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1.
Int J Comput Assist Radiol Surg ; 14(12): 2233-2243, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31440961

RESUMO

PURPOSE: Medical device interoperability in operating rooms (OR) provides advantages for both, patients and physicians. Several approaches were made to provide standards for successful device integration. However, with high heterogeneity of standards in the market, device vendors may reject these approaches. The aim of this work is therefore to provide a proof of concept for the connection of two promising integration solutions OR.NET and SCOT to increase vendor interest. METHODS: The connection of devices between both domains is targeted by implementing an application to map device capabilities between the IEEE 11073 SDC and ORiN standards. Potential properties of the respective architectures are defined. The connection was evaluated by latency measurements in a demonstrator setup utilizing an OR light as an exemplary device. RESULTS: The latency measurements resulted in a similar transmission speed of the GATOR (53.0 ms) and direct SDC-to-SDC (38.0 ms) communication. Direct proprietary ORiN-to-ORiN communication was faster in any case (8.0 ms). CONCLUSION: A connection between both standards was successfully achieved via the GATOR application. The results show comparable magnitudes of the communication between the standards compared to the direct standard-internal communication.


Assuntos
Salas Cirúrgicas , Cirurgia Assistida por Computador/instrumentação , Humanos
2.
Front Pharmacol ; 10: 545, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31164823

RESUMO

Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.

3.
Front Pharmacol ; 10: 546, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31164824

RESUMO

The combinatory use of high-intensity focused ultrasound (HIFU) and epirubicin (EPI)-conjugated polymeric micellar nanoparticles (NC-6300) is thought to be a less invasive and more efficient method of cancer therapy. To investigate the mechanism underlying the combination effect, we examined the effect of trigger-pulsed HIFU (TP-HIFU) and NC-6300 from the perspective of reactive oxygen species (ROS) generation, which is considered the primary function of sonodynamic therapy (SDT), and changes in drug characteristics. TP-HIFU is an effective sequence for generating hydroxyl radicals to kill cancer cells. EPI was susceptible to degradation by TP-HIFU through the production of hydroxyl radicals. In contrast, EPI degradation of NC-6300 was suppressed by the hydrophilic shell of the micelles. NC-6300 also exhibited a sonosensitizer function, which promoted the generation of superoxide anions by TP-HIFU irradiation. The amount of ROS produced by TP-HIFU reached a level that caused structural changes to the cellular membrane. In conclusion, drug-conjugated micellar nanoparticles are more desirable for SDT because of accelerated ROS production and drug protection from ROS. Furthermore, a combination of NC-6300 and TP-HIFU is useful for minimally invasive cancer therapy with cooperative effects of HIFU-derived features, antitumor activity of EPI, and increased ROS generation to cause damage to cancer cells.

5.
Acute Med Surg ; 6(1): 12-24, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30651993

RESUMO

Aim: To describe the registry design of the Osaka Emergency Information Research Intelligent Operation Network system (ORION) and its profile of hospital information, patient and emergency medical service characteristics, and in-hospital outcomes among all patients transported to critical care centers and emergency hospitals in Osaka Prefecture, Japan. Methods: The Osaka Prefecture Government has developed and introduced an information system for emergency patients (the ORION system) that uses a smartphone application (app) for hospital selection by on-scene emergency medical service personnel and has been accumulating all ambulance records. Since January 2015, medical institutions have obtained information on the diagnosis and outcome of patients transported to medical institutions, and the ORION system merged these data with ambulance records including smartphone app data. Results: From January 2015 to December 2016, 753,301 eligible patients were registered. The mean age was 58.7 years, and 51.5% of patients were male. After hospital arrival, 39.7% were hospitalized, 58.2% were discharged from hospital, 1.1% changed hospital, and 1.0% died. The most common diagnoses were injury, poisoning, and certain other consequences of external causes. Among the hospitalized patients, 29.2% were continuously hospitalized, 59.0% discharged, 5.2% changed hospital, and 5.8% were dead at 21 days after hospitalization. The most common confirmed diagnosis was diseases of the circulatory system. Conclusion: Using the ORION system developed and operated by Osaka Prefecture since January 2015, we described the epidemiological data of all emergency patients transported to emergency hospitals. Analysis using the ORION database in the future could lead to improvements in the emergency transport system and patient outcomes.

