Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 105
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Sci Total Environ ; 857(Pt 3): 159544, 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36270371

RESUMO

Contaminated groundwater resources threaten human health and destroy ecosystems in many areas worldwide. Groundwater remediation is crucial for environmental recovery; however, it can be cost prohibitive. Planning a cost-effective remediation design can take a long time, as it may involve the evaluation of many management decisions, and the corresponding simulation models are computationally demanding. Parallel optimization can facilitate much faster management decisions for cost-effective groundwater remediation design using complex pollutant transport models. However, the efficiency of different parallel optimization algorithms varies depending on both the search strategy and parallelism. In this paper, we show the performance of a parallel surrogate-based optimization algorithm called parallel stochastic radial basis function (p-SRBF), which has not been previously used on contaminant remediation problems. The two case problems involve two superfund sites (i.e., the Umatilla Aquifer and Blaine Aquifer), and one objective evaluation takes 5 and 30 min for the two problems, respectively. Exceptional speedup (superlinear) is achieved with 4 to 16 cores, and excellent speedup is achieved using up to 64 cores, obtaining a good solution at 80 % efficiency. We compare our p-SRBF with three different parallel derivative-free optimization algorithms, including genetic algorithm, mesh adaptive direct search, and asynchronous parallel pattern search optimization, in terms of objective quality, computational reduction and robust behavior across multiple trials. p-SRBF outperforms the other algorithms, as it finds the best solution in both the Umatilla and Blaine cases and reduces the computational budget by at least 50 % in both problems. Additionally, statistical comparisons show that the p-SRBF results are better than those of the alternative algorithms at the 5 % significant level. This study enriches theoretical real-world groundwater remediation methods. The results demonstrate that p-SRBF is promising for environmental management problems that involve computationally expensive models.


Assuntos
Recuperação e Remediação Ambiental , Água Subterrânea , Poluentes Químicos da Água , Humanos , Ecossistema , Poluentes Químicos da Água/análise , Algoritmos , Simulação por Computador
2.
Front Pharmacol ; 13: 958882, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36188576

RESUMO

Chemotherapy-induced intestinal mucositis (CIM) is a major dose-limiting side effect of chemotherapy, especially in regimens containing irinotecan (CPT-11). Several studies on the pathologic mechanisms of CIM focused on both the genomics and molecular pathways triggered by chemotherapy. However, systematic evaluation of metabolomic analysis in irinotecan-induced intestinal mucositis (IIM) has not been investigated. This study aimed to comprehensively analyze metabolite changes in main tissues of IIM mouse models. Male ICR mice were assigned to two groups: the model group (n = 11) treated with CPT-11 (20 mg/kg daily; i.p.) and the control group (n= 11) with solvent for 9 days. Gas chromatography-mass spectrometry (GC-MS) was used to investigate the metabolic alterations in the serum, intestinal, colonic, hepatic, and splenic samples of mice between two groups by multivariate statistical analyses, including GC-MS data processing, pattern recognition analysis, and pathway analysis. Forty-six metabolites, including hydrocarbons, amino acids, lipids, benzenoids, hydroxy acids, and amines, had significant changes in levels in tissues and sera of IIM mouse models. The most important pathways related to the identified metabolites were the glycerolipid metabolism in the colon and aminoacyl-tRNA biosynthesis; glycine, serine, and threonine metabolism; and glyoxylate and dicarboxylate metabolism in the liver. Our study firstly provided a comprehensive and systematic view of metabolic alterations of IIM using GC-MS analysis. The characterizations of metabolic changes could offer profound and theoretical insight into exploring new biomarkers for diagnosis and treatment of IIM.

