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1.
Sci Total Environ ; 803: 150084, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-34500274

RESUMO

Currently, the environmental and ecological damage caused by As(V) and Sb(V) co-contamination has attracted widespread attention worldwide. Due to the similar intrinsic structure configuration and electrostatic repulsion of As(V) and Sb(V), the long-standing issue of their low co-removal capacity remains unresolved. In this study, novel Fe-Cu (FC) binary materials with varied Fe/Cu proportions were synthesized via a simple co-precipitation method to co-eliminate aquatic As(V) and Sb(V). A 2/1 ratio of Fe/Cu was determined to be a suitable proportion with a higher co-adsorption capacity, specifically 70.9 mg·g-1 for As(V) and 94.3 mg·g-1 for Sb(V). Detailed morphological and structural analyses indicated that the FC material gradually changed from microscale aggregates to nanoscale spheres with increasing Cu content, accompanied by an increasing crystalline degree and higher surface area. Additionally, the transformation of amorphous ferrihydrite (FO) into FeO(OH) was suppressed by Fe-Cu complexion during the co-adsorption process, in which ferrihydrite (FO) had more adsorption sites than FeO(OH). In addition, the addition of Cu promoted the pHpzc of FC materials from the acidic range into the neutral or alkaline range. The increased potential difference of FC materials accelerated the As(V) and Sb(V) diffusion rate and effectively offset native electrostatic repulsion, which exhibited a considerable effect than the adsorption sites. Through detailed kinetic data analysis, it was determined that the proportion of the diffusion layer thickness around Sb(V) was suppressed to the As(V) level, and the adsorption kinetics of the two species were both promoted by the self-driven force field. All the results indicated that the co-adsorption capacity depended on the coupling contribution of Fe and Cu, where Fe oxide acted as the major adsorption potential and Cu provided a self-driven force for As(V) and Sb(V) diffusion. This study may provide a novel prospective for homogeneous metal ion co-removal.


Assuntos
Óxidos , Poluentes Químicos da Água , Adsorção , Antimônio , Cobre , Concentração de Íons de Hidrogênio , Estudos Prospectivos , Água
2.
Environ Pollut ; 291: 118215, 2021 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-34740293

RESUMO

Laboratory experiments in which earthworms were exposed to four different Sb spiked agricultural soils (acidic, neutral, alkaline and calcareous alkaline soil) were conducted in a climate-controlled room. The study surveyed the toxicity of Sb to the Eisenia fetida at the individual (mortality, growth inhibition, Sb accumulation), physiological (enzymatic activities), subcellular and tissue levels (histological damage), and for the induction of an avoidance response of Sb. The results showed that earthworms clearly avoided Sb spiked soil, and the avoidance response tended to be correlated to the exposure dose. The EC50 values of the net avoidance response in the four soils were as followed: S1 (acidic soil, 135 ± 37 mg kg-1) < S3 (alkaline soil, 430 ± 114 mg kg-1) < S4 (calcareous alkaline soil, 455 ± 29 mg kg-1) < S2 (neutral soil, 946 ± 151 mg kg-1). Different toxic effects of Sb to earthworms cultivated in the four types of soils were observed. Antimony was more toxic in a sandy alkaline soil than that in the other three soils tested. The LC50 of the 28 d mortality ranged as follows: S3 (22.2 ± 0.1 mg kg-1) < S2 (372 ± 177 mg kg-1) < S4 (491 ± 140 mg kg-1) < S1 (497 ± 29 mg kg-1). Changes in oxidative stress and the subcellular distribution of Sb in earthworms induced by Sb exposure differed between soil types. Additionally, histological damage in earthworm's epidermis and intestine were observed under Sb stress. Mortality, growth inhibition and Sb accumulation in the earthworms tended to increase with Sb exposure regardless of soil type and were all significantly correlated with the exposure dose. The growth inhibition and Sb concentration in tissues of earthworms were sensitive indicators of Sb bioavailability. The relatively comprehensive toxicological data provided herein can contribute to the toxicity threshold and assessment of bioavailability of Sb contaminated agricultural soil, and then to the ecological risk assessments.


