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1.
Nihon Shokakibyo Gakkai Zasshi ; 118(11): 1063-1070, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-34759103

RESUMO

An advanced small bowel mucinous adenocarcinoma with Peutz-Jeghers syndrome was resected, and we started capecitabine plus oxaliplatin (CapeOX) as adjuvant therapy. However, local recurrence was noted, and the tumor increased even after CapeOX plus bevacizumab and fluorouracil plus leucovorin plus irinotecan plus panitumumab (FOLFIRI plus panitumumab). Pembrolizumab was administered after confirming high-frequency microsatellite instability, and the tumor shrank markedly and remained shrunk for 20 months.


Assuntos
Adenocarcinoma Mucinoso , Neoplasias Colorretais , Síndrome de Peutz-Jeghers , Adenocarcinoma Mucinoso/tratamento farmacológico , Anticorpos Monoclonais Humanizados , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Bevacizumab/uso terapêutico , Camptotecina/uso terapêutico , Fluoruracila/uso terapêutico , Humanos , Leucovorina/uso terapêutico , Recidiva Local de Neoplasia , Síndrome de Peutz-Jeghers/tratamento farmacológico
2.
Diabetes Res Clin Pract ; 180: 109037, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34481910

RESUMO

AIMS: The aim of this study was to compare the effectiveness of teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and canagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, at reducing a composite outcome of three metabolic risk factors (obesity, hypertension, and dyslipidemia) in Japanese patients with type 2 diabetes mellitus (T2DM) and metabolic risks. METHODS: In this prospective, multicenter, open-label, randomized, parallel-group comparison study, 162 patients with T2DM and one or more metabolic risk factors were randomized into a teneligliptin or canagliflozin group and treated for 24 weeks. The primary endpoint was the composite percentage of subjects who experienced an improvement in at least one metabolic risk after 24 weeks of treatment. RESULTS: The primary endpoint was achieved significantly by more patients in the canagliflozin group than in the teneligliptin group (62.2% vs. 31.3%, p = 0.0004). A ≥ 3% body weight loss was also achieved by significantly more participants in the canagliflozin group than in the teneligliptin group (55.9% vs. 10.5%, p < 0.0001). CONCLUSIONS: This study showed canagliflozin to be more effective at reducing metabolic risks than teneligliptin. In Japanese patients with T2DM and metabolic risk factors, SGLT2 inhibitors may be superior to DPP-4 inhibitors at controlling multiple metabolic risk.


Assuntos
Diabetes Mellitus Tipo 2 , Inibidores da Dipeptidil Peptidase IV , Canagliflozina/uso terapêutico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Diabetes Mellitus Tipo 2/epidemiologia , Inibidores da Dipeptidil Peptidase IV/uso terapêutico , Dipeptidil Peptidases e Tripeptidil Peptidases/uso terapêutico , Quimioterapia Combinada , Glucose/uso terapêutico , Humanos , Hipoglicemiantes/uso terapêutico , Japão/epidemiologia , Estudos Prospectivos , Fatores de Risco , Sódio/uso terapêutico , Tiazolidinas
3.
BMC Emerg Med ; 21(1): 104, 2021 09 16.
Artigo em Inglês | MEDLINE | ID: mdl-34530735

