Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 123
Filtrar
1.
Int J Urol ; 27(2): 149-155, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31721315

RESUMO

OBJECTIVE: To examine the effect of permanent salvage brachytherapy in prostate cancer patients suffering recurrence after three-dimensional conformal external beam radiotherapy. METHODS: The ultra-focal (target lesion alone), hemi-lobe (within a hemi-lobe) or focused whole-gland (focusing on the lesion, but extending into the whole gland) pattern was selected based on the Gleason score for the targeted biopsy, the numbers of positive cores in the targeted and systematic biopsies, and the locations of the positive cores. Novel dosimetry criteria derived from three-dimensional cancer mapping, which was based on targeted magnetic resonance imaging/transrectal ultrasound fusion biopsies, were used in these cases. RESULTS: Permanent salvage brachytherapy was carried out in 13 patients who suffered prostate-specific antigen failure (prostate-specific antigen 2.1-6.8 ng/mL; age range 57-75 years; Gleason score ≤7 [n = 10], Gleason score ≥8 [n = 2] and Gleason score not available [n = 1]) since 2012. The targeted biopsy showed a single focus in three patients. The ultra-focal, hemi-lobe and focused whole-gland patterns were chosen in three, five and five patients, respectively. During the follow-up period (median duration 48 months), prostate-specific antigen failure occurred in zero of three, one of five and three of five of the patients treated with the ultra-focal, hemi-lobe and focused whole-gland patterns, respectively. The 4-year biochemical recurrence-free survival rate was 74%. No grade 3-4 adverse intestinal or urological events occurred. CONCLUSIONS: Targeted fusion biopsy-based three-dimensional cancer mapping should be used for permanent salvage brachytherapy treatment planning to reduce the incidence of treatment-related adverse events while maintaining good oncological outcomes.

2.
Sci Rep ; 9(1): 16472, 2019 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-31712673

RESUMO

We demonstrate a logic gate based on interference of forward volume spin waves (FVSWs) propagating in a 54 nm thick, 100 µm wide yttrium iron garnet waveguide grown epitaxially on a garnet substrate. Two FVSWs injected by coplanar waveguides were made to interfere constructively and destructively by varying their phase difference, showing an XNOR logic function. The reflected and resonant waves generated at the edges of the waveguide were suppressed using spin wave absorbers. The observed isolation ratio was 19 dB for a magnetic field of ~2.80 kOe ( = 223 kA m-1) applied perpendicular to the film. The wavelength and device length were ~8.9 µm and ~53 µm, respectively. Further, the interference state of the SWs was analyzed using three-dimensional radio frequency simulations.

3.
Opt Express ; 27(20): 27573-27579, 2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31684522

RESUMO

Hologram memory is a strong candidate for optical storage due to its high recording density and high data transfer rate. We have studied and engineered a magnetic hologram memory medium using a stable magnetic garnet as recording material. To record a deep and clear magnetic hologram, it is important to control the heat diffusion generated during recording. Numerical simulation suggested that a multilayer structure with transparent heat-dissipation layers would be effective to address this. We fabricated a multilayer magnetic medium for a collinear magnetic hologram. This medium exhibited a diffraction efficiency as high as that of the single layered one, and errorless recording and reconstruction was achieved with the magnetic assist technique.

5.
Acta Haematol ; 141(2): 111-118, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30726834

RESUMO

We assessed the efficacy and safety of weekly cyclophosphamide-bortezomib-dexamethasone (CBD) induction prior to autologous stem cell transplantation (ASCT) in newly diagnosed Japanese patients with multiple myeloma (MM). This regimen consisted of four 28-day cycles of once-weekly oral cyclophosphamide (300 mg/m2), subcutaneous bortezomib (1.3 mg/m2), and oral dexamethasone (40 mg). Responding patients underwent stem cell collection followed by ASCT. The primary endpoint was the postinduction rate of achieving a near complete response (nCR) or better. Among the 38 enrolled patients, a complete response (CR), an nCR, a very good partial response (VGPR), and a partial response (PR) were achieved in 10.5, 2.6, 23.7, and 36.8% of cases, respectively. A grade 4 hematological adverse event (AE) was observed in 1 patient. Grade 3-4 infection, including febrile neutropenia, was observed in 4 patients (10.5%). Although 2 patients dropped out due to AE, 94.7% of the patients completed the induction phase. However, because of a poor response to induction chemotherapy (

Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Bortezomib/administração & dosagem , Ciclofosfamida/administração & dosagem , Dexametasona/administração & dosagem , Mieloma Múltiplo/tratamento farmacológico , Adolescente , Adulto , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Bortezomib/efeitos adversos , Ciclofosfamida/efeitos adversos , Dexametasona/efeitos adversos , Esquema de Medicação , Feminino , Doenças Hematológicas/etiologia , Transplante de Células-Tronco Hematopoéticas , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Mieloma Múltiplo/diagnóstico , Mieloma Múltiplo/mortalidade , Análise de Sobrevida , Transplante Autólogo , Resultado do Tratamento , Adulto Jovem
6.
J Stroke Cerebrovasc Dis ; 28(3): 612-618, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30472173

RESUMO

OBJECTIVE: To investigate the prevalence and outcomes of asymptomatic coronary artery disease (CAD) in patients with the first episode of ischemic stroke. METHODS: Patients admitted to our hospital between November 2001 and January 2009 for the episode of an acute ischemic stroke/transient ischemic attack were included. Stress-Tl-201 scintigraphy was performed and followed by coronary angiography (CAG). The prevalence and risks for asymptomatic CAD, and long-term outcomes were studied. RESULTS: Of 1309 patients, only 15 (1.1%) patients presented with a history of CAD. Excluding 406 patients because of severity, systemic infection, early transfer to another hospital, or a refusal to participate, myocardial scintigraphy was performed in 903 patients (mean age, 72 ± 10 years, male 63.9%), and myocardial ischemia was diagnosed in 214 patients (23.7%). Of these patients, 76 patients underwent CAG, and showed significant stenosis (>75%) of a coronary artery in 61 (80.3%) patients. The risk factors for positive scintigraphy findings and CAG were high-grade premature complexes via Holter monitoring (P < .0001), enlarged left ventricle (P = .0051) and wall motion abnormalities (P = .0014) observed on echocardiography, and carotid artery stenosis observed in magnetic resonance angiography imaging (P < .0001). During the follow-up periods of 83 ± 47 months and of 91 ± 47 months, 17.2% of scintigraphy-positive and 2.8% of scintigraphy-negative patients developed episodes of myocardial ischemia, respectively (P < .001). CONCLUSIONS: Symptomatic CAD was rare in Japanese patients with the first episode of ischemic stroke, but asymptomatic CAD was identified by stress Tl-201 myocardial scintigraphy in one-quarter of the patients. Positive scintigraphy was associated with asymptomatic CAD and future cardiac events.


Assuntos
Isquemia Encefálica/epidemiologia , Doença da Artéria Coronariana/epidemiologia , Acidente Vascular Cerebral/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Doenças Assintomáticas , Isquemia Encefálica/diagnóstico por imagem , Isquemia Encefálica/terapia , Angiografia Cerebral/métodos , Angiografia por Tomografia Computadorizada , Angiografia Coronária , Doença da Artéria Coronariana/diagnóstico por imagem , Doença da Artéria Coronariana/terapia , Progressão da Doença , Feminino , Humanos , Japão/epidemiologia , Angiografia por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Admissão do Paciente , Tomografia por Emissão de Pósitrons , Prevalência , Prognóstico , Medição de Risco , Fatores de Risco , Acidente Vascular Cerebral/diagnóstico por imagem , Acidente Vascular Cerebral/terapia , Fatores de Tempo
7.
Intern Med ; 58(8): 1111-1118, 2019 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-30568130