Assuntos
Oligoquetos , Poluentes do Solo , Animais , Antimônio/toxicidade , Disponibilidade Biológica , Solo , Poluentes do Solo/análise , Poluentes do Solo/toxicidade
3.
Sci Total Environ ; : 151582, 2021 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-34785215

RESUMO

The Yellow River Estuary and Laizhou Bay are located on the northern Shandong Peninsula in the Bohai Sea in China and have been polluted by intensive anthropogenic activity. However, few studies have focused on the effect of these activities on the microbial communities and their ecological functions in this area. In this study, the combination of 16S rDNA gene sequencing and GeoChip technology was used to analyzed the microbial community component and their functional genes. Thaumarchaeot and Bacteroidetes are the most abundant phyla. The results of correlation analysis and redundancy analysis (RDA) showed water depth (r2 = 0.76, P = 0.005), total Na content (r2 = 0.63, P = 0.021) and total Ca content (r2 = 0.53, P = 0.05) in the sediments were the most significant environmental factors affecting the microbial community. The diversity of the microbial community and signal intensity of functional genes at nearshore sites (N sites) were higher than that at the offshore sites (O sites), but the component of microbial community and functional genes was similar in general. Functional genes for C, N, P and S cycle were detected at both nearshore and offshore sites, which illustrated that microbial communities were active in nutrient cycle. Proteobacteria contributes significantly to material cycle in microbial community. In addition, functional genes related to organic remediation and metal detoxification are also abundant. It indicated that the environmental pollution caused by anthropogenic activities has greatly affected the microbial community components and their biochemical functions in the Yellow River Estuary and surrounding areas. This study reveals the effect of anthropogenic activities on microbial communities and provides the basis for environmental management.

4.
Water Res ; 207: 117838, 2021 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-34775169

RESUMO

Vanadium has been classified as a potentially toxic metal and has been given limited attention in comparison to similar trace metals. Similarly, worldwide and continental vanadium pollution and risks remain contested. Here, we synthesized the worldwide concentration of vanadium in marine ecosystems with the relevant ecological and human health risks. We found that vanadium in biota and seawater collected from Asia shows significant increases over the temporal analysis, with rates similar to those reported for vanadium consumption and production. Furthermore, invertebrates have a higher concentration of vanadium than fishes. Similarly, we demonstrate that sediments classified as polluted have concentrations that are not directly correlated with the highest concentrations across continents. Finally, ecological risks were higher from seawater, with potential impacts to 55% of aquatic species in Asia estimated from chronic species sensitivity distribution (SSD). The concentration endangering only 5% of seawater species (HC5) was estimated as 1.13 (0.05-21.19) µg L-1. Estimated daily intakes revealed that overall, there are none to low health risks from aquatic product consumption, yet high risks are plausible to children with consumption patterns in the 95th percentile.

