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1.
PLoS One ; 17(4): e0267046, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35452470

RESUMO

The enzyme spermine oxidase (SMOX) is involved in polyamine catabolism and converts spermine to spermidine. The enzymatic reaction generates reactive hydrogen peroxide and aldehydes as by-products that can damage DNA and other biomolecules. Increased expression of SMOX is frequently found in lung, prostate, colon, stomach and liver cancer models, and the enzyme also appears to play a role in neuronal dysfunction and vascular retinopathy. Because of growing evidence that links SMOX activity with DNA damage, inflammation, and carcinogenesis, the enzyme has come into view as a potential drug target. A major challenge in cancer research is the lack of characterization of antibodies used for identification of target proteins. To overcome this limitation, we generated a panel of high-affinity rabbit monoclonal antibodies against various SMOX epitopes and selected antibodies for use in immunoblotting, SMOX quantification assays, immunofluorescence microscopy and immunohistochemistry. Immunohistochemistry analysis with the antibody SMAB10 in normal and transformed tissues confirms that SMOX is upregulated in several different cancers. Together, the panel of antibodies generated herein adds to the toolbox of high-quality reagents to study SMOX biology and to facilitate SMOX drug development.


Assuntos
Antineoplásicos Imunológicos , Neoplasias , Oxirredutases atuantes sobre Doadores de Grupo CH-NH , Anticorpos Monoclonais , Humanos , Imuno-Histoquímica , Masculino , Oxirredutases atuantes sobre Doadores de Grupo CH-NH/genética , Espermina/metabolismo
2.
Science ; 375(6582): 779-782, 2022 02 18.
Artigo em Inglês | MEDLINE | ID: mdl-35175813

RESUMO

Lead poisoning occurs worldwide in populations of predatory birds, but exposure rates and population impacts are known only from regional studies. We evaluated the lead exposure of 1210 bald and golden eagles from 38 US states across North America, including 620 live eagles. We detected unexpectedly high frequencies of lead poisoning of eagles, both chronic (46 to 47% of bald and golden eagles, as measured in bone) and acute (27 to 33% of bald eagles and 7 to 35% of golden eagles, as measured in liver, blood, and feathers). Frequency of lead poisoning was influenced by age and, for bald eagles, by region and season. Continent-wide demographic modeling suggests that poisoning at this level suppresses population growth rates for bald eagles by 3.8% (95% confidence interval: 2.5%, 5.4%) and for golden eagles by 0.8% (0.7%, 0.9%). Lead poisoning is an underappreciated but important constraint on continent-wide populations of these iconic protected species.

3.
Hum Vaccin Immunother ; 18(1): 2028514, 2022 12 31.
Artigo em Inglês | MEDLINE | ID: mdl-35103580

RESUMO

Human papillomavirus (HPV) is one of the most common causes of sexually transmitted diseases, and the main etiology of cervical cancer. This study was aimed to assess type-specific cervical HPV prevalence and their association with HPV-specific antibodies in a cohort of female university students. HPV genotyping was performed by amplifying and sequencing a fragment of the L1 protein. A BLAST search was performed to identify HPV types. HPV-specific IgG antibodies were measured by ELISA in serum samples. A total of 129 women participated, with an average age of 21.75 years. The prevalence of vaginal HPV infection was 74.42%. The most predominant high-risk HPV types were 18 (13.95%), 31 (10.85%), and 16 (9.3%). We found that early age at coitarche and a higher number of sexual partners were significantly associated with a high prevalence of HPV infection. In addition to sexual behavior, we observed that the presence of serum-specific IgG antibodies against HPV can impact the prevalence of the virus. Seropositivity to HPV-16 and HPV-18 was associated with a lower prevalence of HPV-16, but not for other HPV types. Of note, there was a lower proportion of HPV-specific seropositivity in women who had the presence of the same HPV type in a cervical specimen, suggesting an immunoregulatory mechanism associated with the viral infection. In conclusion, the prevalence of HPV in university women was higher than expected and it was associated with early age of sexual debut, an increasing number of sexual partners, and a low proportion of HPV seropositivity.


