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1.
J Clin Med ; 10(2)2021 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-33419107

RESUMO

The purpose is to analyze the medical characteristics of children with special health care needs (CSHCN) recommended for dental treatment under general anesthesia (GA), postoperative complications, and dental treatment outcomes under the regulation of the Spanish Dental Care Program (PADI). 111 clinical records were selected. The study population was divided into three age groups. The quantitative data was specified as the mean ± SD. For the qualitative variables, the Chi-Square test was used. One-way ANOVA and Bonferroni tests were used to examine the effect of the "age group" and the number of treatment procedures. A total of 1473 treatment procedures were performed, of which 110 (7.5%) were cleanings, 898 (61%) were restorative procedures, 332 (21.7%) were extractions, 22 (1.6%) were endodontic treatments, 62 (4.2%) were pulpotomies, and 59 (4%) were stainless steel crowns. Regarding the mean number of incisor root canal treatments (RCT), age group 3 received a significantly higher mean number of incisor RCTs than age group 1 (p = 0.02). Age group 1 received a higher average of pulpotomies and stainless-steel crowns (p = 0.00) compared to groups 2 and 3. GA is a safe procedure for the dental treatment of CSHCN, with minimal postoperative complications, which should be included among dental public programs.

2.
Med. oral patol. oral cir. bucal (Internet) ; 25(3): e383-e387, mayo 2020. tab
Artigo em Inglês | IBECS | ID: ibc-196326

RESUMO

BACKGROUND: Previous reports have been analyzed the prevalence/association of apical periodontitis (AP) with systemic diseases. The present study aims to analyze the prevalence of healthy/diseased periapex and endodontic treatments in patients with Multiple Myeloma (MM) and compare the results with those of control subjects. MATERIAL AND METHODS: Panoramic radiographs of 50 individuals with MM were evaluated and compared with 50 controls that were sex and age matched exactly with the diseased group. Radiographic analysis was performed by two experienced endodontists under standardized conditions. The periapical status (presence or not of AP) was assessed using the periapical index (PAI). Data included systemic health, technical quality of root fillings, total number of teeth, quality of restoration, and periapical status. Statistical evaluation of differences between groups used chi-squared tests and Fisher's exact tests. RESULTS: The prevalence of root canal-treated teeth was 10.11% in the MM group and 12.05% in the control group (p = 0.90). The average root canal-treated teeth in the test group was 2,34 and 2.48 in the control group, where the difference was statistically significant (p = 0.05). AP in 1 or more teeth was found in 86 % and in 78% of the patients in the MM and the control groups, respectively. When analyzed by subject, there was no statistically significant difference in the prevalence of AP (p > 0.72). Similarly there was also no statistically significant difference in the prevalence of PA (p = 0.85), when analyzed by tooth, AP was found in 63.2% and 62.9% in MM and control groups. CONCLUSIONS: The presence of AP and endodontic treatment was not significantly different in individuals with MM compared with control subjects. Future studies are needed to elucidate and confirm the association between MM and AP


No disponible


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Periodontite Periapical/epidemiologia , Mieloma Múltiplo/epidemiologia , Prevalência , Periodontite Periapical/complicações , Mieloma Múltiplo/complicações , Radiografia Panorâmica , Fatores de Risco , Espanha/epidemiologia
3.
Materials (Basel) ; 12(22)2019 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-31717445

RESUMO

This study aimed to analyze the biological effects of three new bioactive materials on cell survival, migration, morphology, and attachment in vitro. ACTIVA Kids BioACTIVE Restorative (Pulpdent, Watertown, MA, USA) (Activa), Ionolux (Voco, Cuxhaven, Germany), and Riva Light Cure UV (SDI, Bayswater, Australia) (Riva) were handled and conditioned with a serum-free culture medium. Stem cells from human dental pulp (hDPSCs) were exposed to material extracts, and metabolic activity, cell migration, and cell morphology were evaluated. Cell adhesion to the different materials was analyzed by scanning electron microscopy (SEM). The chemical composition of the materials was evaluated by energy-dispersive X-ray (EDX). One-way analysis of variance followed by a Tukey test was performed (p < 0.05). Ionolux promoted a drastic reduction in metabolic activity and wound closure compared to the control (p < 0.05), whereas Activa induced adequate metabolic activity and cell migration. Moreover, SEM and immunofluorescence analysis showed abundant cells exposed to Activa. The materials showed different surface morphologies, and EDX spectra exhibited different peaks of C, O, Si, S, Ca, and F ions in glass ionomer cements. The results showed that Activa induced cell migration, cell attachment, and cell viability to a greater extent than Riva and Ionolux.