RESUMO

BACKGROUND: Patients with traumatic cardiac arrest (TCA) are known to have poor prognoses. In 2003, the joint committee of the National Association of EMS Physicians and the American College of Surgeons Committee on Trauma proposed stopping unsuccessful cardiopulmonary resuscitation (CPR) sustained for > 15 min after TCA. However, in 2013, a specific time-limit for terminating resuscitation was dropped, due to the lack of conclusive studies or data. We aimed to define the association between emergency medical services transport time and survival to demonstrate the survival curve of TCA. METHODS: A retrospective review of the Japan Trauma Data Bank. Inclusion criteria were age ≥ 16, at least one trauma with Abbreviated Injury Scale score (AIS) ≥ 3, and CPR performed in a prehospital setting. Exclusion criteria were burn injury, AIS score of 6 in any region, and missing data. Estimated survival rate and risk ratio for survival were analyzed according to transport time for all patients. Analysis was also performed separately on patients with sustained TCA at arrival. RESULTS: Of 292,027 patients in the database, 5336 were included in the study with 4141 sustained TCA. Their median age was 53 years (interquartile range (IQR) 36-70), and 67.2% were male. Their median Injury Severity Score was 29 (IQR 22-41), and median transport time was 11 min (IQR 6-17). Overall survival after TCA was 4.5%; however, survival of patients with sustained TCA at arrival was only 1.2%. The estimated survival rate and risk ratio for sustained TCA rapidly decreased after 15 min of transport time, with estimated survival falling below 1%. CONCLUSION: The chances of survival for sustained TCA declined rapidly while the patient is transported with CPR support. Time should be one reasonable factor for considering termination of resuscitation in patients with sustained TCA, although clinical signs of life, and type and severity of trauma should be taken into account clinically.


Assuntos
Reanimação Cardiopulmonar , Serviços Médicos de Emergência , Parada Cardíaca Extra-Hospitalar , Taxa de Sobrevida , Tempo para o Tratamento , Adulto , Idoso , Feminino , Humanos , Escala de Gravidade do Ferimento , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
4.
Sci Rep ; 11(1): 17235, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34446813

RESUMO

Although data catalog analyses have confirmed that volcanic eruptions are triggered by large earthquakes, the triggering mechanism has been under discussion for many decades. In the present study, recent earthquake and volcanic data from the past 35-55 years were analyzed, and it was demonstrated for the first time that the likelihood of new eruptions increases two to three times in the 5-10 years following large earthquakes for volcanoes where the generated static dilatational strain exceeds 0.5 µ, which may, for example, activate gas bubble growth and thereby generate a buoyant force in the magma. In contrast, the eruption likelihood does not increase for volcanoes that are subjected to strong ground motion alone, which affect the magma system and volcanic edifice. These results indicate that we can evaluate the likelihood of triggered eruptions and prepare for new eruptions when a large earthquake occurs.

5.
Nihon Shokakibyo Gakkai Zasshi ; 118(8): 749-756, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-34373394

RESUMO

A 59-year-old man was treated for early gastric cancer with endoscopic submucosal dissection (ESD) 10 years prior to the study. Two months after the first ESD, he was diagnosed with recurrence on the ESD scar and treated via ESD again. The horizontal margin could not be evaluated because of cauterization, and the patient was carefully observed. He was admitted to our hospital complaining of low backache and diagnosed with disseminated carcinomatosis of the bone marrow associated with gastric cancer after examination. Although he started chemotherapy, he died after 6 months. In this study, we report a rare case of disseminated carcinomatosis of the bone marrow associated with gastric cancer, which developed 10 years after ESD.


Assuntos
Ressecção Endoscópica de Mucosa , Neoplasias Peritoneais , Neoplasias Gástricas , Medula Óssea , Ressecção Endoscópica de Mucosa/efeitos adversos , Mucosa Gástrica , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Neoplasias Gástricas/cirurgia , Resultado do Tratamento
6.
Cureus ; 13(3): e14179, 2021 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-33936890

RESUMO

A 49-year-old man transferred to our hospital for dyspnea that developed while transporting significant loads of dry ice, which may have caused potential carbon dioxide intoxication. On admission, he presented hyperventilation and disorientation. Transthoracic echocardiography showed the reduced motion of the anterior wall of the left ventricle with decreased left ventricular ejection fraction. The patient underwent coronary angiography, which did not show apparent coronary arterial stenosis. The electrocardiogram revealed T-wave change and echocardiography results showed the subsided changes on the third hospital day. He was discharged without any symptoms on the fourth hospital day. Our case demonstrates the potential association between carbon dioxide intoxication and Takotsubo cardiomyopathy. Our experience may inform emergency physicians in formulating diagnostic/therapeutic approaches for similar patients experiencing cardiac failure following carbon dioxide intoxication.