Assuntos
Infecções por Papillomavirus , Adulto , Anticorpos Antivirais , DNA Viral/análise , Feminino , Humanos , Imunoglobulina G , México/epidemiologia , Papillomaviridae , Prevalência , Fatores de Risco , Estudos Soroepidemiológicos , Estudantes , Universidades , Adulto Jovem
4.
Rev. ecuat. pediatr ; 22(3): 1-14, 30 de diciembre del 2021.
Artigo em Espanhol | LILACS | ID: biblio-1352441

RESUMO

Introducción: El etiquetado nutricional es una herramienta gráfica para notificar al consumidor sobre las propiedades nutricionales de un alimento lo que facilita su selección. El objetivo del presente estudio fue determinar la influencia del etiquetado nutricional y los factores socioeconómicos, culturales, demográficos, publicitarios en la selección de alimentos en un grupo de padres de niños entre 5-11 años en dos unidades educativas públicas y privadas de Quito. Métodos: Con diseño mixto, cuantitativo- transversal y cualitativa interpretativa se analizó una muestra de opiniones de 240 padres en las Unidades Educativas (UE) Nueva Aurora (Privada) y 235 padres en la UE Julio María Matovelle (Pública) de Quito. Se realizaron tres grupos focales, grabados y transcriptos de forma textual y se aplicó un cuestionario. El paquete esta-dístico usado fue SPSS v24.0. Resultados: Hubo mayor consumo de alimentos procesados en la UE Privada n=79/240 (32.9%). Selección por fácil preparación (39.2% UE Privada y 46.4% UE Pública). El 54.2 % y 57 % de los padres ven publicidad en la televisión. El conocimiento del etiquetado fue superior en la UE privada (94.9%; n=223). Asociación entre edad [OR: 2.3; IC 95%: 1.08-5.04] instrucción [OR: 3.95; IC 95%: 2.12-7.37], exposición a la publicidad [OR: 0.62; IC 95%: 0.36-1.05] y conocimientos (P<0.05). La actitud se asoció con el nivel de instrucción [OR: 2.57; IC 95%: 1.62-4.09] e ingresos (P<0.05). Análisis cualitativo: grado de conocimiento y publicidad elevados, con un impacto importante en la selección de los alimentos. Conclusiones: El conocimiento sobre el etiquetado nutricional fue elevado; pero no fue el principal factor para seleccionar alimentos. El tiempo de preparación y el sabor fueron más importantes que las especificaciones nutricionales


Introduction: Nutrition labeling is a graphic tool to notify consumers about the nutritional properties of a food, which facilitates their selection. The objective of this study was to determine the influence of nutri-tional labeling and socioeconomic, cultural, demographic, and advertising factors on food selection in a group of parents of children between 5-11 years old in two public and private educational units in Quito. Methods: With a mixed, quantitative-transversal and qualitative interpretative design, a sample of opin-ions of 240 parents in the Educational Units (EU) Nueva Aurora (Fiscal) and 235 parents in the EU Julio María Matovelle (Private) of Quito was analyzed. Three focus groups were carried out, recorded and transcribed textually, and a questionnaire was administered. The statistical package used was SPSS v24.0. Results: There was a higher consumption of processed foods in the private EU n = 79/240 (32.9%). Selection for easy preparation (39.2% Private EU and 46.4% Public EU). 54.2% and 57% of parents see advertising on television. Knowledge of labeling was higher in the private EU (94.9%; n = 223). Association between age [OR: 2.3; 95% CI: 1.08-5.04] instruction [OR: 3.95; 95% CI: 2.12-7.37], exposure to advertising [OR: 0.62; 95% CI: 0.36-1.05] and knowledge (P <0.05). Attitude was associated with educational level [OR: 2.57; 95% CI: 1.62-4.09] and admissions (P <0.05). Qualitative analysis: high degree of knowledge and publicity, with a significant impact on food selection. Conclusions: Knowledge about nutritional labeling was high, but it was not the main factor in selecting food. Prep time and flavor were more important than nutritional specifications.