4.
Sci Rep ; 9(1): 3933, 2019 03 08.
Artigo em Inglês | MEDLINE | ID: mdl-30850648

RESUMO

The purpose of this work was to evaluate the physicochemical properties, the cytotoxicity and in vivo biocompatibility of MTA Repair HP (MTA HP) and White MTA (WMTA). The setting time, flow, radiopacity and water solubility were assessed. To the cytotoxicity assay, primary human osteoblast cells were exposed to several dilutions of both materials eluates. MTT assay, apoptosis assay and cell adhesion assay were performed. The in vivo biocompatibility was evaluated through histological analysis using different staining techniques. No differences were observed between MTA HP and WMTA for setting time, radiopacity, solubility and water absorption (P > 0.05). However, MTA HP showed a significantly higher flow when compared to WMTA (P < 0.05). Cell viability results revealed that the extracts of WMTA and MTA HP promoted the viability of osteoblasts. After incubation of cells with the endodontic cement extracts, the percentage of apoptotic or necrotic cells was very low (<3%). Furthermore, SEM results showed a high degree of cell proliferation and adhesion on both groups. MTA HP showed similar in vivo biocompatibility to the WMTA and the control group in all time-points. The MTA HP presented adequate physicochemical and biological properties with improved flow ability when compared to WMTA. Such improved flow ability may be a result of the addition of a plasticizing agent and should be related to an improvement in the handling of MTA HP.


Assuntos
Compostos de Alumínio/química , Compostos de Alumínio/toxicidade , Compostos de Cálcio/química , Compostos de Cálcio/toxicidade , Óxidos/química , Óxidos/toxicidade , Materiais Restauradores do Canal Radicular/química , Materiais Restauradores do Canal Radicular/toxicidade , Silicatos/química , Silicatos/toxicidade , Animais , Apoptose/efeitos dos fármacos , Adesão Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Células Cultivadas , Combinação de Medicamentos , Humanos , Masculino , Teste de Materiais , Microscopia Eletrônica de Varredura , Osteoblastos/citologia , Osteoblastos/efeitos dos fármacos , Ratos , Ratos Wistar , Reologia , Solubilidade , Tela Subcutânea/efeitos dos fármacos , Tela Subcutânea/patologia
5.
Clin Oral Investig ; 23(10): 3915-3924, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30684060

RESUMO

OBJECTIVE: The aim of this study was to analyze the biological effects of MTA Repair HP and ProRoot MTA on human periodontal ligament stem cells (hPDLSCs) after exposure to acidic and neutral environments. MATERIALS AND METHODS: Discs of each material (n = 30) were exposed to phosphate buffered saline (pH = 7.4) or butyric acid (pH = 5.2) for 7 days, and biological testing was carried out in vitro on hPDLSCs. Cell viability and apoptosis assays were performed using eluates of each root-end filling material. To evaluate cell attachment to the different materials, hPDLSCs were directly seeded onto the material surfaces and analyzed by scanning electron microscopy. The chemical composition of the root-end filling materials was determined by energy-dispersive x-ray and eluates were analyzed by inductively coupled plasma-mass spectrometry. Statistical differences were assessed by ANOVA and Tukey test (p < 0.05). RESULTS: Under an acidic environment, both materials displayed similar ion release abilities, with the increased release of Si and Ca ions. Substantial changes in microstructure were observed for both materials after exposure to acidic pH. In addition, material exposure to an acidic environment showed a similar degree of cell adherence, and, surprisingly, MTA Repair HP exhibited higher cell viability rates at pH 5.2 than ProRoot MTA. CONCLUSIONS: Exposure to an acidic environment promoted Si and Ca ion release from ProRoot MTA and MTA Repair HP. Moreover, we observed optimal biological properties of ProRoot MTA and MTA Repair HP in terms of cell viability, cell death, and cell attachment in both environments. CLINICAL RELEVANCE: These results may suggest that MTA Repair HP and ProRoot exhibited optimal biological properties in terms of cell viability, cell death and cell attachment in acidic environment, being considered as materials for root-end filling and perforations.