RESUMO

A 47-year-old man with ulcerative colitis was transferred to our hospital due to progressive dyspnea. Electrocardiography on admission showed ST elevation in leads II, III, aVF, and V5-V6. Coronary angiography revealed no remarkable coronary stenosis, and left ventriculography showed a depressed left ventricular ejection fraction (EF) of 23%. Although the patient received percutaneous cardiopulmonary support, his EF progressively decreased (7-15%), and both ventricular tachycardia (VT) and high-degree atrial-ventricular block occurred. An endomyocardial biopsy showed eosinophilic infiltration in the myocardium. Steroid therapy improved the patient's EF. However, his severe inferior wall hypokinesis and non-sustained VT remained after the abovementioned treatment.


Assuntos
Colite Ulcerativa/complicações , Colite Ulcerativa/tratamento farmacológico , Miocardite/tratamento farmacológico , Intervenção Coronária Percutânea/métodos , Esteroides/uso terapêutico , Taquicardia Ventricular/tratamento farmacológico , Taquicardia Ventricular/etiologia , Eosinofilia/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Miocardite/patologia , Resultado do Tratamento , Função Ventricular Esquerda/efeitos dos fármacos
8.
Sci Technol Adv Mater ; 19(1): 535-542, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30083278

RESUMO

We report a novel and inexpensive fabrication process of multiferroic nanocomposite via liquid phase using an anodic alumina template. The sol-gel spin-coating technique was used to coat the template with ferrimagnetic CoFe2O4. By dissolving the template with NaOH aqueous solution, a unique nanotube array structure of CoFe2O4 was obtained. The CoFe2O4 nanotube arrays were filled with, and sandwiched in, ferroelectric BaTiO3 layers by a sol-gel spin-coating method to obtain the composite. Its multiferroicity was confirmed by measuring the magnetic and dielectric hysteresis loops.

9.
ESC Heart Fail ; 5(4): 675-684, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29757498

RESUMO

AIMS: Patients with fulminant myocarditis (FM) often present with cardiogenic shock and require mechanical circulatory support, including extracorporeal membrane oxygenation (ECMO) and ventricular assist device (VAD) implantation. This study sought to clarify the determinants of successful weaning from ECMO in FM patients. METHODS AND RESULTS: We studied 37 consecutive FM patients supported by ECMO as the initial form of mechanical circulatory support between January 1995 and December 2014 in our hospital. Twenty-two (59%) patients were successfully weaned from ECMO, while 15 (41%) were not. There were significant differences in levels of peak creatine kinase and those of its MB isoform (CK-MB), left ventricular posterior wall thickness (LVPWT), and prevalence of cardiac rhythm disturbances. Receiver operating characteristic curve analysis revealed that a peak CK-MB level of 185 IU/L and LVPWT of 11 mm were the optimal cut-off values for predicting successful weaning from ECMO (areas under the curve, 0.89 and 0.85, respectively). During the follow-up [median 48 (interquartile range 8-147) months], 83% of FM patients who were weaned from ECMO survived, with preserved fractional shortening based on echocardiography. Of the 15 FM patients who were not weaned from ECMO, nine bridged to VAD, and only two were successfully weaned from VAD and survived. CONCLUSIONS: These results indicate that myocardial injury, as evidenced by CK-MB and LVPWT, and prolonged presence of cardiac rhythm disturbances are important clinical determinants of successful weaning from ECMO.