Assuntos
Humanos , Criança , Educação Alimentar e Nutricional , Dietoterapia , Ciências da Nutrição Infantil , Publicidade de Alimentos , Ciências da Nutrição , Alimentos, Dieta e Nutrição , Valor Nutritivo
5.
Plants (Basel) ; 10(12)2021 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-34961030

RESUMO

Cervical cancer represents a public health problem, develops resistance to traditional therapies and cost-of-treatment is high. These disadvantages have led to the search for alternative bioactive-compound-based therapies. Said bioactive compounds include phenolic compounds, flavonoids, and tannins. The present study aimed to evaluate the therapeutic effect of a P. plicata extract on the HeLa cell line. Viability and apoptosis assays were run on the two cell lines treated with the extract. The peptides, up- and down-expressed in both cell lines, were identified by PDQuest analysis software and high-performance liquid chromatography/mass spectrometry/mass spectrometry (HPLC/MS/MS). Our results show that a 500 mg/L treatment deregulated cell viability, with different apoptotic morphologies observed which are associated with the presence of bio-compounds, which up- and down-regulated the peptides. In conclusion, P. plicata regulates proteins associated with apoptosis in HeLa cancer cells.

6.
Clin Kidney J ; 14(6): 1557-1569, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34079618

RESUMO

BACKGROUND: Acute kidney injury (AKI) may develop in coronavirus disease 2019 (COVID-19) patients and may be associated with a worse outcome. The aim of this study is to describe AKI incidence during the first 45 days of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Spain, its reversibility and the association with mortality. METHODS: This was an observational retrospective case-control study based on patients hospitalized between 1 March and 15 April 2020 with SARS-CoV-2 infection and AKI. Confirmed AKI cases were compared with stable kidney function patients for baseline characteristics, analytical data, treatment and renal outcome. Patients with end-stage kidney disease were excluded. RESULTS: AKI incidence was 17.22% among 3182 admitted COVID-19 patients and acute kidney disease (AKD) incidence was 6.82%. The most frequent causes of AKI were prerenal (68.8%) and sepsis (21.9%). Odds ratio (OR) for AKI was increased in patients with pre-existent hypertension [OR 2.58, 95% confidence interval (CI) 1.71-3.89] and chronic kidney disease (CKD) (OR 2.14, 95% CI 1.33-3.42) and in those with respiratory distress (OR 2.37, 95% CI 1.52-3.70). Low arterial pressure at admission increased the risk for Stage 3 AKI (OR 1.65, 95% CI 1.09-2.50). Baseline kidney function was not recovered in 45.73% of overall AKI cases and in 52.75% of AKI patients with prior CKD. Mortality was 38.5% compared with 13.4% of the overall sample population. AKI increased mortality risk at any time of hospitalization (hazard ratio 1.45, 95% CI 1.09-1.93). CONCLUSIONS: AKI is frequent in COVID-19 patients and is associated with mortality, independently of acute respiratory distress syndrome. AKD was also frequent and merits adequate follow-up.

8.
Nefrologia (Engl Ed) ; 2021 Jan 28.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33781578

RESUMO

We present the case of a male patient with severe SARS-CoV-2 pneumonia, with simultaneous onset of p-ANCA positive rapidly progressive glomerulonephritis. We discuss the different therapeutic possibilities, emphasising the appropriateness of their administration according to the time in the course of the infection.