Assuntos
Pemetrexede , Ligamento Periodontal/citologia , Materiais Restauradores do Canal Radicular , Células-Tronco/efeitos dos fármacos , Compostos de Cálcio , Células Cultivadas , Combinação de Medicamentos , Humanos , Teste de Materiais , Óxidos , Silicatos
6.
Materials (Basel) ; 11(8)2018 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-30081464

RESUMO

Background: Cell-Based Therapies (CBT) constitute a valid procedure for increasing the quantity and quality of bone in areas with an inadequate bone volume. However, safety and efficacy should be investigated prior to clinical application. The objective of this study was to evaluate the biodistribution, safety and osteogenic capacity of bone marrow-derived human mesenchymal stem cells (hBMMSCs) pre-seeded into ß-tricalcium phosphate (TCP) and implanted into NOD/SCID mice at subcutaneous and intramuscular sites. Methods: hBMMSCs were isolated, characterized and then cultured in vitro on a porous ß-TCP scaffold. Cell viability and attachment were analyzed and then hBMMSCs seeded constructs were surgically placed at subcutaneous and intramuscular dorsal sites into NOD/SCID mice. Acute and subchronic toxicity, cell biodistribution and efficacy were investigated. Results: There were no deaths or adverse events in treated mice during the 48-hour observation period, and no toxic response was observed in mice. In the 12-week subchronic toxicity study, no mortalities, abnormal behavioral symptoms or clinical signs were observed in the saline control mice or the hBMMSCs/ß-TCP groups. Finally, our results showed the bone-forming capacity of hBMMSCs/ß-TCP since immunohistochemical expression of human osteocalcin was detected from week 7. Conclusions: These results show that transplantation of hBMMSCs/ß-TCP in NOD/SCID mice are safe and effective, and might be applied to human bone diseases in future clinical trials.

7.
Dent Mater ; 34(6): 932-943, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29650250

RESUMO

OBJECTIVE: To evaluate the in vitro cytotoxicity of Equia Forte (GC, Tokyo, Japan) and Ionostar Molar (Voco, Cuxhaven, Germany) on human dental pulp stem cells (hDPSCs). METHODS: hDPSCs isolated from third molars were exposed to several dilutions of Equia Forte and Ionostar Molar eluates (1/1, 1/2 and 1/4). These eluates were obtained by storing material samples in respective cell culture medium for 24h (n=40). hDPSCs in basal growth culture medium were the control. Cell viability and cell migration assays were performed using the MTT and wound-healing assays, respectively. Also, induction of apoptosis and changes in cell phenotype were evaluated by flow cytometry. Changes in cell morphology were analysed by immunocytofluorescence staining. To evaluate cell attachment to the different materials, hDPSCs were directly seeded onto the material surfaces and analyzed by scanning electron microscopy (SEM). The chemical composition of the materials was determined by energy dispersive X-ray (EDX) and eluates were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Statistical analysis was performed with analysis of variance (ANOVA) and Student's t-test (α<0.05). RESULTS: Undiluted Equia Forte extracts led to a similar cell proliferation rates than the control group from 72h onwards. There were no significance differences between Equia Forte and Ionostar Molar in terms of cell apoptosis and phenotype. However, in presence of Equia extracts the migration capacity of hDPSCs was higher than in presence of Ionostar Molar (p<0.05). Also, SEM studies showed a higher degree of cell attachment when Equia Forte extracts were used. Finally, EDX analysis pointed to different weight percentages of C, O and Ca ions in glass ionomer cements, while other elements such as La, Al, Si, W, Mo and F were also detected. SIGNIFICANCE: In summary, Equia Forte promoted better biological responses in hDPSCs than Ionostar Molar.