5.
World J Clin Cases ; 9(28): 8563-8570, 2021 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-34754869

RESUMO

BACKGROUND: Two or multiple primary malignant neoplasms (MPMNs) rarely occur in the same patient. It has been reported that MPMNs are easily misdiagnosed as the recurrence or metastasis of malignancies in clinical practice, affecting the choice of treatment for the patients, thereby resulting in the delay of optimal diagnosis. Next generation sequencing (NGS) can be used to distinguish between multiple primary lung cancers and intrapulmonary metastasis, and may distinguish the origin of tumours in different sites of the body. CASE SUMMARY: We report the case of 66-year-old woman who suffered from different malignant neoplasms in the rectum and esophageal and gastrointestinal tract. The first neoplasm rectal adenocarcinoma was diagnosed and removed in 2016. The second and third lesions were diagnosed with esophageal squamous-cell carcinoma (ESCC) and gastrointestinal stromal tumour (GIST), respectively, in 2019. Next-generation whole exome sequencing was performed on the tissue specimens of rectal carcinoma, esophageal cancer, GIST, and white blood cells to investigate the relationship between malignancies at different timeframe and determine whether the ESCC and GIST evolved from the rectal adenocarcinoma. Mutations including v-Ki-ras2-Kirsten rat sarcoma viral oncogene homolog, adenomatosis polyposis coli, and mothers against decapentaplegic homolog 4 were detected in rectal adenocarcinoma sample, mast/stem cell growth factor receptor was detected in GIST tissue, and lysine methyltransferase 2D was detected in ESCC specimen. Overall, ESCC and GIST were not genetically evolved from rectal adenocarcinoma, and this patient did not have a trunk driven clone. CONCLUSION: NGS is an effective tool to study clonal evolution of tumours and distinguish between MPMNs and intrapulmonary metastasis.

6.
J Hazard Mater ; 424(Pt B): 127487, 2021 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-34655873

RESUMO

We investigated the spatiotemporal distributions, risks, and prioritization of 15 widely used antibiotics in Laizhou Bay (LZB). Water samples (145) were collected from LZB and its estuaries and analyzed. Twelve antibiotics, with total concentrations of 241-1450 and 69-289 ng L-1 in estuarine water and seawater, respectively, were detected, with the contributions of norfloxacin, ciprofloxacin, and amoxicillin exceeding 70%. Amoxicillin was firstly determined, which contributed to 20% and 46% of the total antibiotics during summer and spring, respectively. Higher antibiotic concentrations were observed in the sea located adjacent to aquaculture bases and the Yellow River Estuary, which are significantly influenced by mariculture and riverine inputs, respectively. Veterinary antibiotics showed higher total concentrations in summer compared to spring, indicating a higher degree of their usage in mariculture in summer. The antibiotic mixtures posed high risk to algae and low to medium risks to crustaceans and fish. Amoxicillin and norfloxacin were identified as high-risk pollutants. Additionally, amoxicillin and ciprofloxacin showed medium to high resistance development risks. Previous studies on antibiotics in the LZB did not determined amoxicillin and thus underestimated antibiotic contamination, ecological risk, and resistance development risk. Amoxicillin, norfloxacin, and ciprofloxacin should be prioritized in risk management.

7.
J Hazard Mater ; 424(Pt B): 127482, 2021 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-34655879

RESUMO

Heavy metal (HM) pollution in coastal ecosystems have posed threats to organisms and human worldwide. This study comprehensively investigated the concentrations, sources, trophodynamics, contamination, and risks of six HMs in the coastal ecosystem of Jiaozhou Bay, northern China, by stable isotope analysis, positive matrix factorization (PMF), and Monte Carlo simulation. Overall, Co, Cu, Ni, Pb, and Zn were significantly bio-diluted in the food web, while Cr was significantly biomagnified with a trophic magnification factor of 1.23. In addition, trophodynamics of the six HMs was different among fish, mollusk, and crustacean. Furthermore, detailed transfer pathways of six HMs in the food web including eight trophic levels were different from one another. Bioaccumulation order of the six HMs was Cu > Zn > Co, Cr, Ni, and Pb. Zinc concentrations were the highest in seawater, sediments, and organisms. Anthropogenic sources contributed to 71% for Zn, 31% for Cu and Pb, and 27% for Co, Cr, and Ni in the sediment, which was moderately contaminated with moderate ecological risk. However, the human health risk of HMs from eating seafood was relatively low. To protect the Jiaozhou Bay ecosystem, HM contamination should be further controlled in future.

