic property, all substances transfer heat through microscopic collisions of constituent particles 1 . A solid conducts heat through both transverse and longitudinal acoustic phonons, but a liquid employs only longitudinal vibrations2,3. As a result, a solid is usually thermally more conductive than a liquid. In canonical viewpoints, such a difference also serves as the dynamic signature distinguishing a solid from a liquid. Here, we report liquid-like thermal conduction observed in the crystalline AgCrSe2. The transverse acoustic phonons are completely suppressed by the ultrafast dynamic disorder while the longitudinal acoustic phonons are strongly scattered but survive, and are thus responsible for the intrinsically ultralow thermal conductivity. This scenario is applicable to a wide variety of layered compounds with heavy intercalants in the van der Waals gaps, manifesting a broad implication on suppressing thermal conduction. These microscopic insights might reshape the fundamental understanding on thermal transport properties of matter and open up a general opportunity to optimize performances of thermoelectrics.

11.
Leukemia ; 32(1): 168-175, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-28652579

##### RESUMO

Although it is known that human leukocyte antigen (HLA)-DPB1 disparity has a strong impact on outcomes in unrelated hematopoietic transplantation with induction of acute graft-versus-host disease (GVHD) and a graft-versus-leukemia (GVL) effect, its role in unrelated umbilical cord blood transplantation (UR-CBT) has yet to be fully clarified. Our current study is being conducted to elucidate the impact of HLA-DPB1 mismatch, along with the effect of other HLA loci mismatches at the allele level. HLA six loci alleles were retrospectively typed in 1157 Japanese donors and patients with leukemia or myelodysplastic syndrome who underwent transplantation with a single unit of cord blood. HLA-DPB1 mismatch was associated with a significant reduction in leukemia relapse (hazard ratio 0.61, P<0.001), whereas the other HLA loci allele-level mismatches did not. No significant effect of HLA-DPB1 mismatch was observed in the risk of acute GVHD, engraftment or mortality. This HLA-DPB1 GVL effect without induction of severe acute GVHD or deterioration of survival rate has not been reported in unrelated bone marrow or peripheral blood stem cell transplantations, suggesting apparent advantages of UR-CBT. Accordingly, selection of an HLA-DPB1 mismatch cord blood might be the preferable choice for single-unit UR-CBT.

##### Assuntos
Doença Enxerto-Hospedeiro/imunologia , Efeito Enxerto vs Leucemia/imunologia , Cadeias beta de HLA-DP/imunologia , Leucemia/imunologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Alelos , Transplante de Medula Óssea/métodos , Criança , Pré-Escolar , Transplante de Células-Tronco de Sangue do Cordão Umbilical/métodos , Feminino , Transplante de Células-Tronco Hematopoéticas/métodos , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Síndromes Mielodisplásicas/imunologia , Transplante de Células-Tronco de Sangue Periférico/métodos , Transplante Homólogo/métodos , Doadores não Relacionados , Adulto Jovem
12.
Dis Esophagus ; 31(4)2018 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-29190316

##### RESUMO

Although no consensus is available on the treatment of esophageal squamous cell carcinoma (ESCC) invading adjacent organs (T4), establishing effective induction treatments is crucial to altering an unresectable status and achieving curative resection. Here, we evaluated the efficacy of chemotherapy using 5-fluorouracil, cisplatin, and docetaxel (DCF) as the initial induction treatment for T4 ESCC. Fifty patients without distant metastasis who underwent initial induction chemotherapy using DCF for T4 ESCC were propensity score-matched with 50 patients who underwent radiotherapy concurrent with cisplatin and 5-fluorouracil (CRT). In the DCF group, 24 (48.0%) patients underwent surgery, achieving a 64% clinical response rate compared to 72.0% for induction CRT. CRT was also performed in another 24 (48.0%) patients in the DCF group in whom surgical resection was not indicated. The DCF group had significantly higher overall resectability than the CRT group (78.0% vs. 48.0%, P = 0.0017). The esophageal perforation rate during induction treatments was significantly lower in the DCF group than the CRT group (4.0% vs. 18.0%, P = 0.0205). Prognosis was significantly better in the DCF group than the CRT group (5-year cancer-specific survival 42.1% vs. 22.2%, P = 0.0146). Thus, induction DCF chemotherapy in patients with T4 ESCC reduced esophageal perforation and increased overall resectability, leading to better survival than CRT alone. Therefore, DCF chemotherapy may be an effective and safe option for initial induction treatment of T4 ESCC.

##### Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Carcinoma de Células Escamosas/terapia , Cisplatino/administração & dosagem , Neoplasias Esofágicas/terapia , Fluoruracila/administração & dosagem , Quimioterapia de Indução/métodos , Taxoides/administração & dosagem , Idoso , Carcinoma de Células Escamosas/patologia , Quimiorradioterapia/métodos , Docetaxel , Neoplasias Esofágicas/patologia , Carcinoma de Células Escamosas do Esôfago , Esofagoscopia/estatística & dados numéricos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pontuação de Propensão , Resultado do Tratamento
13.
Ann Oncol ; 29 Suppl 8: viii231, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32136507
14.
Ann Oncol ; 29 Suppl 8: viii240, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32136535
15.
Ann Oncol ; 29 Suppl 8: viii329, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32136772
16.
Ann Oncol ; 29 Suppl 8: viii331, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32136783
17.
J Fish Biol ; 91(5): 1435-1448, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28990668

##### RESUMO

Population structure and demographic history of the Japanese Spanish mackerel Scomberomorus niphonius a highly piscivorous and migratory marine fish, were assessed using mitochondrial DNA control region sequences (n = 720) and microsatellite genotypes at five loci (n = 1331) for samples collected on Japanese coasts from 2001 to 2010. The population structure was panmictic and the haplotype and allele frequencies were temporally stable even during the recent recovery process. Demographic expansion was strongly supported throughout the Pleistocene, suggesting that the oscillating glacial and interglacial climate conditions in the Pleistocene had no substantial impact on the demographic history of S. niphonius.

##### Assuntos
Variação Genética , Comportamento de Retorno ao Território Vital , Perciformes/fisiologia , Animais , Clima , DNA Mitocondrial/genética , Demografia , Frequência do Gene , Haplótipos , Repetições de Microssatélites , Perciformes/genética , Filogenia , Dinâmica Populacional , Reprodução , Comportamento Sexual Animal
18.
Dis Esophagus ; 30(11): 1-8, 2017 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-28881906

##### RESUMO

Although 3-field lymph node dissection (3-FLD) is often performed for thoracic esophageal squamous cell carcinoma (ESCC), the clinical effects of cervical lymph node dissection in addition to mediastinal and abdominal dissections on postoperative complications remain unclear. A total of 367 ESCC patients who underwent curative esophagectomy for thoracic esophageal cancer in our hospital from 2010 to 2015 were included in the study: 157 patients who underwent 2-field lymph node dissection (2-FLD) and 210 patients who underwent 3-FLD. Clinicopathological parameters and postoperative complications based on the Clavien-Dindo classification were compared between the two groups. We performed propensity score matching (PSM) analyses to compare the groups with well-balanced backgrounds. In terms of patient background, clinical T (p < 0.001), N (p < 0.001), and M (p = 0.002) stage of tumor was significantly more advanced; therefore, preoperative treatment was more frequently performed in the 3-FLD group than in the 2-FLD group (91.0% vs. 79.0%, P< 0.001). However, perioperative parameters including operation time, blood loss, and the number of dissected mediastinal and abdominal lymph nodes did not differ between the groups. In terms of postoperative complications, the occurrence rate of pneumonia increased significantly in patients with 3-FLD compared to 2-FLD (grade III or higher: 10.5% vs. 3.2%, P= 0.025). Although the duration of systemic inflammatory response syndrome (SIRS) was longer in the 3-FLD group than in the 2-FLD group (median 3 days vs. 2 days, P= 0.025), other postoperative parameters (including the highest level of postoperative serum C-reactive protein, intensive care unit stay, re-operation rate, and postoperative hospital stay) were similar between the groups. After PSM, the differences in the background between the groups disappeared. PSM analysis showed that there was no significant difference in each complication between the groups. The duration of SIRS tended to be longer in the 3-FLD group than in the 2-FLD group, but the difference was not significant. The field of lymphadenectomy negatively impacted the short-term outcome in ESCC patients in terms of pneumonia and inflammatory response. However, because the results of the PSM analyses indicate that the short-term outcome was similar between the two groups, 3-FLD could be as feasible as 2-FLD in ESCC patients.