6.
J Neurol Surg A Cent Eur Neurosurg ; 80(2): 96-101, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30583303

RESUMO

BACKGROUND: Dissection and division of tissues are widely performed in microscopic neurosurgery, especially in brain tumor resection. Dissection maneuvers can be divided into two types: sharp dissection with microscissors and blunt dissection using a dissector. It is essential to use the appropriate method according to the intraoperative situation and conditions. Therefore, specific tools for each type of dissection maneuver are required. We developed an ultrasonic microdissector, a newly designed tool that functions as both microscissors and dissector to further advance brain tumor surgery. This preliminary experimental study was performed to evaluate the usefulness of this new device. METHODS: Solfy F (J. Morita Mfg. Corp., Kyoto, Japan), a dental ultrasonic instrument, was used to provide power in this study. Two experiments were performed. The first one involved touching the brain parenchyma of a pig cadaver with the tip of the ultrasonic microdissector under various conditions to investigate its side effects. In the second experiment, the rat femoral artery, vein, and nerve were dissected from surrounding structures using a prototype of the ultrasonic microdissector. The effects of this device were then investigated histologically. RESULTS: The amount of tissue damage was greater with the higher ultrasonic power. No irrigation and a long manipulation time also affected tissue degeneration. Dissection using the ultrasonic microdissector was superior to conventional dissection methods in terms of time (p < 0.05) and safety without any additional histologic damages. CONCLUSIONS: The newly developed ultrasonic microdissector can dissect soft tissue without damage to the surrounding tissue. Further studies are required to determine the optimal intensity for its clinical use.


Assuntos
Encéfalo/cirurgia , Dissecação/instrumentação , Microcirurgia/instrumentação , Procedimentos Neurocirúrgicos/instrumentação , Terapia por Ultrassom/instrumentação , Animais , Ratos , Suínos , Técnicas de Cultura de Tecidos
7.
BMJ Case Rep ; 20182018 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-30368477

RESUMO

Desmoplastic fibroblastoma (DF) is a rare benign soft tissue with spindle-to-stellate-shaped fibroblasts and myofibroblasts embedded in a prominent collagenous background. DF, mainly affecting subcutaneous and muscle tissue, very rarely occurs in the oral cavity. Hitherto, only one case of DF on the tongue has been reported. Here, we report another case. A 66-year-old woman was referred to our hospital with a mass formation in the tongue. On examination, a well-circumscribed, elastic, soft tumour with normal surface mucosa, measuring 13×12 mm, was observed on the left dorsal surface of her tongue. MRI and ultrasonography confirmed the mass, and a benign tongue tumour was suspected. The tumour was surgically resected under general anaesthesia 1 month later, leading to the histopathological diagnosis of DF. She experienced an uneventful clinical recovery after surgery, with no recurrence noted for more than 1 year postoperatively.


Assuntos
Fibroma Desmoplásico/cirurgia , Neoplasias da Língua/cirurgia , Idoso , Feminino , Fibroma Desmoplásico/diagnóstico , Humanos , Imagem por Ressonância Magnética , Neoplasias da Língua/diagnóstico
8.
World Neurosurg ; 119: e661-e665, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30092468

RESUMO

BACKGROUND: Based on our previous reports, stabilizing the surgeon's arm with an intraoperative armrest is linked to improved precision of microsurgical and endoscopic procedures. We developed the robotic intelligent surgeon's arm supporting system iArmS, which automatically follows the surgeon's arm and fixes it at an adequate position. METHODS: iArmS has 3 states-free, hold, and wait-which can be carefully chosen automatically as follows: In free state, the armholder follows the surgeon's arm. In hold state, iArmS supports the surgeon's arm weight by fixing the armholder. In wait state, the surgeon can move his or her arm away from the armholder. Also, the surgeon can change the armrest position while looking through the microscope and can continue the microsurgical procedure while holding surgical instruments. From February 2015 to January 2017, iArmS was used in 108 microsurgeries at 3 of the authors' institutions by 14 board-certified neurosurgeons, including the authors. After using iArmS, to quantify neurosurgeons' satisfaction, a scaling evaluation guide based on visual analog scales was designed to be completed by contributing neurosurgeons, including authors. RESULTS: iArmS decreased fatigue and reduced hand trembles experienced by surgeons. Continuous accurate motions of microinstruments were performed without any difficulties. There were no complications related to use of iArmS. CONCLUSIONS: iArmS allows continuous precise manipulations that provide high-quality surgical results in neurosurgical techniques. Moreover, iArmS is a useful automatic tool for holding and following the surgeon's arm.