8.
Proc Natl Acad Sci U S A ; 118(43)2021 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-34663725

RESUMO

Early identification of atypical infant movement behaviors consistent with underlying neuromotor pathologies can expedite timely enrollment in therapeutic interventions that exploit inherent neuroplasticity to promote recovery. Traditional neuromotor assessments rely on qualitative evaluations performed by specially trained personnel, mostly available in tertiary medical centers or specialized facilities. Such approaches are high in cost, require geographic proximity to advanced healthcare resources, and yield mostly qualitative insight. This paper introduces a simple, low-cost alternative in the form of a technology customized for quantitatively capturing continuous, full-body kinematics of infants during free living conditions at home or in clinical settings while simultaneously recording essential vital signs data. The system consists of a wireless network of small, flexible inertial sensors placed at strategic locations across the body and operated in a wide-bandwidth and time-synchronized fashion. The data serve as the basis for reconstructing three-dimensional motions in avatar form without the need for video recordings and associated privacy concerns, for remote visual assessments by experts. These quantitative measurements can also be presented in graphical format and analyzed with machine-learning techniques, with potential to automate and systematize traditional motor assessments. Clinical implementations with infants at low and at elevated risks for atypical neuromotor development illustrates application of this system in quantitative and semiquantitative assessments of patterns of gross motor skills, along with body temperature, heart rate, and respiratory rate, from long-term and follow-up measurements over a 3-mo period following birth. The engineering aspects are compatible for scaled deployment, with the potential to improve health outcomes for children worldwide via early, pragmatic detection methods.

9.
Nat Methods ; 18(10): 1192-1195, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34594030

RESUMO

DeepImageJ is a user-friendly solution that enables the generic use of pre-trained deep learning models for biomedical image analysis in ImageJ. The deepImageJ environment gives access to the largest bioimage repository of pre-trained deep learning models (BioImage Model Zoo). Hence, nonexperts can easily perform common image processing tasks in life-science research with deep learning-based tools including pixel and object classification, instance segmentation, denoising or virtual staining. DeepImageJ is compatible with existing state of the art solutions and it is equipped with utility tools for developers to include new models. Very recently, several training frameworks have adopted the deepImageJ format to deploy their work in one of the most used softwares in the field (ImageJ). Beyond its direct use, we expect deepImageJ to contribute to the broader dissemination and reuse of deep learning models in life sciences applications and bioimage informatics.


Assuntos
Aprendizado Profundo , Processamento de Imagem Assistida por Computador/métodos , Software , Disciplinas das Ciências Biológicas , Redes Neurais de Computação
10.
Adv Biol (Weinh) ; : e2101063, 2021 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-34693668

RESUMO

The number of samples in biological experiments is continuously increasing, but complex protocols and human error in many cases lead to suboptimal data quality and hence difficulties in reproducing scientific findings. Laboratory automation can alleviate many of these problems by precisely reproducing machine-readable protocols. These instruments generally require high up-front investments, and due to the lack of open application programming interfaces (APIs), they are notoriously difficult for scientists to customize and control outside of the vendor-supplied software. Here, automated, high-throughput experiments are demonstrated for interdisciplinary research in life science that can be replicated on a modest budget, using open tools to ensure reproducibility by combining the tools OpenFlexure, Opentrons, ImJoy, and UC2. This automated sample preparation and imaging pipeline can easily be replicated and established in many laboratories as well as in educational contexts through easy-to-understand algorithms and easy-to-build microscopes. Additionally, the creation of feedback loops, with later pipetting or imaging steps depending on the analysis of previously acquired images, enables the realization of fully autonomous "smart" microscopy experiments. All documents and source files are publicly available to prove the concept of smart lab automation using inexpensive, open tools. It is believed this democratizes access to the power and repeatability of automated experiments.

