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1.
BMC Med Ethics ; 20(1): 95, 2019 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-31842842

RESUMO

People with lived experience are individuals who have first-hand experience of the medical condition(s) being considered. The value of including the viewpoints of people with lived experience in health policy, health care, and health care and systems research has been recognized at many levels, including by funding agencies. However, there is little guidance or established best practices on how to include non-academic reviewers in the grant review process. Here we describe our approach to the inclusion of people with lived experience in every stage of the grant review process. After a budget was created for a specific call, a steering committee was created. This group included researchers, people with lived experience, and health systems administrators. This group developed and issued the call. After receiving proposals, stage one was scientific review by researchers. Grants were ranked by this score and a short list then reviewed by people with lived experience as stage two. Finally, for stage three, the Steering Committee convened and achieved consensus based on information drawn from stages one and two. Our approach to engage people with lived experience in the grant review process was positively reviewed by everyone involved, as it allowed for patient perspectives to be truly integrated. However, it does lengthen the review process. The proposed model offers further practical insight into including people with lived experience in the review process.

2.
An Pediatr (Barc) ; 2019 Apr 09.
Artigo em Espanhol | MEDLINE | ID: mdl-30979682

RESUMO

INTRODUCTION: Neonatal jaundice is common, especially in premature infants. Compliance with treatment protocols and standard serum bilirubin curves forces the clinician to separate the child from the mother after birth for short phototherapy. The objective of this study is to evaluate the effectiveness and safety of two innovative devices for phototherapy including a LED light mesh: one sleeping bag and one blanket compared to conventional hospital or ambulatory phototherapy. METHODS: Two randomised clinical trials were conducted: one with newborns >2,000g at birth in the Neonatal Care Unit and the other with premature infants followed-up in an outpatient clinic (PMC). The gold standard for bilirubin measurement was serum bilirubin, and ambulatory controls were performed with the Bilicheck®. Parents and health personnel completed a questionnaire on comfort and perceptions. RESULTS: In the study using the bag, a linear regression was performed for the decrease in bilirubin in mg/dL/h, controlling by early jaundice (<36h) and the device type. The results were similar between the 2 devices. For the blanket trial in the PMC, the decrease in bilirubin levels with the new device was significantly greater with no differences in temperatures, duration of phototherapy, re-admission, mortality, or side effects for both trials. Parents and staff satisfaction with the two devices was identical for the 2 trials. CONCLUSION: These 2 small studies add a 'grain of sand' to humanisation of newborn care, avoiding the mother-and-child separation for both the intra-hospital high-risk hyperbilirubinaemia, as well as for the lower-risk hyperbilirubinaemia in an outpatient clinic.

4.
Glob Public Health ; 14(6-7): 977-995, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30407893

RESUMO

Social Determination of Health (SDH)/Collective Health is a Latin American framework that sees the Marxist core concept of social class as fundamental for understanding health inequalities. In contrast to social stratification approaches, Marxist proposals seek to understand health as part of the historical transformations of capitalism's mode of production. In this article we aim to analyze the relationship between social class and health inequalities using data from the IV Oral Health National Study in Colombia. We conducted hierarchical cluster analyses to classify the population in five class positions and three living conditions clusters, which reflect how the spheres of production and social reproduction relate to social classes in Colombia. To measure oral health we use DMFT, as well as care and treatment needs indexes. Through variance analysis models we found that people from more exploited class positions and worse living conditions have more active disease and higher treatment needs. Despite technical and conceptual challenges, we conclude that a social class analytical framework can be operationalised via the interrelated spheres of production and social reproduction, which sheds light on the relationship between health inequalities and the class structure of the capitalist system.

5.
Buenos Aires; Médica Panamericana; 2019. 160 p. ilus, tab.
Monografia em Espanhol | LILACS | ID: biblio-1026447

RESUMO

Las consultas pediátricas por temas infectológicos son frecuentes y relevantes durante toda la infancia, desde la etapa neonatal hasta la adolescencia. En este nuevo volumen de las Series Garrahan: El ñino y las infecciones, se han seleccionado temas específicos, sobre la base de la actualización del conocimiento, los cambios epidemiológicos y de las conductas clínicas ocurridos en los últimos años y la necesidad del manejo adecuado de estas afecciones, ya sea ambulatorio o durante la internación. Entre sus aspectos sobresalientes se incluyen: El estudio de temas destacados como el abordaje del niño febril; las infecciones de piel y partes blandas, incluidas las asociadas con mordeduras; las infecciones en el recién nacido; las infecciones respiratorias bajas, incluida la tuberculosis; y las infecciones osteoarticulares, del sistema nervioso central e intraabdominales. La inclusión de un capítulo especial sobre la prevención de infecciones para ayudar a reducir su incidencia. El enfoque práctico, con discusión de casos clínicos y definición de conductas, y ubicando al pediatra en un papel central como coordinador de la atención interdisciplinaria. Aspectos clave y lecturas recomendadas en el cierre de cada capítulo. Una obra actualizada que aporta información científica y la experiencia de los profesionales del Hospital Garrahan, dedicada a todos los miembros del equipo de salud que atienden y cuidan niños dondequiera que trabajen al servicio de la salud infantil