Assuntos
Polpa Dentária/citologia , Cimentos de Ionômeros de Vidro/toxicidade , Células-Tronco/efeitos dos fármacos , Apoptose/efeitos dos fármacos , Movimento Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Células Cultivadas , Citometria de Fluxo , Humanos , Teste de Materiais , Microscopia Eletrônica de Varredura , Dente Serotino , Fenótipo , Espectrometria por Raios X , Espectrofotometria Atômica
8.
J Endod ; 44(1): 126-132, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29079052

RESUMO

INTRODUCTION: The aim of the present study was to evaluate the in vitro cytotoxicity of MTA Repair HP, NeoMTA Plus, and Biodentine, new bioactive materials used for dental pulp capping, on human dental pulp stem cells (hDPSCs). METHODS: Biological testing was carried out in vitro on hDPSCs. Cell viability and cell migration assays were performed using eluates of each capping material. To evaluate cell morphology and cell attachment to the different materials, hDPSCs were directly seeded onto the material surfaces and analyzed by scanning electron microscopy. The chemical composition of the pulp-capping materials was determined by energy-dispersive X-ray and eluates were analyzed by inductively coupled plasma-mass spectrometry. Statistical differences were assessed by analysis of variance and Tukey test (P < .05). RESULTS: Cell viability was moderate after 24 and 48 hours in the presence of MTA Repair HP and NeoMTA Plus, whereas at 48 and 72 hours, Biodentine showed higher rates of cell viability than MTA Repair HP and NeoMTA Plus (P < .001). A cell migration assay revealed adequate cell migration rates for MTA Repair HP and NeoMTA Plus, both similar to the control group rates, meanwhile the highest cell migration rate was observed in the presence of Biodentine (P < .001). Scanning electron microscope studies showed a high degree of cell proliferation and adhesion on Biodentine disks but moderate rates on MTA Repair HP and NeoMTA Plus disks. Energy-dispersive X-ray pointed to similar weight percentages of C, O, and Ca in all 3 materials, whereas other elements such as Al, Si, and S were also found. CONCLUSIONS: The new pulp-capping materials MTA Repair HP, NeoMTA Plus, and Biodentine showed a suitable degree of cytocompatibility with hDPSCs, and good cell migration rates, although Biodentine showed higher rates of proliferation time-dependent.


Assuntos
Materiais Biocompatíveis , Compostos de Cálcio , Polpa Dentária/citologia , Agentes de Capeamento da Polpa Dentária e Pulpectomia , Silicatos , Células-Tronco , Sobrevivência Celular , Humanos , Teste de Materiais
9.
J Endod ; 43(5): 816-822, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28343929

RESUMO

INTRODUCTION: The aim of the present study was to evaluate the in vitro cytotoxicity of endodontic sealers (GuttaFlow Bioseal, GuttaFlow2, and MTA Fillapex) on human periodontal ligament stem cells (hPDLSCs). As a reference, AH Plus was compared with the more recent endodontic sealers regarding cell viability and cell attachment. METHODS: Biological testing was carried out in vitro on hPDLSCs. Cell viability assay was performed by using eluates from each endodontic sealer. To assess cell morphology and attachment to the different sealers, the hPDLSCs were directly seeded onto the material surfaces and analyzed by scanning electron microscopy. Chemical composition of the sealers was determined by energy-dispersive x-ray, and eluates were analyzed by inductively coupled plasma mass spectrometry. Statistical differences were assessed by analysis of variance and Tukey test (P < .05). RESULTS: Cell viability was evident after 24 hours in the presence of GuttaFlow Bioseal and GuttaFlow 2 but not in the case of AH Plus or MTA Fillapex. At 168 hours, GuttaFlow Bioseal and GuttaFlow 2 exhibited high and moderate cell viability, respectively, whereas AH Plus and MTA Fillapex revealed low rates of cell cell viability (P < .001). Finally, scanning electron microscopy studies revealed a high degree of proliferation, cell spreading, and attachment, especially when using GuttaFlow Bioseal disks. CONCLUSIONS: GuttaFlow Bioseal and GuttaFlow2 showed lower cytotoxicity than MTA Fillapex and AH plus. Further in vitro and in vivo investigations are required to confirm the suitability of GuttaFlow Bioseal for clinical application.