7.
Trauma Surg Acute Care Open ; 6(1): e000694, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33912687

RESUMO

Purpose: Self-inflicted injury is one of the most common causes of suicide. Extremity injury is thought to occur most frequently among penetrating injury; however, epidemiology among patients attempting suicide is unknown. This study aims to find the characteristics of penetrating self-inflicted trauma patients. Methods: This is a retrospective cohort study of Japanese nation-wide trauma registry (the Japan National Trauma Data Bank) between January 1, 2004 and December 31, 2017. Patients who attempted suicide with penetrating injury were eligible. We evaluated the occurrence of injury based on injury site (neck/face, chest, abdomen, extremity) as a dependent variable and aging as an independent variable using a generalized linear model and compare those groups with spline models. Results: 4576 trauma patients were eligible. Excluding patients with missing age, missing survival data, and missing abbreviate injury score, 4183 patients were enrolled in this study. Common injury site is follows: abdomen 1772 patients (42.4%), extremity 1344 patients (32.0%), neck/face 1253 patients (30.0%), and chest 993 patients (23.7%). The occurrence of neck/face injury, chest injury, and abdominal injury increased with age. On contrary, the rate of extremity injury decreased with age. Conclusions: Among self-inflicted trauma patients, abdominal injury was the most common injury, and neck/face injury, chest injury, and abdominal injury were related with aging. On the contrary, the rate of extremity injury decreased as patients' age progressed. Level of evidence: Retrospective cohort study, Level III.

8.
Sci Rep ; 11(1): 6319, 2021 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-33737622

RESUMO

We present one of the first studies on source location determination for volcanic earthquakes and characterization of volcanic subsurfaces using data from a distributed acoustic sensing (DAS) system. Using the arrival time difference estimated from well-correlated waveforms and a dense spatial distribution of seismic amplitudes recorded along the fiber-optic cable, we determine the hypocenters of volcanic earthquakes recorded at Azuma volcano, Japan. The sources are located at a shallow depth beneath active volcanic areas with a range of approximately 1 km. Spatial distribution of the site amplification factors determined from coda waves of regional tectonic earthquakes are well correlated with old lava flow distributions and volcano topography. Since DAS observation can be performed remotely and buried fiber-optic cables are not damaged by volcanic ash or bombs during eruptions, this new observation system is suitable for monitoring of volcanoes without risk of system damage and for evaluating volcanic structures.

9.
Am J Phys Anthropol ; 174(4): 839-845, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33438763

RESUMO

OBJECTIVES: Nasal passages adjust the temperature of inhaled air to reach the required body temperature for the lungs. The nasal regions of primates including humans are believed to have experienced anatomical modifications that are adaptive to effective conditioning of the atmospheric air in the habitat for a given species. Measurements of the nasal temperature are required to understand the air-conditioning performance for a given species. Unfortunately, repeated direct measurements within the nasal passage have been technically precluded in most nonhuman primates. MATERIALS AND METHODS: Computational fluid dynamics (CFD) simulation is a potential approach for examining the temperature profile in the nasal passage without any direct measurements. The CFD simulation model mainly comprises a computational model to simulate physiological mechanisms and a wall model to simulate the nasal passage's anatomical and physical properties. We used a computational model developed for humans and examined corrections for the developed wall model based on human properties for predicting its performance in Japanese macaques. RESULTS: This study confirmed that the epithelium layer thickness of the wall model affects the accuracy of the predictions for macaques. A convenient correction of the thickness based on body mass allows us to simulate the actual air temperature profile in macaques' nasal passage. DISCUSSION: The CFD simulations of the wall model corrected with body mass can be applied to other nonhuman primates and mammals. This convenient corrective approach allows us to examine the functional contributions of a specific morphology to the air-conditioning performance without any direct measurements to improve our understanding of primates' functional morphology and physical adaptations to the temperature environment in their habitat.