3.
Trials ; 23(1): 875, 2022 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-36242061

RESUMO

BACKGROUND: Since early 2022, patients with 2019 novel coronavirus (COVID-19) infection have increased rapidly in Shanghai, China. Nevertheless, there is no widely used unified rehabilitation treatment available for discharged patients with post-infection sequelae such as dyspnea, depression, and fatigue. To promote the rehabilitation of discharged patients, our team formulated Kangyi Qiangshen Gong exercise prescription on the basis of traditional Chinese medicine rehabilitation exercises (TCMRE). We designed a randomized controlled trial to evaluate the efficacy of rehabilitation and advantages of KQG for discharged patients with post-COVID-19 syndrome. METHODS/DESIGN: This is a parallel-design, two-arm, analyst assessor-blinded, randomized controlled trial. In total, 60 discharged patients with COVID-19 sequelae, aged from 20 to 80 years will be recruited and randomly assigned to the World Health Organization instructed breathing techniques (BT) group and the Kangyi Qiangshen Gong exercise prescription (KQG) group at a ratio of 1:1. The patients in the BT group will perform breathing techniques exercise, and the patients in the KQG group will perform KQG exercise. Both groups will perform exercises twice a day for 3 months. The primary outcome will be measured with the Modified Medical Research Council Dyspnea Scale, and the secondary outcomes will include the Modified Borg Scale, Fatigue Scale-14, Patient Health Questionnaire-9 Scale, Pittsburgh Sleep Quality Index, and the Respiratory Symptoms Scale. Clinical scales will be assessed at three points (pre-exercise, 3 months post-exercise, and 3 months follow-up). Adverse events will be recorded for safety assessment. DISCUSSION: This trial will serve high-quality evidence of the value of KQG for treating discharged patients with COVID-19 in rehabilitation period. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR2200059504. Registered on 03 May 2022. DISSEMINATION: The results will be published in peer-reviewed journals and disseminated through the study's website, and conferences.


Assuntos
COVID-19 , COVID-19/complicações , China , Dispneia/etiologia , Terapia por Exercício/efeitos adversos , Fadiga , Humanos , Prescrições , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
4.
Front Cardiovasc Med ; 9: 900313, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35833187

RESUMO

Background: Hereditary transthyretin amyloid cardiomyopathy (ATTR-CM) is a genotypically heterogeneous disorder with a poor prognosis. There is limited literature describing the variants responsible for ATTRv in areas outside the United State, the United Kingdom and Europe. This study was performed to describe the clinical characteristics and genotypic profiles of this disease in South China. Methods: This was a single-center retrospective study that evaluated 29 patients with a confirmed diagnosis of hereditary transthyretin amyloid cardiomyopathy enrolled from January 2016 to November 2021. Results: 93.1% patients were male and the median age of symptom onset was 53 (46, 62.5) years old. The initial manifestations of ATTR-CM were cardiovascular symptoms (55.2%), neuropathy (41.4%) and vitreous opacity (3.4%). Phenotypes at diagnosis were mixed (82.8%), predominant cardiac (6.9%), neurological (6.9%) and ophthalmic (3.4%). Poor R-wave progression (41%), pseudo-infarct (31%) and low-voltage (31%) patterns were common findings on electrocardiogram. Unexplained increased wall thickness was observed in all 29 patients, with mean septal and posterior wall thicknesses of 14.25 ± 6.26 mm and 15.34 ± 2.84 mm, respectively. Diastolic dysfunction was also seen in all 29 patients, and 17 (58%) had a restrictive fill pattern at diagnosis. Nine different missense mutations of the TTR gene were found in 29 patients from 23 families, with c.349G>T (p.Ala117Ser) the most common mutation. The median survival time after diagnosis was 47.6 (95% CI 37.9-57.4) months, with 1, 3 and 5-year survival rates of 91.2%, 74% and 38% respectively. Patients with advanced heart failure (National Amyloidosis Staging stage II/III) had worse survival than stage I [Breslow (Generalized Wilcoxon), χ2 = 4.693, P = 0.03)]. Conclusions: ATTR amyloidosis genotypes and phenotypes are highly heterogeneous. Advanced heart failure predicts a poor prognosis. Understanding the different clinical profiles of ATTR cardiac amyloidosis with different genotype is important to its early recognition.

5.
Front Chem ; 10: 936936, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35844647

RESUMO

A series of hetero-binuclear superatom motifs involving chloride/bromide ligands, that is, MM'X4 - (M = Li, Na; M' = Be, Mg, Ca; X = Cl, Br) anions, have been characterized by using many-body perturbation theory calculations. Large vertical electron detachment energies (VDEs, 5.470-6.799 eV) confirm the superhalogen identity of these anions. A larger VDE value can be obtained by introducing small M or large M' central atoms and small halogen ligand atoms. Thus, one isomer of LiCaCl4 - possesses the largest VDE value. Besides, when the extra electron is shared by all ligand atoms or three bridging ligand atoms, the isomers have relatively larger VDE values.

