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1.
Oper Dent ; 2019 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-31661352

RESUMO

OBJECTIVE: To evaluate the clinical performance of a glass hybrid restorative compared with a resin composite in the restoration of large and deep Class II cavities after 24 months. METHODS AND MATERIALS: A total of 108 extended size, with the width of the proximal box not interfering with the peak of the cusps and the proximal box in occlusion, Class II lesions in 37 patients were either restored with a glass hybrid restorative or with a micro-hybrid composite resin in combination with selective etching by two experienced operators according to the manufacturer's instructions. Two independent examiners evaluated the restorations at baseline and at the six-, 12-, 18-, and 24-month recalls according to the modified US Public Health Service criteria. Negative replicas at each recall were observed under scanning electron microscopy (SEM) to examine surface characteristics. Data were analyzed statistically. RESULTS: After 24 months, 90 restorations were evaluated in 32 patients (recall rate: 86.5%). Four glass hybrid restorations were missing; three were due to bulk and one was due to proximal fracture at 12 months. Only six restorations were scored as bravo at baseline and at the six-, 12-, 18-, and 24-month recalls for color (p<0.05). No significant differences were observed between the two restorative materials for the other criteria evaluated (p>0.05). SEM observations exhibited acceptable surface and marginal adaptation characteristics for both restorative materials at 24 months. CONCLUSIONS: Although glass hybrid restorations showed significant mismatch in color, both restorative materials exhibited successful performance for the restoration of large Class II cavities after 24 months.

2.
Niger J Clin Pract ; 22(6): 833-841, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31187770

RESUMO

Objective: To evaluate the mechanical properties of a glass hybrid (GH) restorative system (EQUIA Forte/GC) and compare it with a microhybrid composite (G-aenial Posterior/GC) by compressive strength (CS) and fracture resistance (FR) tests. Materials and Methods: Cylindrical specimens were subjected to a CS test (n = 12). There were about 48 mandibular molars were used for a FR test and divided into four groups: Group 1 (positive control), sound teeth; Group 2 (negative control), extended size Class 2 cavities prepared on the mesial surfaces of teeth; Group 3, extended size Class 2 cavities restored with a composite; and Group 4, extended size Class 2 cavities restored with GH. Specimens were subjected to loading until a fracture occurred. Data were analyzed statistically (α = 0.05). Results: The fracture modes were examined by scanning electron microscope (SEM). The CS values of the composite and GH were 278.20 ± 17.34 MPa and 164.62 ± 25.72 MPa, respectively (P < 0.05). No differences were observed between the FR of restored groups (P > 0.05). Conclusions: The GH exhibited sufficient mechanical properties as a restorative material, and could be preferred for extensive caries lesions on posterior teeth.


Assuntos
Resinas Compostas , Força Compressiva , Cárie Dentária/terapia , Vidro , Fraturas dos Dentes/diagnóstico por imagem , Preparo da Cavidade Dentária , Restauração Dentária Permanente , Humanos , Teste de Materiais , Microscopia Eletrônica de Varredura , Dente Molar
3.
J Physiol Pharmacol ; 68(5): 765-777, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29375052

RESUMO

In order to elucidate the contribution of cycloxygenase (COX) enzymes in the anti-oxidant and anti-inflammatory mechanisms of nesfatin-1, which improves the healing process of chronic gastric ulcers, either acetic acid (80%; ulcer groups; n = 40) or saline (control groups; n = 40) was applied to the serosal surface of male Sprague Dawley rats' stomachs for 1 min. Both the control and ulcer groups were treated daily with either i.p. saline or nesfatin-1 (0.3 µg/kg; for 3 days). Nesfatin-1-treatment was preceded with i.p. saline, COX-2 inhibitor NS-398 (2 mg/kg), COX-1 inhibitor ketorolac (3 mg/kg) or non-selective COX inhibitor indomethacin (5 mg/kg) for 3 days. The rats were decapitated at the end of the third day, and their trunk blood was collected for the measurements of tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß) and IL-10 using ELISA. The induction of ulcers resulted in increased macroscopic scores, along with elevated gastric malondialdehyde, luminol- and lucigenin-enhanced chemiluminescence levels and myeloperoxidase activity. On the other hand, nesfatin-1 treatment abolished these elevations. Depleted glutathione, superoxide dismutase and catalase activity levels in the saline-treated ulcer group were preserved in the nesfatin-1-treated ulcer group. Increased levels of serum TNF-α, IL-1ß, IL-10 in the saline-treated ulcer group, as compared to control group, were significantly decreased in the nesfatin-1-treated ulcer group. The inhibition of COX-1, and/or COX-2 reversed most of the alterations induced with nesfatin-1, but COX-2-blockade was consistently more effective to abolish all nesfatin-1-induced changes. Our results suggest that nesfatin-1 ameliorates ulcer-induced inflammatory response through the modulation of oxidant-antioxidant balance. As selective pharmacological inhibition of COX-1 or COX-2 suppresses the antioxidant/anti-inflammatory effects of nesfatin-1, it appears that nesfatin-1 decreases inflammatory mediators and neutrophil migration by a COX-dependent mechanism, especially by a COX-2- dependent mechanism, during the ulcer healing stage.