Assuntos
Simulação por Computador , Cavidade Nasal/fisiologia , Temperatura , Movimentos do Ar , Animais , Feminino , Humanos , Hidrodinâmica , Macaca fuscata , Cavidade Nasal/diagnóstico por imagem , Tomografia Computadorizada por Raios X
10.
J Voice ; 35(5): 805.e1-805.e15, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33388229

RESUMO

This study investigates the effect of the ventricular folds on fundamental frequency (fo) in the voice production of domestic pigs (Sus scrofa domesticus). The excised larynges of six subadult pigs were phonated in two preparation stages, with the ventricular folds present (PS1) and removed (PS2). Vocal fold resonances were tested with a laser vibrometer, and a four-mass computational model was created. Highly significant fo differences were found between PS1 and PS2 (means at 93.7 and 409.3 Hz, respectively). Two tissue resonances were found at 115 Hz and 250-290 Hz. The computational model had unique solutions for abducted and adducted ventricular folds at about 150 and 400 Hz, roughly matching the fo measured ex vivo for PS1 and PS2. The differing fo encountered across preparation stages PS1 and PS2 is explained by distinct activation of either a high or a low eigenfrequency mode, depending on the engagement of the ventricular folds. The inability of the investigated larynges to vibrate at frequencies below 250 Hz in PS2 suggests that in vivo low-frequency calls of domestic pigs (pre-eminently grunts) are likely produced with engaged ventricular folds. Allometric comparison suggests that the special, mechanically coupled "double oscillator" has evolved to prevent signaling disadvantages. Given these traits, the porcine larynx might - apart from special applications relating to the involvement of ventricular folds - not be an ideal candidate for emulating human voice production in excised larynx experimentation.


Assuntos
Laringe , Voz , Animais , Fonação , Sus scrofa , Suínos , Vibração , Prega Vocal/cirurgia
13.
In Vivo ; 34(5): 2769-2774, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32871813

RESUMO

BACKGROUND/AIM: Radiotherapy is widely accepted as the treatment of choice for early glottic squamous cell carcinoma (EGSCC), although it varies greatly with respect to dose, dose per fraction, and treatment techniques. The study aim was to evaluate the use of accelerated fractionation strategy (AFS) for EGSCC in standard clinical practice. PATIENTS AND METHODS: Patients treated with definitive radiotherapy for EGSCC between 2008 and 2019 were retrospectively identified and received either conventional fractionation, hypofractionation, or hyperfractionation. RESULTS: One hundred six patients were analyzed, and 19, 71, and 16 patients underwent conventional fractionation, hypofractionation, and hyperfractionation, respectively. The median follow-up was 56 months. The 5-year local control and overall survival rates were 79% and 83%; 78% and 79%; and 87% and 77%, respectively, and no significant difference was observed between the fractionation schedules. CONCLUSION: Our findings confirmed the utility of AFS in standard clinical practice and support its use for patients with EGSCC.


Assuntos
Carcinoma de Células Escamosas , Glote , Neoplasias de Cabeça e Pescoço , Carcinoma de Células Escamosas/radioterapia , Fracionamento da Dose de Radiação , Glote/patologia , Neoplasias de Cabeça e Pescoço/radioterapia , Humanos , Dosagem Radioterapêutica , Estudos Retrospectivos
14.
Proc Natl Acad Sci U S A ; 117(35): 21251-21257, 2020 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-32817513