11.
Sci Total Environ ; 806(Pt 1): 150540, 2021 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-34583074

RESUMO

Phosphorus contamination in urbanized bays has been a major concern because the bay restoration is often hindered by complex P sources and behaviors. This study examined the spatiotemporal changes of P species and exchange potential in/between the water and sediment of the Jiaozhou Bay. The results indicated that dissolved P (TDP) and inorganic P (DIP) in the water ranged from 7.8-128.7 and 1.8-14.1 µg/L, respectively; while total P (TP) in the sediment ranged from 213.4-638.7 mg/kg. The TDP and DIP concentrations in the water were high in winter and low in summer, and generally decreased from northeastern or northern areas to southwestern or southern areas mainly due to phytoplankton bloom cycles and riverine and wastewater inputs. TP in the sediment was lower in the northwestern area due to solid dilution effect by the settlement of settled coarser suspended particles. Changes in aquatic geochemical conditions from rivers to bay caused P accumulation in estuarine sediment, with higher P partition in organic fraction (40%). Compared to the estuarine sediment, higher fractions of P were associated with carbonate (34%) and iron oxide (17%) minerals in the bay sediment. Equilibrium P concentrations at zero sorption (EPC0) were 4.1-149.8 µg/L, which was substantially higher than the DIP concentration, demonstrating P release potential from the sediment. In addition, the P release potential was high in the northeastern area while P partition coefficient or buffer intensity (Kd) was high in the northwestern area. EPC0 was significantly positively correlated with soluble and exchangeable P in the sediment while Kd was significantly negatively correlated. These results can provide improved insights into P behaviors in an urbanized bay, particularly the P release potential and spatiotemporal change.

12.
Microbiol Resour Announc ; 10(39): e0068021, 2021 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-34591684

RESUMO

We report the complete genome sequence of Caulobacter sp. strain S6, generated from Oxford Nanopore and Illumina sequencing. The assembled genome comprises a chromosome with a length of 5.5 Mb and a plasmid of 96,014 bp.

13.
Environ Pollut ; 290: 118074, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34523525

RESUMO

In this study, water and sediment samples from the Jiaozhou Bay and surrounding rivers were collected to analyze the seasonal occurrence and allocation of 12 organophosphate esters (OPEs) and the associated ecological risk. The higher contamination of OPEs in the adjacent rivers indicated the impact of terrestrial input. Tris(1-chloropropan-2-yl) phosphate (TCIPP) was the predominant OPE in the four environmental sample groups investigated. The spatial distribution of OPEs in seawater varied greatly seasonally and was mainly affected by terrestrial input, with OPEs being redistributed under the influence of tidal currents. The partition coefficients (log Koc) of the OPEs were calculated, and their strong correlation with the log Kow (octanol-water) values suggested that the water-sediment allocation was significantly affected by hydrophobicity. The homologous relationships among the 7 OPEs with detection frequencies greater than 40% were identified by principal component analysis (PCA). The partial least squares regression (PLSR) model explicated that ∑OPEs cycling dynamics and principal controlling factors were dissimilar in the bay versus surrounding rivers. The risk quotient (RQ) faced by typical organisms in seawater and river water indicated that short-term OPEs exposure was safe for green algae, daphnia and fish. The organisms in rivers faced the higher ecological risk of OPEs in spring than in summer and winter. Therefore, the terrestrial transport of OPEs in spring should be controlled.


Assuntos
Retardadores de Chama , Poluentes Químicos da Água , Animais , Baías , China , Monitoramento Ambiental , Ésteres/análise , Retardadores de Chama/análise , Organofosfatos/análise , Estações do Ano , Poluentes Químicos da Água/análise
14.
J Reconstr Microsurg ; 2021 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-34553344

