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1.
J Cardiol ; 2020 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-32192846

RESUMO

BACKGROUND: Ischemic cardiovascular disease (ICVD) has high incidence and high mortality worldwide. The studies of its risk factors were mostly concentrated on an individual level, and there are scarce studies on the two levels of risk factors which include individual and regional levels. METHODS: The data were obtained from a community-based study in 4 cities and 6 counties of Henan, China. Risk factors were initially screened by one-way analysis of variance or chi-square test. Then, they were re-analyzed using a two-level logistic regression model to construct a personal disease risk prediction model. RESULTS: A two-level ICVD risk prediction model comprised 11 variables: age, body mass index (BMI), family history of hypertension, marital status, salt intake, smoking, moderate recreational physical activities, alcohol intake, and education at the individual level. Among the unalterable risk factors, for each additional unit of age and family history of hypertension, the risk of ICVD increased by 1.08 and 1.07 units [ß95% confidence interval (95%CI): 0.99-1.16, 0.97-1.17, both p < 0.0001], respectively. Among the modifiable risk factors, the ICVD risk increases by 0.67, 0.27, and 0.28 units for each additional unit of BMI, marital status, and education (ß95%CI: 0.60-0.74, p < 0.0001; ß95%CI: 0.14-0.40, p = 0.0012, 0.18-0.37, p = 0.0001). CONCLUSIONS: The two-level ICVD risk model can predict that the risk of one person for ICVD will be lower if one is younger, thinner, and well-educated without a family history of hypertension. Overall, the two-level ICVD risk prediction model gets a better fitting effect than the single-level model.

2.
Chem Biodivers ; 2020 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-32180346

RESUMO

Three dimeric cassane diterpenoids, caesalpanins A-C ( 1-3 ), were isolated from the seeds of Caesalpinia sappan L.. Their structures were determined via analysis of 1D-, 2D-NMR, and HR-ESI-MS data. Compounds 1 and 2 were the second examples of nitrogen containing cassane diterpenoid dimer linked through one ether bond between C-19 and C-20'. Compound 2 exhibited moderate cytotoxic activity against MCF-7 cell line with IC 50 value of 29.98 µ M. Compounds 1 and 2 had weak inhibitory effects against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages at 50 µ M with inhibitory rate of 36.01% and 32.93%, respectively.Three dimeric cassane diterpenoids, caesalpanins A-C ( 1-3 ), were isolated from the seeds of Caesalpinia sappan L., as well as three known compounds ( 4-6 ). Their structures were determined via analysis of 1D-, 2D-NMR, and HR-ESI-MS data. Compounds 1 and 2 were the second and third compounds that presented a nitrogen containing cassane diterpenoid dimer linked through one ether bond between C-19 and C-20'. Compound 2 exhibited moderate cytotoxic activity against MCF-7 cell line with IC 50 value of 29.98 µ M. Compounds 1 and 2 had weak inhibitory effects against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages at 50 µ M with inhibitory rate of 36.01% and 32.93%, respectively.

3.
Phys Rev Lett ; 124(2): 023603, 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-32004058

RESUMO

Exploring the properties and applications of topological quantum states is essential to better understand topological matter. Here, we theoretically study a quasi-one-dimensional topological atom array. In the low-energy regime, the atom array is equivalent to a topological superatom. Driving the superatom in a cavity, we study the interaction between light and topological quantum states. We find that the edge states exhibit topology-protected quantum coherence, which can be characterized from the photon transmission. This quantum coherence helps us to find a superradiance-subradiance transition, and we also study its finite-size scaling behavior. The superradiance-subradiance transition also exists in symmetry-breaking systems. More importantly, it is shown that the quantum coherence of the subradiant edge state is robust to random noises, allowing the superatom to work as a topologically protected quantum memory. We suggest a relevant experiment with three-dimensional circuit QED. Our study may have applications in quantum computation and quantum optics based on topological edge states.