Assuntos
Oxigenação por Membrana Extracorpórea/métodos , Ventrículos do Coração/diagnóstico por imagem , Miocardite/terapia , Choque Cardiogênico/terapia , Doença Aguda , Adulto , Biópsia , Creatina Quinase Forma MB/sangue , Ecocardiografia , Feminino , Seguimentos , Ventrículos do Coração/fisiopatologia , Coração Auxiliar , Humanos , Masculino , Pessoa de Meia-Idade , Miocardite/complicações , Miocardite/diagnóstico , Miocárdio/patologia , Estudos Retrospectivos , Choque Cardiogênico/sangue , Choque Cardiogênico/etiologia , Resultado do Tratamento , Adulto Jovem
11.
Am J Cardiol ; 122(2): 206-212, 2018 07 15.
Artigo em Inglês | MEDLINE | ID: mdl-29747859

RESUMO

Although current guidelines have highlighted the importance of evidence-based optimal medical therapy (OMT) in patients with previous coronary artery bypass grafting (CABG), the effect of OMT on post-CABG patients requiring secondary coronary revascularization on prognosis remains unknown. We sought to examine the impact of OMT on post-CABG patients who underwent percutaneous coronary intervention (PCI) as secondary revascularization. A total of 632 consecutive post-CABG patients who underwent PCI between 2001 and 2013 at our hospital (84% men, median age 71 years) were divided into 2 groups: patients who were discharged with OMT and patients who were discharged without OMT (non-OMT). OMT was defined as the combination of an antiplatelet agent, statin, ß blocker, and angiotensin-converting enzyme inhibitor or angiotensin receptor blocker. Despite having a higher prevalence of clinical comorbidities, patients with OMT (n = 163) had a lower prevalence of all-cause death than those without OMT (n = 469) during a median follow-up of 95 months (OMT group 21.5%, non-OMT group 34.1%, p = 0.002). Both groups had similar procedural success rates. In a propensity-matched cohort (n = 146 each), OMT was associated with lower rates of all-cause death and cardiac death than non-OMT 8 years after PCI. In multivariable analysis, OMT was an independent predictor of all-cause death (hazard ratio [HR] 0.49, 95% confidence interval [CI] 0.34 to 0.72, p <0.001). In conclusion, OMT plays a protective role and reduces all-cause death in post-CABG patients requiring subsequent PCI. Outside of the domain of coronary revascularization, OMT could be considered an essential treatment in this patient population.


Assuntos
Ponte de Artéria Coronária/métodos , Doença da Artéria Coronariana/mortalidade , Fibrinolíticos/uso terapêutico , Intervenção Coronária Percutânea/métodos , Terapia Trombolítica/métodos , Idoso , Causas de Morte/tendências , Doença da Artéria Coronariana/terapia , Feminino , Seguimentos , Humanos , Masculino , Prognóstico , Reoperação , Estudos Retrospectivos , Fatores de Risco , Taxa de Sobrevida/tendências , Fatores de Tempo
12.
Chemistry ; 24(29): 7398-7409, 2018 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-29504636

RESUMO

The combination of the redox-active mesogenic anion [NiII (Bdt)(BdtSQ)]- (Bdt=1,2-benzenedithiolato; BdtSQ=1,2-dithia-semi-benzoquinonato) with alkyl-substituted ammonium cations afforded a series of redox-active ionic complexes of the type [NR4 ][NiII (Bdt)(BdtSQ)] [R=nC16 H33 (NC164 Ni) and C8,10 (NC8,104 Ni); C8,10=6-octylhexadecyl] or [NMe2 R2 ][NiII (Bdt)(BdtSQ)] [R=nC16 H33 (NMe2 C162 Ni) and C8,10 (NMe2 C8,102 Ni)]. X-ray crystallographic analyses of NMe2 C162 Ni and NC164 Ni revealed the formation of cation-dependent integrated ionic layers separated by interdigittated alkyl chains. Complexes NMe2 C162 Ni and NC164 Ni commonly form crystalline phases at room temperature, whereas complexes NMe2 C8,102 Ni and NC8,104 Ni, which contain branched alkyl chains, form a metastable mesophase and an amorphous phase at the same temperature, respectively. Furthermore, complexes NMe2 C162 Ni, NMe2 C8,102 Ni, and NC164 Ni commonly form a smectic A phase (SmA) at 375, 317, and 342 K, respectively. For the four complexes, well-defined cyclic voltammetry responses, derived from ligand-based oxidation and reduction, were observed in solution and the condensed phases, that is, upon casting these complexes on an indium-doped tin oxide working electrode. The present study demonstrates the tunability of the mesomorphism of ionic molecular assemblies composed of alkyl-substituted quaternary ammonium cations, while maintaining the well-defined redox responses of the anions even in the condensed phases.