6.
J Cell Mol Med ; 26(16): 4401-4415, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35775112

RESUMO

Lung adenocarcinoma (LUAD) is the most challenging neoplasm to treat in clinical practice. Ankyrin repeat domain 49 protein (ANKRD49) is highly expressed in several carcinomas; however, its pattern of expression and role in LUAD are not known. Tissue microarrays, immunohistochemistry, χ2 test, Spearman correlation analysis, Kaplan-Meier, log-rank test, and Cox's proportional hazard model were used to analyse the clinical cases. The effect of ANKRD49 on the LUAD was investigated using CCK-8, clonal formation, would healing, transwell assays, and nude mice experiment. Expressions of ANKRD49 and its associated downstream protein molecules were verified by real-time PCR, Western blot, immunohistochemistry, and/or immunofluorescence analyses. ANKRD49 expression was highly elevated in LUAD. The survival rate and Cox's modelling analysis indicated that there may be an independent prognostic indicator for LUAD patients. We also found that ANKRD49 promoted the invasion and migration in both in in vitro and in vivo assays, through upregulating matrix metalloproteinase (MMP)-2 and MMP-9 activities via the P38/ATF-2 signalling pathway Our findings suggest that ANKRD49 is a latent biomarker for evaluating LUAD prognosis and promotes the metastasis of A549 cells via upregulation of MMP-2 and MMP-9 in a P38/ATF-2 pathway-dependent manner.


Assuntos
Adenocarcinoma de Pulmão , Neoplasias Pulmonares , Proteínas Musculares/metabolismo , Fator 2 Ativador da Transcrição/metabolismo , Adenocarcinoma de Pulmão/genética , Adenocarcinoma de Pulmão/metabolismo , Animais , Linhagem Celular Tumoral , Movimento Celular/genética , Proliferação de Células , Regulação Neoplásica da Expressão Gênica , Neoplasias Pulmonares/patologia , Metaloproteinase 9 da Matriz/metabolismo , Camundongos , Camundongos Nus , Transdução de Sinais
7.
Food Res Int ; 156: 111355, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35650981

RESUMO

In this study, carboxymethyl chitosan (CMCS) and N-acetylneuraminic acid (NeuAc) were used to develop C-NeuAc hydrogels to encapsulate Pediococcus pentosaceus QK-1. The mechanical properties, thermal stability, in vitro degradation, and pH sensitivity of the hydrogel were evaluated. The C-NeuAc concentration required for optimal hydrogel performance was 3% (w/v). Hydrogel swelling behaviour was effectively assessed by Fickian diffusion and Schott's second-order kinetic models. The hydrogel demonstrated excellent biocompatibility and low in vitro cytotoxicity. An in vitro assay revealed that the viability of Pediococcus pentosaceus QK-1 in C-NeuAc had decreased by only 1.41 log (CFU/ mL) after exposure to simulated acidic gastric fluid. Moreover, the survival rate of the encapsulated and free Pediococcus pentosaceus QK-1 cells were 80.1% and virtually zero, respectively, after passage through the gastrointestinal tract. It was empirically determined that low temperature and freeze-drying were the ideal condition and method to ensure storage longevity of the hydrogel-encapsulated probiotic. Hence, C-NeuAc hydrogel is highly desirable as a food-grade probiotic delivery vehicle.


Assuntos
Quitosana , Hidrogéis , Quitosana/química , Hidrogéis/química , Concentração de Íons de Hidrogênio , Ácido N-Acetilneuramínico , Pediococcus pentosaceus
8.
Front Genet ; 13: 915679, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35769992

RESUMO

Taper implants differ greatly from anatomical teeth in shape. In this study, seven three-dimensional finite element models were established, including a conventional taper implant and six root-analog implants with different root numbers and shapes. Vertical, horizontal, and oblique instantaneous loads of 100 N were applied to the models to obtain stress distribution in the implant, mucosa, cortical bone, and cancellous bone. ANSYS was used to perform the analysis under hypothetical experimental conditions. We find the stresses in all the implants and surrounding tissues varied by loading direction, the sequence of stress magnitude is vertical load, oblique load, and then horizontal load. The maximum stress values in root-analog implants were significantly less than in the taper implant. Moreover, stress distribution in the former was equalized contrary to the concentrated stress in the latter. Root-analog implants with different root geometry also revealed a pattern: stresses in multiple-root implant models were lower than those in single-root implants under the same load. The implant with a long and rounded root distributed the stress more uniformly, and it was mainly concentrated on the implant itself and cancellous bone. However, the opposite effect was observed in the short implant on mucosa and cortical bone. The root geometry of anatomical teeth can modify their functions. A uniform-shaped implant can hardly meet their functional requirements. Thus, the root-analog implant could be a possible solution.