5.
Int J Biol Macromol ; 149: 116-126, 2020 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-31987948

RESUMO

The development of ideal organic-inorganic composite scaffold with porous structure and favorable osteoinductive properties that mimics the extracellular matrix composition of bone, is essential for the guidance of new bone formation in orthopaedic practice. Nowadays, numerous efforts have been dedicated to constructing implantable biocomposite scaffolds with appropriate structure and bioactivity for repairing bone defects. In this study, we fabricated chitosan-alginate-gelatin (CAG)-based porous biocomposite scaffolds with calcium phosphate coating on the surface and dexamethasone (DEX)-loaded mesoporous silica nanoparticles within the scaffold, which allows sustained release of DEX for bone tissue engineering application. The inorganic components of calcium phosphate crystals formed on the wall of scaffolds were obtained through electrochemical deposition method. The hybrid mineralized scaffolds demonstrate significantly high mechanical strength and reduced swelling property compared with pristine CAG scaffolds. The in vitro proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs) cultured on biocomposite scaffolds were significantly enhanced. Furthermore, in vivo experiments revealed that biocomposite scaffolds with minerals deposition and DEX loading showed better new bone formation ability, as compared to pure CAG scaffold and single mineralized scaffold. Therefore, the developed biocomposite scaffolds may be highly promising as local implantable scaffolds for potential applications in bone tissue engineering.

6.
Adv Mater ; : e1906513, 2020 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-31943380

RESUMO

Ferroelectric materials with spontaneous polarization-induced internal electric fields have drawn increasing attention in solar fuel production due to the intrinsic polarized structure. However, the origination of charge separation in these materials at the nano/microlevel is ambiguous owing to the complexity of the multielectric fields. Besides, the observed charge separation ability is far from theoretical expectation. Herein, by spatially resolved surface photovoltage spectroscopy, it is clearly demonstrated that the depolarization field in single-domain ferroelectric PbTiO3 (PTO) nanoplates is the main driving force for charge separation and it can effectively drive photogenerated electrons and holes to the positive and negative polarization facets, respectively. Moreover, the charge separation ability of PTO nanoplates increases with increasing particle size along the polarization direction, due to the increasing potential difference between the opposite polarization facets. Furthermore, this driving force for charge separation directly contributes to the enhancement of the photocatalytic hydrogen evolution reaction activity in ferroelectrics. Finally, it is proved that the screening field compensates part of the depolarization field and can be diminished by adding a dielectric layer on the ferroelectric surface. These findings demonstrate the importance of increasing the depolarization field and decreasing the screening field for efficient charge separation in ferroelectric semiconductor photocatalysts.

7.
Chem Commun (Camb) ; 56(7): 1007-1021, 2020 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-31898694

RESUMO

Nanoparticle photocatalysts present the obvious characteristic of heterogeneity in structure, energy, and function at spatial and temporal scales. Understanding the nature of spatial variations and reaction dynamics in photosynthetic solar energy conversion systems at the single particle level is of crucial importance to clarify the underlying mechanism of photocatalytic reactions. In this review, we focus on advanced characterization tools employed to reveal the physical and chemical properties of photocatalysts in space and time. We highlight the recent significant progress to elucidate the microscopic mechanisms of photogenerated charge generation, transfer and recombination and surface reaction kinetics. We also discuss the primary advantages and limitations of these characterization approaches and the development of powerful tools in photocatalysis in the future.

8.
Macromol Rapid Commun ; 41(5): e1900624, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31977130

RESUMO

A 2D conjugated polyelectrolyte (CPE), PBDTTh-TT-NBr, having the same backbone as the highly efficient donor polymer PTB7-Th and the quaternary ammonium pendant, is synthesized as a cathode interlayer (CIL) material for PTB7-Th-based fullerene and non-fullerene solar cells. The quaternary ammonium group is connected to the 2D conjugated backbone by a long, flexible alkyl chain, facilitating the modification of cathode via forming interface dipoles. Moreover, compared with another CPE analogue to PTB7, PBDT-TT-NBr, without the 2D conjugated backbone, the PBDTTh-TT-NBr presents a higher similarity in polymer structure to the donor polymer PTB7-Th. This feature makes it more compatible with the PTB7-Th-based active-layer film, improving the electron transport. With the PBDTTh-TT-NBr as the CIL, devices afford higher performances than those using the PBDT-TT-NBr in both fullerene and non-fullerene systems. This work offers guidance on choosing the CIL material that ought to possess a highly similar structure to the active-layer component.