13.
Sci Rep ; 7(1): 15398, 2017 11 13.
Artigo em Inglês | MEDLINE | ID: mdl-29133943

RESUMO

Diode-pumped solid-state micro lasers are compact (centimetre-scale), highly stable, and efficient. Previously, we reported Q-switched lasers incorporating rare-earth substituted iron garnet (RIG) film. Here, the first demonstration of the magnetooptical (MO) Q-switch in an Nd:YAG laser cavity is performed. We fabricate a quasi-continuous-wave (QCW) diode-pumped Nd:YAG laser cavity, which is shortened to 10 mm in length and which contains an RIG film and a pair of small coils. This cavity yields a 1,064.58-nm-wavelength pulse with 25-ns duration and 1.1-kW peak power at a 1-kHz repetition ratio. Further, the polarisation state is random, due to the isotropic crystal structure of Nd:YAG and the fact that the MO Q-switch incorporating the RIG film does not require the presence of polarisers in the cavity. This is also the first report of an MO Q-switch producing random polarisation.

14.
Sci Rep ; 7(1): 12835, 2017 10 09.
Artigo em Inglês | MEDLINE | ID: mdl-28993640

RESUMO

Hologram memory is expected to be the next-generation of optical data storage technology. Bismuth-substituted yttrium iron garnet is typically used for rewritable magnetic hologram media. The diffraction efficiency of magnetic holography depends on the Faraday rotation angle, but the experimental diffraction efficiency is not as high as that expected from calculations. This difference could be caused by incomplete magnetization reversal at the recorded region. In this study, we investigated the effects of magnetic assist (MA) recording through numerical simulation and experiment to improve the diffraction efficiency and the resulting reconstructed images. The improvement of diffraction efficiency was more effective in garnet films thinner than the width of a fringe, and a suitable value of the assist magnetic field was identified for the improvement. In addition, MA recording improved the intensity of reconstructed images and broadened the non-error recording conditions to the low energy region. This technique shows promise in improving the reconstructed quality of magnetic hologram data.

15.
Int Heart J ; 58(5): 778-786, 2017 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-28966327

RESUMO

High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, promotes angiogenesis and tissue repair, resulting in restored cardiac function after myocardial infarction (MI). Although dipeptidyl peptidase 4 (DPP4) degrades certain peptides, it remains unclear as to whether HMGB1 is a substrate of DPP4 and whether DPP4 inhibition prevents the cleavage of HMGB1.In transgenic mice with cardiac-specific overexpression of HMGB1 (TG) and wild-type mice (WT), a diabetic state was induced by streptozotocin, and MI was created by ligation of the left anterior descending coronary artery. To inhibit DPP4 activity, a DPP4 inhibitor anagliptin was used. The plasma levels of HMGB1, infarct size, echocardiographic data, angiogenesis, and vascular endothelial growth factor (VEGF) expression in the peri-infarct area were compared among non-diabetic MI WT/TG, diabetic MI WT/TG, and anagliptin-treated diabetic MI WT/TG mice.DPP4 activity was increased in the diabetic state and blocked by anagliptin administration. The HMGB1 plasma levels were reduced in the diabetic TG compared with the non-diabetic TG mice, but DPP4 inhibition with anagliptin increased HMGB1 plasma levels in the diabetic TG mice. The infarct area was significantly larger in the diabetic TG than in the non-diabetic TG mice, and it was reduced by DPP4 inhibition. Cardiac function, angiogenesis, and VEGF expression were impaired in the diabetic TG mice, but they were ameliorated by the DPP4 inhibition to levels similar to those found in the non-diabetic TG mice.The DPP4 inhibitor ameliorated cardiac function by inhibiting the inactivation of HMGB1 in diabetic mice after MI.