9.
Appl Immunohistochem Mol Morphol ; 30(6): 418-424, 2022 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-35639405

RESUMO

Lung squamous cell carcinoma (LUSC) is associated with poor clinical outcomes and identifying novel biomarkers that are involved in the progression of LUSC is important for prognosis and targeted treatment. Herein, ankyrin repeat domain 49 (ANKRD49) protein in LUSC versus paired noncancerous lung tissues was tested and its clinical significance was evaluated through χ 2 test, log-rank test, and Cox proportional hazards model. The results showed the ANKRD49 protein in LUSC was elevated and correlated with the tumor-node-metastasis stage, lymph node metastasis, distal metastasis, and differentiation. Patients with higher ANKRD49 had lower overall survival rate and higher ANKRD49 expression in lung tissues may be used as an independent prognostic marker for LUSC patients.


Assuntos
Carcinoma Pulmonar de Células não Pequenas , Carcinoma de Células Escamosas , Neoplasias Pulmonares , Biomarcadores Tumorais , Carcinoma Pulmonar de Células não Pequenas/patologia , Carcinoma de Células Escamosas/patologia , Humanos , Estimativa de Kaplan-Meier , Pulmão/patologia , Neoplasias Pulmonares/patologia
10.
Environ Sci Pollut Res Int ; 29(46): 69831-69848, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-35576028

RESUMO

Agricultural irrigation water in Northwest China accounts for more than 80% of total local water consumption, which is 1.23 times that of China. However, Northwest China is the most water-scarce place in China. Water scarcity in restricts crop growth and production. Reference crop evapotranspiration (ET0) is important for agricultural water management. Understanding the reason for ET0 change is helpful to provide a basis for rational planning of agricultural irrigation systems to conserve water. This study investigated the temporal and spatial variation characteristics of ET0 at 181 meteorological stations in Northwest China from 2000 to 2019. And the sensitive factors and dominant factors affecting ET0 change were quantitatively identified based on sensitivity analysis and contribution rate evaluation. Results showed that (1) a significant increase in maximum and minimum temperature (Tmax and Tmin), a significant decrease in sunshine duration (SD) and relative humidity (RH), and a slight increase in wind speed at 10 m height (U10) were observed. (2) Annual ET0 had an insignificant increasing trend. Spring and autumn ET0 contributed greatly to the growth of annual ET0, especially in March, May, September, October, and November. ET0 in HH (Yellow River Basin area) had decreased at annual scale, while other subregions were the opposite trend. Significant differences in monthly and seasonal changes in the spatial distribution of ET0. (3) U10 was the dominating contribution factor related to annual ET0 variability, followed by Tmin, RH, Tmax, and SD. In seasonal time scale, Tmin, SD, U10, and RH were the most dominant factors in spring, summer, autumn, and winter respectively. (4) Spatial distribution for contribution rates of various meteorological factors showed significant diversity among various subregions. The positive contribution of U10 was the major cause of the increase in ET0 in semi-arid grassland area (BGH), the southwest of "Qice line" (QCXXN), and the southeast of "Qice line" (QCXDN); the significant increase in Tmin contributed most in Qaidam Basin (CDM), Hexi inland river basin (HX), the northeast of "Qice line" (QCXDB), and the northwest of "Qice line" (QCXXB), while the contribution of decreasing SD offsets the positive effects of other factors, leading to the decrease in ET0 in HH. Our work illustrates that water management measures should be different at different spatial and temporal scales. The effect of U10 can be offset by covering, to reduce evaporation and maintain water in BGH, QCXXN, and QCXDN. And high-temperature resistant varieties are planted to adapt to temperature growth in CDM, HX, QCXDB, and QCXXB. Agricultural water management strategies should be formulated and selected according to local conditions.