9.
Heliyon ; 7(3): e06086, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33732915

RESUMO

Metals in the environment have been an increasing research topic over the past decade, since they can be found in both natural and drinking water, including irrigation of crops and edible plants with contaminated water. The aim of this study was to investigate the uptake of Cr by arugula (Eruca sativa) in a greenhouse experiment, simulating the open field irrigation conditions. We also evaluate the toxic effects of Cr on oxidative stress by measuring the antioxidant capacity and polyphenol profile in the plant. The study examines the irrigation of arugula, during 15 and 21 days, with four Cr (VI) concentrations, ranging from 0 (control) to 250 µg. L-1. Arugula plants were able to accumulate Cr when irrigated during 15 and 21 days in all the Cr concentrations evaluated. The estimated daily intake (EDI) shows that the amount of Cr accumulated by arugula plants does not represent a threat to human health. Application of Cr levels induced some changes in content, profile and capacity of antioxidants depending on Cr concentration and time of exposure. Taking into account that E. sativa is consumed due to its polyphenol-related health benefits, the allowable Cr limits in irrigation water should be reviewed, in order to maximize health benefits associated with its consumption, and also to improve vegetable quality. Arugula is a valuable and nutritious food, that should not be excluded from a balanced diet. Chromium concentration in irrigation water as well as the speciation forms present in vegetables should be controlled.

11.
Int J Psychol Res (Medellin) ; 13(2): 14-24, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33329874

RESUMO

Due to the scarcity of evaluation instruments on the construct of difficulties in emotional regulation in the Ecuadorian university context, the objective of the present study was to adapt linguistically and to study the psychometric properties of the Difficulty Scale in Emotional Regulation (DERS) in a sample of Ecuadorian university students. A non-probability sample of 1172 participants between 17 and 32 years of age (M = 21.99; DT = 2.49), which consisted of 58.6% women and 41.4% men, was used. The research was carried out in three stages. The first study evaluated the Ecuadorian linguistic adaptation of the scale. The second study referred to the factorization by main axes identifying five factors (Lack of emotional understanding; Limited access to regulation strategies; Difficulties in impulse control; Interferences in goal-directed behaviors; Lack of emotional clarity) theoretically interpretable, which explain 49.22% of the variance. The third study developed a confirmatory factor analysis that specified an acceptable fit of the model (GFI = .95; AGFI = .95; NFI = .94; RMR = .11). The reliability coefficients are acceptable as .90 Cronbach's alpha and .91 McDonald's omega. In conclusion, it is mentioned that the Ecuadorian version of the DERS in a university sample exhibits good psychometric characteristics of internal structure and responses.


Debido a la escasez de instrumentos de evaluación sobre el constructo de dificultades en la regulación emocional en el contexto universitario ecuatoriano, el objetivo del presente estudio fue adaptar lingüísticamente y estudiar las propiedades psicométricas de la Escala de dificultades en la regulación emocional (DERS) en una muestra de estudiantes universitarios ecuatorianos. Se empleó una muestra no probabilística de 1172 participantes de 17 a 32 años de edad (M = 21.99; DT = 2.49), de los cuales 58.6% eran mujeres y 41.4% hombres. La investigación se desplegó en tres etapas: el primer estudio desarrolló la adaptación lingüística ecuatoriana de la escala. El segundo estudio se refirió a la factorización por ejes principales identificando cinco factores (Falta de compresión emocional; Acceso limitado a estrategias de regulación; Dificultades en el control de impulsos; Interferencias en conductas dirigidas a metas; Falta de claridad emocional) interpretables teóricamente, que explican el 49.22% de la varianza. El tercer estudio desarrolló un análisis factorial confirmatorio, el cual indicó un ajuste aceptable del modelo (GFI = .95; AGFI = .95; NFI = .94; RMR = .11). Los coeficientes de fiabilidad se revelaron aceptables de .90 alfa de Cronbach y .91 omega de McDonald. Como conclusión se menciona que la versión ecuatoriana de la DERS en una muestra universitaria exhibe buenas características psicométricas de estructura interna y fiabilidad.