9.
Xenotransplantation ; 27(1): e12556, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31578787

RESUMO

BACKGROUND: The dysfunction of islet grafts is generally attributed to hypoxia-induced damage. Mesenchymal stem cells (MSCs) are currently thought to effectively protect cells from various risk factors via regulating autophagy. In our study, we investigated if human umbilical cord-derived MSCs could ameliorate hypoxia-induced apoptosis in porcine islets by modulating autophagy, and we explored the underlying mechanisms. METHODS: Neonatal porcine islet cell clusters (NICCs) were cultured with human umbilical cord-derived MSC conditioned medium (huc-MSC-CM) and RPMI-1640 medium (control) under hypoxic conditions (1% O2 ) in vitro. NICCs were treated with 3-methyladenine (3-MA) and chloroquine (CQ) to examine the role of huc-MSC-CM in regulating autophagy. Finally, the levels of several cytokines secreted by huc-MSCs were detected by ELISAs, and the corresponding inhibitors were applied to investigate which cytokine mediates the protective effects of huc-MSC-CM. The effects of huc-MSC-CM on NICCs viability and autophagy were examined using AO/PI staining, flow cytometry analysis, transmission electron microscopy (TEM) and confocal fluorescence microscopy analysis. The insulin secretion of NICCs was tested with an insulin immunoradiometric assay kit. RESULTS: Compared to the control, the huc-MSC-CM treatment improved the viability of NICCs, inhibited apoptosis, increased autophagic activity and the levels of PI3K class III and phosphorylated Akt, while the ratio of phosphorylated mTOR/mTOR was reduced. These changes were reversed by CQ and 3-MA treatments. High concentrations of IL-6 were detected in hu-MSC-CM. Furthermore, recombinant IL-6 pre-treatment exerted similar effects as huc-MSC-CM, and these effects were reversed by a specific inhibitor of IL-6 (Sarilumab). CONCLUSIONS: Our results demonstrated that huc-MSC-CM improved islet viability and function by increasing autophagy through the PI3K/Akt/mTOR pathway under hypoxic conditions. Additionally, IL-6 plays an important role in the function of huc-MSC-CM.

10.
Exp Mol Pathol ; 112: 104346, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31758917

RESUMO

Atorvastatin is a commonly prescribed statin drug for the control of lipid synthesis and recent studies have shown the cardiac protection potential of atorvastatin. Cardiac fibrosis is a critical process that impairs heart function. In the current study, the anti-fibrosis potential of atorvastatin was assessed and the mechanism associated with the treatment was explored. Fibrotic symptoms were induced using transverse aortic constriction (TAC) method in vivo and using TGF-ß1 in vitro. The effect of atorvastatin on the development of cardiac fibrosis was firstly measured. Moreover, the influence of miR-143-3p induction on the anti-fibrosis function of atorvastatin was determined. TAC administration induced cardiac fibrosis and heart weight increase, which was associated with the induced expressions of TGF-ß1, miR-143-3p, p-Smad2, and collagens. Atorvastatin restored the levels of TGF-ß1, miR-143-3p, p-Smad2, and collagens. The administration of TGF-ß1 induced the expressions of miR-143-3p, p-Smad2, and collagens in cardiac fibroblasts (CFs) and the effect was inhibited by atorvastatin. However, the function of atorvastatin was blocked by miR-143-3p mimics. The current study demonstrated that the suppression of miR-143-3p contributed to the anti-fibrosis effect of atorvastatin on myocardial tissues, which subsequently inhibited Smad2-mediated production of collagens.

