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2.
Leuk Res Rep ; 10: 37-40, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30186759

RESUMO

We describe a patient with MDS/MPN with ring sideroblasts and thrombocytosis who had deletions of long arm of chromosome 5 (5q-) and chromosome 20 (20q-). Molecular studies showed an exon 9, frame shift mutation in the calreticulin (CALR) gene, and absence of mutations in JAK2, MPL, SETBP1 or SF3B1. Treatment with lenalidomide resulted in durable clinical remission which has lasted 2 years.

3.
Breast Cancer (Auckl) ; 12: 1178223418788074, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30083055

RESUMO

The association between pathologic complete response (pCR) following to neoadjuvant chemotherapy (NAC) and the improved survival in breast cancer has been previously reported. The aim of this study was is to explore the expression of several biomarkers described during epithelial-mesenchymal transition (EMT) and the achievement of pCR in different molecular subtypes of breast cancer. We identified archived pathology tissue from patients with breast cancer who received NAC during the year 2014. We performed immunohistochemical analysis of vimentin, nuclear factor κB (NF-κB), epidermal growth factor receptor (EGFR), E-cadherin, estrogen receptor (ER), progesterone receptor, and Her2neu and studied the association between the expression of these markers and pCR. A Fisher exact test for categorical cofactors, an unpaired t test and a nonparametric Wilcoxon test for continuous cofactors were used. The results showed a significant expression of vimentin in triple-negative breast cancer (TNBC; P = .023). An inverse correlation between vimentin and the ER expression (P = .032) was observed. No significant association was noted for vimentin, NF-κB, EGFR, and E-cadherin was associated with pCR. This study suggests that the evaluated EMT related biomarkers are not associated with pCR after NAC chemotherapy in an unselected breast cancer population. Vimentin and NF-κB expressions were associated with TNBC and could be further explored as potential therapeutic targets in this subgroup. A prevalence of vimentin and NF-κB among Hispanic patients with breast cancer warrants further investigation as a possibly contributing to the prevalence of TNBC and adverse prognosis in this population.

4.
Am J Case Rep ; 18: 1347-1350, 2017 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-29249796

RESUMO

BACKGROUND Radiation-associated breast angiosarcoma is a rare clinical entity that is thought to be increasing in incidence. CASE REPORT Here we present the case of a 67-year-old female with a history of left breast invasive ductal carcinoma who received breast conserving surgery and radiation therapy eight years ago. She then presented with a painless mild skin discoloration of the left breast that had been present for over one year. Mammograms and ultrasounds were normal. A punch biopsy and a subsequent excisional biopsy revealed the diagnosis of angiosarcoma. The patient was treated with mastectomy and had no subsequent recurrences. CONCLUSIONS The long-term clinical surveillance for all patients who receive breast conservation surgery is recommended and a high degree of suspicion should be exercised in view of potential atypical presentations of this disease.


Assuntos
Neoplasias da Mama/etiologia , Hemangiossarcoma/etiologia , Neoplasias Induzidas por Radiação , Transtornos da Pigmentação/etiologia , Radioterapia Adjuvante/efeitos adversos , Idoso , Neoplasias da Mama/patologia , Neoplasias da Mama/radioterapia , Carcinoma Ductal de Mama/radioterapia , Feminino , Hemangiossarcoma/patologia , Humanos , Transtornos da Pigmentação/patologia
5.
Proc (Bayl Univ Med Cent) ; 30(3): 365-367, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28670090

RESUMO

Neurocysticercosis is a parasitic infection of the central nervous system with the cysts of Taenia solium, the pig tapeworm. Infection presents with a pleomorphic picture depending on the stage and location of the infection and the immune response of the infected host. Historically confined to the developing world, neurocysticercosis is no longer limited to endemic regions, as globalization, travel, and immigration permit the spread of the infection. We report a young Hispanic patient who was diagnosed with neurocysticercosis of the fourth ventricle and subsequent hydrocephalus.