Assuntos
Compostos de Alumínio/efeitos adversos , Compostos de Cálcio/efeitos adversos , Dimetilpolisiloxanos/efeitos adversos , Resinas Epóxi/efeitos adversos , Guta-Percha/efeitos adversos , Óxidos/efeitos adversos , Ligamento Periodontal/efeitos dos fármacos , Materiais Restauradores do Canal Radicular/efeitos adversos , Silicatos/efeitos adversos , Células-Tronco/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Combinação de Medicamentos , Humanos , Ligamento Periodontal/citologia
10.
Stem Cells Dev ; 25(22): 1742-1754, 2016 11 15.
Artigo em Inglês | MEDLINE | ID: mdl-27503546

RESUMO

Graphene represents one of the most interesting additions to the tissue engineering toolbox. Novel graphene-based composites are required to improve the beneficial graphene properties in terms of tridimensional polymeric structure, conferring a higher mechanical strength and favoring the differentiation of human mesenchymal stem cells. Here, we have demonstrated in a wide range of composite combinations, the successful use of graphene and silk-fibroin constructs for future bioengineering applications in the field of clinical regenerative dentistry using human periodontal ligament stem cells. Our results provide exciting new data for the development of suitable scaffolds that allow good cell engrafting, preservation of cell viability and proliferation, promotion of spontaneous osteoblastic differentiation, and importantly, stimulation of a higher cementum physiological synthesis than using other different available biomaterials.


Assuntos
Materiais Biocompatíveis/farmacologia , Diferenciação Celular/efeitos dos fármacos , Cemento Dentário/citologia , Fibroínas/farmacologia , Grafite/farmacologia , Osteoblastos/citologia , Ligamento Periodontal/citologia , Células-Tronco/citologia , Calcificação Fisiológica/efeitos dos fármacos , Calcificação Fisiológica/genética , Adesão Celular/efeitos dos fármacos , Adesão Celular/genética , Morte Celular/efeitos dos fármacos , Morte Celular/genética , Diferenciação Celular/genética , Proliferação de Células/efeitos dos fármacos , Proliferação de Células/genética , Forma Celular/efeitos dos fármacos , Forma Celular/genética , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/genética , Células Cultivadas , Cemento Dentário/efeitos dos fármacos , Cemento Dentário/metabolismo , Regulação da Expressão Gênica/efeitos dos fármacos , Humanos , Células-Tronco Mesenquimais/citologia , Células-Tronco Mesenquimais/efeitos dos fármacos , Células-Tronco Mesenquimais/metabolismo , Osteoblastos/efeitos dos fármacos , Osteoblastos/metabolismo , Fenótipo , Células-Tronco/efeitos dos fármacos , Células-Tronco/ultraestrutura
12.
Med Oral Patol Oral Cir Bucal ; 11(3): E261-6, 2006 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-16648765

RESUMO

Cerebrovascular accident (CVA) is the third cause of death in industrialized countries, following cardiovascular disease and cancer. It is therefore a significant public health issue, not only due to its high incidence, but also to the high costs involved in the physical and psychological rehabilitation of these patients. Dental Practitioners, as health care providers, ought to play their part in this issue and contribute, within their means, to the early detection of patients at risk of having a CVA. Since the eighties, different authors have described the possibility of detecting calcified atheroma plaques located at carotid artery bifurcation through panoramic radiograph. In this way, the Dental Practitioner s possibilities in this field have been extended. However, this new use of panoramic radiograph must overcome certain obstacles before it is implemented as a new screening method for patients at risk of having a CVA. Amongst these, we would have, on the one hand, the assessment of the real clinical significance, as regards prognosis, of atheroma plaque calcification as well as its usefulness as a factor for predicting the appearance of CVA symptoms and, on the other hand, the possibility of making a correct differential diagnosis regarding other calcified structures that may appear on panoramic radiograph.