Assuntos
Microcirurgia/instrumentação , Procedimentos Neurocirúrgicos/instrumentação , Procedimentos Cirúrgicos Robóticos/instrumentação , Desenho de Equipamento , Humanos , Estudos Prospectivos , Instrumentos Cirúrgicos
9.
Sci Rep ; 8(1): 5092, 2018 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-29572467

RESUMO

Most interesting phenomena of condensed matter physics originate from interactions among different degrees of freedom, making it a very intriguing yet challenging question how certain ground states emerge from only a limited number of atoms in assembly. This is especially the case for strongly correlated electron systems with overwhelming complexity. The Verwey transition of Fe3O4 is a classic example of this category, of which the origin is still elusive 80 years after the first report. Here we report, for the first time, that the Verwey transition of Fe3O4 nanoparticles exhibits size-dependent thermal hysteresis in magnetization, 57Fe NMR, and XRD measurements. The hysteresis width passes a maximum of 11 K when the size is 120 nm while dropping to only 1 K for the bulk sample. This behavior is very similar to that of magnetic coercivity and the critical sizes of the hysteresis and the magnetic single domain are identical. We interpret it as a manifestation of charge ordering and spin ordering correlation in a single domain. This work paves a new way of undertaking researches in the vibrant field of strongly correlated electron physics combined with nanoscience.

10.
Biomed Tech (Berl) ; 63(1): 31-37, 2018 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-29161232

RESUMO

Currently, networking has not progressed in the treatment room. Almost every medical device in the treatment room operates as a stand-alone device. In this project, we aim to develop a networked operating room called "Smart Cyber Operating Theater (SCOT)". Medical devices are connected using Open Resource interface for the Network (ORiN) technology. In this paper, we describe the concept of the SCOT project. SCOT is integrated using the communication interface ORiN, which was originally developed for industry. One feature of ORiN is that the system can be constructed flexibly. ORiN creates abstracts of the same type of devices and increases the robustness of the system for device exchange. By using ORiN technology, we are developing new applications, such as decision-making navigation or a precision guided treatment system.


Assuntos
Salas Cirúrgicas , Humanos , Integração de Sistemas , Interface Usuário-Computador
11.
Acute Med Surg ; 4(1): 114-118, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-29123846

RESUMO

Cases: Case 1: A 63-year-old woman was referred for coughing blood. Although cardiorespiratory dynamics were stabilized by artificial respiration under sedation, severely poor ventilation developed from asphyxia associated with massive respiratory tract hemorrhage. One-lung ventilation was temporarily secured by endotracheal tube insertion into the left main bronchus just prior to cardiopulmonary arrest.Case 2: A 72-year-old man was referred for massive hemoptysis after coughing, then intubated and placed on a respirator. During angiography, blood clots collected with bronchoscopy confirmed extravascular leakage into the right main bronchus. Outcomes: Both showed no hemoptysis recurrence after bronchial artery embolization and were discharged. Case 1 required intensive treatment for 6 days, including artificial respiratory management. Conclusion: Emergency one-lung ventilation was required for asphyxia in Case 1, and we had difficulties with bleeding point identification and hemostatic therapy. From that experience, we noted hemoptysis during angiography using bronchoscopy in Case 2, enabling prompt bronchial artery embolization.