6.
Diagn Cytopathol ; 45(5): 426-432, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28261978

RESUMO

BACKGROUND: Endoscopic ultrasound (EUS) fine needle aspiration (FNA) is an integral part in the diagnosis of pancreatic, intestinal and extra-intestinal masses or lesions. There is no clear data on the superiority of the core biopsy needle over standard 22-gauge needles. The aim of this study is to prospectively compare the cellularity yield of three commonly used 22-gauge FNA needles available in the US market. METHODS: This is a prospective, randomized study comparing the cellularity yield of three commercially available EUS needles (two standard FNA needles and core biopsy needle). Two blinded pathologists evaluated the cytology specimens based on an already agreed upon cytology score. We included adult patients (18-80 years old) who presented to our endoscopy unit for FNA of pancreatic or extrapancreatic masses. RESULTS: 109 patients (57 F, 52 M) were recruited to the study, 88 lesions were pancreatic lesions. 39 patients were recruited in the EZ Shot 2™ group, 36 in the Procore® group and 34 in the Expect™ group. The average cellularity score and the mean number of passes (SD) were not different between the three needles; P = 0.91 and P = 0.16, respectively. There was no difference between the three needles in obtaining an onsite diagnosis (P = 0.627) and no difference in reported adverse events between the three groups. CONCLUSION: The cellularity yields, the mean number of passes and reported adverse events were similar in the three compared 22-gauge needles. Diagn. Cytopathol. 2017;45:426-432. © 2017 Wiley Periodicals, Inc.


Assuntos
Adenocarcinoma/diagnóstico , Biópsia com Agulha de Grande Calibre/instrumentação , Aspiração por Agulha Fina Guiada por Ultrassom Endoscópico/instrumentação , Agulhas/classificação , Neoplasias Pancreáticas/diagnóstico , Adenocarcinoma/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Desenho de Equipamento , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Pâncreas , Neoplasias Pancreáticas/patologia , Estudos Prospectivos
7.
Am J Case Rep ; 17: 89-92, 2016 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-26876112

RESUMO

BACKGROUND: Burkitt's lymphoma (BL) is an uncommon cause of non-Hodgkin lymphoma in adults and accounts for only 0.1-0.5% of all malignant tumors of the colon and rectum. Very few cases of rectosigmoid and stomach BL have been reported in adults. CASE REPORT: A 51-year-old Hispanic woman presented with a 1-month history of hematochezia, associated with a foreign-body sensation in the rectum and 7 kg weight loss. Initial laboratory workup showed normocytic anemia and positive fecal occult blood. Computed tomography of the abdomen revealed an asymmetric appearance of the stomach and pylorus with nodularity of the mucosa and thickening of the posterior wall, and a 10.8-cm rectal mass. Esophagogastroduodenoscopy and colonoscopy were performed and biopsies of the stomach and rectum were obtained; histopathology demonstrated involvement by Burkitt's lymphoma in the gastric body nodule and rectal mass. After 4 cycles of chemotherapy, a follow-up abdominal CT demonstrated complete resolution of the mural thickening of the rectum and no intra-abdominal lymphadenopathy. CONCLUSIONS: Our case illustrates the importance of considering BL in the extensive differential diagnosis of rectal bleeding, change in bowel habits, and other lower and upper GI symptoms, since the rapidly growing nature of this rare malignancy requires a prompt diagnosis and initiation of appropriate therapy.


Assuntos
Linfoma de Burkitt/diagnóstico , Hemorragia Gastrointestinal/etiologia , Neoplasias Retais/diagnóstico , Neoplasias Gástricas/diagnóstico , Endoscopia do Sistema Digestório , Feminino , Humanos , Pessoa de Meia-Idade
8.
Proc (Bayl Univ Med Cent) ; 28(3): 350-2, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26130886

RESUMO

Pulmonary veno-occlusive disease (PVOD) represents a rare form of precapillary pulmonary arterial hypertension. We present a young patient hospitalized with progressive dyspnea, with initial workup suggestive of pulmonary hypertension and unexplained noncardiogenic pulmonary edema. His subsequent clinical course was consistent with the diagnosis of PVOD.

9.
Breast Dis ; 33(3): 115-9, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22668813

RESUMO

Spindle cell carcinoma of the breast is a rare subtype of metaplastic carcinoma with likelihood of aggressive behavior and lack of specific treatment options. Spindle cell carcinomas of the breast are typically "Triple Negative" and have distinct clinical, radiographic and pathological characteristics. We present, in this report, the case of a woman diagnosed with spindle cell carcinoma of the breast, and review the literature on this rare but intriguing disease.


