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1.
Vaccine ; 38(4): 890-896, 2020 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-31706810

RESUMO

Domestic dogs constitute the main reservoir of Leishmania infantum and play a key role in transmission to humans. The main tool for controlling infection spread is a safe and effective vaccine, as successful immunization of dogs could significantly reduce the incidence of human visceral leishmaniosis (VL) and is the most cost-effective control strategy. The factors that determine disease progression in canine leishmaniosis (CanL) remain poorly understood, though a previous study in naturally infected dogs has demonstrated a clear relationship between the presence of circulating immune complexes (CIC) in the blood and disease progression. Thus, the aim of this study was to compare CIC levels in serum samples from dogs vaccinated or unvaccinated with LetiFend®, a new vaccine containing recombinant Protein Q, and experimentally infected with L. infantum. CIC were isolated from vaccinated or unvaccinated dogs after experimental infection with L. infantum and their levels measured by ELISA. Furthermore, reverse phase-liquid chromatography-mass spectrometry (RP-LC-MS/MS) analysis was used to investigate the protein composition of precipitated CIC. At all the time points analyzed after infection, the amount of CIC was lower in the vaccinated group compared to the placebo group. Furthermore, there were differences in the protein composition of precipitated CIC between the vaccinated and unvaccinated groups. In conclusion, administration of LetiFend® was able to reduce CIC elicited after experimental infection with L. infantum in a dog model in a process that may be related to complement system activation.

2.
Vet Parasitol ; 274: 108921, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31536867

RESUMO

Dogs are the main domestic reservoir of Leishmania infantum, and in cases of uncontrolled infection, a strong humoral immune response is elicited, which is inefficient against the parasites. Previous studies have suggested that an adequate antigen/antibody ratio, with a moderate prevalence of antigens with respect to the antibodies, could result in the formation of circulating immune complexes (CIC) in canine leishmaniosis (CanL). Deposition of these complexes in tissues has been associated with vasculitis, uveitis, arthritis, dermatitis and especially glomerulonephritis and renal failure. However, little is known about the relationship between the presence of CIC and disease progression. The aim of this study was to evaluate serum CIC level and its correlation with disease severity in infected dogs with different stages of disease and non-infected animals as a control. A total of 60 dogs were included in the study, classified according to the proposed LeishVet classification criteria: healthy non-infected (n = 13); healthy infected (n = 12); sick stage I (n = 9); sick stage II (n = 17); sick stage III (n = 8); and sick stage IV (n = 1). CIC were isolated from serum samples using a modified polyethylene glycol precipitation method, and their levels measured by ELISA and bicinchoninic acid protein assay. A nanoparticle tracking analysis was performed to investigate the relationship between the molecular size distribution of the CIC and disease progression. In conclusion, the results confirmed a positive association between CIC levels, their molecular size and disease progression that suggests a potential use of CIC as biomarkers of CanL.


Assuntos
Complexo Antígeno-Anticorpo/sangue , Doenças do Cão/sangue , Imunofluorescência/veterinária , Leishmaniose/veterinária , Animais , Anticorpos Antiprotozoários/sangue , Biomarcadores/sangue , Doenças do Cão/diagnóstico , Doenças do Cão/imunologia , Doenças do Cão/parasitologia , Cães , Leishmaniose/imunologia , Leishmaniose/patologia
3.
Head Neck ; 41(5): 1290-1296, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30537291

RESUMO

BACKGROUND: Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC). OBJECTIVE: To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients. METHODS: FAK and cortactin expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 100 patients with cSCC, and correlated with the clinical data. RESULTS: FAK overexpression was a significant risk factor for nodal metastasis with crude and adjusted ratios (HRs) of 2.04, (95% CI [1.08-3.86], [P = 0.029]) and 2.23 (95% CI [1.01-4.91], [P = 0.047]), respectively. Cortactin expression was not a significant risk factor for nodal metastasis. CONCLUSION: These findings demonstrate that FAK overexpression is an independent predictor of nodal metastasis that might be helpful for risk stratification and management of patients with cSCC.