11.
Adv Healthc Mater ; 9(2): e1901307, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31814332

RESUMO

A nanoplatform that integrates diagnostic and therapeutic functions with intrinsic tumor microenvironment-responsive biodegradability is highly desired. Herein, a biodegradable nanotheranostic agent based on hollow mesoporous organosilica nanoparticles (HMONs), followed by encapsulating of heat shock protein 90 (Hsp 90) inhibitor is described. Then, the pore-engineering including gating with bovine serum albumin-iridium oxide nanoparticles (BSA-IrO2 ) and conjugation of polyethylene glycol (PEG) is conducted to yield 17AAG@HMONs-BSA-IrO2 -PEG (AHBIP) nanotheranostics for multimode computed tomography (CT)/photoacoustic (PA) imaging-guided photodynamic therapy (PDT) and low-temperature photothermal therapy (PTT). Such nanoplatforms show extraordinary photothermal conversion efficiency, high cargo loading (35.4% for 17AAG), and stimuli-responsive release of 17AAG for inhibition of Hsp90, which induces cell apoptosis at low-temperatures (≈41 °C). Also, the IrO2 simultaneously endows the nanotheranostics with catalytic activity in triggering the decomposition of H2 O2 into O2 and thus reducing the tumor hypoxia, as well as protecting normal tissues against H2 O2 -induced inflammation. AHBIP shows good photocatalysis activity for PDT as a result of the generation of superoxide anion by laser irradiation. The resulting AHBIP-mediated synergistic PTT/PDT offers an outstanding therapeutic outcome both in vitro and in vivo. Overall, the incorporation of the BSA-IrO2 and biodegradable HMONs into one nanoplatform has great potential for clinical applications.

12.
Biol Trace Elem Res ; 2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31773485

RESUMO

This study was to investigate the effects of dietary zinc (Zn) supplementation on performance, zinc transporter gene expression, and immune function in aged laying hens. In experiment 1, twenty 31-week-old hens (young) and twenty 60-week-old hens (old) with the same genetic background were fed with the same diet for 4 weeks. In experiment 2, a basal diet supplemented with zinc sulfate (ZnS) and zinc glycine chelate (ZnG) at 30, 60, 90, and 120 mg Zn/kg to constitute nine experimental diets. Eight hundred and ten 60-week-old layers were distributed in a completely randomized experimental design with 9 treatments, 6 replicates of 15 birds each, and birds were fed for 10 weeks. In experiment 1, results showed that zinc and metallothionein (MT) concentration in the shell gland of old hens was significantly lower than young layers (P < 0.05). Zinc transporters ZnT1, 4, 5, 6, and 7 messenger RNA (mRNA) abundance in old layers were significantly lower versus the young (P < 0.05). In experiment 2, results indicated that dietary zinc supplementation did not significantly affect the laying rate, average feed intake, egg weight, feed conversion efficiency, broken egg rate, or mortality (P > 0.05). Supplemental ZnG significantly improved eggshell breaking strength than ZnS, with a higher alkaline phosphatase (ALP) activity and more abundant ZnT4 expression in shell gland versus ZnS (P < 0.05). ZnG supplementation at 90 mg Zn/kg affected the duodenal mucus by significantly increasing ZnT1, 6, 7, ZIP13, and MT-4 mRNA level (P < 0.05). Zinc level significantly increased bovine serum albumin (BSA) antibody concentration on 14 day after BSA injection (P < 0.05). Supplementation of ZnG improved eggshell quality of aged layers by upgrading zinc transporter expression in the shell gland and intestine also enhanced humoral immunity.