Assuntos
Produtos Agrícolas , Transpiração Vegetal , China , Temperatura , Água
11.
Front Med (Lausanne) ; 9: 855141, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35462993

RESUMO

Introduction: Rheumatoid arthritis (RA) due to systemic inflammation and insulin resistance increases the risk of cardiovascular disease and reduces life expectancy. In order to develop cardiac death prevention strategies, it is necessary to estimate the prevalence of metabolic syndrome (MetS) in these patients. Methods: This systematic review and meta-analysis was performed to estimate the prevalence of MetS among patients with RA. International databases (i.e., Scopus, PubMed, Web of Science, and Google Scholar) were searched during the period of October 1 and October 10, 20121. Heterogeneity among the included studies was assessed through the Cochrane Q test statistics and I2 test. Finally, a random-effects meta-analysis model was computed to estimate the pooled prevalence of MetS. Results: Sixty-one articles with 96 groups and a sample size of 13,644 people were analyzed. The pooled prevalence of MetS was 32% (95% CI: 29.6-34.4). The highest prevalence of MetS is related to studies conducted in Asia (32.7%, 95% CI: 29-36.3) and Europe (32.7%, 95% CI: 27.5.37.9) and the lowest Prevalence was also related to studies conducted in Africa (28%, 95% CI: 28.8-32.2). The prevalence of MetS in men was 33% (95% CI: 26-39) and 34% (95% CI: 29-40) in women. Findings by diagnostic criteria showed that the highest and lowest prevalence of MetS was related to ATP III (37.5%, 95% CI: 30.9-44.2) and EGIR (14.4%, 95% CI: 10.5-18.5), respectively. Conclusions: MetS is highly prevalent in patients with RA and identification of high-risk patients is necessary to prevent cardiovascular mortality.

12.
Front Genet ; 13: 855355, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35480301

RESUMO

Gastric cancer is a kind of gastrointestinal tumor with high morbidity and mortality. Finding effective methods for early diagnosis and treatment of gastric cancer has important significance and application prospects. MicroRNAs without protein coding potential affect the occurrence and development of gastric cancer. This study aims to explore the biological function and mechanism of microRNA-107 (miR-107) in gastric cancer. The results show that miR-107 is low expressed in gastric cancer, while TRIAP1 is highly expressed; the overexpression of miR-107 can inhibit the progression of gastric cancer in vivo and in vitro, while the overexpression plasmid of TRIAP1 can restore the miR-107 mimic-induced cell proliferation and metastasis inhibition, and the small interfering RNA of TRIAP1 can inhibit the cell proliferation and invasion induced by miR-107 inhibitor. In conclusion, the results of this study show that miR-107 can inhibit the proliferation of gastric cancer in vivo and in vitro by targeting TRIAP1.

13.
Plant Dis ; 106(9): 2470-2479, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35286131

RESUMO

Bacterial infections are the cause of rhizome rot in ginger (Zingiber officinale). Key members of the endophytic microbial community in ginger rhizomes have not been identified, and their impact on the decay of rhizomes during the activation of adventitious bud development has not been investigated. High-throughput, 16S rRNA amplicon sequencing and inoculation experiments were used to analyze the microbial diversity, community structure and composition, and pathogenicity of isolated bacteria. Our results indicated that the composition of the endophytic microbiota underwent a shift during the progression of rhizome rot disease. Enterobacteriaceae, Lachnospiraceae, and the bacterial genera Clostridium, Bacteroides, Acrobacter, Dysgonomonas, Anaerosinus, Pectobacterium, and Lactococcus were relatively abundant in the bacterial community of rhizomes exhibiting bacterial decay symptoms but were also present in asymptomatic rhizomes. The presence of Enterobacteriaceae and Pseudomonadaceae were positively correlated (ρ = 0.83) at the beginning of the sampling period in the symptomatic group, while a positive correlation (ρ = 0.89) was only observed after 20 days in the asymptomatic group. These data indicate that the co-occurrence of Enterobacteriaceae and Pseudomonadaceae may be associated with the development of ginger rot. Bacterial taxa isolated from ginger rhizomes, such as Enterobacter cloacae, E. hormaechei, and Pseudomonas putida, induced obvious rot symptoms when they were inoculated on ginger rhizomes. Notably, antibiotic-producing bacterial taxa in the Streptococcaceae and Flavobacteriaceae were also relatively abundant in rhizomes with rot and appeared to be linked to the onset of rhizome rot disease. Our results provide important information on the establishment and management of disease in ginger rhizomes.