4.
Australas J Dermatol ; 54(1): e22-4, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23373892

RESUMO

Herein, we describe a patient with lesions of cutaneous herpes simplex virus 1 (HSV-1) infection over the knuckles of both hands in the context of an outbreak among boxers. Interestingly, the infection had an unusually long duration (4 weeks), and was not acquired directly through skin-to-skin contact, as it usually does among athletes (herpes gladiatorum). In our case, transmission was acquired through the use of shared boxing gloves contaminated by HSV-1. To the best of our knowledge, herpes gladiatorum, or wrestler's herpes, has not been described previously in boxers and infection over the knuckles is not commonly reported.


Assuntos
Boxe , Mãos , Herpes Simples/diagnóstico , Herpesvirus Humano 1 , Adulto , Herpes Simples/terapia , Humanos , Masculino
5.
Australas J Dermatol ; 53(2): 128-30, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22571562

RESUMO

There is accumulating evidence showing a relationship between psoriasis and an increased risk of developing cardiovascular risk factors, including diabetes mellitus type 2 and ischemic heart disease. Our aim was to investigate if there is any difference in the diabetes risk profile among psoriatic patients based on clinical findings. To test this, we carried out a prospective and descriptive hospital-based study. Our results suggest that the highest risk of suffering from diabetes mellitus type 2 among psoriatic patients is in patients suffering from non-familial and late-onset disease and in patients suffering from psoriatic arthritis.


Assuntos
Diabetes Mellitus Tipo 2/epidemiologia , Psoríase/epidemiologia , Adulto , Índice de Massa Corporal , Feminino , Humanos , Hipertensão/epidemiologia , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/epidemiologia , Prevalência , Fatores de Risco , Fumar , Espanha/epidemiologia
6.
Curr Stem Cell Res Ther ; 7(1): 15-25, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21190529

RESUMO

Neural stem cells (NSCs) with self-renewal and multilineage potential are considered good candidates for cell replacement of damaged nerve tissue. Several studies have focused on the ability of the neurotrophic factors coadministration to improve the efficiency of grafted NSCs. Liver growth factor (LGF) is an hepatic mitogen that promotes regeneration of damaged tissues, including brain tissue. It has neurogenic activity and has partially restored the nigrostriatal dopaminergic system in an experimental model of Parkinson's disease. Present results demonstrate that in the dopamine- depleted striatum of 6-hydroxydopamine-lesioned rats, grafted NSCs retained their ability to differentiate into neurons, astrocytes, and oligodendrocytes. NSCs also differentiated into microglia/macrophages and endothelial cells. Thus, 23 ± 5.6% of them were inmunoreactive for isolectin IB4, and a small population integrated into blood vessels, showing an endothelial-like morphology. Intrastriatal infusion of LGF promoted the viability of the implants, and favored their differentiation to an endothelial-like phenotype. Moreover, LGF infusion raised the expression of the anti-apoptotic protein Bcl-2 by 3.9 ± 0.9 fold without affecting the levels of the pro-apoptotic protein Bax. Since LGF-treated rats also showed a significant reduction in apomorphine-induced rotational behavior, our results suggest that administration of this factor might be a convenient treatment for Parkinson's disease cell replacement therapies based on NSCs transplantation.


Assuntos
Bilirrubina/administração & dosagem , Neurônios Dopaminérgicos/efeitos dos fármacos , Doença de Parkinson/terapia , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Albumina Sérica/administração & dosagem , Transplante de Células-Tronco , Animais , Diferenciação Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Corpo Estriado/efeitos dos fármacos , Corpo Estriado/patologia , Modelos Animais de Doenças , Neurônios Dopaminérgicos/metabolismo , Neurônios Dopaminérgicos/patologia , Células Endoteliais/patologia , Feminino , Regulação da Expressão Gênica/efeitos dos fármacos , Humanos , Oxidopamina/administração & dosagem , Doença de Parkinson/patologia , Doença de Parkinson/fisiopatologia , Proteínas Proto-Oncogênicas c-bcl-2/genética , Ratos , Ratos Sprague-Dawley , Recuperação de Função Fisiológica , Albumina Sérica Humana
7.
Matronas prof ; 12(1): 3-8, ene.-mar. 2011. tab
Artigo em Espanhol | IBECS | ID: ibc-87587

