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1.
Pol Merkur Lekarski ; 47(277): 31-34, 2019 Jul 29.
Artigo em Polonês | MEDLINE | ID: mdl-31385945

RESUMO

Age-related macular degeneration (AMD) is the leading cause of blindness in the world and may affect about 30-50 million people. Due to prevalence of this disease and the progressive population aging in recent years, in addition to conventional methods of treatment of AMD, there are more preventive and treatment support factors that can be used. An adequate diet, especially rich in antioxidant compounds, seems to play an important role in this case. Available scientific data suggest that an important role in AMD prevention and / or delay may play the appropriate selection of macronutrients, in particular fats and carbohydrates. In this work, based on the available data, the study reviews the relationship between the intake of selected nutrients and age-related macular degeneration.

2.
Pol Merkur Lekarski ; 47(277): 35-39, 2019 Jul 29.
Artigo em Polonês | MEDLINE | ID: mdl-31385946

RESUMO

Age-related macular degeneration (AMD) is a progressively degenerative disease at the central area of the retina, which results in severe visual impairment. It is the leading cause of irreversible blindness among people aged over 65 in developed countries. Therapies that focus on prevention through optimization of modifiable risk factors such as diet and nutritional status are key approaches to reducing the burden of disease. An adequate diet, especially rich in antioxidant compounds, seems to play an important role in this case. Available scientific data suggest that vitamins A, E, C and carotenoids, in particular lutein and zeaxantine and some minerals, may play an important role in the prevention and / or delay of AMD. There are also new data on the importance of other ingredients such as flavonoids in the AMD development. In this work, based on the available data, the study reviews the relationship between the intake of selected antioxidant nutrients and age-related macular degeneration.

3.
Haematologica ; 2019 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-31248967

RESUMO

Glutathione peroxidase 4 (GPX4) is unique as it is the only enzyme that can prevent detrimental lipid peroxidation in vivo by reducing lipid peroxides to the respective alcohols thereby stabilizing oxidation products of unsaturated fatty acids. During reticulocyte maturation, 15-lipoxygenase-mediated lipid peroxidation in humans and rabbits and by 12/15-lipoxygenase (ALOX15) in mice had been considered as the initiating event for the elimination of mitochondria which is now known to occur through mitophagy. Yet, genetic ablation of the Alox15 gene in mice failed to provide evidence for this hypothesis. We designed a different genetic approach to tackle this open conundrum. Since either other lipoxygenases or non-enzymatic autooxidative mechanisms may compensate for the loss of Alox15, we asked whether ablation of GPX4 in the hematopoietic system would result in perturbation of reticulocyte maturation. Quantitative assessment of erythropoiesis indices in the blood, bone marrow and spleen of chimeric mice with GPX4 ablated in hematopoietic cells revealed anemia with an increase in the fraction of erythroid precursor cells and reticulocytes. Additional dietary vitamin E depletion strongly aggravated the anemic phenotype. Despite strong extramedullary erythropoiesis reticulocytes failed to mature and accumulated large autophagosomes with engulfed mitochondria. GPX4-deficiency in hematopoietic cells led to systemic hepatic iron overload and simultaneous severe iron demand in the erythroid system. Despite extremely high erythropoietin and erythroferrone levels in the plasma, hepcidin expression remained unchanged. Conclusively, perturbed reticulocyte maturation in response to GPX4 loss in hematopoietic cells thus causes ineffective erythropoiesis, a phenotype partially masked by dietary vitamin E supplementation.

4.
Adv Exp Med Biol ; 1176: 89-99, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31134553

RESUMO

Birth weight is a key determinant of perinatal outcomes which affect physical development and metabolic function. In this study, we evaluated the potential role of maternal body composition and nutritional status in programing fetal birth weight. This was a longitudinal study that included 29 pregnant women and their full-term newborns. Maternal dietary energy and fluid intake and body adipose tissue were assessed. In addition, we measured the serum content of copeptin, aldosterone, and angiotensin II in maternal and umbilical cord blood. The measurements were done across the three trimesters of pregnancy, on average, at 11.6 weeks, 18.3 weeks, and 30.2 weeks. Each newborn's birth weight was determined at the percentile line, using the World Health Organization (WHO) standards based on the gestational age, gender, and weight. We found no appreciable relation of fetal birth weight to the maternal dietary and fluid intakes, and the content of angiotensin II, aldosterone, or copeptin. However, birth weight correlated with increases in body adipose tissue in early pregnancy stages. Further, birth weight correlated positively with copeptin and adversely with angiotensin II in cord blood. We conclude that the present findings may be helpful in the assessment of a critical level of body adipose tissue in women of child-bearing age, above which the potential risk of macrosomia appears. The female population of child-bearing age needs a continual update on the nutritional knowledge to prevent modifiable maternal and fetal perinatal complications.