12.
Nefrología (Madrid) ; 40(6): 608-622, nov.-dic. 2020. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-197197

RESUMO

ANTECEDENTES Y OBJETIVO: Recientemente, se han desarrollado en España las Unidades de Enfermedad Renal Crónica Avanzada (UERCA) con el objetivo de ofrecer una mayor calidad de vida a los pacientes con ERCA, mejorar su supervivencia y disminuir la morbilidad en esta fase de la enfermedad. Al día de hoy, hay poca evidencia en la literatura española e internacional con respecto a la estructura y cómo conseguir estos objetivos en las UERCA. Desde el grupo de trabajo ERCA de la Sociedad Española de Nefrología (SEN) se impulsa este proyecto para mejorar la atención a los pacientes ERCA a través de la definición de estándares de calidad para el funcionamiento de las UERCA. MATERIAL Y MÉTODOS: Se conformó una propuesta inicial de estándares de calidad sobre el funcionamiento de las UERCA a través de la consulta de principales fuentes de referencias y el asesoramiento de un grupo de trabajo de expertos a través de reuniones presenciales y no presenciales. A partir de esta propuesta inicial de estándares, se diseñó y envío una encuesta vía correo electrónico a 121 especialistas de nefrología y profesionales de enfermería con experiencia en UERCA españolas para conocer entre otros, la idoneidad de cada estándar, es decir, su obligatoriedad o recomendación como estándar. Se permitió acceso a la encuesta entre el 16 de julio de 2018, hasta el 26 de septiembre de 2018. RESULTADOS: Participaron un total de 95 (78,5%) profesionales de los 121 que fueron invitados a participar. De éstos, 80 fueron especialistas en nefrología y 15 profesionales de enfermería, obteniéndose una variada representación de profesionales de la geografía española. Tras analizar las opiniones de estos participantes, los estándares quedaron definidos a un total de 68, 37 de ellos (54,4%) obligatorios y 31 de ellos (45,5%) recomendables. Además, se observó que el volumen de pacientes atendidos en las UERCA se sitúa usualmente por encima de los 100 pacientes, y que el criterio de derivación por regla general está por debajo de 25-29 mL/min/1,73 m2 de filtración glomerular. CONCLUSIONES: Este trabajo constituye una primera propuesta de estándares de calidad para el funcionamiento de una UERCA en España. La definición de estos estándares ha permitido establecer las bases para la estandarización de la organización de las UERCA, y trabajar posteriormente en la configuración de un manual de estándares para la acreditación de estas Unidades


BACKGROUND AND OBJECTIVE: Recently, the Advanced Chronic Kidney Disease Units (UERCA, in Spanish) have been developed in Spain to offer a better quality of life to patients with advanced chronic kidney disease (ACKD), improving their survival and reducing morbidity in this phase of the disease. Nowadays, there is not much evidence in the Spanish and international literature regarding the structure and how to achieve these objectives in the UERCA. From the ERCA working group of the Spanish Society of Nephrology (SEN), this project is promoted to improve care for ERCA patients through the definition of quality standards for the operation of the UERCA. MATERIAL AND METHODS: An initial proposal for quality standards concerning the operation of the UERCA was configured through consultation with the main sources of references and the advice of an expert working group through face-to-face and telematic meetings. Base on this initial proposal of standards, a survey was conducted and sent it via email to 121 nephrology specialist and nursing professionals with experience in Spanish UERCA to find out, among others, the suitability of each standards, that is, its mandatory nature or recommendation as standards. The access to the survey was allowed between July 16th, 2018, until September 26th, 2018. RESULTS: A total of 95 (78.5%) professionals participated out of the 121 who were invited to participate. Of these, 80 of the participants were nephrology specialists and 15 nursing professionals, obtaining a varied representation of professionals from the Spanish geography. After analyzing the opinions of these participants, the standards were defined to a total of 68, 37 of them (54.4%) mandatory and 31 of them (45.5%) recommended. Besides, it was observed that the volume of patients attended in the UERCA is usually above 100 patients, and the referral criteria is generally below 25-29 mL/min/1.73 m2 of glomerular filtration. CONCLUSIONS: This work constitutes a first proposal of quality standards for the operation of UERCA in Spain. The definition of these standards has made it possible to establish the bases for the standardization of the organization of UERCA, and to subsequently work on the configuration of a standards manual for the accreditation of ERCA Units