Assuntos
Aterosclerose/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Doenças das Artérias Carótidas/diagnóstico por imagem , Radiografia Panorâmica , Aterosclerose/complicações , Calcinose/complicações , Doenças das Artérias Carótidas/complicações , Humanos , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/prevenção & controle
13.
Med. oral patol. oral cir. bucal (Internet) ; 11(3): E261-E266, mayo 2006. ilus
Artigo em Espanhol | IBECS | ID: ibc-045962

RESUMO

Los accidentes cerebrovasculares (ACV) constituyen la tercera causa de muerte en los países industrializados, tras la cardiopatía isquémica y el cáncer. Se trata pues de un importante problema de Salud pública, no sólo por su elevada incidencia, sino también por el alto costo que genera la rehabilitación física y psicológica de estos pacientes. El Odontoestomatólogo, como profesional de la salud, debe implicarse ante esta situación y contribuir, dentro de sus posibilidades, a la detección precoz de los pacientes con riesgo de sufrir un ACV. Desde la década de los ochenta, distintos autores han descrito la posibilidad de detectar las placas de ateroma calcificadas localizadas en la bifurcación de la arteria carótida a través de la ortopantomografía (OPG). De este modo, las posibilidades del Odontoestomatólogo en este campo han sido ampliadas. Esta nueva aplicación de la OPG, sin embargo, debe superar ciertos obstáculos antes de poder afianzarse como una nueva medida de cribaje de pacientes con riesgo de sufrir un ACV. Entre éstos estaría, por una parte, la valoración del auténtico significado clínico, a nivel pronóstico, de la calcificación de las placas de ateroma al igual que su utilidad como factor predictor de aparición de cuadros de ACV y por otra, el realizar un correcto diagnóstico diferencial con otras estructuras calcificadas que pueden aparecer en la ortopantomografía


Cerebrovascular accident (CVA) is the third cause of death in industrialized countries, following cardiovascular disease and cancer. It is therefore a significant public health issue, not only due to its high incidence, but also to the high costs involved in the physical and psychological rehabilitation of these patients. Dental Practitioners, as health care providers, ought to play their part in this issue and contribute, within their means, to the early detection of patients at risk of having a CVA. Since the eighties, different authors have described the possibility of detecting calcified atheroma plaques located at carotid artery bifurcation through panoramic radiograph. In this way, the Dental Practitioner’s possibilities in this field have been extended. However, this new use of panoramic radiograph must overcome certain obstacles before it is implemented as a new screening method for patients at risk of having a CVA. Amongst these, we would have, on the one hand, the assessment of the real clinical significance, as regards prognosis, of atheroma plaque calcification as well as its usefulness as a factor for predicting the appearance of CVA symptoms and, on the other hand, the possibility of making a correct differential diagnosis regarding other calcified structures that may appear on panoramic radiograph


Assuntos
Humanos , Arteriosclerose , Calcinose , Doenças das Artérias Carótidas , Radiografia Panorâmica , Arteriosclerose/complicações , Calcinose/complicações , Doenças das Artérias Carótidas/complicações , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/prevenção & controle
14.
Med. oral patol. oral cir. bucal (Internet) ; 10(5): 412-421, nov.-dic. 2005. tab
Artigo em Espanhol | IBECS | ID: ibc-042643