5.
Ginekol Pol ; 89(11): 581-586, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30508208

RESUMO

OBJECTIVES: Maintaining proper nutrition during pregnancy is crucial for pregnant women and especially for who have been diagnosed with type 1 diabetes mellitus (T1DM) or who develop gestational diabetes mellitus (GDM). MATERIAL AND METHODS: To measure differences in vitamin and mineral intakes among women with normal pregnancies, pregnant women with GDM, and pregnant women with pre-gestational T1DM; and to assess the women's dietary intakes in comparison with Polish nutritional guidelines. The analysis was conducted among 83 pregnant women (29 GDM patients, 26 T1DM patients and 28 normal pregnancy participants) from whom we collected seven-day 24-hour dietary records during the second part of their pregnancies. RESULTS: There were no statistically significant differences observed for most of the vitamin and mineral intakes across the three groups. However, we did observe a significant difference in the vitamin C and calcium intakes between groups. The mean vitamin C and calcium intakes were significantly higher in the control group than among the diabetic patients. Insufficient dietary calcium intakes were found among 52.3% of the GDM patients and 61.6% of the T1DM participants, while only 28.6% of the normal pregnancy patients experienced a calcium deficiency. The highest incidence of inadequate intake in each of the GDM, T1DM and control groups was observed for vitamin D (100%, 100%, 100%), folate (97.7%, 100%, 100%), iron (97.7%, 100%, 100%), and iodine (97.7%, 92.4%, 85.7%), respectively. CONCLUSIONS: Diet alone may not be enough to provide adequate levels of vitamins and minerals for most micronutrients. Supplement use reduces the risk of inadequate intake for many micronutrients, but diet-related issues during pregnancy and pregnancy diagnosed with diabetes remain, and they deserve to be addressed during public health interventions.

6.
Adv Exp Med Biol ; 2018 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-30362028

RESUMO

This study seeks to evaluate the metabolic parameters such as body mass index (BMI), percentage of total body fat percentage (%BF), blood glucose, homeostatic index for quantification of insulin resistance and beta-cell function (HOMA-IR), sleep efficiency, and physical activity in liver transplant patients. The study group consisted of 24 male and 18 female patients, which enabled the inter-gender comparison. We found that a majority of patients had exceeded the norms for BMI and %BF. The excessive weight was distinctly accentuated in male patients. Only 40.5% of patients have a correct BMI and 21.4% of patients have a correct %BF. The indices of glucose metabolism were increased, pointing to enhanced insulin resistance. Resting energy expenditure and metabolic equivalent of task were characteristic of sedentary lifestyle, and they were lower in female patients. Almost 65% of patients had sleep efficiency below the desired 85% cut-off level. Further, sleep efficiency was decreasing with increasing BMI, %BF, and blood glucose level. In conclusion, liver transplant patients are characterized by excessive body mass and less physical activity and have a shortened sleep duration, all of which may lead to a worse glucose metabolism and increased disease risk and may also have an impact on quality of life.

7.
Adv Exp Med Biol ; 2018 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-29516309

RESUMO

Overweight and obesity, a cluster of multiple risk factors for atherosclerosis such as elevated blood pressure, elevated glucose level, and dyslipidemia, increase the risk of all-cause mortality and cardiovascular morbidity and mortality. Physical activity and a proper diet are essential preventive measures. The aim of the study was to evaluate the effects of a two-month intervention program consisting of a low-caloric diet (1,500 kcal) and increased physical activity on the anthropometric parameters, body composition, resting metabolic rate, and maximum oxygen uptake. The study was conducted in 22 women aged 20-38 with diagnosed overweight or obesity. We found that after completing the eight-week-long intervention program, there were significant changes in body composition, consisting of a smaller proportion of body fat and increased lean body mass. Further, we observed a decrease in body weight by 4.3 ± 2.5 kg (p < 0.01), a reduction in waist and hip circumference of 2.6 ± 4.5 cm (p < 0.01) and 4.4 ± 2.9 cm (p < 0.01), respectively, and an increase in maximum oxygen uptake by about 5.2 ± 8.4 ml/kg/min (p < 0.01). We conclude that the intervention program consisting of counseling on diet and physical activity may be highly motivational for patients with excess body weight and care givers should give it a try before commencing more aggressive psychopharmacological therapies.