RESUMO

A large brain combined with an upright posture in humans has resulted in a high cephalopelvic proportion and frequently obstructed labor. Fischer and Mitteroecker [B. Fischer, P. Mitteroecker, Proc. Natl. Acad. Sci. U.S.A. 112, 5655-5660 (2015)] proposed that the morphological covariations between the skull and pelvis could have evolved to ameliorate obstructed labor in humans. The availability of quantitative data of such covariation, especially of the fetal skull and maternal pelvis, however, is still scarce. Here, we present direct evidence of morphological covariations between the skull and pelvis using actual mother-fetus dyads during the perinatal period of Macaca mulatta, a species that exhibits cephalopelvic proportions comparable to modern humans. We analyzed the covariation of the three-dimensional morphology of the fetal skull and maternal pelvis using computed tomography-based models. The covariation was mostly observed at the pelvic locations related to the birth canal, and the forms of the birth canal and fetal skull covary in such a way that reduces obstetric difficulties. Therefore, cephalopelvic covariation could have evolved not only in humans, but also in other primate taxa in parallel, or it could have evolved already in the early catarrhines.


Assuntos
Desproporção Cefalopélvica/fisiopatologia , Pelve/anatomia & histologia , Crânio/anatomia & histologia , Animais , Antropologia Física/métodos , Evolução Biológica , Desproporção Cefalopélvica/genética , Parto Obstétrico , Feminino , Feto , Hominidae , Humanos , Macaca mulatta/embriologia , Macaca mulatta/crescimento & desenvolvimento , Parto/fisiologia , Pelve/fisiologia , Gravidez , Crânio/fisiologia
15.
BMC Gastroenterol ; 20(1): 217, 2020 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-32650722

RESUMO

BACKGROUND: Nonalcoholic fatty liver disease is characterized by excessive hepatic fat accumulation. Some individuals frequently present elevated gamma-glutamyl transferase (GGT) levels without fatty liver ultrasound images and other abnormal liver enzymes levels. However, whether these individuals are at an elevated risk for developing fatty liver is unclear. We compared fatty liver change rates and risk factors between individuals with frequently elevated GGT levels and those with normal levels. METHODS: We designed a retrospective cohort study on the basis of complete medical checkup records. One group of individuals had presented normal serum GGT levels during the observation period (Normal-GGT group, n = 2713). Another group had had abnormal elevated serum GGT levels frequently (Abnormal-GGT group, n = 264). We determined the fatty liver change incident rates before and after propensity score matching. We explored confounding factors affecting fatty changes in each group using univariate and multivariate Cox models. RESULTS: The change incidence rates were 5.80/1000 and 10.02/1000 person-years in the Normal-GGT and Abnormal-GGT groups, respectively. After propensity score matching, the incidence rates were 3.08/1000 and 10.18/1000 person-years in the Normal-GGT and Abnormal-GGT groups, respectively (p = 0.026). The factors associated with fatty liver changes in the Normal-GGT group included body mass index (BMI), hemoglobin, alanine aminotransferase (ALT), albumin, triglyceride (TG), fasting blood sugar, and high-density lipoprotein levels. Those in the Abnormal-GGT group were platelet counts and TG. In our multivariable analysis, BMI, ALT, albumin, and TG levels were independent predictors of fatty changes in the Normal-GGT group, and high TG level was the only independent predictor in the Abnormal-GGT group. CONCLUSIONS: The incidence rate of fatty liver change in the Abnormal-GGT group was higher than that in the Normal-GGT group. Consecutive elevated GGT levels increase the risk for fatty liver, and high TG levels in those individuals further independently increase the risk.


Assuntos
Hepatopatia Gordurosa não Alcoólica , gama-Glutamiltransferase , Alanina Transaminase , Humanos , Testes de Função Hepática , Hepatopatia Gordurosa não Alcoólica/diagnóstico por imagem , Hepatopatia Gordurosa não Alcoólica/epidemiologia , Estudos Retrospectivos
16.
J Trauma Acute Care Surg ; 89(3): 514-522, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32544105