RESUMO

BACKGROUND: Current near-infrared spectroscopy (NIRS)-based systems for continuous flap monitoring are limited to flaps which carry a cutaneous paddle. As such, this useful and reliable technology has not previously been applicable to muscle-only free flaps where other modalities with substantial limitations continue to be utilized. METHODS: We present the first NIRS probe which allows continuous monitoring of local tissue oxygen saturation (StO2) directly within the substance of muscle tissue. This probe is flexible, subcentimeter in scale, waterproof, biocompatible, and is fitted with resorbable barbs which facilitate temporary autostabilization followed by easy atraumatic removal. This novel device was compared with a ViOptix T.Ox monitor in a porcine rectus abdominus myocutaneous flap model of arterial and venous occlusions. During these experiments, the T.Ox device was affixed to the skin paddle, while the novel probe was within the muscle component of the same flap. RESULTS: The intramuscular NIRS device and skin-mounted ViOptix T.Ox devices produced very similar StO2 tracings throughout the vascular clamping events, with obvious and parallel changes occurring upon vascular clamping and release. The normalized cross-correlation at zero lag describing correspondence between the novel intramuscular NIRS and T.Ox devices was >0.99. CONCLUSION: This novel intramuscular NIRS probe offers continuous monitoring of oxygen saturation within muscle flaps. This experiment demonstrates the potential suitability of this intramuscular NIRS probe for the task of muscle-only free flap monitoring, where NIRS has not previously been applicable. Testing in the clinical environment is necessary to assess durability and reliability.

15.
J Med Internet Res ; 23(9): e21974, 2021 09 09.
Artigo em Inglês | MEDLINE | ID: mdl-34499042

RESUMO

BACKGROUND: Consumer health informatics (CHI) originated in the 1990s. With the rapid development of computer and information technology for health decision making, an increasing number of consumers have obtained health-related information through the internet, and CHI has also attracted the attention of an increasing number of scholars. OBJECTIVE: The aim of this study was to analyze the research themes and evolution characteristics of different study periods and to discuss the dynamic evolution path and research theme rules in a time-series framework from the perspective of a strategy map and a data flow in CHI. METHODS: The Web of Science core collection database of the Institute for Scientific Information was used as the data source to retrieve relevant articles in the field of CHI. SciMAT was used to preprocess the literature data and construct the overlapping map, evolution map, strategic diagram, and cluster network characterized by keywords. Besides, a bibliometric analysis of the general characteristics, the evolutionary characteristics of the theme, and the evolutionary path of the theme was conducted. RESULTS: A total of 986 articles were obtained after the retrieval, and 931 articles met the document-type requirement. In the past 21 years, the number of articles increased every year, with a remarkable growth after 2015. The research content in 4 different study periods formed the following 38 themes: patient education, medicine, needs, and bibliographic database in the 1999-2003 study period; world wide web, patient education, eHealth, patients, medication, terminology, behavior, technology, and disease in the 2004-2008 study period; websites, information seeking, physicians, attitudes, technology, risk, food labeling, patient, strategies, patient education, and eHealth in the 2009-2014 study period; and electronic medical records, health information seeking, attitudes, health communication, breast cancer, health literacy, technology, natural language processing, user-centered design, pharmacy, academic libraries, costs, internet utilization, and online health information in the 2015-2019 study period. Besides, these themes formed 10 evolution paths in 3 research directions: patient education and intervention, consumer demand attitude and behavior, and internet information technology application. CONCLUSIONS: Averaging 93 publications every year since 2015, CHI research is in a rapid growth period. The research themes mainly focus on patient education, health information needs, health information search behavior, health behavior intervention, health literacy, health information technology, eHealth, and other aspects. Patient education and intervention research, consumer demand, attitude, and behavior research comprise the main theme evolution path, whose evolution process has been relatively stable. This evolution path will continue to become the research hotspot in this field. Research on the internet and information technology application is a secondary theme evolution path with development potential.


Assuntos
Informática Médica , Telemedicina , Bibliometria , Informática Aplicada à Saúde dos Consumidores , Humanos , Internet
16.
J Reconstr Microsurg ; 2021 Aug 17.
Artigo em Inglês | MEDLINE | ID: mdl-34404105