RESUMO

Objetivo: El objetivo de este trabajo es validar lingüísticamente laBreastfeeding Self-Efficacy Scale-Short Form (BSES-SF) al español y determinarsus características psicométricas.Personas y método: Estudio instrumental que se llevó a cabo en doshospitales de la provincia de Alicante. Tras los procedimientos de traduccióny retrotraducción, una muestra accidental de 150 madres lactantescumplimentaron, a las 48 horas del parto y aún hospitalizadas,la versión española de la BSES-SF y un cuestionario con variables sociodemográficas,obstétricas y sobre el estatus de lactancia materna (LM)al alta. A las 6 semanas posparto se obtuvieron, nuevamente, datos sobreel estatus de LM mediante una encuesta telefónica.Resultados: El coeficiente alfa de Cronbach fue de 0,79. Las mujerescon experiencia previa y con experiencia previa muy positiva en LM, conpuntuaciones más altas en el ítem global de autoeficacia y con máshijos, tuvieron mayores puntuaciones en la versión española de laBSES-SF. Dos de los ítems (9 y 10) de la versión española presentaroncorrelaciones ítems-test corregidas <0,30, y saturaron por debajo de0,30 al forzar la extracción a un factor en el análisis de componentesprincipales. Las puntuaciones de la escala al alta hospitalaria no guardaronrelación con el estatus de LM a las 6 semanas posparto.Conclusiones: El instrumento muestra aceptables evidencias de fiabilidady validez, aunque dos de los ítems deberían ser revisados (AU)


Aim: To translate the Breastfeeding Self-Efficacy Scale-Short Form(BSES-SF) into Spanish and assess its psychometric properties.Subjects and method: Instrumental study took place in two hospitalsin the Spanish region of Alicante. Following translation andback-translation procedures, an accidental sample of 150 mothersbreastfeeding (BF) their babies, completed, at 48 hours after deliveryand still hospitalized, the Spanish version of the BSES-SF and a questionnairewith socio demographic, obstetric and BF variables. At 6weeks postpartum data on the status of BF were obtained again,through a telephone survey.Results: The Cronbach’s alpha coefficient was of 0.79. Women withprevious experience and with very positive prior experience in BF, withhigher scores on the global item of self-efficacy and with previous childrenhad higher scores on the Spanish version of the BSES-SF. Two ofthe items (9 and 10) of the Spanish version show item-corrected testcorrelations <0.30 and saturated below 0.30 in the analysis of principalcomponents when one factor was forced. The scores at discharge werenot related to the status of BF at 6 weeks postpartum.Conclusions: The instrumental study shows acceptable evidencesof reliability and validity, although two of the items should be reviewed (AU)


Assuntos
Humanos , Feminino , Recém-Nascido , Aleitamento Materno , Inquéritos e Questionários , Autoeficácia , Reprodutibilidade dos Testes , Psicometria
8.
Australas J Dermatol ; 52(1): 56-8, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21332695

RESUMO

Cetuximab, an epidermal growth factor receptor inhibitor, is a chemotherapeutical agent featuring well-known adverse dermatological effects related to tumour-response prognosis. In psoriasis, the epidermal growth factor receptor is overexpressed; hence, the expectation would be that an epidermal growth factor receptor inhibitor could improve psoriatic lesions. We report a case of psoriasis induced by cetuximab, which was a surprising adverse effect.


Assuntos
Anticorpos Monoclonais/efeitos adversos , Antineoplásicos/efeitos adversos , Psoríase/induzido quimicamente , Anticorpos Monoclonais Humanizados , Cetuximab , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
9.
J Histochem Cytochem ; 57(5): 491-502, 2009 May.
Artigo em Inglês | MEDLINE | ID: mdl-19188487