8.
Ginekol Pol ; 89(12): 659-666, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30618032

RESUMO

OBJECTIVES: Pregnancy is a critical period during which environmental factors such as nutrition can affect development. Maintaining proper nutrition becomes even more significant when pregnant women have diabetes. The aim of this study was to measure changes in energy and macronutrient intakes among pregnant women and patients diagnosed either with gestational diabetes mellitus (GDM) during pregnancy, or, type 1 diabetes mellitus (T1DM) before pregnancy, and to assess the pregnant women's dietary intakes in comparison with Polish Institute of Food and Nutrition nutritional guidelines. MATERIAL AND METHODS: The analysis was conducted among 83 pregnant women (29 GDM patients, 26 T1DM patients and 28 normal pregnancy patients - the control group) from whom we gathered nutritional data during the second part of their pregnancies. Data on each woman's diet during pregnancy was collected is self-completed dietary records during seven consecutive 24-hour periods. RESULTS: The mean macronutrient intake of the GDM patients was 32.1% fat, 19.5% protein, and 48.3% carbohydrates; in the T1DM group the results were 34.2%, 19.4% and 46.4% respectively; and in control group they were 31.8%, 17.6% and 50.5% respectively. This study showed that many of the pregnant women did not reach the recommended level of energy intake during pregnancy. Moreover, most of the women exceeded their fat requirements, and fat intake as a proportion of energy intakes also exceeded the guidelines in more than 60% of the women across all groups. CONCLUSIONS: The implications and possible causes of excessive fat intake during pregnancy and pregnancies complicated by diabetes are underestimated and undertreated by obstetricians and warrant further investigation, especially in association with gestational weight gain, maternal and fetal perinatal complications, and post-gestational diabetes.


Assuntos
Diabetes Mellitus Tipo 1/epidemiologia , Diabetes Gestacional/epidemiologia , Dieta/estatística & dados numéricos , Comportamento Alimentar , Avaliação Nutricional , Adulto , Estudos de Casos e Controles , Carboidratos da Dieta/administração & dosagem , Gorduras na Dieta/administração & dosagem , Fibras na Dieta/administração & dosagem , Proteínas na Dieta/administração & dosagem , Feminino , Humanos , Fenômenos Fisiológicos da Nutrição Materna , Valor Nutritivo , Polônia , Guias de Prática Clínica como Assunto , Gravidez , Recomendações Nutricionais , Adulto Jovem
9.
J Exp Med ; 214(10): 3015-3035, 2017 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-28798029

RESUMO

Type-2 immune responses are well-established drivers of chronic inflammatory diseases, such as asthma, and represent a large burden on public health systems. The transcription factor PPARγ is known to promote M2-macrophage and alveolar macrophage development. Here, we report that PPARγ plays a key role in both T cells and dendritic cells (DCs) for development of type-2 immune responses. It is predominantly expressed in mouse Th2 cells in vitro and in vivo as well as human Th2 cells from allergic patients. Using conditional knockouts, we show that PPARγ signaling in T cells, although largely dispensable for IL-4 induction, is critical for IL-33-driven Th2 effector function in type-2 allergic airway responses. Furthermore, we demonstrate that IL-4 and IL-33 promote up-regulation of PPARγ in lung-resident CD11b+ DCs, which enhances migration to draining lymph nodes and Th2 priming capacity. Thus, we uncover a surprising proinflammatory role for PPARγ and establish it as a novel, important mediator of DC-T cell interactions in type-2 immunity.