Assuntos
Gengibre , Microbiota , Bactérias/genética , Gengibre/química , Gengibre/genética , Gengibre/microbiologia , Extratos Vegetais , RNA Ribossômico 16S/genética
14.
J Environ Manage ; 310: 114753, 2022 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-35228165

RESUMO

The design of groundwater exploitation schedules with constraints on pumping-induced land subsidence is a computationally intensive task. Physical process-based groundwater flow and land subsidence simulations are high-dimensional, nonlinear, dynamic and computationally demanding, as they require solving large systems of partial differential equations (PDEs). This work is the first application of a parallelized surrogate-based global optimization algorithm to mitigate land subsidence issues by controlling the pumping schedule of multiple groundwater wellfields over space and time. The application was demonstrated in a 6500 km2 region in China, involving a large-scale coupled groundwater flow-land subsidence model that is computationally expensive in terms of computational resources, including runtime and CPU memory for one single evaluation. In addition, the optimization problem contains 50 decision variables and up to 13 constraints, which adds to the computational effort, thus an efficient optimization is required. The results show that parallel DYSOC (dynamic search with surrogate-based constrained optimization) can achieve an approximately 100% parallel efficiency when upscaling computing resources. Compared with two other widely used optimization algorithms, DYSOC is 2-6 times faster, achieving computational cost savings of at least 50%. The findings demonstrate that the integration of surrogate constraints and dynamic search process can aid in the exploration and exploitation of the search space and accelerate the search for optimal solutions to complicated problems.


Assuntos
Água Subterrânea , Algoritmos , China
15.
J Hazard Mater ; 429: 128369, 2022 05 05.
Artigo em Inglês | MEDLINE | ID: mdl-35236039

RESUMO

To properly manage nuclear wastes is critical to sustainable utilization of nuclear power and environment health. Here, we show an innovative carbiding strategy for sustainable management of radioactive graphite through digestion of carbon in H2O2. The combined action of intermolecular oxidation of graphite by MoO3 and molybdenum carbiding demonstrates success in gasifying graphite and sequestrating uranium for a simulated uranium-contaminated graphite waste. The carbiding process plays a triple role: (1) converting graphite into atomic carbon digestible in H2O2, (2) generating oxalic ligands in the presence of H2O2 to favor U-precipitation, and (3) delivering oxalic ligands to coordinate to MoVI-oxo anionic species to improve sample batching capacity. We demonstrate > 99% of uranium to be sequestrated for the simulated waste with graphite matrix completely gasifying while no detectable U-migration occurred during operation. This method has further been extended to removal of surface carbon layers for graphite monolith and thus can be used to decontaminate monolithic graphite waste with emission of a minimal amount of secondary waste. We believe this work not only provides a sustainable approach to tackle the managing issue of heavily metal contaminated graphite waste, but also indicates a promising methodology toward surface decontamination for irradiated graphite in general.


Assuntos
Grafite , Resíduos Radioativos , Radioatividade , Urânio , Carbono , Digestão , Resíduos Perigosos , Peróxido de Hidrogênio , Molibdênio , Resíduos Radioativos/análise , Resíduos Radioativos/prevenção & controle
16.
Foods ; 11(6)2022 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-35327295

RESUMO

This study was designed to co-load sialic acid (SA) and chitosan in a water-in-oil (W/O) emulsion and investigated its characterization and stability. Emulsions were prepared using two different oils (olive oil and maize oil) and polyglycerol polyricinoleate (PGPR) alone or in combination with lecithin (LE) as emulsifiers. The results revealed that the aqueous phase of 5% (w/v) SA and 2% (w/v) chitosan could form a stable complex and make the aqueous phase into a transparent colloidal state. Increasing the concentration of PGPR and LE presented different effects on emulsion formation between olive oil-base and maize oil-base. Two stable W/O emulsions that were olive oil-based with 1.5% (w/v) PGPR+ 0.5% (w/v) LE and maize oil-based with 2% (w/v) PGPR+ 0% (w/v) LE were obtained. Initial droplet size distribution curves of the two stable emulsions displayed unimodal distribution, and the rheological curves displayed the characteristics of shear thinning and low static shear viscosity. Moreover, the storage stability showed that there was no significant change in droplet size distribution and Sauter mean diameter of the emulsions at room temperature (25 °C) for 30 days. These results indicated that the W/O emulsions could effectively co-load and protect sialic acid and chitosan and thus could be a novel method for increasing the stability of these water-soluble bioactive compounds.