##### Assuntos
Carcinoma de Células Escamosas/cirurgia , Neoplasias Esofágicas/cirurgia , Esofagectomia/métodos , Excisão de Linfonodo/métodos , Linfonodos/cirurgia , Complicações Pós-Operatórias/etiologia , Abdome , Adulto , Idoso , Idoso de 80 Anos ou mais , Proteína C-Reativa/análise , Carcinoma de Células Escamosas/sangue , Carcinoma de Células Escamosas/patologia , Neoplasias Esofágicas/sangue , Neoplasias Esofágicas/patologia , Carcinoma de Células Escamosas do Esôfago , Feminino , Humanos , Tempo de Internação , Linfonodos/patologia , Masculino , Mediastino , Pessoa de Meia-Idade , Pescoço , Duração da Cirurgia , Pneumonia/etiologia , Período Pós-Operatório , Pontuação de Propensão , Estudos Prospectivos , Estudos Retrospectivos , Síndrome de Resposta Inflamatória Sistêmica/etiologia , Fatores de Tempo , Resultado do Tratamento
19.
J Oral Rehabil ; 44(9): 673-682, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28581686

##### RESUMO

The purpose of this study was to investigate the changes in tongue-palatal contact patterns using electropalatography (EPG) before and after sagittal split ramus osteotomy (SSRO) in patients with mandibular prognathism. Nine clients who underwent SSRO for mandibular setback and seven control subjects were participated in this study. Tongue-palatal contact patterns for /t/, /s/ and /k/ production were investigated using EPG before surgery and 3 months after surgery. The mean value of whole total of palate contact (WT) in the maximum contact frame was examined before and after SSRO. The correlation quantity between the change of center of gravity (COG) value and the amount of mandibular setback was also evaluated. The mean value of WT for /t/ and /s/ significantly increased after SSRO, and the EPG pattern became normal. However, a remarkable change in WT for /k/ was not observed, and the mean value was significantly larger in the SSRO group before and after surgery than in the control group. A negative correlation between COG variation and the amount of mandibular setback for /t/ and positive correlation for /s/ was observed. This study demonstrated that tongue-palatal contact patterns for /t/ and /s/ articulation improved clearly after SSRO. There was a significant correlation between COG variation and the amount of mandibular setback. However, no significant change was detected through perceptual assessment before and after SSRO. Further investigation is needed to determine whether these results will change over time.

##### Assuntos
Eletrodiagnóstico , Mandíbula/cirurgia , Osteotomia Sagital do Ramo Mandibular , Prognatismo/cirurgia , Língua/fisiopatologia , Adulto , Força de Mordida , Feminino , Humanos , Masculino , Mandíbula/anatomia & histologia , Mandíbula/fisiopatologia , Prognatismo/diagnóstico por imagem , Prognatismo/fisiopatologia , Propriocepção , Fatores de Tempo , Língua/anatomia & histologia , Resultado do Tratamento , Adulto Jovem
20.
Andrologia ; 49(3)2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27246358

##### RESUMO

Accumulating evidence indicates that varicocele repair improves sperm quality. However, longitudinal changes in sperm parameters and predictors of improved semen characteristics after surgery have not been fully investigated. We retrospectively reviewed data from 100 men who underwent microsurgical subinguinal varicocele repair at a single centre. Follow-up semen examinations were carried out at 3, 6 and 12 months post-operatively. Logistic regression was used to identify predictors of early (3 months) and late (≥6 months) improvement in semen parameters after varicocele repair. At 3 months post-operatively, 76.1% of the patients had improved total motile sperm counts, which continued to improve significantly up to 12 months post-operatively (p = .016). When comparing changes in semen parameters between younger (<37 years) and older (≥37 years) men, post-operative improvements in sperm concentration and motility were greater among younger men. Multivariate analysis showed that younger age was associated with early (p = .043) and late (p = .010) post-operative improvement in total motile sperm count. Our findings indicate that early varicocele repair improved semen parameters after surgery.

##### Assuntos
Microcirurgia , Análise do Sêmen , Sêmen/fisiologia , Varicocele/cirurgia , Adulto , Fatores Etários , Feminino , Seguimentos , Humanos , Infertilidade Masculina , Masculino , Análise Multivariada , Gravidez , Estudos Retrospectivos , Cordão Espermático/irrigação sanguínea , Procedimentos Cirúrgicos Vasculares