Assuntos
Ácido Acético/toxicidade , Proteínas de Ligação ao Cálcio/uso terapêutico , Ciclo-Oxigenase 1/metabolismo , Ciclo-Oxigenase 2/metabolismo , Proteínas de Ligação a DNA/uso terapêutico , Proteínas de Membrana/metabolismo , Proteínas do Tecido Nervoso/uso terapêutico , Úlcera Gástrica/tratamento farmacológico , Úlcera Gástrica/metabolismo , Animais , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/uso terapêutico , Proteínas de Ligação ao Cálcio/farmacologia , Proteínas de Ligação a DNA/farmacologia , Relação Dose-Resposta a Droga , Masculino , Proteínas de Membrana/antagonistas & inibidores , Proteínas do Tecido Nervoso/farmacologia , Distribuição Aleatória , Ratos , Ratos Sprague-Dawley , Úlcera Gástrica/induzido quimicamente
4.
Int Nurs Rev ; 63(3): 395-405, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27557745

RESUMO

BACKGROUND: Compassion is considered the cornerstone of nursing practice. However, the recent failures in delivering high-quality compassionate nursing care in the UK's National Health Service have brought the topic of compassion to the attention of the public, service providers, policy makers and academics. AIM: The aim of this study was to explore the nurses' views and experiences of a number of compassion-related issues in nursing and describe similarities and differences at an international level as well as from the different nursing roles of the participating nurses. METHODS: An exploratory, cross-sectional descriptive study, using the International Online Compassion Questionnaire. A total of 1323 nurses from 15 countries completed the questionnaire. RESULTS: The majority of participants (59.5%) defined compassion as "Deep awareness of the suffering of others and wish to alleviate it" but definitions of compassion varied by country. Of participants, 69.6% thought compassion was very important in nursing and more than half (59.6%) of them argued that compassion could be taught. However, only 26.8% reported that the correct amount and level of teaching is provided. The majority of the participants (82.6%) stated that their patients prefer knowledgeable nurses with good interpersonal skills. Only 4.3% noted that they are receiving compassion from their managers. A significant relationship was found between nurses' experiences of compassion and their views about teaching of compassion. CONCLUSION: Our study is unique in identifying the views and experiences of nurses from 15 different countries worldwide. The findings reveal that compassion is neither addressed adequately in nursing education nor supported in the practice environment by managers. LIMITATIONS: Self-report bias was inherent to our survey study design. Furthermore, the individual cultural differences and similarities in the findings are difficult to extrapolate owing to the fact that our analysis was at country level, as well as at the level of the participating nurses. IMPLICATIONS FOR NURSING POLICY: Understanding the influence of culture on nurses' views about compassion is critical in the current multicultural healthcare environment and merits further research. This will potentially drive changes in nursing education (ensuring that compassion is taught to nurses) and in the way healthcare leaders and managers foster a compassionate culture within their organizations (e.g. by leading by example and compassionate to their staff).