RESUMO

La mucositis oral es la inflamación que tiene lugar en el epiteliooral, a consecuencia de los tratamientos antineoplásicostales como la radioterapia, la quimioterapia o el transplante demédula ósea, siendo muy frecuente en los tratamientos de losprocesos oncohematológicos. Las consecuencias de esta inflamación,no sólo afectan a la calidad de vida del paciente, sinoque además puede suponer una limitación en la aplicación deltratamiento, así como un aumento de la estancia hospitalaria yde los gastos terapéuticos. Un obstáculo principal a la hora deestudiar la mucositis, ha sido la falta de un sistema adecuadopara su valoración mediante el examen oral. Los métodos desarrolladospara medir y cuantificar los cambios producidos enel epitelio oral, como consecuencia del tratamiento del cáncer,van desde los más sencillos, tales como escalas generales concuatro o cinco grados de severidad que permiten relacionar lamucositis con el estado de salud oral, hasta llegar a las escalasespecíficas de tratamiento, en las que se distingue el tipo detratamiento antineoplásico que dio lugar a la mucositis, pasandopor las escalas de múltiples variables, en las que se valorandistintos aspectos y se estudia su correspondencia con el estadode salud oral y su función, obteniendo una puntuación globalde severidad de la mucositis; es importante el establecimientode una escala común para la valoración de la mucositis, no sólocon fines clínicos sino también para la investigación del gradode toxicidad de los distintos regímenes terapéuticos que danlugar a mucositis


Oral mucositis is the inflammation that takes place in the oralepithelium, as a result of antineoplastic treatments such as radiotherapy,chemotherapy or bone marrow transplant, being veryfrequent in these treatments for oncohematologic disease. Theconsequences of this inflammation, not only affect the qualityof life of the patient, but can also suppose a limitation in the applicationof the treatment, as well as an increase in the hospitalstay and therapeutic costs. A main obstacle for the study of themucositis, has been the lack of a system adapted for its valuationby means of the oral examination. Methods developed tomeasure and quantify the changes produced in oral epitheliumas a result of treatment of cancer can be very varied from moresimple methods, such as general scales with four or five degreesof severity that link the mucositis to the state of oral health, tospecific scales of treatment. In this last type of scale the type ofantineoplastic treatment that gave rise to the mucositis is identifiedgiving a global severity score for the mucositis.The establishment of a common scale for the evaluation ofmucositis is important, not only for clinical purposes but alsofor the investigation of the degree of toxicity of the differenttherapeutic regimes that give rise to the mucositis


Assuntos
Humanos , Antineoplásicos/efeitos adversos , Mucosa Bucal/imunologia , Estomatite/imunologia , Estomatite/patologia , Radioterapia/efeitos adversos , Transplante de Medula Óssea/efeitos adversos , Transtornos de Deglutição/diagnóstico , Transtornos de Deglutição/etiologia , Leucemia/terapia , Mucosa Bucal , Mucosa Bucal/patologia , Mucosa Bucal/efeitos da radiação , Estomatite/etiologia , Índice de Gravidade de Doença , Neoplasias Hematológicas/terapia
15.
Med Oral Patol Oral Cir Bucal ; 10(5): 412-21, 2005.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-16264377

RESUMO

Oral mucositis is the inflammation that takes place in the oral epithelium, as a result of antineoplastic treatments such as radiotherapy, chemotherapy or bone marrow transplant, being very frequent in these treatments for oncohematologic disease. The consequences of this inflammation, not only affect the quality of life of the patient, but can also suppose a limitation in the application of the treatment, as well as an increase in the hospital stay and therapeutic costs. A main obstacle for the study of the mucositis, has been the lack of a system adapted for its valuation by means of the oral examination. Methods developed to measure and quantify the changes produced in oral epithelium as a result of treatment of cancer can be very varied from more simple methods, such as general scales with four or five degrees of severity that link the mucositis to the state of oral health, to specific scales of treatment. In this last type of scale the type of antineoplastic treatment that gave rise to the mucositis is identified giving a global severity score for the mucositis. The establishment of a common scale for the evaluation of mucositis is important, not only for clinical purposes but also for the investigation of the degree of toxicity of the different therapeutic regimes that give rise to the mucositis.


Assuntos
Antineoplásicos/efeitos adversos , Transplante de Medula Óssea/efeitos adversos , Mucosite/patologia , Radioterapia/efeitos adversos , Estomatite/patologia , Transtornos de Deglutição/diagnóstico , Transtornos de Deglutição/etiologia , Neoplasias Hematológicas/terapia , Humanos , Leucemia/terapia , Mucosa Bucal/efeitos dos fármacos , Mucosa Bucal/patologia , Mucosa Bucal/efeitos da radiação , Mucosite/etiologia , Índice de Gravidade de Doença , Estomatite/etiologia
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