Assuntos
Células Dendríticas/fisiologia , PPAR gama/fisiologia , Pneumonia/fisiopatologia , Linfócitos T/fisiologia , Animais , Modelos Animais de Doenças , Citometria de Fluxo , Imunidade Celular/fisiologia , Interleucina-33/fisiologia , Interleucina-4/fisiologia , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Células Th2/fisiologia
10.
Rocz Panstw Zakl Hig ; 66(2): 97-105, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26024397

RESUMO

A Western-type diet, characterized by a significant share of highly processed and refined foods and high content of sugars, salt, fat and protein from red meat, has been recognized as an important factor contributing to the development of metabolic disorders and the obesity epidemic around the world. Excessive body fat causes metabolic pathologies, such as insulin resistance, type 2 diabetes, dyslipidemia, cardiovascular diseases, hypertension, non-alcoholic fatty liver disease and cancer. According to the World Health Organization 1.5 billion adults are overweight, nearly 500 million are obese and 220 million suffer from type 2 diabetes. The Western-type diet is also associated with an increased incidence of chronic kidney disease. It is known that a combination of nutrients typical for this diet contributes to impaired renal function, renal steatosis and inflammation, hypertension and dysfunctional renal hormonal regulation. The Western diet is also associated with a chronic inflammatory process that is involved in all stages of atherosclerosis development and is increasingly recognized as a universal mechanism of various chronic degenerative diseases, such as autoimmune diseases, some neoplasms or osteoporosis. The present article is focused on the results of the most recent research investigating the effects of dietary macronutrients and the type of fatty acids on selected mechanisms associated with the occurrence of the most common diet-related diseases.


Assuntos
Doença Crônica/epidemiologia , Dieta/estatística & dados numéricos , Suplementos Nutricionais , Preferências Alimentares , Estado Nutricional , Ocidente , Dieta/efeitos adversos , Comportamentos Relacionados com a Saúde , Humanos , Fenômenos Fisiológicos da Nutrição
11.
Proc Natl Acad Sci U S A ; 111(7): 2494-9, 2014 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-24550273

RESUMO

Tripartite motif (TRIM) proteins make up a large family of coiled-coil-containing RING E3 ligases that function in many cellular processes, particularly innate antiviral response pathways. Both dimerization and higher-order assembly are important elements of TRIM protein function, but the atomic details of TRIM tertiary and quaternary structure have not been fully understood. Here, we present crystallographic and biochemical analyses of the TRIM coiled-coil and show that TRIM proteins dimerize by forming interdigitating antiparallel helical hairpins that position the N-terminal catalytic RING domains at opposite ends of the dimer and the C-terminal substrate-binding domains at the center. The dimer core comprises an antiparallel coiled-coil with a distinctive, symmetric pattern of flanking heptad and central hendecad repeats that appear to be conserved across the entire TRIM family. Our studies reveal how the coiled-coil organizes TRIM25 to polyubiquitylate the RIG-I/viral RNA recognition complex and how dimers of the TRIM5α protein are arranged within hexagonal arrays that recognize the HIV-1 capsid lattice and restrict retroviral replication.


Assuntos
Evolução Molecular , Modelos Moleculares , Conformação Proteica , Fatores de Transcrição/genética , Ubiquitina-Proteína Ligases/genética , Sequência de Bases , Cristalografia por Raios X , Dimerização , Fluorometria , Humanos , Dados de Sequência Molecular , Estrutura Terciária de Proteína/genética , Corantes de Rosanilina , Análise de Sequência de DNA , Fatores de Transcrição/química , Proteínas com Motivo Tripartido , Ubiquitina-Proteína Ligases/química , Ultracentrifugação
12.
Wiad Lek ; 67(2 Pt 1): 119-23, 2014.
Artigo em Polonês | MEDLINE | ID: mdl-25764787

RESUMO

Water is essential for life. There wouldn't be the proper functioning of body processes without it. An inadequate water intake relative to recommendation contributes to the decline in physical capacity and adversely effects on cognitive function and mood. On the other hand, an adequate water intake helps maintain the balance between total energy intake and daily energy expenditure and determines the correct rate of fat oxidation. This might be useful and commonly used in weight reduction and thus might favorably affect on body composition in overweight and obese people by increasing the total body water and lean muscle mass and might contribute to a decrease in body fat. Research results indicate clearly that drinking water instead of caloric beverages might be an effective way to reduce daily total energy consumption and in this way might may contribute to the reduction of weight, body circumferences and body fat.


Assuntos
Ingestão de Líquidos/fisiologia , Água/metabolismo , Ganho de Peso/fisiologia , Perda de Peso/fisiologia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Adulto Jovem
13.
Wiad Lek ; 67(2 Pt 1): 124-32, 2014.
Artigo em Polonês | MEDLINE | ID: mdl-25764788

RESUMO

The article encloses definition of water role and its body requirement, review of water balance and management in older persons regarding characteristic of this age group and concomitant disorders. Based on current literature and expert's opinion the recommendations for water consumption were expressed with estimation of insufficient apply and oversupply, evaluation of hydration state, domestic water sources in diet with accent on influence of proper hydration on comfort and good health.