Assuntos
Educação em Enfermagem , Empatia , Papel do Profissional de Enfermagem , Estudos Transversais , Humanos , Inquéritos e Questionários
5.
Adv Exp Med Biol ; 910: 23-30, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26820732

RESUMO

Sarcoidosis is a systemic granulomatous disease. Atherosclerosis is a chronic inflammatory vessel disease. The aim of our present study was to investigate whether sarcoidosis could be associated with increased risk of atherosclerotic vessel changes. Angiological analysis and blood tests were performed in 71 sarcoidosis patients and 12 matched controls in this prospective cross-sectional study. Specifically, angiological measurements comprised ankle brachial index (ABI), central pulse wave velocity (cPWV), pulse wave index (PWI), and duplex sonography of central and peripheral arteries. Sarcoidosis activity markers (angiotensin converting enzyme, soluble interleukin-2 receptor) and cardiovascular risk parameters such as cholesterol, lipoprotein(a), C-reactive protein, interleukin 6, fibrinogen, d-dimer, and blood count were analyzed in blood. We found no relevant differences in ABI, cPWV, and plaque burden between the sarcoidosis and control groups (1.10 ± 0.02 vs. 1.10 ± 0.02, 6.7 ± 0.5 vs. 6.1 ± 1.2, 53.7 % vs. 54.5 %, respectively). However, PWI was significantly higher in sarcoidosis patients (146.2 ± 6.8) compared with controls (104.9 ± 8.8), irrespectively of the activity of sarcoidosis and immunosuppressive medication. Except for increased lipoprotein(a) and d-dimer in sarcoidosis, the remaining cardiovascular markers were similar in both groups. We conclude that sarcoidosis is associated with increased pulse wave index, which may indicate an early stage of atherosclerosis.


Assuntos
Aterosclerose/fisiopatologia , Placa Aterosclerótica/fisiopatologia , Sarcoidose/metabolismo , Índice Tornozelo-Braço , Aterosclerose/diagnóstico por imagem , Aterosclerose/epidemiologia , Aterosclerose/metabolismo , Biomarcadores/metabolismo , Velocidade do Fluxo Sanguíneo , Proteína C-Reativa/metabolismo , Doenças Cardiovasculares/diagnóstico por imagem , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/metabolismo , Estudos de Casos e Controles , Colesterol/metabolismo , HDL-Colesterol/metabolismo , LDL-Colesterol/metabolismo , Estudos Transversais , Feminino , Produtos de Degradação da Fibrina e do Fibrinogênio/metabolismo , Fibrinogênio/metabolismo , Humanos , Interleucina-6/metabolismo , Lipoproteína(a)/metabolismo , Masculino , Pessoa de Meia-Idade , Peptidil Dipeptidase A/metabolismo , Placa Aterosclerótica/diagnóstico por imagem , Placa Aterosclerótica/epidemiologia , Placa Aterosclerótica/metabolismo , Estudos Prospectivos , Análise de Onda de Pulso , Receptores de Interleucina-2/metabolismo , Fatores de Risco , Sarcoidose/epidemiologia , Ultrassonografia
6.
Hum Exp Toxicol ; 35(1): 101-5, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25733729

RESUMO

INTRODUCTION: ST segment elevation myocardial infarction (STEMI) due to coronary artery occlusion caused by intracoronary thrombosis in the setting of acute carbon monoxide (CO) poisoning is a very rare presentation. We present a case of intracoronary large and mobile thrombus formation after CO poisoning. CASE PRESENTATION: A previously healthy 50-year-old woman was referred for CO poisoning. She had chest pain after exposure to CO. Her initial mental status was preoccupied with chest pain. Her initial CO fraction was 28.1%, and initial laboratory data showed creatine kinase-myocardial isoenzyme of 134 U/L (upper limit 25 U/L) and troponin I of >50 ng/mL (upper limit 0.06 ng/mL). Electrocardiography was carried out on admission, revealing an ST segment elevation in the inferolateral leads. After initial evaluation, coronary angiography was performed and an intracoronary large mobile thrombus was seen in the proximal left anterior descending (LAD) artery with no significant stenosis. We administered tenecteplase with heparin. After the thrombolytic therapy, ST elevation in the inferolateral leads resolved. Repeat angiography was performed after 24 h; the thrombus in LAD had resolved. The patient was discharged after 5 days, with persistent Q wave in the inferior leads and mild hypokinesia of the inferoposterior wall suggesting myocardial injury. CONCLUSION: We describe intracoronary thrombus formation induced by CO poisoning. Because intracoronary thrombus can result in myocardial infarction, its consideration following CO poisoning is important. Patients with CO poisoning who have symptoms of STEMI should be carefully evaluated with serial electrocardiograms, cardiac biomarkers, and an echocardiogram. When there is evidence of acute myocardial injury, a primer in coronary angiography can determine which patients could benefit from intervention.