RESUMO

Neural stem cells with self-renewal and multilineage potential persist in the subventricular zone of the adult mammalian forebrain. These cells remain relatively quiescent but, under certain conditions, can be stimulated, giving rise to new neurons. Liver growth factor (LGF) is a mitogen for liver cells that shows biological activity in extrahepatic sites and is useful for neuroregenerative therapies. The aim of this study was to investigate the potential neurogenic activity of LGF in the 6-hydroxydopamine rat model of Parkinson's disease. Proliferation was significantly increased in the subventricular zone and denervated striatum of rats receiving ICV LGF infusions, and 25% of the proliferating cells were doublecortin-positive neurons. Doublecortin-positive cells with the morphology of migrating neuroblasts were also observed in the dorsal and ventral regions of the striatum of LGF-infused animals. Moreover, some newly generated cells were neuronal nuclei-positive mature neurons. LGF also stimulated microglia and induced astrogliosis, both phenomena associated with generation and migration of new neurons in the adult brain. In summary, our study shows that LGF stimulates neurogenesis when applied intraventricularly in 6-hydroxydopamine-lesioned rats. Considering that this factor also promotes neuronal migration into damaged tissue, we propose LGF as a novel factor useful for neuronal replacement in neurodegenerative diseases.


Assuntos
Bilirrubina/farmacologia , Mitógenos/farmacologia , Neurônios/efeitos dos fármacos , Oxidopamina , Doença de Parkinson Secundária/patologia , Albumina Sérica/farmacologia , Células-Tronco/efeitos dos fármacos , Animais , Bilirrubina/administração & dosagem , Movimento Celular , Proliferação de Células , Ventrículos Cerebrais/efeitos dos fármacos , Ventrículos Cerebrais/patologia , Corpo Estriado/efeitos dos fármacos , Corpo Estriado/patologia , Feminino , Injeções Intraventriculares , Macrófagos/efeitos dos fármacos , Macrófagos/fisiologia , Microglia/efeitos dos fármacos , Microglia/fisiologia , Mitógenos/administração & dosagem , Atividade Motora/efeitos dos fármacos , Neurogênese , Neurônios/fisiologia , Doença de Parkinson Secundária/induzido quimicamente , Doença de Parkinson Secundária/fisiopatologia , Ratos , Ratos Sprague-Dawley , Albumina Sérica/administração & dosagem , Albumina Sérica Humana , Células-Tronco/fisiologia , Comportamento Estereotipado/efeitos dos fármacos , Tirosina 3-Mono-Oxigenase/metabolismo
10.
Curr Stem Cell Res Ther ; 3(4): 247-53, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19075759

RESUMO

Neural stem cells are defined as clonogenic cells with self-renewal capacity and the ability to generate all neural lineages. Cells with these characteristics have been isolated from the embryonic and adult Central Nervous System. Numerous reports show that extrinsic factors and intracellular mechanisms may trigger both endogenous and in vitro cultured neural stem cells to differentiate into desired cell outcomes. This plasticity opens new approaches for the use of neural stem cells as a source of cells for replacement therapy in damaged brain. In this review we present the evidence for the involvement of trophic factors, neurotransmitters, second messengers, aminoacids, and factors released by endothelial and glial cells, which have been reported to influence neural stem cells phenotypic choice in vitro and in vivo.


Assuntos
Separação Celular , Sistema Nervoso Central/embriologia , Neurogênese , Neurônios/fisiologia , Células-Tronco/fisiologia , Animais , Sistema Nervoso Central/citologia , Citocinas/metabolismo , Epigênese Genética , Humanos , Peptídeos e Proteínas de Sinalização Intercelular/metabolismo , Camundongos , Neurogênese/genética , Neurônios/citologia , Neurotransmissores/metabolismo , Ratos , Células-Tronco/citologia
11.
Med. cután. ibero-lat.-am ; 35(6): 295-297, nov.-dic. 2007. ilus
Artigo em Espanhol | IBECS | ID: ibc-62576

RESUMO

El síndrome auriculotemporal o síndrome de Frey se caracteriza por la aparición de enrojecimiento, hiperhidrosis, o ambos, en la zona inervada por elnervio auriculotemporal como respuesta a un estímulo gustativo desencadenado por la ingesta de distintos alimentos. Por este motivo puede confundirseen ocasiones con alergias alimentarias. Se debe generalmente a una lesión del nervio auriculotemporal, si bien en ocasiones no existe ningún antecedentetraumático. Su aparición en la infancia y su presentación bilateral, como el caso que presentamos a continuación, son muy poco frecuentes


Frey syndrome or auriculotemporal nerve syndrome manifests as flushing, sweating, or both, localized to the distribution of the auriculotemporal nerve,in response to gustatory stimuli. Ocasionally it may be misinterpreted as foog allergy. It usually occurs as a result of injury to auriculotemporal nerve, butthere are cases with no known previous trauma. It is rarely described in children as well as the bilateral involvement, as the case we presented


