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1.
J Hosp Infect ; 103(3): 280-283, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31170422

RESUMO

The aim of the study was to assess antimicrobial prescribing patterns, and variation in practice, in India. A point prevalence survey (PPS) was conducted in October to December 2017 in 16 tertiary care hospitals across India. The survey included all inpatients receiving an antimicrobial on the day of PPS and collected data were analysed using a web-based application of the University of Antwerp. In all, 1750 patients were surveyed, of whom 1005 were receiving a total of 1578 antimicrobials. Among the antimicrobials prescribed, 26.87% were for community-acquired infections; 19.20% for hospital-acquired infections; 17.24% for medical prophylaxis; 28.70% for surgical prophylaxis; and 7.99% for other or undetermined reasons. Antibiotic prescribing quality indicators, such as reason in notes and post-prescription review score, were low. This PPS showed widespread antibiotic usage, underlining the need for antibiotic stewardship to promote evidence-based practice.


Assuntos
Antibacterianos/uso terapêutico , Uso de Medicamentos/estatística & dados numéricos , Humanos , Índia , Inquéritos e Questionários , Centros de Atenção Terciária
3.
Indian J Med Microbiol ; 32(1): 44-8, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24399387

RESUMO

BACKGROUND: The incidence of fungal infections has increased significantly, contributing to morbidity andmortality. This is caused by an alarming increase in infections with multi-drug resistant bacteria leading to overuse of broad-spectrum antimicrobials, which lead to overgrowth of Candida, thus enhancing its opportunity to cause disease. Candida are major human fungal pathogens that cause both mucosal and deep tissue infections. OBJECTIVE: The aim of our study was to identify the distribution of Candida species among clinical isolates and their sensitivity pattern for common antifungal drugs. MATERIALS AND METHODS: Two hundred and thirty-sevendifferent clinical isolates of Candida were collected from patients visiting to a tertiary care centre of Indore from 2010 to 2012. Identification of Candida species as well antifungal sensitivity testing was performed with Vitek2 Compact (Biomerieux France) using ID-YST Kits. Antifungal susceptibility testing was performed with AST YS01 KitsonVitek2 Compact. RESULTS: We found that the non-albicans Candida were more prevalent than Candida albicans in paediatric (<3 year) and older (>60 year) patients than other age group (4-18, 19-60 years) patients and also in intensive care unit (ICU) patients as compared to out patient department (OPD) patients. Resistance rates for amphotericin B, fluconazole, flucytosine, itraconazole, and voriconazolewere 2.9%, 5.9%, 0.0%, 4.2% and 2.5%%, respectively. All the strains of C. krusei were found resistant to fluconazole with intermediate sensitivity to flucytosine. CONCLUSION: Species-level identification of Candidaand their antifungal sensitivity testing should be performed to achieve better clinical results.


Assuntos
Antifúngicos/farmacologia , Candida/classificação , Candida/efeitos dos fármacos , Candidíase/microbiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Candida/isolamento & purificação , Candidíase/epidemiologia , Criança , Pré-Escolar , Farmacorresistência Fúngica , Feminino , Humanos , Índia/epidemiologia , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Prevalência , Centros de Atenção Terciária , Adulto Jovem
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