Assuntos
Intoxicação por Monóxido de Carbono/complicações , Fibrinolíticos/uso terapêutico , Infarto do Miocárdio/tratamento farmacológico , Ativador de Plasminogênio Tecidual/uso terapêutico , Feminino , Humanos , Pessoa de Meia-Idade , Infarto do Miocárdio/etiologia , Tenecteplase
7.
J Physiol Pharmacol ; 66(5): 741-50, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26579580

RESUMO

Mucosal balance impairment, bacterial over-proliferation, cytokines, inflammatory mediators are known as responsible for inflammatory bowel disease. Besides known anorexigenic, neuroprotective, and anti-apoptotic effects, the major effect of nesfatin-1 on colitis is unknown. Our aim was to investigate the possible anti-inflammatory effects of nesfatin-1 in acetic acid induced colitis model and potential underlying mechanisms. Male Spraque-Dawley rats were anesthetized by intraperitoneal ketamine (100 mg/kg) and chlorpromazine (0.75 mg/kg). For nesfatin-1 and antagonist applications some of the rats were intracerebroventricularly (i.c.v.) cannulated. In colitis group, intrarectally (i.r.) 4% acetic acid solution (1 ml) and 10 minutes later i.c.v. nesfatin-1 (0.05 µg/5 µl) or vehicle (5 µl) were administered. Treatments continued for 3 days. In control group, physiological saline solution was used intrarectally. To identify the underlying effective mechanism of nesfatin-1, rats were divided into 3 subgroups, 5 minutes following colitis induction; i.c.v. atosiban (oxytocin receptor antagonist), SHU9119 (melanocortin receptor antagonist) or GHSR-1a antagonist (ghrelin receptor antagonist) were administered, 5 minutes later nesfatin-1 was administered for 3 days. On the fourth day, rats were decapitated, and colon tissues were sampled. Macroscopic and microscopic damage scores of distal colon, and colonic tissue malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, catalase, luminol and lucigenin chemiluminescence measurements were analysed. The increased myeloperoxidase activity, malondialdehyde levels, luminol and lucigenin chemiluminescence measurements, macroscopic and microscopic damage scores with colitis induction (P < 0.05 - 0.001) were decreased with nesfatin-1 treatment (P < 0.05 - 0.001). Nesfatin-1 may show this effect by inhibiting neutrophil infiltration through tissues and by decreasing formation of free oxygen radicals. Atosiban and GHSR-1a administration alleviated the protective effect of nesfatin-1 from microscopic and oxidant damage parameters and lipid peroxidation (P < 0.05 - 0.001). The results of the study suggest that nesfatin-1 had a protective effect from colitis induction, and the anti-inflammatory and antioxidant effects of nesfatin-1 on colitis might occur via oxytocin and ghrelin receptors.


Assuntos
Anti-Inflamatórios/farmacologia , Antioxidantes/farmacologia , Proteínas de Ligação ao Cálcio/farmacologia , Colite/prevenção & controle , Proteínas de Ligação a DNA/farmacologia , Proteínas do Tecido Nervoso/farmacologia , Ácido Acético/toxicidade , Animais , Modelos Animais de Doenças , Glutationa/metabolismo , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Malondialdeído/metabolismo , Peroxidase/metabolismo , Ratos , Ratos Sprague-Dawley
9.
J Clin Pediatr Dent ; 39(3): 241-6, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26208069

RESUMO

AIM: The aim of this study was to evaluate the flexural and µTBS of bulk-fill materials. STUDY DESIGN: Bulk-fill materials SDR, X-trabase (XTR) and TetricEvoCeramBulkFill (EVO) were used in this study. To test flexural strength, 25x2x2mm samples were prepared and tested with three point bending test. To test the microtensile bond strength (µTBS), two blocks (4x4x4mm) were prepared for each material. In Group A+B, acid-etching was applied to the surface of one of these blocks and no acid-etching was applied in Group B. After applying bonding agent, two blocks were placed into the mold and composite resin (COMP; Tetric N-Ceram) was applied with incremental layering. To evaluate the µTBS of primary dentin, the bulk-fill materials were applied to flat dentin up to 4mm. The new blocks and the teeth were sectioned to obtain sticks and the sticks were loaded in tension until failure. Flexural and microtensile bond strength was calculated based on failure load. RESULTS: The ranking of materials with regards to flexural strength values were SDR>XTR>EVO>COMP,respectively. In GroupA+B, the µTBS values were XTR>SDR>EVO and were XTR>EVO>SDR in GroupB (p>0.05). The µTBS values of these materials to dentin were XTR>EVO>SDR (p>0.05). CONCLUSION: Within the limitations of this study, the use of a bonding agent without acid-etching showed positive interactions between base materials and composite resin and there were no significant differences in µTBS of these materials to dentin.