Assuntos
Humanos , Masculino , Lactente , Sudorese Gustativa/diagnóstico , Hipersensibilidade Alimentar/diagnóstico , Diagnóstico Diferencial
13.
Dermatol Surg ; 30(4 Pt 1): 566-9, 2004 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15056154

RESUMO

BACKGROUND: The detection of tumor-associated glycoprotein-72 in the serum of patients with carcinomas, basically of the colon, has proved to be of great use in the follow-up of these gastrointestinal adenocarcinomas. RESULTS: We report the case of a male patient presenting adenopathies in the right axilla. The histologic study of an adjacent skin tumor enabled the diagnosis of a cutaneous apocrine carcinoma. Among the studies made, the increase in the serum antibody CA72.4 can be highlighted. The tumor marker was negative after the extirpation of the skin tumor and the axillary adenopathies. CONCLUSION: To our best knowledge, this is the first case in which a tumor serum marker is associated with a cutaneous apocrine carcinoma, a fact that should be confirmed with further patients. Its use in the monitoring of this infrequent skin neoplasia is also noteworthy.


Assuntos
Antígenos de Neoplasias/sangue , Glândulas Apócrinas/patologia , Biomarcadores Tumorais/sangue , Carcinoma/patologia , Glicoproteínas/sangue , Neoplasias das Glândulas Sudoríparas/patologia , Idoso , Axila , Carcinoma/sangue , Carcinoma/complicações , Humanos , Doenças Linfáticas/sangue , Doenças Linfáticas/etiologia , Doenças Linfáticas/patologia , Metástase Linfática , Masculino , Sensibilidade e Especificidade , Neoplasias das Glândulas Sudoríparas/sangue , Neoplasias das Glândulas Sudoríparas/complicações
14.
Actas dermo-sifiliogr. (Ed. impr.) ; 94(2): 65-79, mar. 2003. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-113015

RESUMO

El eosinófilo es una célula efectora de la respuesta inmune con importante tropismo hacia los tejidos. Las enfermedades cutáneas en las que existe una infiltración tisular por eosinófilos constituyen un grupo aparentemente heterogéneo. Se realiza una revisión de las características principales de las enfermedades conocidas como dermatosis eosinofílicas. En esta primera parte del trabajo se incluye la foliculitis pustulosa eosinofílica, la celulitis eosinofílica, la hiperplasia angiolinfoide con eosinofilia, el granuloma facial, la úlcera eosinofílica de la mucosa oral, la papuloeritrodermia y la dermatitis eosinofílica paquidérmica. En analogía a la visión integradora aceptada para las dermatosis neutrofílicas se discutirá la posible unidad patogénica de este grupo de enfermedades (AU)


Assuntos
Humanos , Eosinofilia/complicações , Dermatite/imunologia , Dermatite Esfoliativa/imunologia , Celulite/imunologia , Hiperplasia Angiolinfoide com Eosinofilia/imunologia
15.
Actas dermo-sifiliogr. (Ed. impr.) ; 93(8): 501-506, oct. 2002. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-16989

RESUMO

El eritema elevatum et diutinum es una forma localizada, crónica y benigna de vasculitis leucocitoclástica cutánea que evoluciona hacia una peculiar fibrosis concéntrica y depósito secundario de material lipídico. Su causa es desconocida, pero se supone en relación con el depósito vascular de inmunocomplejos. Entre los posibles problemas médicos asociados se incluyen enfermedades hematológicas, especialmente la gammapatía monoclonal IgA. Una mujer de 24 años presentaba múltiples pápulas y placas localizadas simétricamente sobre la superficie de extensión de las extremidades, especialmente en torno a zonas articulares. La exploración reveló además múltiples placas elevadas, firmes, que afectaban por completo la superficie palmar de las manos. La biopsia de un elemento reciente descubrió un infiltrado neutrofílico dérmico y polvillo nuclear alrededor de vasos con vasculitis leucocitoclástica. En los estudios complementarios se encontró positividad para anticuerpos anticitoplasma de neutrófilo (p-ANCA) (anti-mieloperoxidasa [MPO]). El tratamiento con sulfona 100 mg/día condujo a una respuesta clínica espectacular. Describimos un ejemplo de eritema elevatum et diutinum con una distribución atípica afectando las palmas, circunstancia escasamente referida. Además discutimos el posible significado de la asociación con una prueba positiva para p-ANCA. (AU)