13.
Nat Commun ; 10(1): 5277, 2019 11 21.
Artigo em Inglês | MEDLINE | ID: mdl-31754099

RESUMO

Mitochondrial calcium ([Ca2+]mito) dynamics plays vital roles in regulating fundamental cellular and organellar functions including bioenergetics. However, neuronal [Ca2+]mito dynamics in vivo and its regulation by brain activity are largely unknown. By performing two-photon Ca2+ imaging in the primary motor (M1) and visual cortexes (V1) of awake behaving mice, we find that discrete [Ca2+]mito transients occur synchronously over somatic and dendritic mitochondrial network, and couple with cytosolic calcium ([Ca2+]cyto) transients in a probabilistic, rather than deterministic manner. The amplitude, duration, and frequency of [Ca2+]cyto transients constitute important determinants of the coupling, and the coupling fidelity is greatly increased during treadmill running (in M1 neurons) and visual stimulation (in V1 neurons). Moreover, Ca2+/calmodulin kinase II is mechanistically involved in modulating the dynamic coupling process. Thus, activity-dependent dynamic [Ca2+]mito-to-[Ca2+]cyto coupling affords an important mechanism whereby [Ca2+]mito decodes brain activity for the regulation of mitochondrial bioenergetics to meet fluctuating neuronal energy demands as well as for neuronal information processing.

14.
Int J Cancer ; 2019 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-31583695

RESUMO

This study aimed to compare the differences in characteristics and prognoses between Asian and white patients receiving immunotherapy for nonsmall cell lung cancer (NSCLC). We studied 390 patients who received atezolizumab as part of the POPLAR or OAK trial, and analyzed the differences in baseline characteristics, outcomes and genetic mutations in blood samples between Asian and white patients. Overall survival (OS) was longer in Asian compared to white patients (median OS: 18.7 vs. 11.1 months; p = 0.005). Race was identified as an independent prognostic factor for OS (Asian vs. white: hazard ratio 0.647, 95% confidence interval 0.447-0.936, p = 0.021), together with performance status, histology, baseline sum of the longest tumor diameters (BLSLD) and number of metastatic sites. The two groups also differed in terms of characteristics including smoking history, BLSLD, epidermal growth factor receptor (EGFR) mutation frequency, programmed death-ligand 1 expression and blood-based tumor-mutation burden. Blood mutations of STK11, EGFR, KEAP1, POLE, GRM3, ATM and STAG2 were associated with treatment response, and TP53, KEAP1, APC, RB1, CREBBP, EPHA5 and STAG2 mutations were associated with OS. The blood-based mutation profiles differentiated between Asian and white patients, especially in relation to EGFR (23.8 vs. 8.5%), TP53 (30.2 vs. 46.9%) and STK11 (1.6 vs. 12.3%) mutations (all p < 0.05). The different clinicopathological features and mutation profiles in Asian and white patients may explain the superior outcome following atezolizumab treatment in Asian patients with NSCLC. The results of this study have important implications for further studies on racial disparities in relation to immunotherapy.

15.
Artigo em Inglês | MEDLINE | ID: mdl-31545751

RESUMO

The analysis of cell mitotic behavior plays important role in many biomedical research and medical diagnostic applications. To improve the accuracy of mitosis detection in automated analysis systems, this paper proposes the sequential saliency guided deep neural network (SSG-DNN) to jointly identify and localize mitotic events in time-lapse phase contrast microscopy images. It consists of three key modules. First, the module of visual context learning extracts static visual feature and dynamic visual transition within individual volumetric cell regions. Secondly, with these information, the module of sequential saliency modeling aims to discover the saliency distribution over all successive frames in each volumetric region. Finally, the module of sequence structure modeling can leverage both visual context and saliency distribution for mitosis identification and localization. SSG-DNN can jointly realize visual feature learning and sequential structure modeling in the end-to-end framework. Moreover, the proposed method is independent of complicated preconditioning methods for mitotic candidate extraction and can be applied for mitosis detection in one-shot manner. To our knowledge, it is the first weakly supervised work to realize joint mitosis identification and localization only with sequence-wise labels. In our experiments, we evaluate its performances of both tasks on the popular C3H10 dataset and a novel and large-scale dataset, C2C12-16, which contains much more mitotic events and is more challenging owing to diverse cell culture conditions. Experimental results can demonstrate the superiority of the proposed method.

