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1.
Rev. méd. Chile ; 125(8): 922-6, ago. 1997. ilus
Artigo em Espanhol | LILACS | ID: lil-207131

RESUMO

We report and eight years old boy presenting with a pyogenic granuloma of the scalp, generalized alopecia, descamative plates in the neck, trunk and limbs and nail involvement. Cultures for fungus of all these lesions disclosed Microspore canis. The patient was treated with oral griseofulvin, miconazole and topical tolnaftate. Five years later and after several incomplete treatments, the patient returns with a fistulous mass of 12 x 8 cm in the dorsal area whose culture revealed Microspore canis. The mass was excised and oral ketoconazole was indicated. After three months of follow up, the patient was lost from control


Assuntos
Humanos , Masculino , Criança , Microsporum/patogenicidade , Micetoma/microbiologia , Alopecia/microbiologia , Cloxacilina/uso terapêutico , Gentamicinas/uso terapêutico , Granuloma Piogênico/cirurgia , Griseofulvina/uso terapêutico , Miconazol/uso terapêutico , Micetoma/terapia , Tolnaftato/uso terapêutico
2.
Rev. méd. Chile ; 124(10): 1193-9, oct. 1996. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-185168

RESUMO

Mallory bodies are hepatocyte intracytoplasmic inclusions frequently observed in liver diseases. They contain altered intermediary filaments that have immunoreactivity with epidermic antikeratin antibodies (A-QEp). They also contain Ubiquitin (Ubq) a 76 residue polypeptide that has an important role in the proteolysis of rapid exchange and abnormal cytosol proteins. To standarize an immunohistochemical method for the detection of Mallory bodies in percutaneous liver biopsies. A-QEp and A-Ubq polyclonnal antibodies were used in the study of 131 percutaneous liver biopsies obtained from patients with different liver diseases. Mallory body immunoreactivity was confirmed with immunoelectron microscopy demonstrated that Mallory bodies are partially formed by altered intermediate filaments. In conclusion, antibodies againnst ubiquitin may be very useful for the detection of Mallory bodies in liver biopsies


Assuntos
Humanos , Corpos de Inclusão/imunologia , Imuno-Histoquímica/métodos , Queratinas/isolamento & purificação , Ubiquitina/isolamento & purificação , Biópsia/estatística & dados numéricos , Hematoxilina , Hepatopatias/imunologia , Microscopia Eletrônica
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