Assuntos
Adulto , Feminino , Humanos , Eritema/complicações , Eritema/diagnóstico , Eritema/tratamento farmacológico , Vasculite Leucocitoclástica Cutânea/diagnóstico , Vasculite Leucocitoclástica Cutânea/complicações , Vasculite Leucocitoclástica Cutânea/tratamento farmacológico , Paraproteinemias/diagnóstico , Paraproteinemias/tratamento farmacológico , Dermatoses da Mão/complicações , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/tratamento farmacológico , Dermatoses da Perna/complicações , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/tratamento farmacológico , Biópsia/métodos , Sulfonas/uso terapêutico , Anticorpos Anticitoplasma de Neutrófilos/análise , Dermatopatias Vasculares/diagnóstico , Dermatopatias Vasculares/tratamento farmacológico , Imunoglobulinas , Gamopatia Monoclonal de Significância Indeterminada , Dermatopatias/diagnóstico , Dermatopatias/tratamento farmacológico , Cadeias alfa de Imunoglobulina , Cadeias gama de Imunoglobulina , Necrose , Vasculite Leucocitoclástica Cutânea/fisiopatologia , Vasculite Leucocitoclástica Cutânea/imunologia
16.
Actas dermo-sifiliogr. (Ed. impr.) ; 92(11): 515-520, nov. 2001. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-959

RESUMO

La xantogranulomatosis subcutánea es una peculiar xantomatosis que probablemente corresponde a una variante muy xantomatizada y con elementos múltiples del xantogranuloma juvenil subcutáneo. Los individuos afectados presentan múltiples nódulos subcutáneos de consistencia firme y localización preferente en el tronco. Los nódulos corresponden a masas xantomatosas subcutáneas que no se acompañan de xantomas cutáneos. Desde el punto de vista histológico se trata de cúmulos celulares bien circunscritos, localizados en dermis profunda e hipodermis y compuestos por una mezcla de células xantomatosas y células gigantes de tipo cuerpo extraño y de tipo Touton. Los estudios analíticos de los lípidos séricos resultan normales. Un varón de 52 años consultó porque a lo largo de los últimos años toda la piel de la espalda y zona superior del tórax había ido adquiriendo un aspecto irregular, laxo y plegado. En estas zonas presentaba múltiples lesiones nodulares subcutáneas, de consistencia firme. Microscópicamente los nódulos estaban constituidos por una población predominante de células xantomatosas y algunas células gigantes multinucleadas. En el interior del citoplasma de muchas de las células gigantes se observó la presencia de cuerpos asteroides. Además presentaba xantomas en las conjuntivas bulbares y un intenso linfedema en ambas piernas. Consideramos que este caso es un ejemplo más de la denominada xantogranulomatosis subcutánea con dos peculiaridades clínicas: el hallazgo de piel laxa en las zonas afectadas y la asociación con linfedema y elefantiasis cutánea en miembros inferiores. Por otra parte hemos reseñado el peculiar hallazgo histológico de cuerpos asteroides en el interior de las células gigantes del infiltrado xantomatoso (AU)


Assuntos
Masculino , Pessoa de Meia-Idade , Humanos , Xantomatose/complicações , Xantomatose/diagnóstico , Xantomatose/terapia , Cútis Laxa/complicações , Cútis Laxa/diagnóstico , Cútis Laxa/terapia , Linfedema/complicações , Linfedema/diagnóstico , Linfedema/etiologia , Elefantíase/complicações , Elefantíase/diagnóstico , Elefantíase/terapia , Cútis Laxa/epidemiologia , Cútis Laxa/patologia , Manifestações Cutâneas , Histiocitose de Células não Langerhans/diagnóstico , Histiocitose de Células não Langerhans/etiologia , Histiocitose de Células não Langerhans/terapia , Linfedema/complicações , Linfedema/diagnóstico , Linfedema/terapia
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