RESUMO

BACKGROUND: Current near-infrared spectroscopy (NIRS)-based systems for continuous flap monitoring are highly sensitive for detecting malperfusion. However, the clinical utility and user experience are limited by the wired connection between the sensor and bedside console. This wire leads to instability of the flap-sensor interface and may cause false alarms. METHODS: We present a novel wearable wireless NIRS sensor for continuous fasciocutaneous free flap monitoring. This waterproof silicone-encapsulated Bluetooth-enabled device contains two light-emitting diodes and two photodetectors in addition to a battery sufficient for 5 days of uninterrupted function. This novel device was compared with a ViOptix T.Ox monitor in a porcine rectus abdominus myocutaneous flap model of arterial and venous occlusions. RESULTS: Devices were tested in four flaps using three animals. Both devices produced very similar tissue oxygen saturation (StO2) tracings throughout the vascular clamping events, with obvious and parallel changes occurring on arterial clamping, arterial release, venous clamping, and venous release. Small interdevice variations in absolute StO2 value readings and magnitude of change were observed. The normalized cross-correlation at zero lag describing correspondence between the novel NIRS and T.Ox devices was >0.99 in each trial. CONCLUSION: The wireless NIRS flap monitor is capable of detecting StO2 changes resultant from arterial vascular occlusive events. In this porcine flap model, the functionality of this novel sensor closely mirrored that of the T.Ox wired platform. This device is waterproof, highly adhesive, skin conforming, and has sufficient battery life to function for 5 days. Clinical testing is necessary to determine if this wireless functionality translates into fewer false-positive alarms and a better user experience.

17.
Sci Total Environ ; 789: 148073, 2021 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-34323828

RESUMO

Antimony (Sb) primarily exists in trivalent (III) and pentavalent (V) speciation in the soil environment and poses a potential threat to ecological soil function as a toxic metalloid element. To evaluate the ecological effect of Sb in soil, the effects of different concentrations of Sb(III) and Sb(V) on microbial biomass carbon (MBC), soil basal respiration (SBR), potential nitrification rate (PNR), five enzyme activities and bacterial community structure were investigated using biochemical methods and high-throughput sequencing technology during the 1st and 8th weeks of exposure. The results of these experiments indicated that MBC and SBR were influenced, and PNR, FDA hydrolysis activity and urease activity were significantly inhibited by Sb(III) and Sb(V), while the activities of dehydrogenase, acid phosphatase and ß-glucosidase had no clear effects on the amounts of Sb(III) or Sb(V). Meanwhile, there are some discrepancies regarding the effects of Sb(III) and Sb(V) on the same microbial indicators, and incubation time is not a neglected factor. Sequencing analysis revealed that Sb(III) decreased the bacterial diversity indexes and abundances of specific bacteria at the phylum level, whereas Sb(V) had little effect on them. The bacterial community structure at the genus level was altered by Sb(III) and Sb(V), in which the abundances of some functional microbes were increased, while the abundances of some functional microbes were reduced under Sb pollution. In general, PNR, FDA hydrolysis activity, urease activity and the abundances of specific functional microbes (i.e., Nitrospira) could be considered as sensitive indicators of Sb contamination. This study highlights the ecological effect of Sb(III) and Sb(V) on agricultural soil and will provides references for environmental monitoring and assessment.

18.
Front Public Health ; 9: 678276, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34211956

RESUMO

Aim: With the improvement in people's living standards, the incidence of chronic renal failure (CRF) is increasing annually. The increase in the number of patients with CRF has significantly increased pressure on China's medical budget. Predicting hospitalization expenses for CRF can provide guidance for effective allocation and control of medical costs. The purpose of this study was to use the random forest (RF) method and least absolute shrinkage and selection operator (LASSO) regression to predict personal hospitalization expenses of hospitalized patients with CRF and to evaluate related influencing factors. Methods: The data set was collected from the first page of data of the medical records of three tertiary first-class hospitals for the whole year of 2016. Factors influencing hospitalization expenses for CRF were analyzed. Random forest and least absolute shrinkage and selection operator regression models were used to establish a prediction model for the hospitalization expenses of patients with CRF, and comparisons and evaluations were carried out. Results: For CRF inpatients, statistically significant differences in hospitalization expenses were found for major procedures, medical payment method, hospitalization frequency, length of stay, number of other diagnoses, and number of procedures. The R 2 of LASSO regression model and RF regression model are 0.6992 and 0.7946, respectively. The mean absolute error (MAE) and root mean square error (RMSE) of the LASSO regression model were 0.0268 and 0.043, respectively, and the MAE and RMSE of the RF prediction model were 0.0171 and 0.0355, respectively. In the RF model, and the weight of length of stay was the highest (0.730). Conclusions: The hospitalization expenses of patients with CRF are most affected by length of stay. The RF prediction model is superior to the LASSO regression model and can be used to predict the hospitalization expenses of patients with CRF. Health administration departments may consider formulating accurate individualized hospitalization expense reimbursement mechanisms accordingly.


Assuntos
Hospitalização , Falência Renal Crônica , China/epidemiologia , Humanos , Pacientes Internados , Falência Renal Crônica/epidemiologia , Estudos Retrospectivos
19.
Environ Pollut ; 287: 117588, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34153606

RESUMO

Endocrine-disrupting chemicals (EDCs) in water are receiving particular attention as they pose adverse effects on aquatic systems, even at trace concentrations. A comprehensive study was conducted on 14 EDCs (five estrogens and nine household and personal care products (HPCPs)) in the water of the urbanized Jiaozhou Bay in the Yellow Sea during summer and winter. Results showed that the total concentration of 14 EDCs ranged from 100 to 658 ng L-1 and 56.7-212 ng L-1 in the estuarine and bay water, respectively. The average total concentration of five estrogens in summer was significantly (p < 0.05) lower than that in winter due to the higher precipitation dilution and degradations during summer, whereas the average total concentration of nine HPCPs was significantly (p < 0.05) higher during the summer than that during the winter because of the higher usage and emissions during the summer. Estrogens and HPCPs were dominated by 17α-ethinylestradiol and p-hydroxybenzoic acid (PHBA), respectively. High PHBA concentrations may be related to the hydrolysis of parabens. The total concentrations of EDCs were higher in the eastern coastal seawater of the bay due to the strong influence of domestic and industrial wastewater discharge. Estrogens may interfere with the endocrine system of aquatic organisms in the bay because the total estradiol equivalent concentration exceeded 1 ng L-1. 17α-ethinylestradiol was the main contributor to the estrogenic activity. The EDC mixtures posed high risks (RQ > 1) to mollusks, crustaceans, and fish, and low to moderate risks (RQ < 1) to algae. Fish was the most sensitive aquatic taxon to the EDC mixtures. Given the concentration and frequency of EDCs, the optimized risk quotient method revealed that 17α-ethinylestradiol, estrone, triclocarban, triclosan, and 17ß-estradiol should be prioritized in ecological management because of their high risks (prioritization index of >1).


Assuntos
Disruptores Endócrinos , Poluentes Ambientais , Poluentes Químicos da Água , Animais , Baías , China , Disruptores Endócrinos/análise , Monitoramento Ambiental , Estrogênios/análise , Medição de Risco , Poluentes Químicos da Água/análise
20.
Ultrasound Med Biol ; 47(9): 2514-2522, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34147311

RESUMO

This study aimed to determine the prevalence of radioiodine-induced salivary gland damage by evaluating progressive changes in salivary glands using ultrasound. Four hundred forty-six patients with differentiated thyroid carcinoma who underwent total or near-total thyroidectomy and postoperative radioiodine therapy were retrospectively reviewed. From the first to the fifth follow-up visits, the positive rate of major salivary gland changes on ultrasound gradually increased from 2.0% to 33.0% (P<0.001) and possibly stabilized at the fifth visit (approximately 36 months). The first positive result was detected at an average of 20.78±8.72 months. Only 21 of the 161 positive cases eventually achieved negative ultrasound results (Fisher's test, P<0.001), and the 21 cases simply showed a coarse echotexure. In conclusion, ultrasound changes appeared late, and most of these changes were not reversed.

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