RESUMO

BACKGROUND: Direct oral anticoagulants (DOACs) are widely used among patients requiring anticoagulant therapy. These drugs are associated with a lower risk of bleeding than vitamin K antagonists (VKAs). However, the outcomes of elderly trauma patients receiving DOACs are not well known. METHODS: We reviewed data from trauma patients at our level I trauma center (University of Pittsburgh Medical Center, Presbyterian Hospital) seen from January 2011 to July 2018. We identified trauma patients taking DOACs or VKAs and compared these cohorts using 1:1 propensity score-matching based on patient characteristics, antiplatelet use, comorbidities, and laboratory values. The primary outcome was in-hospital mortality. Secondary outcomes included the proportion of patients discharged to skilled nursing facility/rehabilitation facility discharge or to home, and transfusion volume. RESULTS: Of 32,272 trauma patients screened, 530 were taking DOACs and 1,702 were taking VKAs. We matched 668 patients in a 1:1 ratio (DOACs group, 334 vs. VKAs group, 334). The DOACs group had similar mortality (4.8% vs. 1.6%; odds ratio (OR), 3.0; 95% confidence interval (CI), 0.31-28.8; p = 0.31) among patients younger than 65 years, but mortality differed (3.0% vs. 6.6%; OR, 0.41; 95% CI, 0.17-0.99; p = 0.048) among patients older than 65 years. The proportion of patients discharged to skilled nursing facility/rehabilitation facility (50.0% vs. 50.6%; OR, 0.98; 95% CI, 0.72-1.32; p = 0.88) and to home (40.4% vs. 38.6%; OR, 1.08; 95% CI, 0.79-1.47; p = 0.64) were similar. Patients in the DOACs group received fewer fresh frozen plasma (p = 0.032), but packed red blood cells (p = 0.86) and prothrombin complex concentrate (p = 0.48) were similar. CONCLUSION: In this matched cohort of anticoagulated trauma patients, DOACs were associated with the decreased in-hospital mortality and decreased administration of fresh frozen plasma compared with VKAs among trauma patients 65 years or older taking anticoagulant therapy. LEVEL OF EVIDENCE: Prognostic/Epidemiological, level III.


Assuntos
Anticoagulantes/efeitos adversos , Inibidores da Agregação Plaquetária/efeitos adversos , Vitamina K/antagonistas & inibidores , Ferimentos e Lesões/tratamento farmacológico , Ferimentos e Lesões/mortalidade , Administração Oral , Idoso , Idoso de 80 Anos ou mais , Anticoagulantes/administração & dosagem , Feminino , Mortalidade Hospitalar/tendências , Humanos , Masculino , Pennsylvania , Inibidores da Agregação Plaquetária/administração & dosagem , Estudos Retrospectivos , Análise de Sobrevida , Centros de Traumatologia , Índices de Gravidade do Trauma , Ferimentos e Lesões/cirurgia
17.
Clin J Gastroenterol ; 13(5): 834-838, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32232770

RESUMO

We report a case of idiopathic hypereosinophilic syndrome (IHES) characterized by multiple liver mass lesions in an 82-year-old man. Numerous hypoechoic lesions were observed on ultrasonography and were mainly distributed in the S4, S6, and S7 segments. Plain computed tomography (CT) scans revealed low-density lesions. Dynamic CT images revealed arterial and portal vein branches passing through these lesions, with marginal areas enhanced during the arterial phase. The enhanced areas were extended during the portal venous phase. Contrast-enhanced ultrasonography (CEUS) images revealed enhanced vasculature in the early vascular phase. CEUS images obtained in the late vascular phase revealed enhanced areas containing microbubbles extended into the parenchyma; a prolonged enhancement pattern was observed. Kupffer-phase images revealed large portions of the lesion filled with microbubbles and a star-like defect at the center of the nodule. F18-2-fluoro-2-deoxyglucose (FDG) positron emission tomography/CT scans revealed intense FDG uptake by these lesions, which was similar to that by the segments S4, S6, and S7. Liver biopsy revealed diffused eosinophils infiltrated. The patient was closely followed up and was completely cured 11 weeks later without any treatment. This is a rare case of IHES with multiple liver mass lesions, which was well researched using multi-imaging equipment and cured without any treatment.