Assuntos
Neoplasias da Mama/patologia , Carcinoma/patologia , Idoso , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/cirurgia , Carcinoma/diagnóstico por imagem , Carcinoma/cirurgia , Feminino , Humanos , Doenças Raras/diagnóstico por imagem , Doenças Raras/patologia , Doenças Raras/cirurgia , Ultrassonografia
10.
Am J Surg Pathol ; 28(10): 1371-8, 2004 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-15371954

RESUMO

Neuroendocrine secretory protein-55 (NESP-55), the latest addition to the chromogranin family, is a product of a genomically imprinted gene transcribed exclusively from the maternal allele. Initial studies have shown it to have a less widespread distribution than that of chromogranin A in normal tissues. It has also been suggested that NESP-55 may be a marker of neuroendocrine tumors differentiating toward the adrenal chromaffin and pancreatic islet cells. Metastatic gastrointestinal and pulmonary carcinoids may occasionally be difficult to distinguish from pancreatic endocrine tumors (PETs) and pheochromocytomas on morphologic grounds alone. We studied neuroendocrine tumors from these sites to see if NESP-55 expression could reliably discriminate pulmonary and gastrointestinal carcinoids from neuroendocrine tumors arising in the pancreas or the adrenal medulla. Sixty-three neuroendocrine tumors positive for one or more immunohistochemical marker of neuroendocrine differentiation (chromogranin A, chromogranin B, synaptophysin, secretogranin II, neuron-specific enolase) were selected for the study and consisted of 34 typical carcinoids (15 pulmonary, 11 ileal, 4 gastric, and 4 rectal), 19 PETs, and 10 pheochromocytomas (4 sporadic, 3 MEN-2, 2 neurofibromatosis type 1, and 1 VHL). All cases were stained for NESP-55 after microwave antigen retrieval using a rabbit polyclonal antibody at a dilution of 1:1000. Sections of normal adrenal medulla were used as positive controls for NESP-55 staining. Negative controls consisted of omission of primary antibody and replacement with normal rabbit serum at an equivalent concentration. NESP-55 immunoreactivity was seen as brown finely granular cytoplasmic staining with prominent perinuclear accentuation. All gastric and ileal carcinoids studied were completely negative for NESP-55. One of four rectal and 1 of 15 pulmonary carcinoids showed focal positivity for it in less than 5% of tumor cells. In contrast, all 10 pheochromocytomas and 14 of 19 PETs showed strong immunohistochemical staining in a variable proportion of tumor cells. Diffuse positivity (>75% of tumor cells) was seen in 6 of 14 PETs and 8 of 10 pheochromocytomas. Our results indicate that, in contrast to the other granins, NESP-55 reactivity is restricted to endocrine tumors of the pancreas and the adrenal medulla. Immunohistochemical expression of NESP-55 may thus be useful in assigning a pancreatic or adrenal origin to metastatic endocrine tumors of unknown origin.


Assuntos
Neoplasias das Glândulas Suprarrenais/diagnóstico , Tumor Carcinoide/diagnóstico , Subunidades alfa Gs de Proteínas de Ligação ao GTP/análise , Neoplasias Gastrointestinais/diagnóstico , Ilhotas Pancreáticas , Neoplasias Pulmonares/diagnóstico , Neoplasias Pancreáticas/diagnóstico , Feocromocitoma/diagnóstico , Neoplasias das Glândulas Suprarrenais/química , Tumor Carcinoide/química , Cromograninas , Diagnóstico Diferencial , Neoplasias Gastrointestinais/química , Humanos , Neoplasias Pulmonares/química , Neoplasias Pancreáticas/química , Feocromocitoma/química
11.
Int J Surg Pathol ; 11(4): 353-6, 2003 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-14615837

RESUMO

Primary intrapulmonary thymoma is a rare lesion with around 20 cases reported so far in the literature. A pure spindle cell morphology in these lesions is rarer still with only a single case recorded to date. We report herein an interesting case of a 47-year-old-man, status post surgical resection and radiotherapy for a squamous cell carcinoma of the floor of mouth, who was being followed up for a radiologic opacity in the right lower lobe of the lung. The lesion remained stable in size for almost 5 years and then an increase in size was noted. A right lower lobectomy was performed with a preoperative suspicion of metastasis. Histologic and immunohistochemical evaluation revealed a primary intrapulmonary spindle cell thymoma that displayed a prominent granulomatous reaction, a phenomenon not described so far in the literature. We discuss the possible embryologic origins and the pitfalls in diagnosis of these rare neoplasms. The remarkable granulomatous response observed in the tumor raises the possibility that similar lesions might conceivably occur in the thymus as well.


Assuntos
Granuloma/patologia , Neoplasias Pulmonares/patologia , Timoma/patologia , Biomarcadores Tumorais , Diagnóstico Diferencial , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/metabolismo , Neoplasias Pulmonares/ultraestrutura , Linfoma/patologia , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Segunda Neoplasia Primária/patologia , Neoplasias de Células Escamosas/patologia , Timoma/metabolismo , Timoma/ultraestrutura
12.
Buenos Aires; El Ateneo; 17. ed; 1997. 294 p. ilus. (103996).
Monografia em Espanhol | BINACIS | ID: bin-103996
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