12.
Sci Rep ; 7(1): 16579, 2017 11 29.
Artigo em Inglês | MEDLINE | ID: mdl-29185485

RESUMO

Secondary batteries are important energy storage devices for a mobile equipment, an electric car, and a large-scale energy storage. Nevertheless, variation of the local electronic state of the battery materials in the charge (or oxidization) process are still unclear. Here, we investigated the local electronic state of cobalt-hexacyanoferrate (Na x Co[Fe(CN)6]0.9), by means of resonant inelastic X-ray scattering (RIXS) with high energy resolution (~100 meV). The L-edge RIXS is one of the most powerful spectroscopic technique with element- and valence-selectivity. We found that the local electronic state around Co2+ in the partially-charged Na1.1Co2+0.5Co3+0.5[Fe2+(CN)6]0.9 film (x = 1.1) is the same as that of the discharged Na1.6Co2+[Fe2+(CN)6]0.9 film (x = 1.6) within the energy resolution, indicating that the local electronic state around Co2+ is invariant against the partial oxidization. In addition, the local electronic state around the oxidized Co3+ is essentially the same as that of the fully-charged film Co3+[Fe2+(CN)6]0.3[Fe3+(CN)6]0.6 (x = 0.0) film. Such a strong localization of the oxidized Co3+ state is advantageous for the reversibility of the redox process, since the localization reduces extra reaction within the materials and resultant deterioration.

13.
Anticancer Res ; 37(9): 4889-4897, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28870910

RESUMO

BACKGROUND: It is essential that cytotoxic T-lymphocytes (CTLs) recognize tumor-associated antigens (TAAs) and exhibit antitumor effects in immunological responses for tumor rejection. However, only a few cases with oral squamous cell carcinoma (OSCC) have been studied for these antitumor mechanisms. We established a cancer cell line and autologous CTL pair for identifying TAAs in OSCC, despite difficulties in establishing such a pair. MATERIALS AND METHODS: A cell line (OTM) from a primary lesion and a CTL line (TcOTM) were derived from OSCC in a 64-year-old female patient. CTL clones were generated by repetitive limiting dilutions. Accurate characterization was performed by in vitro analysis. RESULTS: The TcOTM clone showed specific cytotoxic activity against OTM cells in an human leukocyte antigen (HLA)-A24-restricted manner. Furthermore, it exerted cytotoxicity against the allogenic HLA-A24 cell lines. CONCLUSION: These data indicated that the TcOTM clone recognized a TAA presented by HLA-A24 cells. This unique method will allow for identification of unknown TAAs for OSCC in the future.


Assuntos
Antígenos de Neoplasias/imunologia , Linfócitos T CD8-Positivos/imunologia , Carcinoma de Células Escamosas/imunologia , Antígenos HLA-A/imunologia , Neoplasias Bucais/imunologia , Linfócitos T Citotóxicos/imunologia , Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/patologia , Feminino , Humanos , Ativação Linfocitária , Pessoa de Meia-Idade , Neoplasias Bucais/metabolismo , Neoplasias Bucais/patologia , Células Tumorais Cultivadas
14.
Ultrasound Med Biol ; 43(10): 2295-2301, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-28705555

RESUMO

Sonodynamic therapy (SDT) is currently considered as one of the promising minimally invasive treatment options for solid cancers. SDT is based on the combined use of a sonosensitizer drug and high-intensity focused ultrasound (HIFU) to produce cytotoxic reactive oxygen species (ROS) in and around neoplastic cells. Anthracycline drugs, including epirubicin (EPI), have been well known as effective sonosensitizers after interaction with focused ultrasound. Recently a new anticancer drug delivery system (DDS), NC-6300, has been developed that comprises EPI through an acid-labile hydrazone bond. In previous in vivo studies, NC-6300 showed basic drug safety and an excellent concentration property of EPI, and recently has been tested in clinical trials. For realizing minimally invasive cancer treatment, the present study demonstrated the effectiveness and feasibility of DDS-based SDT, which combined a small dose of NC-6300 and low energy of HIFU in mouse models of colon cancer and pancreatic cancer.