17.
J Hazard Mater ; 432: 128631, 2022 06 15.
Artigo em Inglês | MEDLINE | ID: mdl-35306412

RESUMO

Mercury (Hg), and its organic forms, are some of the most hazardous elements, with strong toxicity, persistence, and biological accumulation in marine organisms. Hg accumulation in continuous trophic levels (TL) in marine food chains remains unclear. In this study, individual invertebrate and fish samples collected from the Yellow River Estuary adjacent sea were grouped into continuous TL ranges, and the bioaccumulations of total Hg (THg) and methylmercury (MeHg) were analyzed. The trophic magnification factor in invertebrates and fish was 1.40 and 1.72 for THg, and 2.56 and 2.17 for MeHg, indicating that both THg and MeHg were significantly biomagnified with increasing TL in both invertebrates and fish through trophic transfer. To evaluate the health risk of seafood consumption, the target hazard quotient (THQ) was calculated. Increasing THQ values indicated that the health risks of invertebrate and fish consumption in humans, especially children, were both elevated with increasing TL. THQ values > 1 indicated that consumption of invertebrates at a TL above 4.0 and fish above 4.5 may pose a relatively higher risk for children. Therefore, the consumption of both individual invertebrates and fish at high trophic positions may present greater health risk, especially in young children.


Assuntos
Mercúrio , Compostos de Metilmercúrio , Poluentes Químicos da Água , Animais , Bioacumulação , Monitoramento Ambiental , Estuários , Peixes , Cadeia Alimentar , Invertebrados , Mercúrio/análise , Compostos de Metilmercúrio/análise , Isótopos de Nitrogênio , Rios , Poluentes Químicos da Água/análise
18.
Acta Biochim Biophys Sin (Shanghai) ; 54(2): 173-178, 2022 01 25.
Artigo em Inglês | MEDLINE | ID: mdl-35130627

RESUMO

Chronic obstructive pulmonary disease (COPD) has been increasingly accounted for global morbidity and mortality worldwide. Although it is partially reversible, the obstructive ventilatory schema of COPD often causes chronic inflammation that primarily affects peripheral airways, pulmonary parenchyma, and the development of lung lymphoid follicles. Among various T-helper (Th) cell types associated with COPD, Th1, Th2 and Th17 cell numbers are increased in COPD patients, whereas Treg cell number is reduced. Here, we reviewed recent advance in understanding the roles of Th1/Th2 and Th17/Treg in the pathogenesis of COPD and discussed the potential underlying mechanism.


Assuntos
Doença Pulmonar Obstrutiva Crônica , Linfócitos T CD4-Positivos/metabolismo , Humanos , Pulmão/metabolismo , Doença Pulmonar Obstrutiva Crônica/patologia , Linfócitos T Reguladores/metabolismo , Células Th17/metabolismo
19.
Cell Mol Gastroenterol Hepatol ; 13(1): 19-33, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34547535

RESUMO

The stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high mortality rate and limited treatment options. The heterogeneous nature of GC makes it poorly suited for current "one size fits all" standard treatments. In this review, we discuss the rapidly evolving field of gastric organoids, with a focus on studies expanding cultures from primary human tissues and describing the benefits of mouse organoid models. We introduce the differing methods for culturing healthy gastric tissue from adult tissues or pluripotent stem cells, discuss the promise these systems have for preclinical drug screens, and highlight applications of organoids for precision medicine. Finally, we discuss the limitations of these models and look to the future to present potential ways gastric organoids will advance treatment options for patients with GC.


Assuntos
Organoides , Neoplasias Gástricas , Animais , Modelos Animais de Doenças , Humanos , Camundongos , Medicina de Precisão
20.
Exp Ther Med ; 22(6): 1386, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34650634

RESUMO

Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease characterized by incomplete reversible airflow limitation. The diagnosis of COPD is mainly based on pulmonary function examination. In recent years, it has been indicated that small airway dysfunction occurs in patients with all stages of COPD, even in high-risk smoking groups who have not yet met the diagnostic criteria for COPD. Early recognition of small airway dysfunction and early initiation of small airway targeted therapy have become foci of research. In the present review, the methods of evaluating small airway function were summarized and their merits and shortcomings were discussed. Furthermore, the potential of targeted treatment of small airways in patients with COPD was outlined.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...