Assuntos
Diabetes Mellitus Experimental/complicações , Dipeptidil Peptidase 4/efeitos dos fármacos , Proteína HMGB1/biossíntese , Infarto do Miocárdio/metabolismo , Miocárdio/metabolismo , Pirimidinas/farmacologia , Função Ventricular Esquerda/efeitos dos fármacos , Animais , Western Blotting , Dipeptidil Peptidase 4/metabolismo , Inibidores da Dipeptidil Peptidase IV/farmacologia , Ecocardiografia , Ensaio de Imunoadsorção Enzimática , Proteína HMGB1/efeitos dos fármacos , Masculino , Camundongos , Camundongos Transgênicos , Infarto do Miocárdio/diagnóstico , Infarto do Miocárdio/etiologia , Miocárdio/patologia
16.
Opt Express ; 25(13): 15349-15357, 2017 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-28788962

RESUMO

Magnetic holographic memory is expected as a rewritable high-capacity data storage technology. To improve the reconstructed image, we investigate recording conditions by numerical simulation and experiments. We found experimentally that four diffracted beams from a digital micromirror device interfere with each other at a suitable defocus recording point, and such overlapping is favorable to obtain clear reconstruction images without diffuser. Subsequently, we modify the shape of the reference beam to ensure more effective interference. As a result, we achieve error-free image reconstruction from the magnetic hologram. Our results indicate that magnetic holograms can potentially be utilized as holographic memory.

17.
Sci Rep ; 7(1): 7898, 2017 08 11.
Artigo em Inglês | MEDLINE | ID: mdl-28801630

RESUMO

In the fifty years since the postulation of Moore's Law, the increasing energy consumption in silicon electronics has motivated research into emerging devices. An attractive research direction is processing information via the phase of spin waves within magnonic-logic circuits, which function without charge transport and the accompanying heat generation. The functional completeness of magnonic logic circuits based on the majority function was recently proved. However, the performance of such logic circuits was rather poor due to the difficulty of controlling spin waves in the input junction of the waveguides. Here, we show how Snell's law describes the propagation of spin waves in the junction of a Ψ-shaped magnonic majority gate composed of yttrium iron garnet with a partially metallized surface. Based on the analysis, we propose a magnonic counterpart of a core-cladding waveguide to control the wave propagation in the junction. This study has therefore experimentally demonstrated a fundamental building block of a magnonic logic circuit.

