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1.
Angew Chem Int Ed Engl ; 57(4): 929-932, 2018 01 22.
Artigo em Inglês | MEDLINE | ID: mdl-29193510

RESUMO

We report meta- and para-selective linear alkylation reactions of anilides with alkenes by nickel/N-heterocyclic carbene (NHC) and aluminum catalysis. With a less bulky NHC, the alkylation reaction of N-methyl-N-phenylcyclohexanecarboxamides proceeded mainly at the meta position. In contrast, a bulky NHC ligand led to the para-selective alkylation of N-sec-alkyl anilides.

2.
Org Lett ; 19(3): 584-587, 2017 02 03.
Artigo em Inglês | MEDLINE | ID: mdl-28080066

RESUMO

A method for the para-selective alkylation of a variety of arenesulfonamides and aromatic sulfones with 1-alkenes by cooperative nickel/aluminum catalysis has been developed. Taking advantage of the sulfornyl functionality serving as a removable ortho-directing group, the reaction can be applied to facile access to 1,3-dialkyl-substitued benzenes.

3.
J Am Chem Soc ; 138(44): 14699-14704, 2016 11 09.
Artigo em Inglês | MEDLINE | ID: mdl-27759372

RESUMO

We report a method that ensures the selective alkylation of benzamides and aromatic ketones at the para-position via cooperative nickel/aluminum catalysis. Using a bulky catalyst/cocatalyst system allows reactions between benzamides and alkenes to afford the corresponding para-alkylated products. The origin of the high para-selectivity has also been investigated by density functional theory calculations.

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