Assuntos
Síndrome Hipereosinofílica , Neoplasias Hepáticas , Idoso de 80 Anos ou mais , Meios de Contraste , Humanos , Síndrome Hipereosinofílica/complicações , Síndrome Hipereosinofílica/diagnóstico por imagem , Neoplasias Hepáticas/diagnóstico por imagem , Masculino , Ultrassonografia
18.
Surg Today ; 50(9): 1016-1023, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32124084

RESUMO

PURPOSE: An association between the prognoses of trauma and sarcopenia has not been well documented. The purpose of this study was to compare the outcomes of elderly Japanese trauma patients with sarcopenia and those without sarcopenia. METHODS: The medical records of patients aged ≧ 65 years old and Injury Severity Scores above 15 treated for trauma between 2010 and 2017 were reviewed, retrospectively. We measured the psoas muscle index (PMI), defined as the psoas muscle area at the third lumbar vertebra level divided by the body surface area. Patients of each gender with a PMI less than the lower interquartile range were included in the sarcopenia group. A questionnaire was mailed to the patients or their families to collect data on 1-year mortality and activities of daily living. RESULTS: There were 405 patients included in this study: 304 in the non-sarcopenia group (Group NS) and 101 in the sarcopenia group (Group S). Mortality was significantly higher in Group S than in Group NS (NS; 7.9% vs. S; 15.8%, OR, 2.20; 95% CI, 1.12-4.32; p = 0.027). Only 175 of the questionnaires were completed and the responses did not reveal any significant differences between the groups. CONCLUSIONS: Sarcopenia as defined by the PMI may be used as an indicator for mortality risk for geriatric trauma patients.


Assuntos
Músculos Psoas/diagnóstico por imagem , Músculos Psoas/patologia , Sarcopenia/diagnóstico , Centros de Traumatologia , Ferimentos e Lesões/mortalidade , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Comorbidade , Feminino , Previsões , Humanos , Japão , Masculino , Prognóstico , Estudos Retrospectivos , Risco , Sarcopenia/epidemiologia , Sarcopenia/patologia , Inquéritos e Questionários , Tomografia Computadorizada por Raios X , Índices de Gravidade do Trauma , Ferimentos e Lesões/epidemiologia
19.
Nat Commun ; 11(1): 76, 2020 01 03.
Artigo em Inglês | MEDLINE | ID: mdl-31900388

RESUMO

In many plant species, roots maintain specific growth angles relative to the direction of gravity, known as gravitropic set point angles (GSAs). These contribute to the efficient acquisition of water and nutrients. AtLAZY1/LAZY1-LIKE (LZY) genes are involved in GSA control by regulating auxin flow toward the direction of gravity in Arabidopsis. Here, we demonstrate that RCC1-like domain (RLD) proteins, identified as LZY interactors, are essential regulators of polar auxin transport. We show that interaction of the CCL domain of LZY with the BRX domain of RLD is important for the recruitment of RLD from the cytoplasm to the plasma membrane by LZY. A structural analysis reveals the mode of the interaction as an intermolecular ß-sheet in addition to the structure of the BRX domain. Our results offer a molecular framework in which gravity signal first emerges as polarized LZY3 localization in gravity-sensing cells, followed by polar RLD1 localization and PIN3 relocalization to modulate auxin flow.


Assuntos
Proteínas de Arabidopsis/metabolismo , Arabidopsis/fisiologia , Arabidopsis/genética , Arabidopsis/crescimento & desenvolvimento , Proteínas de Arabidopsis/genética , Transporte Biológico , Gravitropismo , Sensação Gravitacional , Ácidos Indolacéticos/metabolismo , Raízes de Plantas/genética , Raízes de Plantas/crescimento & desenvolvimento , Raízes de Plantas/fisiologia , Brotos de Planta , Ligação Proteica
20.
Primates ; 60(6): 577, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31555929

RESUMO

In the original publication of this article, the abbreviations in Fig. 2 caption should be as follows.

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