Assuntos
Antibióticos Antineoplásicos/administração & dosagem , Sistemas de Liberação de Medicamentos/métodos , Epirubicina/administração & dosagem , Terapia por Ultrassom/métodos , Animais , Terapia Combinada/métodos , Relação Dose-Resposta a Droga , Camundongos , Modelos Animais
15.
Phys Rev Lett ; 117(22): 227001, 2016 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-27925717

RESUMO

Motivated by recent pump-probe experiments indicating enhanced coherent c-axis transport in underdoped YBCO, we study Josephson junctions periodically driven by optical pulses. We propose a mechanism for this observation by demonstrating that a parametrically driven Josephson junction shows an enhanced imaginary part of the low-frequency conductivity when the driving frequency is above the plasma frequency, implying an effectively enhanced Josephson coupling. We generalize this analysis to a bilayer system of Josephson junctions modeling YBCO. Again, the Josephson coupling is enhanced when the pump frequency is blue detuned to either of the two plasma frequencies of the material. We show that the emergent driven state is a genuine, nonequilibrium superconducting state, in which equilibrium relations between the Josephson coupling, current fluctuations, and the critical current no longer hold.

16.
Artigo em Inglês | MEDLINE | ID: mdl-27614812

RESUMO

OBJECTIVE: Epithelial-mesenchymal transition (EMT) plays an important role in cancer invasion and metastasis induced by hypoxia. Here, we examined whether phosphorylation of GSK3-ß via phosphoinositide 3-kinase (PI3 K)/Akt signaling is involved in enhancing the hypoxia-induced EMT in oral squamous cell carcinoma (OSCC). STUDY DESIGN: Experiments were performed in OSCC cell lines (HSC-2, HSC-3, HSC-4, SAS, and HO-1-U-1) under normoxic or hypoxic conditions. The EMT was assessed by Matrigel invasion assays and wound healing assays. OSCC cell lines (HSC-2 and HSC-4) overexpressing hypoxia-inducible factor (HIF)-1α were established to examine the effects of HIF-1α on EMT-related factors. Immunohistochemical staining was performed to examine phosphorylation of GSK3-ß in 33 cases of tongue squamous cell carcinoma. RESULTS: Under hypoxic conditions, OSCC cell lines exhibited HIF-1α expression and showed evidence of the EMT. In cells overexpressing HIF-1α, the levels of phospho-Akt and phospho-GSK3-ß were increased, resulting in induction of the EMT. Inhibition of GSK3-ß phosphorylation suppressed these effects. Moreover, the intensity of pGSK3-ß staining was significantly increased with cN stage and cTNM stage in patients with tongue squamous cell carcinoma. CONCLUSIONS: Our data showed that the hypoxia-induced EMT in OSCC was enhanced by GSK3-ß phosphorylation, suggesting that GSK3-ß may be important in the invasion and metastasis of OSCC.


Assuntos
Carcinoma de Células Escamosas/enzimologia , Transição Epitelial-Mesenquimal , Quinase 3 da Glicogênio Sintase/metabolismo , Hipóxia , Fosfatidilinositol 3-Quinases/metabolismo , Neoplasias da Língua/enzimologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Western Blotting , Carcinoma de Células Escamosas/patologia , Linhagem Celular Tumoral , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Gradação de Tumores , Metástase Neoplásica , Estadiamento de Neoplasias , Fosforilação , Reação em Cadeia da Polimerase em Tempo Real , Transdução de Sinais , Coloração e Rotulagem , Neoplasias da Língua/patologia
17.
Inorg Chem ; 55(20): 10152-10160, 2016 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-27673751

RESUMO

The Co 2p3/2 X-ray absorption spectroscopy and high-energy-resolution (∼0.09 eV fwhm) 2p3d resonant inelastic X-ray scattering (RIXS) spectra of the single-cobalt-centered polyoxometalate K5H[CoW12O40]·xH2O were measured. The low-energy dd transition features at 0.55 eV, unmeasurable with ultraviolet-visible (UV/vis) spectroscopy, were experimentally revealed in 2p3d RIXS spectra. RIXS simulations based on ligand-field multiplet theory were performed to assess the potential cobalt tetragonal symmetry distortion, which is described with the ligand-field parameters 10Dq (-0.54 eV), Ds (-0.08 eV), and Dt (0.005 eV). Because 2p3d RIXS probes not only the optical spin-allowed transitions but also the spin-forbidden transitions, we show that the current 2p3d RIXS simulation enables a series of dd feature assignments with higher accuracy than those from previous optical data. Furthermore, by wave-function decomposition analyses, we demonstrate the more realistic and detailed origins of a few lowest dd transitions using both one-electron-orbital and term-symbol descriptions.