Assuntos
Idoso de 80 Anos ou mais/fisiologia , Idoso/fisiologia , Ingestão de Líquidos/fisiologia , Recomendações Nutricionais , Adulto , Bebidas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
14.
Wiad Lek ; 67(1): 39-44, 2014.
Artigo em Polonês | MEDLINE | ID: mdl-25782216

RESUMO

Metabolic syndrome is the name for a group of risk factors that occur together and increase the risk for atherogenic dyslipidemia, impaired glucose tolerance, central obesity and hypertension. It is the most important cause of the development of cardiovascular diseases and diabetes type II. In the last few years studies have focused on the influence of the nutrient components of the disease, especially calcium and protein intake from dairy products. Studies have shown that varying degrees, and the mechanism may favourably affect the risk factors, but most of them do not take into consideration people with the full symptoms of the metabolic syndrome. Dairy products may play an important role in the prevention and mitigation components of the metabolic syndrome. It is not clear which ingredients of the food groups may be responsible for the positive health effects, and the possible mechanism for their actions.


Assuntos
Cálcio na Dieta/administração & dosagem , Laticínios , Proteínas na Dieta/administração & dosagem , Síndrome Metabólica/prevenção & controle , Prevenção Primária/métodos , Doenças Cardiovasculares/prevenção & controle , Humanos , Obesidade/prevenção & controle , Fatores de Risco
15.
Acta Biochim Pol ; 60(4): 595-602, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24432310

RESUMO

Growth arrest and DNA damage-inducible (GADD) 45 proteins are regulators of cell death and survival. The proinflammatory cytokine IL-1ß strongly increases the level of the transcript encoding GADD45α in rat insulin-producing INS-1E cells. The activation of Gadd45α gene is clearly dependent on JNK and NF-κB activation and the synthesis of the secondary mediator nitric oxide (NO). Interestingly, the observed twelve-fold increase in the GADD45α-coding transcript level is not followed by increased expression of GADD45α at the protein level. An analysis of IL-1ß toxicity in INS-1E cells overexpressing GADD45α revealed no correlation between the GADD45α protein level and the sensitivity to IL-1ß toxicity. These findings suggest that the potential engagement of GADD45α in IL-1ß toxicity towards beta cells is limited to the effects induced by the basal expression level of this protein.


Assuntos
Proteínas de Ciclo Celular/metabolismo , Células Secretoras de Insulina/metabolismo , Insulina/metabolismo , Interleucina-1beta/metabolismo , Proteínas Nucleares/metabolismo , Animais , Proteínas de Ciclo Celular/genética , Morte Celular/genética , Sobrevivência Celular/genética , Regulação da Expressão Gênica , Interleucina-1beta/genética , Óxido Nítrico/metabolismo , Proteínas Nucleares/genética , Ratos
16.
Rocz Panstw Zakl Hig ; 62(1): 47-52, 2011.
Artigo em Polonês | MEDLINE | ID: mdl-21735979

RESUMO

The aim of this study was to analyze the intakes of selected micronutrients by obese children and adolescents aged 7-13 years before and after nutrition counselling. The study showed that the introduction of hypocaloric diet did not bring about any significant reductions in body weight of subjects expressed as body mass index BMI. Dietary counseling did not result in changes in the intakes of vitamin B12, folates, vitamin E, calcium, magnesium, potassium, which fell below the recommended values. The consumption of vitamin B6 vitamin C was in accordance with the recommended daily intake (RDI), but the intakes of sodium exceeded the RDI. In order to prevent the development of non-communicable diseases in adulthood, the diets of investigated subjects need to be improved.


Assuntos
Aconselhamento , Ingestão de Alimentos , Micronutrientes/administração & dosagem , Avaliação Nutricional , Obesidade/dietoterapia , Obesidade/prevenção & controle , Adolescente , Índice de Massa Corporal , Criança , Contraindicações , Dieta Redutora , Ingestão de Energia , Feminino , Humanos , Masculino , Inquéritos Nutricionais , Necessidades Nutricionais
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