16.
Lung Cancer ; 135: 138-144, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31446986

RESUMO

OBJECTIVES: Whether epidermal growth factor receptor tyrosine-kinase inhibitors (EGFR-TKIs) plus local consolidative therapy (LCT) has survival benefit over EGFR-TKIs alone in lung adenocarcinoma patients with EGFR mutation and bone oligometastases remains controversial. MATERIALS AND METHODS: We conducted a retrospective study to assess the effects of LCT in lung adenocarcinoma patients with bone oligometastases and EGFR mutation. The primary endpoint was overall survival (OS); the secondary endpoints was progression-free survival (PFS). RESULTS: A total of 127 lung adenocarcinoma patients with EGFR mutation and bone oligometastases were assessed, including 65 patients received EGFR-TKIs alone (monotherapy group) and 62 patients received EGFR-TKIs plus local consolidative therapy (LCT) (combination group). Addition of LCT was associated with significantly longer OS (36.3 vs. 21.0 months, P = 0.01; hazard ratio [HR] = 0.537, 95% confidence interval [CI]: 0.360-0.801, p = 0.01) and PFS (14.0 vs. 8.1 months, P = 0.01; HR = 0.613, 95%CI: 0.427-0.879, p = 0.01) in the whole cohort. CONCLUSION: In lung adenocarcinoma patients with EGFR-mutation and bone oligometastases, LCT plus EGFR-TKIs therapy is associated with significantly longer OS and PFS compared with EGFR-TKIs therapy alone, indicating that LCT plus EGFR-TKIs therapy might be a better therapeutic option for this patient population.

17.
Cancer Imaging ; 19(1): 47, 2019 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-31292000

RESUMO

OBJECTIVE: To evaluate the relationship between clinicopathologic characteristics and prognosis in patients with invasive mucinous adenocarcinoma (IMA) of the lung. METHODS: A total of 68 patients who underwent surgical resection for primary lung IMA were reviewed during the period of 2009 and 2017. Tumors were classified as solitary-type or pneumonic-type according to the computed tomography (CT) findings. Cox proportional hazards model was used to assess the effects of clinicopathological characteristics on univariate and multivariable analyses of disease-free survival (DFS). RESULTS: Solitary-type was found in 54 patients, while pneumonic-type was found in 14 patients. The patients' age varied between 56 and 68 years (patients' median age was 61 years). Besides, 50 patients had T1/T2 tumor stage (73.5%). Compared with solitary-type, higher T stage, N stage, and pathological stage (P < 0.001) were found in pneumonic-type. Moreover, the survival analysis showed that the pneumonic-type had a significantly poorer DFS compared with solitary-type (P = 0.004). Univariate analysis showed that pneumonic pattern on CT scan, T stage, pathologic stage, and thyroid transcription factor-1 (TTF-1) were significant predictive factors of survival (P = 0.011, 0.014, 0.013, 0.029, respectively). Multivariate analysis further indicated that pneumonic-type was the only independent prognostic factor for poor survival [hazard ratio (HR) = 6.764, 95% confidence interval (CI): 1.563-29.269, P = 0.011]. CONCLUSIONS: Based on CT findings, the solitary-type IMA is associated with a lower stage and better prognosis compared with the pneumonic-type IMA.


Assuntos
Adenocarcinoma de Pulmão/diagnóstico por imagem , Adenocarcinoma Mucinoso/diagnóstico por imagem , Neoplasias Pulmonares/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Adenocarcinoma de Pulmão/patologia , Adenocarcinoma Mucinoso/patologia , Adulto , Idoso , Intervalo Livre de Doença , Feminino , Humanos , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Tomografia Computadorizada por Raios X/normas
18.
Target Oncol ; 14(4): 491, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31317306

RESUMO

The article Epidermal Growth Factor Receptor (EGFR)-Tyrosine Kinase Inhibitors (TKIs) Combined with Chemotherapy Delay Brain Metastasis in Patients with EGFR-Mutant Lung Adenocarcinom, written by Changhui Li, Bo Zhang, Jindong Guo, Fang Hu, Wei Nie, Xiaoxuan Zheng, Lixin Wang, Yuqing Lou, Yinchen Shen, Baohui Han, Xueyan Zhang, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 03 July 2019 with open access. With the author(s)' decision to step back from Open Choice, the copyright of the article changed on 17 July 2019 to © Springer Nature Switzerland AG 2019 and the article is forthwith distributed under the terms of copyright.