18.
Neurol Med Chir (Tokyo) ; 55(4): 311-6, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25797774

RESUMO

Experienced neurosurgeons reduce hand tremble by placing their hand beside the operative field when performing microneurosurgery conventionally. Another solution to reduce hand tremble is an armrest. However, the reduction of hand tremble by using an armrest or finger-placing technique has not been rigorously measured in microneurosurgery. This study was performed to provide a quantitative assessment of the efficacy of an armrest to reduce hand tremble in comparison with the finger-placing technique. Hand tremble was evaluated in 11 board-certified neurosurgeons in a simulated microneurosurgery. The loci of surgical forceps handled by neurosurgeons were measured by a three-dimensional optical coordinate measuring machine. A static task was performed under four conditions: with/without the finger-placing technique and/or an armrest. The radius of an imaginative sphere including 95% of each locus was calculated and reviewed according to the four conditions. Hand tremble was significantly larger when the finger-placing technique was not implemented compared to when the technique was used (P<0.05). The armrest also reduced hand tremble (P<0.05) similar to the finger-placing technique. Non-inferiority was retained between the finger-placing technique and the armrest. Concomitant use of the armrest and the finger-placing technique did not interfere with the efficacy of the technique to reduce neurosurgeon's hand tremble. The finger-placing technique was confirmed to reduce hand tremble. Resting the neurosurgeon's forearm on an armrest also reduced the hand tremble. An armrest is a device that reduces hand tremble in neurosurgeons like the finger-placing technique.


Assuntos
Mãos , Microcirurgia/instrumentação , Procedimentos Neurocirúrgicos/instrumentação , Tremor/prevenção & controle , Desenho de Equipamento , Humanos , Imagem Tridimensional , Masculino
19.
Phys Rev Lett ; 114(2): 026802, 2015 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-25635556

RESUMO

Analysis of the spatial dependence of current-voltage characteristics obtained from scanning tunneling microscopy experiments indicates that the charge density wave (CDW) occurring in NbSe_{2} is subject to locally strong pinning by a non-negligible density of defects, but that on the length scales accessible in this experiment the material is in a "Bragg glass" phase where dislocations and antidislocations occur in bound pairs and free dislocations are not observed. An analysis based on a Landau theory is presented showing how a strong local modulation may produce only a weak long range effect on the CDW phase.

20.
Conf Proc IEEE Eng Med Biol Soc ; 2013: 6695-8, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24111279

RESUMO

Soft tissue balance measurement is necessary for effective total knee arthroplasty (TKA). If optimal ligament balance is not achieved during surgery, it results in laxity of the knee or repeat surgery. In this paper, a newly developed robotic tensor system for measurement of soft tissue balance during TKA is described. The development concepts of the system were to measure collateral ligament balance (joint gap distance and varus angle) after cutting of the tibia and femur and to generate arbitrary lifting force to the knee joint during surgery. The system was created according to the development concepts. The prototype system has an active prismatic joint and a passive rotation joint to assess the joint gap and varus angle. The maximum lifting force is 250 N, the measurement range of the joint gap is 30 mm, and the varus angle is ± 15°. To confirm the force control ability, a basic experiment was performed. The input target force was 100, 150, 200, 250 N, and the output result showed an error within 3N. This experimental result shows that the newly developed system appears to have better accuracy than previous instrumental methods.


Assuntos
Artroplastia do Joelho , Articulação do Joelho/fisiologia , Prótese do Joelho , Ligamentos Laterais do Tornozelo/fisiopatologia , Fêmur/patologia , Fêmur/fisiopatologia , Humanos , Articulação do Joelho/cirurgia , Ligamentos Laterais do Tornozelo/patologia , Tíbia/fisiopatologia , Tíbia/cirurgia
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