Assuntos
Resinas Compostas/química , Colagem Dentária , Materiais Dentários/química , Ataque Ácido Dentário/métodos , Luzes de Cura Dentária/classificação , Análise do Estresse Dentário/instrumentação , Dentina/ultraestrutura , Humanos , Teste de Materiais , Metacrilatos/química , Ácidos Fosfóricos/química , Maleabilidade , Ácidos Polimetacrílicos/química , Estresse Mecânico , Propriedades de Superfície , Temperatura Ambiente , Resistência à Tração , Fatores de Tempo , Dente Decíduo/ultraestrutura , Água/química
11.
Niger J Clin Pract ; 18(3): 400-4, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25772926

RESUMO

AIM: The aim of this in vitro study was to compare the effects of different cavity-disinfectants and potassium titanyl phosphate (KTP) laser on microtensile bond strength to primary dentin. Chlorhexidine (CHX), propolis (PRO), ozonated water (OW), gaseous ozone (OG) and KTP laser were used for this purpose. METHODOLOGY: Twelve primary molar teeth were used in this study. One-third of the teeth (from coronal portion) were removed to obtain flat surfaces. After applying the cavity-disinfectants, an adhesive (prime and bond NT) was applied to dentin surfaces, and composite crowns were built up. One group received no pretreatment and was set as a control (CONT). Ten sticks were obtained from these samples and were stressed in tension until failure using a universal testing machine and the data were recorded. RESULTS: The mean strength values (in MPa) of the sticks were OW (11.12) > KTP (9.58) > CHX (7.58) > PRO (7.42) > CONT (6.38) > OG (5.84) and OW showed significantly higher results than the other groups, except KTP group (P < 0.05). CONCLUSIONS: OW and KTP might be used safely without compromising the bond strength of restorative materials.


Assuntos
Colagem Dentária/métodos , Dentina/efeitos dos fármacos , Desinfetantes/química , Desinfetantes/farmacologia , Resistência à Tração/efeitos dos fármacos , Clorexidina/química , Clorexidina/farmacologia , Dentina/fisiologia , Adesivos Dentinários/química , Humanos , Dente Molar/efeitos dos fármacos , Ozônio , Fosfatos/química , Fosfatos/farmacologia , Resistência à Tração/fisiologia , Titânio/química , Titânio/farmacologia
13.
Andrologia ; 47(5): 545-52, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24909239

RESUMO

We focussed on evaluating the protective effect of lycopene and resveratrol on post-thaw bull sperm and oxidative stress parameters. Nine ejaculates for each bull were used in the study. Each ejaculate, splitted into three equal aliquots and diluted at 37 °C with base extenders containing lycopene (1 × 10(-3)  g ml(-1) ) and resveratrol (1 mm), and no antioxidant (control), was cooled to 5 °C and then frozen. Frozen straws were thawed in a water bath for evaluation. The supplementation of the semen extender with lycopene and resveratrol increased the percentages of post-thawed computer-assisted sperm analysis (CASA) motility (55.8 ± 3.8 and 61.9 ± 4.0%) and progressive motility (38 ± 2.4 and 37 ± 8.8), compared with the controls (50.7 ± 2.65 and 33.3 ± 3.74%, respectively, P < 0.05). Resveratrol provided a higher ALH (4.3 ± 0.1), in comparison with the control (3.9 ± 0.3, P < 0.05). The supplementation of the semen extender with lycopene and resveratrol produced a higher mitochondrial activity (24.6 ± 2.9 and 30.1 ± 6.5% respectively), compared with that of the control (11.8 ± 9.5%, P < 0.05). It was determined that both antioxidants resulted in a lower percentage of sperm with damaged DNA than that of the control (P < 0.05). Sperm motion characteristics except for ALH, acrosome integrity, sperm viability and oxidative stress parameters were not affected by the adding of lycopene and resveratrol.