19.
Target Oncol ; 14(4): 423-431, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31270661

RESUMO

BACKGROUND: Whether epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) combined with chemotherapy can delay the occurrence of brain metastasis (BM) is unclear. OBJECTIVE: This retrospective study aimed to evaluate whether EGFR-TKIs combined with chemotherapy can delay BM and decrease the incidence of BM as initial progression. PATIENTS AND METHODS: The data of 100 patients with EGFR-mutant advanced lung adenocarcinoma were retrospectively reviewed. The patients had no BM at initial diagnosis, and BM occurred during the treatment. Patients received EGFR-TKI only or EGFR-TKI combined with chemotherapy. Intracranial progression-free survival (iPFS), systemic progression-free survival (PFS), and overall survival (OS) were evaluated. RESULTS: The overall median OS was 39 months (95% confidence interval (CI), 35.6-42.4 months). The median OS of EGFR-TKI combined with chemotherapy and EGFR-TKI only are 41 months (95% CI 35.5-46.5 months) and 39 months (95% CI 36.8-41.2 months), respectively. Patients in the combination treatment group had longer PFS (16 vs. 10 months; P = 0.030) and iPFS (21 vs. 14 months; P = 0.026). Further, as initial progression, fewer patients developed BM in the combined treatment group compared with the EGFR-TKI-only group (30.6% vs. 52.9%, P = 0.002) with a hazard ratio of 0.64 (95% CI 0.43-0.96). After controlling for significant covariables in a multivariable model, the different treatment strategies were independently associated with improved iPFS. CONCLUSIONS: In this retrospective analysis, EGFR-TKIs combined with chemotherapy could improve PFS. Further, the combined treatment could delay BM occurrence and decrease the incidence of BM as initial progression.

20.
Biosens Bioelectron ; 141: 111450, 2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31247454

RESUMO

Nanozymes have fascinated increasing attention in the field of artificial enzyme. Designing an ideal nanozyme usually requires a synergic advantage of reasonable nanostructures and large specific surface area for ensuring excellent mimicking-enzyme catalytic activity. Here we report a CuS nanozyme with hollow nanocube structure (h-CuS NCs), which has a large surface area of 57.84 m2 g-1, and thus realizes excellent mimicking-enzyme catalytic activity. Expectedly, our directed design of h-CuS NCs nanozymes has an affinity for H2O2 of 0.94 mM, which is outstanding among the state-of-the-art Cu-based nanozymes. Furthermore, this nanozyme acts as a multifunctional catalyst to induce luminol chemiluminescence and oxide 3, 3', 5, 5'-tetramethylbenzidine (TMB) in the presence of H2O2, and displays distinguished electrocatalytic activity to glucose oxidation. More intriguingly, the nanozyme can produce a promising photothermal effect under the illumination of near-infrared light. This work will provide a prototype for rational design of distinct nanostructures as multifunctional nanozymes in the area of electrochemical sensing, mimicking-enzyme catalytic biosening and cancer therapy.


Assuntos
Colorimetria/métodos , Cobre/química , Dopamina/análise , Glucose/análise , Nanoestruturas/química , Sulfetos/química , Benzidinas/química , Técnicas Biossensoriais/métodos , Catálise , Técnicas Eletroquímicas/métodos , Peróxido de Hidrogênio/química , Substâncias Luminescentes/química , Luminol/química , Nanoestruturas/ultraestrutura , Oxirredução
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