Assuntos
Humanos , Garantia da Qualidade dos Cuidados de Saúde/normas , Insuficiência Renal Crônica/terapia , Hospitais de Doenças Crônicas/normas , Segurança do Paciente/normas , Hospitais de Doenças Crônicas/estatística & dados numéricos , Inquéritos e Questionários , Espanha
13.
Nefrologia (Engl Ed) ; 40(6): 608-622, 2020.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33032839

RESUMO

BACKGROUND AND OBJECTIVE: Recently, the Advanced Chronic Kidney Disease Units (UERCA, in Spanish) have been developed in Spain to offer a better quality of life to patients with advanced chronic kidney disease (ACKD), improving their survival and reducing morbidity in this phase of the disease. Nowadays, there is not much evidence in the Spanish and international literature regarding the structure and how to achieve these objectives in the UERCA. From the ERCA working group of the Spanish Society of Nephrology (SEN), this project is promoted to improve care for ERCA patients through the definition of quality standards for the operation of the UERCA. MATERIAL AND METHODS: An initial proposal for quality standards concerning the operation of the UERCA was configured through consultation with the main sources of references and the advice of an expert working group through face-to-face and telematic meetings. Base on this initial proposal of standards, a survey was conducted and sent it via email to 121 nephrology specialist and nursing professionals with experience in Spanish UERCA to find out, among others, the suitability of each standards, that is, its mandatory nature or recommendation as standards. The access to the survey was allowed between July 16th, 2018, until September 26th, 2018. RESULTS: A total of 95 (78.5%) professionals participated out of the 121 who were invited to participate. Of these, 80 of the participants were nephrology specialists and 15 nursing professionals, obtaining a varied representation of professionals from the Spanish geography. After analyzing the opinions of these participants, the standards were defined to a total of 68, 37 of them (54.4%) mandatory and 31 of them (45.5%) recommended. Besides, it was observed that the volume of patients attended in the UERCA is usually above 100 patients, and the referral criteria is generally below 25-29 mL/min/1.73 m2 of glomerular filtration. CONCLUSIONS: This work constitutes a first proposal of quality standards for the operation of UERCA in Spain. The definition of these standards has made it possible to establish the bases for the standardization of the organization of UERCA, and to subsequently work on the configuration of a standards manual for the accreditation of ERCA Units.


Assuntos
Recursos em Saúde , Segurança do Paciente , Insuficiência Renal Crônica/terapia , Unidade Hospitalar de Urologia/normas , Acreditação , Taxa de Filtração Glomerular , Pesquisas sobre Serviços de Saúde/estatística & dados numéricos , Humanos , Nefrologistas/estatística & dados numéricos , Enfermagem em Nefrologia/estatística & dados numéricos , Melhoria de Qualidade , Qualidade da Assistência à Saúde , Qualidade de Vida , Insuficiência Renal Crônica/fisiopatologia , Sociedades Médicas , Espanha , Unidade Hospitalar de Urologia/organização & administração , Unidade Hospitalar de Urologia/estatística & dados numéricos
16.
Nefrología (Madrid) ; 40(3): 345-350, mayo-jun. 2020. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-201535

RESUMO

La relación entre parásitos y glomerulonefritis (GN) está bien documentada en determinadas parasitosis, no así en casos de Strongyloides stercolaris (S. stercolaris), donde hay pocos casos descritos, siendo la mayoría GN de cambios mínimos. Reportamos un caso de hiperinfestación por S. stercolaris en un paciente afectado de una GN membranosa tratado con corticoides por vía oral con resultado fatal para el paciente. Este caso nos aporta una doble enseñanza: en primer lugar, acerca de una asociación rara de estrongiloidiasis y GN membranosa, y en segundo lugar, sobre la importancia de establecer un diagnóstico de sospecha y tratamiento adecuados ante determinadas infecciones o enfermedades con poca expresividad clínica antes de iniciar cualquier tratamiento inmunosupresor