18.
Blood Adv ; 1(15): 1001-1015, 2017 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-29296743

RESUMO

High-mobility group AT-hook 2 (HMGA2) is crucial for the self-renewal of fetal hematopoietic stem cells (HSCs) but is downregulated in adult HSCs via repression by MIRlet-7 and the polycomb-recessive complex 2 (PRC2) including EZH2. The HMGA2 messenger RNA (mRNA) level is often elevated in patients with myelofibrosis that exhibits an advanced myeloproliferative neoplasm (MPN) subtype, and deletion of Ezh2 promotes the progression of severe myelofibrosis in JAK2V617F mice with upregulation of several oncogenes such as Hmga2. However, the direct role of HMGA2 in the pathogenesis of MPNs remains unknown. To clarify the impact of HMGA2 on MPNs carrying the driver mutation, we generated ΔHmga2/JAK2V617F mice overexpressing Hmga2 due to deletion of the 3' untranslated region. Compared with JAK2V617F mice, ΔHmga2/JAK2V617F mice exhibited more severe leukocytosis, anemia and splenomegaly, and shortened survival, whereas severity of myelofibrosis was comparable. ΔHmga2/JAK2V617F cells showed a greater repopulating ability that reproduced the severe MPN compared with JAK2V617F cells in serial bone marrow transplants, indicating that Hmga2 promotes MPN progression at the HSC level. Hmga2 also enhanced apoptosis of JAK2V617F erythroblasts that may worsen anemia. Relative to JAK2V617F hematopoietic stem and progenitor cells (HSPCs), over 30% of genes upregulated in ΔHmga2/JAK2V617F HSPCs overlapped with those derepressed by Ezh2 loss in JAK2V617F/Ezh2Δ/Δ HSPCs, suggesting that Hmga2 may facilitate upregulation of Ezh2 targets. Correspondingly, deletion of Hmga2 ameliorated anemia and splenomegaly in JAK2V617F/Ezh2Δ/wild-type mice, and MIRlet-7 suppression and PRC2 mutations correlated with the elevated HMGA2 mRNA levels in patients with MPNs, especially myelofibrosis. These findings suggest the crucial role of HMGA2 in MPN progression.

19.
Sci Rep ; 6: 38679, 2016 12 08.
Artigo em Inglês | MEDLINE | ID: mdl-27929119

RESUMO

A 10-mm cavity length magnetooptically Q-switched Nd:GdVO4 laser was demonstrated using a single-crystalline ferrimagnetic rare-earth iron garnet film. To design the Q-switching system, the magnetic, optical, and magnetooptical properties of the garnet film were measured. The diode pumped solid-state laser cavity was constructed using a 190-µm-thick garnet film with 58% transmittance. The garnet film had maze-shaped magnetic domains, and the domain walls disappeared when a field of over 200 Oe was applied. Therefore, the polarization state of the transmitted light was modified by modulating the magnetization, and a Q-switched pulse output with a pulse width of 5 ns and peak power of 255 W was achieved in the 10-mm-long cavity. The physical limitation of the pulse width was discussed with the calculated results.

20.
ESC Heart Fail ; 3(2): 77-85, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27774270

RESUMO

BACKGROUND: Heart failure (HF) and diabetes mellitus (DM) often co-exist. Treatment of DM in HF patients is challenging because some therapies for DM are contraindicated in HF. Although previous experimental studies have reported that dipeptidyl peptidase-4 (DPP-4) inhibitors improve cardiovascular function, whether DPP-4 inhibition improves mortality of HF patients with DM remains unclear. Therefore, we examined the impact of DPP-4 inhibition on mortality in hospitalized HF patients using propensity score analyses. METHODS AND RESULTS: We performed observational study analysed by propensity score method with 962 hospitalized HF patients. Of these patients, 293 (30.5%) had DM, and 122 of these DM patients were treated with DPP-4 inhibitors. Propensity scores for treatment with DPP-4 inhibitors were estimated for each patient by logistic regression with clinically relevant baseline variables. The propensity-matched 1:1 cohorts were assessed based on propensity scores (DPP-4 inhibitors, n = 83, and non-DPP-4 inhibitors, n = 83). Kaplan-Meier analysis in the propensity score-matched cohort demonstrated that cardiac and all-cause mortality was significantly lower in the DPP-4 inhibitor group than in the non-DPP-4 inhibitor group (cardiac mortality: 4.8% vs. 18.1%, P = 0.015; all-cause mortality: 14.5% vs. 41.0%, P = 0.003, by a log-rank test). In the multivariable Cox proportional hazard analyses, after adjusting for other potential confounding factors, the use of DPP-4 inhibitors was an independent predictor of all-cause mortality (pre-matched cohort: hazard ratio 0.467, P = 0.010; post-matched cohort: hazard ratio 0.370, P = 0.003) in HF patients with DM. CONCLUSIONS: Our data suggest that DPP-4 inhibitors may improve cardiac and all-cause mortality in hospitalized HF patients with DM.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA