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1.
Salud Publica Mex ; 61(5): 601-608, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31661737

RESUMO

OBJECTIVE: To describe the rationale and the methodology of a multicenter project to study the etiology of breast cancer in young Latin American women. MATERIALS AND METHODS: The International Agency for Research on Cancer has established an international collaborative population-based case-control study in four countries in Latin America: Chile, Colombia, Costa Rica, and Mexico (the PRECAMA study). Standardized methodologies were developed to collect information on reproductive variables, lifestyle, anthropometry, diet, clinical and pathological data, and biological specimens. The study will be extended to other countries in the region. CONCLUSIONS: PRECAMA is unique in its multidisciplinary approach that combines genetics, genomics, and metabolomics with lifestyle factors. Then data generated through this project will be instrumental to identify major risk factors for molecular subtypes of breast cancer in young women, which will be important for pre- vention and targeted screening programs in Latin America.


Assuntos
Neoplasias da Mama/etiologia , Adulto , Mama/patologia , Neoplasias da Mama/genética , Neoplasias da Mama/patologia , Estudos de Casos e Controles , Chile , Colômbia , Costa Rica , Ingestão de Alimentos , Exercício Físico , Feminino , Humanos , Consentimento Livre e Esclarecido , América Latina , Estilo de Vida , México , Seleção de Pacientes , Fatores de Risco , Manejo de Espécimes/métodos , Adulto Jovem
2.
Salud pública Méx ; 61(5): 601-608, sep.-oct. 2019.
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1127323

RESUMO

Abstract: Objective: To describe the rationale and the methodology of a multicenter project to study the etiology of breast cancer in young Latin American women. Materials and methods: The International Agency for Research on Cancer has established an international collaborative population-based case-control study in four countries in Latin America: Chile, Colombia, Costa Rica, and Mexico (the PRECAMA study). Standardized methodologies were developed to collect information on reproductive variables, lifestyle, anthropometry, diet, clinical and pathological data, and biological specimens. The study will be extended to other countries in the region. Conclusion: PRECAMA is unique in its multidisciplinary approach that combines genetics, genomics, and metabolomics with lifestyle factors. The data generated through this project will be instrumental to identify major risk factors for molecular subtypes of breast cancer in young women, which will be important for prevention and targeted screening programs in Latin America.


Resumen: Objetivo: Describir la justificación y la metodología para el establecimiento de un proyecto multicéntrico sobre el cáncer de mama en mujeres jóvenes de América Latina. Material y métodos: La Agencia Internacional para la Investigación del Cáncer (IARC) ha establecido un estudio colaborativo internacional de casos y controles con base poblacional en cuatro países de América Latina: Chile, Colombia, Costa Rica y México (el estudio PRECAMA). Se han desarrollado metodologías estandarizadas para recolectar información sobre variables reproductivas, estilos de vida, antropometría y dieta, datos clínicos y patológicos y muestras biológicas. Conclusión: PRECAMA es único en su enfoque multidisciplinario. Los datos generados a través de este proyecto serán fundamentales para identificar los principales factores de riesgo del cáncer de mama en mujeres jóvenes. Los hallazgos serán relevantes para la prevención y los programas de detección oportuna en América Latina, con beneficios clínicos inmediatos.

3.
Salud pública Méx ; 61(5): 601-608, sep.-oct. 2019.
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1127343

RESUMO

Abstract: Objective: To describe the rationale and the methodology of a multicenter project to study the etiology of breast cancer in young Latin American women. Materials and methods: The International Agency for Research on Cancer has established an international collaborative population-based case-control study in four countries in Latin America: Chile, Colombia, Costa Rica, and Mexico (the PRECAMA study). Standardized methodologies were developed to collect information on reproductive variables, lifestyle, anthropometry, diet, clinical and pathological data, and biological specimens. The study will be extended to other countries in the region. Conclusion: PRECAMA is unique in its multidisciplinary approach that combines genetics, genomics, and metabolomics with lifestyle factors. The data generated through this project will be instrumental to identify major risk factors for molecular subtypes of breast cancer in young women, which will be important for prevention and targeted screening programs in Latin America.


Resumen: Objetivo: Describir la justificación y la metodología para el establecimiento de un proyecto multicéntrico sobre el cáncer de mama en mujeres jóvenes de América Latina. Material y métodos: La Agencia Internacional para la Investigación del Cáncer (IARC) ha establecido un estudio colaborativo internacional de casos y controles con base poblacional en cuatro países de América Latina: Chile, Colombia, Costa Rica y México (el estudio PRECAMA). Se han desarrollado metodologías estandarizadas para recolectar información sobre variables reproductivas, estilos de vida, antropometría y dieta, datos clínicos y patológicos y muestras biológicas. Conclusión: PRECAMA es único en su enfoque multidisciplinario. Los datos generados a través de este proyecto serán fundamentales para identificar los principales factores de riesgo del cáncer de mama en mujeres jóvenes. Los hallazgos serán relevantes para la prevención y los programas de detección oportuna en América Latina, con beneficios clínicos inmediatos.

4.
Travel Med Infect Dis ; 18: 57-66, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28487212

RESUMO

OBJECTIVE: Geographical information systems (GIS) have been demonstrated earlier to be of great use to inform public health action against vector-borne infectious diseases. METHODS: Using surveillance data on the ongoing ZIKV outbreak from Pereira, Colombia (2015-2016), we estimated incidence rates (cases/100,000 population), and developed maps correlating with the ecoepidemiology of the area. RESULTS: Up to October 8, 2016, 439 cases of ZIKV were reported in Pereira (93 cases/100,000 pop.), with highest rates in the South-West area. At the corregiments (sub-municipalities) of Pereira, Caimalito presented the highest rate. An urban area, Cuba, has 169 cases/100,000 pop., with a low economical level and the highest Aedic index (9.1%). Entomological indexes were associated with ZIKV incidence at simple and multiple non-linear regressions (r2 > 0.25; p < 0.05). CONCLUSIONS: Combining entomological, environmental, human population density, travel patterns and case data of vector-borne infections, such as ZIKV, leads to a valuable tool that can be used to pinpoint hotspots also for infections such as dengue, chikungunya and malaria. Such a tool is key to planning mosquito control and the prevention of mosquito-borne diseases in local populations. Such data also enable microepidemiology and the prediction of risk for travelers who visit specific areas in a destination country.


Assuntos
Surtos de Doenças , População Rural/estatística & dados numéricos , Viagem , População Urbana/estatística & dados numéricos , Infecção por Zika virus , Animais , Colômbia/epidemiologia , Culicidae/virologia , Surtos de Doenças/prevenção & controle , Surtos de Doenças/estatística & dados numéricos , Sistemas de Informação Geográfica , Humanos , Incidência , Larva/virologia , Saúde Pública , Medicina de Viagem , Infecção por Zika virus/epidemiologia , Infecção por Zika virus/prevenção & controle , Infecção por Zika virus/transmissão
5.
Biomedica ; 36(2): 182-7, 2016 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-27622479

RESUMO

The Li-Fraumeni syndrome is characterized clinically by the appearance of tumors in multiple organs generally at an early age. This hereditary condition is caused by germinal mutations in the TP53 gene, which codifies for the tumoural suppressor gene p53. We present the case of a patient aged 31 with clinical and molecular diagnosis of Li-Fraumeni syndrome who presented two synchronous tumors: a leiomyosarcoma on the forearm and a phyllodes breast tumour. She had a family history of cancer, including a son diagnosed with a cortical adrenal carcinoma when he was three years old, who died at five from the disease. Furthermore, her maternal grandmother and great-grandmother died of stomach cancer at 56 and 60 years old, respectively, while her other great-grandmother and a great aunt presented with breast cancer at the ages of 60 and 40, respectively. After genetic counseling, complete sequencing and analysis of duplications and deletions in the TP53 gene were ordered prior to diagnosis. The molecular analysis of a DNA sample taken from peripheral blood lymphocytes revealed the germinal mutation c.527G>T (p.Cys176Phe) on exon 5 of the TP53 gene, a deleterious mutation described previously in tumoural tissues. To our knowledge, this is the first published case in Colombia of Li-Fraumeni syndrome with confirmed molecular diagnosis. The diagnosis and management of Li-Fraumeni syndrome should be performed by a multidisciplinary team, and genetic counselling should be offered to patients and their relatives.


Assuntos
Neoplasias da Mama/diagnóstico , Éxons/genética , Éxons/fisiologia , Genes p53/genética , Genes p53/fisiologia , Síndrome de Li-Fraumeni , Mutação/genética , Mutação/fisiologia , Neoplasias Gástricas/diagnóstico , Proteína Supressora de Tumor p53/genética , Proteína Supressora de Tumor p53/metabolismo , Humanos , Proteína Supressora de Tumor p53/química
6.
Oncologist ; 21(7): 832-9, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-27286788

RESUMO

BACKGROUND: Numerous epidemiological factors affect the probability of developing breast or ovarian cancer, but no predictor is as determinant as inheriting a mutation in BRCA1 or BRCA2. The concept of the founder effect explains the reduced genetic variability in some populations, according to the theory that new populations can be formed from a reduced number of individuals, so the new population would carry only a small fraction of the genetic variability of the original population. The main purpose of this review is to provide an update on the state of the art in founder mutations and some recurrent mutations that have recently been described in Latin America. METHODS: A literature search was performed in the electronic databases of PUBMED, EMBASE, LILACS, and BIREME using the terms BRCA1, BRCA2, founder mutation, Latin American population, and Hispanic. Sixty-two papers were identified, of which 38 were considered relevant for this review. Each result is shown per country. RESULTS: In Latin America, clear founder effects have been reported in Mexico (BRCA1 del exons 9-12), Brazil (BRCA1 5382insC and BRCA2 c.156_157insAlu), and Colombia (BRCA1 3450del4, A1708E, and BRCA2 3034del4) and in Latinas residing in Southern California (BRCA1 185delAG, IVS5+1G>A, S955x, and R1443x). Of these, mutation BRCA1 3450del4 has also been reported in Brazil and Chile, whereas mutation BRCA2 3034del4 has been reported in Argentina and Peru. These data support the idea that although most Hispanic populations are the result of a mixture between Europeans, Africans, and Amerindians, the relative proportion of each genetic component varies throughout the Hispanic populations, making it necessary to identify the mutations characteristic of each population to generate mutation profiles adjusted to each one of them. CONCLUSION: In Latin American countries, and even among regions of the same country, there is great heterogeneity of ancestors. Therefore, Latinas should not be analyzed like other population groups without taking into account their genetic ancestry. The presence of founder mutations in specific population groups represents a cost-effective analysis. The importance of determining the founder mutations lies mainly in the decrease in costs. If we manage to decrease costs, screenings could be offered more widely and cover a larger number of women. IMPLICATIONS FOR PRACTICE: Hispanic and African-American populations are four to five times less likely than other populations worldwide to receive screening for BRCA mutations, a main reason being the high costs of these tools. The present study seeks to identify the prevalent mutations and the founder effect in the BRCA gene in the Hispanic population to address specific panels for this population group in the future and develop strategies for population screening.


Assuntos
Genes BRCA1 , Genes BRCA2 , Mutação , Hispano-Americanos , Humanos , América Latina
7.
Biomédica (Bogotá) ; 36(2): 182-187, jun. 2016. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-791107

RESUMO

El síndrome de Li-Fraumeni se caracteriza por la aparición de tumores en múltiples órganos, generalmente a temprana edad. Esta condición hereditaria es causada por mutaciones germinales en el gen TP53 , que codifica el gen supresor tumoral p53 . Se presenta el caso de una paciente de 31 años con diagnóstico clínico y molecular de síndrome de Li-Fraumeni, que presentó dos tumores sincrónicos a los 31 años: un leiomiosarcoma de antebrazo y un tumor filoides de mama. Tenía el antecedente de un hijo con diagnóstico de carcinoma cortical suprarrenal a los tres años, que falleció a los cinco años debido a la enfermedad. Además, su abuela y su bisabuela maternas habían fallecido de cáncer gástrico a los 56 y 60 años, respectivamente, y la madre y una hermana de su abuelo materno presentaron cáncer de mama pasados los 60 y los 40 años de edad, respectivamente. Después de una asesoría genética, se ordenó hacer la secuenciación completa y el análisis de duplicaciones y deleciones en el gen TP53 . El estudio molecular en una muestra de ADN proveniente de linfocitos de sangre periférica reveló la mutación germinal c.527G>T (p.Cys176Phe) en el exón 5 del gen, mutación deletérea descrita anteriormente en tejidos tumorales. Hasta donde se sabe, este es el primer caso que se publica en Colombia de síndrome de Li-Fraumeni con diagnóstico molecular confirmado. El diagnóstico y el manejo del síndrome de Li-Fraumeni deben estar a cargo de un equipo multidisciplinario, y debe contarse con asesoría genética para el paciente y sus familiares.


The Li-Fraumeni syndrome is characterized clinically by the appearance of tumors in multiple organs generally at an early age. This hereditary condition is caused by germinal mutations in the TP53 gene, which codifies for the tumoural suppressor gene p53 . We present the case of a patient aged 31 with clinical and molecular diagnosis of Li-Fraumeni syndrome who presented two synchronous tumors: a leiomyosarcoma on the forearm and a phyllodes breast tumour. She had a family history of cancer, including a son diagnosed with a cortical adrenal carcinoma when he was three years old, who died at five from the disease. Furthermore, her maternal grandmother and great-grandmother died of stomach cancer at 56 and 60 years old, respectively, while her other great-grandmother and a great aunt presented with breast cancer at the ages of 60 and 40, respectively. After genetic counseling, complete sequencing and analysis of duplications and deletions in the TP53 gene were ordered prior to diagnosis. The molecular analysis of a DNA sample taken from peripheral blood lymphocytes revealed the germinal mutation c.527G>T (p.Cys176Phe) on exon 5 of the TP53 gene, a deleterious mutation described previously in tumoural tissues. To our knowledge, this is the first published case in Colombia of Li-Fraumeni syndrome with confirmed molecular diagnosis. The diagnosis and management of Li-Fraumeni syndrome should be performed by a multidisciplinary team, and genetic counselling should be offered to patients and their relatives.


Assuntos
Genes p53 , Síndrome de Li-Fraumeni , Colômbia , Aconselhamento Genético , Síndromes Neoplásicas Hereditárias , Tumor Filoide
8.
Colomb Med (Cali) ; 46(3): 104-8, 2015 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-26600624

RESUMO

INTRODUCTION: Breast Phyllodes tumors are rare breast tumors present in less than 1% of new cases of breast cancer, usually occurring among middle-aged women (40-50 yrs). OBJECTIVE: This study shows diagnostic experience, surgical management and follows up of patients with this disease during a period of ten years in a oncology referral center. METHODS: Retrospectively, breast cancer registries at the institution were reviewed, identifying 77 patients with Phyllodes tumors between 2002 and 2012, who had been operated on at the Instituto de Cancerología - Clínica Las Américas, in Medellín (Colombia). Clinical and histopathological data belonging to these cases was captured and analyzed and descriptive statistics were used. RESULTS: The follow up median was 22.5 months (IQR: 10.5-60.0), average age was 47.2 yrs (SD: 12.4), mean tumor size was 3.6 cm (SD: 4.6), 88.3% of the patients (68 cases) presented negative margins and none of them received adjuvant chemotherapy. Of the patients with Phyllodes tumors; 33.8% had benign, 31.2% had borderline and 35.0% had malignant tumor. Disease-free survival was 85.8% and overall survival was 94.5%. DISCUSSION: Reported data in this article is in accordance with what has been reported in worldwide literature. In our cohort even the high mean size of the tumors, the risk of local relapse and metastatic disease is low than previously reported in literature. Trials with longer follow up and molecular trials in Phyllodes tumors are necessary to understand the behavior of these tumors in Hispanics population.


Assuntos
Neoplasias da Mama/patologia , Tumor Filoide/patologia , Adulto , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/cirurgia , Colômbia , Intervalo Livre de Doença , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Tumor Filoide/diagnóstico , Tumor Filoide/cirurgia , Estudos Retrospectivos , Taxa de Sobrevida
9.
Colomb. med ; 46(3): 104-108, July-Sept. 2015. ilus
Artigo em Inglês | LILACS | ID: lil-765509

RESUMO

Introduction: Breast Phyllodes tumors are rare breast tumors present in less than 1% of new cases of breast cancer, usually occurring among middle-aged women (40-50 yrs). Objective: This study shows diagnostic experience, surgical management and follows up of patients with this disease during a period of ten years in a oncology referral center. Methods: Retrospectively, breast cancer registries at the institution were reviewed, identifying 77 patients with Phyllodes tumors between 2002 and 2012, who had been operated on at the Instituto de Cancerología - Clínica Las Américas, in Medellín (Colombia). Clinical and histopathological data belonging to these cases was captured and analyzed and descriptive statistics were used. Results: The follow up median was 22.5 months (IQR: 10.5-60.0), average age was 47.2 yrs (SD: 12.4), mean tumor size was 3.6 cm (SD: 4.6), 88.3% of the patients (68 cases) presented negative margins and none of them received adjuvant chemotherapy. Of the patients with Phyllodes tumors; 33.8% had benign, 31.2% had borderline and 35.0% had malignant tumor. Disease-free survival was 85.8% and overall survival was 94.5%. Discussion: Reported data in this article is in accordance with what has been reported in worldwide literature. In our cohort even the high mean size of the tumors, the risk of local relapse and metastatic disease is low than previously reported in literature. Trials with longer follow up and molecular trials in Phyllodes tumors are necessary to understand the behavior of these tumors in Hispanics population.


Introducción: Los tumores phyllodes mamarios son Tumores infrecuentes en la mama presentes en menos del 1% de los casos nuevos de cáncer mamario, por lo general ocurre en mujeres de mediana edad (40-50 años) Objetivo: Este estudio muestra la experiencia de diagnóstico, tratamiento quirúrgico y seguimiento de los pacientes con esta variedad de tumor durante un período de diez años en un centro de referencia oncológico. Métodos: Retrospectivamente, los registros de cáncer de mama en la institución fueron revisados, se identificaron 77 pacientes con tumores phyllodes entre 2002 y 2012, que habían sido operados en el Instituto de Cancerología - Clínica Las Américas, en Medellín (Colombia). Los datos clínicos e histopatológicos pertenecientes a estos casos fueron recolectados y analizados utilizando técnicas de estadística descriptivas. Resultados: La mediana de seguimiento fue de 22.5 meses (RIC: 10.5-60.0), la Media de edad fue de 47.2 años (DE: 12.4), tamaño medio del tumor fue de 3.6 cm (DE: 4.6), 88.3% de los pacientes (68 casos) presentaron márgenes negativos y ninguno de ellos recibieron quimioterapia adyuvante. De los pacientes con tumores phyllodes; 33.8% fueron benignos, 31.2% Borderline y 35.0% phyllodes maligno. Supervivencia libre de enfermedad fue 85.8% y la supervivencia global fue de 94.5%. Discusión: Los datos reportados en este artículo están acordes con lo que se ha reportado en la literatura mundial. En nuestra cohorte, a pesar de que el tamaño promedio de los tumores fue mayor, el riesgo de recidiva local y las tasas de enfermedad metastásica es menor que el reportado previamente en la literatura. Los ensayos con seguimiento más prolongado, y los ensayos moleculares en tumores phyllodes son necesarios para comprender de una manera mas precisa el comportamiento de estos tumores en la población hispana.


Assuntos
Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias da Mama/patologia , Tumor Filoide/patologia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/cirurgia , Colômbia , Intervalo Livre de Doença , Seguimentos , Tumor Filoide/diagnóstico , Tumor Filoide/cirurgia , Estudos Retrospectivos , Taxa de Sobrevida
10.
Ecancermedicalscience ; 9: 562, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26316883

RESUMO

BACKGROUND: Neoadjuvant chemotherapy (NAC) is the standard treatment for patients with locally advanced breast cancer, showing improvement in disease-free survival (DFS) and overall survival (OS) rates in patients achieving pathological complete response (pCR). The relationship between immunohistochemistry-based molecular subtyping (IMS), chemo sensitivity and survival is currently a matter of interest. We explore this relationship in a Hispanic cohort of breast cancer patients treated with NAC. METHODS: A retrospective survival analysis was performed on Colombian females with breast cancer treated at Instituto de Cancerología-Clinica Las Américas between January 2009 and December 2011. Patients were classified according to immunohistochemistry-based subtyping into the following five groups: Luminal A, Luminal B, Luminal B/HER 2+, HER2-enriched, and triple-negative breast cancer. Demographic characteristics, recurrence pattern, and survival rate were reviewed by bivariate and multivariate analysis. RESULTS: A total of 328 patients fulfilled the study's inclusion parameters and the distribution of subtypes were as follows: Luminal A: 73 (22.3%), Luminal B/HER2-: 110 (33.5%), Luminal B/HER2+: 75 (22.9%), HER2-enriched: 30 (9.1%), and triple-negative: 40 (12.2%). The median follow-up was 41 months (interquartile range: 31-52). Pathological response to NAC was as follows: complete pathological response (pCR) in 28 (8.5%) patients, partial 247 (75.3%); stable disease 47 (14.3%), and progression 6 (1.8%) patients. The presence of pCR had a significant DFS and OS in the entire group (p = 0.01) but subtypes had different DFS in Luminal B (p = 0.01) and triple negative (p = 0.02) and also OS in Luminal B (p = 0.01) and triple negative (p = 0.01). CONCLUSIONS: pCR is associated with an improved overall survival and disease-free survival rates in this group of Hispanics patients. Advanced stages, Luminal B subtypes, triple-negative tumours and non-pCR showed lower DFS.

11.
Rev. colomb. cancerol ; 16(2): 91-99, jun. 2012.
Artigo em Espanhol | LILACS | ID: lil-662993

RESUMO

Objetivos: Establecer la prevalencia y describir las características clínico-patológicas de las pacientes con cáncer de mama triple-negativo subtipo (basal-like y no basal-like) mediante técnicas de inmunohistoquímica que fueron atendidas en el Instituto Nacional de Cancerología (INC) y el Hospital San José (HSJ) durante el periodo 2006- 2008. Métodos: Se realizó un estudio descriptivo de corte transversal, en mujeres mayores de 17 años con diagnóstico histológico confirmado de adenocarcinoma de mama. Se excluyó a las pacientes cuyos bloques de parafina no se conservaron, o a quienes no se les pudieron realizar todos los marcadores inmunohistoquímicos requeridos por el estudio, y se procedió a realizar los marcadores de inmunohistoquímica considerados en el estudio (EFGR, CK5, CK6, S100, P65, CK 14). Se procesaron las muestras siguiendo las recomendaciones de la casa matriz. Se procedió a analizar la información con el programa estadístico Stata10. Resultados: Un total de 1922 casos de cáncer de mama invasor fueron diagnosticados en el periodo comprendido 2006-2008 de los cuales fueron identificados 154 casos de tumores triple negativos (RE negativo, RP negativo, HER-2 Negativo). De estos casos se obtuvo información completa de 84 casos. 50 (59,52%) casos corresponden al tipo basal-like, mientras que 34 (40,48%) corresponden a tumores no basal-like. Conclusiones: El presente estudio es el primero en Colombia que busca determinar mediante inmunohistoquímica la prevalencia del cáncer de mama triple-negativo de tipo basal-like en población colombiana; se halló así una prevalencia del 8,01%, porcentaje que se encuentra por debajo de lo reportado en la literatura mundial (11,9%-25%).


Objectives: To use immunohistochemistry to provide a description of and to ascertain the prevalence of clinical-pathological characteristics in patients with triple-negative (basal-like and non basal-like) subtype breast cancer treated at the National Cancer Institute (NCI) and the San José Hospital (SJH) from 2006 to 2008. Methods: A descriptive cross sectional study was carried out among women over 17 years of age with confirmed diagnosis of breast adenocarcinoma. Patients whose paraffin blocks were not preserved and those on whom it was not possible to carry out the entirety of the immunohistochemical markers requisite for this study were excluded before collection of the immunohistochemical markers considered essential for this study (EFGR, CK5, CK6, S100, P65, CK 14) was performed. Samples were processed according to manufacturer´s instructions; information was analyzed with Stata 10 software. Results: A total of 1,922 invasive breast cancer cases were diagnosed from 2006 to 2008, 154 of which were triple-negative (ER negative, PR negative, HER-2 negative). Complete information was obtained in 84 of these cases: 50 cases (59.52%) were basal-like and 34 cases (40.48%) were non basal-like tumors. Conclusions: This study, the first in Colombia which seeks to determine through immunohistochemistry the prevalence of triple-negative basal-like breast cancer in the Colombian population, found said tumor prevalence to be at 8.01%, which is below that reported in worldwide literature (11.9%-25%).


Assuntos
Humanos , Feminino , Adolescente , Adulto , Estudos de Coortes , Estudos Transversais , Estudos Epidemiológicos , Imuno-Histoquímica/classificação , Imuno-Histoquímica/métodos , Neoplasias da Mama/classificação , Neoplasias da Mama/epidemiologia , Neoplasias da Mama/patologia , Colômbia/epidemiologia
12.
Rev. colomb. cancerol ; 16(2): 84-90, jun. 2012.
Artigo em Espanhol | LILACS | ID: lil-662994

RESUMO

Objetivos: El presente estudio describe las características clínicas y epidemiológicas de las pacientes con cáncer de mama a quienes se les aplicó la técnica del ganglio centinela en el Servicio de Seno y Tejidos Blandos del Instituto Nacional de Cancerología (INC), en 10 años de experiencia. Métodos: Serie de casos de pacientes con diagnóstico de cáncer de mama temprano en estadios 0-IIB (T3N0M0), a quienes se les realizó la técnica. A partir de registros de los servicios de Patología, Medicina Nuclear y Cirugía de Seno y Tejidos Blandos del INC, se realizó la captura de datos aplicando un cuestionario previamente elaborado. Resultados: Se tomaron en cuenta 289 casos; las técnicas usadas incluyeron: radio coloides (Tecnecio 99) en 256 casos; colorante, en 5; y ambas técnicas, en los 28 restantes. El ganglio centinela fue identificado en 283 casos, con una tasa de detección del 98,0%. En carcinoma invasor, el tamaño tumoral promedio fue 2,2 cm (DE 1,1). En promedio, fueron resecados 1,5 ganglios (0,99 DE); de estos casos, 85 (30%) fueron metastásicos. Hubo 24 eventos adversos; el más común fue la formación de seroma. La media de seguimiento fue de 647 días (DE 693 días); el porcentaje de pacientes libres de enfermedad al seguimiento, del 94,4%; hubo recaída axilar en 1 paciente. Conclusiones: Según los autores de la experiencia descrita, la técnica de ganglio centinela es segura, pues permite una estadificación adecuada de la axila. Las características tumorales del ganglio centinela en la población objeto de estudio guardan similitud con las reportadas en la literatura mundial.


Objectives: This study describes the clinical and epidemiologic characteristics of breast cancer patients who were treated with sentinal node in breast service and soft tissue procedure at the National Cancer Institute during a 10-year period. Methods: Two hundred and eighty-nine (289) cases were included, and the techniques used were: radio colloids (Technetium 99) in 256 cases; dye in 5 cases; and both procedures in the remaining 28 cases. Sentinal lymph nodes were identified in 283 cases with a detection rate of 98.0%. In the case of invasive carcinoma, average tumor size was 2.2 cm (DE 1.1). On average, 1.5 ganglia (0.99) were resected; of these cases, 85 were metastatic (30%). There were 24 adverse events, the most frequent being seroma formation. Mean follow-up was 647 days (DE 693 days); percentage of disease-free patients during follow-up was 94.4%; axillary relapse occurred in 1 patient. Results: The procedure was performed on a series of patient cases with early breast cancer diagnosis in stages O-11B (T3NOMO). Data were compiled by utilizing a previously prepared questionnaire and on the basis of registries from the departments of pathology, nuclear medicine and breast and soft tissue surgeries at the National Cancer Institute. Conclusions: In our experience, the sentinal node procedure has proven to safely allow for the adequate stratification of the axilla. The tumoral characteristics of the sentinal lymph node in the population under study shared similarities with those reported in the international literature.


Assuntos
Humanos , Feminino , Biópsia de Linfonodo Sentinela/efeitos adversos , Biópsia de Linfonodo Sentinela/métodos , Estudos Epidemiológicos , Neoplasias , Neoplasias da Mama/epidemiologia , Neoplasias da Mama/radioterapia , Estudos Retrospectivos , Colômbia/epidemiologia
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