Assuntos
Antioxidantes/farmacologia , Carotenoides/farmacologia , Criopreservação/métodos , DNA/efeitos dos fármacos , Mitocôndrias/efeitos dos fármacos , Preservação do Sêmen/métodos , Motilidade Espermática/efeitos dos fármacos , Espermatozoides/efeitos dos fármacos , Estilbenos/farmacologia , Acrossomo/efeitos dos fármacos , Animais , Bovinos , Dano ao DNA/efeitos dos fármacos , Licopeno , Masculino , Estresse Oxidativo/efeitos dos fármacos , Resveratrol
14.
Eur J Paediatr Dent ; 15(4): 381-4, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25517584

RESUMO

AIM: The aim of this study was to evaluate the accuracy and reliability of three apex locators (EndoMaster, Raypex, DentaPort ZX) and visual assessment in primary molar teeth in vitro. MATERIALS AND METHODS: Twenty-four extracted human primary molar teeth with and without root resorption were used in this study. After endodontic access preparation, root canal length was visually measured by means of a K file; then the teeth were embedded into alginate and the roots were measured again by mans of the three apex locators. The results were collected in SPSS 15.0 and statistical evaluations were completed by one-way ANOVA and Kruksal-Wallis test. RESULTS: The measurements closest to the visually determined length were obtained with EndoMaster. No statistically significant differences were found between visual and apex locators lengths (p>0.05). CONCLUSION: Within the limitations of this study, the use of apex locators would be useful in the endodontic treatment of primary teeth.


Assuntos
Cavidade Pulpar/anatomia & histologia , Odontometria/instrumentação , Preparo de Canal Radicular/instrumentação , Reabsorção da Raiz/patologia , Ápice Dentário/anatomia & histologia , Dente Decíduo/anatomia & histologia , Equipamentos e Provisões Elétricas/estatística & dados numéricos , Desenho de Equipamento , Humanos , Dente Molar/anatomia & histologia , Odontometria/estatística & dados numéricos , Exame Físico/estatística & dados numéricos , Reprodutibilidade dos Testes , Preparo de Canal Radicular/estatística & dados numéricos
15.
Int J Immunopathol Pharmacol ; 27(3): 421-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25280033

RESUMO

Ataxia-telangiectasia (AT) is a rare multisystem, neurodegenerative genetic disorder that is characterised by progressive neurological abnormalities, oculocutaneous telangiectasias and immunodeficiency. Delay in diagnosis or misdiagnosis is probable due to its wide clinical heterogeneity in infancy. Recurrent sinopulmonary infections are often the only presenting symptom and usually patients have decreased immunoglobulins. A total 10% of patients who present with decreased serum immunoglobulin G and A and with normal or elevated immunoglobulin M levels are often misdiagnosed as hyperimmunoglobulin M syndrome. Definitive diagnosis is made if a patient with progressive cerebellar ataxia has a disease causing mutation on the ATM gene. Ataxia-telangiectasia guideline of the European Society for Immunodeficiencies defines the probable diagnosis criteria. We evaluated twenty ataxia-telangiectasia patients (mean age 13.8±4.1 years) retrospectively who were followed-up for a mean of 38.6±27.0 months. Twelve patients had a family history of consanguinity. A total of 80% patients suffered from various infections. Neoplasms occurred in three of them. Patients showed immunological abnormalities as low IgG (45%), low IgA (65%) and elevated IgM (60%) levels. CD3+CD4+ T lymphocyte frequency was low in 45% patients. The mean AFP concentration at the diagnosis was 191.9±140.1 ng/mL and the raised IgM values did not show any statistically significant relationship with high AFP concentrations. Frequency of the elevated IgM concentrations in (60%) patients raises the concerns about thinking this finding has to be accepted as a probable diagnosis criterium.


Assuntos
Ataxia Telangiectasia/imunologia , Imunoglobulina M/sangue , Adolescente , Adulto , Ataxia Telangiectasia/diagnóstico , Ataxia Telangiectasia/genética , Proteínas Mutadas de Ataxia Telangiectasia/genética , Criança , Consanguinidade , Feminino , Humanos , Masculino , Mutação , alfa-Fetoproteínas/análise
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