The relationship between parasites and glomerulonephritis (GN) is well documented in certain parasitoses, but not in cases of Strongyloides stercolaris (S. stercolaris) where there are few cases described being the majority GN of minimal changes. We report a case of hyperinfestation by S. stercolaris in a patient affected by a membranous GN treated with oral corticosteroids with fatal outcome for the patient. This case provides a double teaching: first about a rare association of strongyloid and membranous GN and second about the importance of establishing a diagnosis of suspected and appropriate treatment for certain infections or diseases with little clinical expression before starting any immunosuppressive treatment


Assuntos
Humanos , Animais , Masculino , Pessoa de Meia-Idade , Glomerulonefrite Membranosa/complicações , Imunossupressores/efeitos adversos , Prednisona/efeitos adversos , Strongyloides stercoralis , Estrongiloidíase/complicações , Síndrome de Resposta Inflamatória Sistêmica/etiologia , Criptococose/complicações , Diagnóstico Tardio , Quimioterapia Combinada , Equador/etnologia , Enterococcus faecium , Infecções por Escherichia coli/complicações , Evolução Fatal , Glomerulonefrite Membranosa/tratamento farmacológico , Glomerulonefrite Membranosa/urina , Infecções por Bactérias Gram-Positivas/complicações , Hospedeiro Imunocomprometido , Imunossupressores/uso terapêutico , Pneumopatias Fúngicas/complicações , Meningites Bacterianas/complicações , Pneumonia Bacteriana/complicações , Prednisona/uso terapêutico , Choque Séptico/etiologia , Stenotrophomonas maltophilia , Estrongiloidíase/diagnóstico
19.
Environ Toxicol Chem ; 39(4): 882-892, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32022303

RESUMO

Lead poisoning of scavenging birds is a global issue. However, the drivers of lead exposure of avian scavengers have been understood from the perspective of individual species, not cross-taxa assemblages. We analyzed blood (n = 285) and liver (n = 226) lead concentrations of 5 facultative (American crows [Corvus brachyrhynchos], bald eagles [Haliaeetus leucocephalus], golden eagles [Aquila chrysaetos], red-shouldered hawks [Buteo lineatus], and red-tailed hawks [Buteo jamaicensis]) and 2 obligate (black vultures [Coragyps atratus] and turkey vultures [Cathartes aura] avian scavenger species to identify lead exposure patterns. Species and age were significant (α < 0.05) predictors of blood lead exposure of facultative scavengers; species, but not age, was a significant predictor of their liver lead exposure. We detected temporal variations in lead concentrations of facultative scavengers (blood: median = 4.41 µg/dL in spring and summer vs 13.08 µg/dL in autumn and winter; p = <0.001; liver: 0.32 ppm in spring and summer vs median = 4.25 ppm in autumn and winter; p = <0.001). At the species level, we detected between-period differences in blood lead concentrations of bald eagles (p = 0.01) and red-shouldered hawks during the winter (p = 0.001). During summer, obligate scavengers had higher liver lead concentrations than did facultative scavengers (median = 1.76 ppm vs 0.22 ppm; p = <0.001). These data suggest that the feeding ecology of avian scavengers is a determinant of the degree to which they are lead exposed, and they highlight the importance of dietary and behavioral variation in determining lead exposure. Environ Toxicol Chem 2020;39:882-892. © 2020 SETAC.


Assuntos
Doenças das Aves/induzido quimicamente , Dieta , Exposição Ambiental/análise , Poluentes Ambientais/toxicidade , Intoxicação por Chumbo/veterinária , Chumbo/toxicidade , Animais , Ecologia , Poluentes Ambientais/análise , Feminino , Chumbo/análise , Fígado/química , Estações do Ano , Especificidade da Espécie , Estados Unidos
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