Assuntos
Humanos , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Osteomielite , Peritonite , Pneumonia , Febre Recorrente , Dermatopatias Infecciosas , Tuberculose , Mordeduras e Picadas , Artrite Infecciosa , Coqueluche , Vacinação , Meningites Bacterianas , Antibioticoprofilaxia , Febre , Febre de Causa Desconhecida , Encefalite Infecciosa , Sepse Neonatal
6.
Soc Sci Med ; 215: 142-150, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30236829

RESUMO

Chagas disease (CD) is a Latin America endemic and neglected tropical disease that affects primarily poor people living in rural areas. Its current low profile leads to many diagnostic, treatment, and control challenges. This study aimed to identify and characterize the sociocultural dynamics that influence CD health care in Colombia. Data for our ethnographic study was collected in 2013 and included participant observation in two main endemic areas in Colombia. In addition, 81 people belonging to four groups (patients and family members; health care workers; researchers; and officers) were recruited through snowball sampling technique and participated in informal and semi-structured interviews. People from the first two groups also participated in social cartography excercises. Data analysis resulted in the identification of three main sociocultural dynamics. Local Understandings: Patients reported confusions around disease transmission, treatment effectiveness and development of future complications. Providers' Knowledge and Training: Failures in professional's knowledge and training mostly affect the primary level of care in rural areas. Professionals undergo minimal training during medical school and lack access to continuous education. In contrast, clinicians working at tertiary university hospitals or at the CD unit of the Colombian National Institute of Health (NIH) exhibited great knowledge and competency. Health Care System Barriers: The Colombian market-based health care reform augmented access barriers, which impacted CD care greatly. We identified geographic and bureaucratic itineraries that depended on type of insurance plan, insurance contracts with service providing institutions, and levels of care. This study shows that people's experience of these sociocultural dynamics vary depending on their mobility from rural to urban contexts. It unveils the importance of analyzing the structure of the health care system. In the Colombian case, its for-profit orientation has become one of the most important obstacles for comprehensive, integrated, and timely health care responses.


Assuntos
Doença de Chagas/terapia , Assistência à Saúde/métodos , Fatores Socioeconômicos , Adulto , Idoso , Antropologia Cultural/métodos , Colômbia , Feminino , Humanos , Masculino , Relações Profissional-Paciente , Comportamento Social
7.
Glob Public Health ; 12(10): 1228-1241, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-27079365

RESUMO

This article offers a conceptual framework that arises out of the Latin American Social Medicine/Collective Health (LASM/CH) tradition to comprehend inequalities in oral health. We conducted a dialogue between the LASM/CH proposal called social determination of health (in particular one of its nuclear categories 'ways of living together') and studies that address social inequalities and oral health. This dialogue allowed us to redefine oral health-disease-treatment as a process that either promotes or harms well-being and is modulated by different ways of living together where not only patients and professionals, but also governments, supranational bodies, and national and international markets represented by food, pharmaceutical, insurance, personal care, and cosmetic companies interact. The article proposes the cycle particular-consumption care/institutional-consumption care as the construct that allows investigators to think about how ways of living together relate to oral health inequalities. 'Particular-consumption care' includes ways and possibilities to access healthy foods and practice protective hygienic measures. 'Institutional-consumption care' refers to institutional responses related to supply, access to services, capabilities for resolution, and pedagogical practices.


Assuntos
Disparidades nos Níveis de Saúde , Saúde Bucal , Medicina Social , Grupos Focais , Humanos , América Latina , Pesquisa Qualitativa
8.
Psychol. av. discip ; 10(1): 113-123, ene.-jun. 2016. ilus
Artigo em Espanhol | LILACS-Express | ID: biblio-956056

RESUMO

Resumen El objetivo de este estudio fue reducir los niveles de celos en seis mujeres, estudiantes universitarias, con edades entre los 18 y 35 años de edad, que presentaban celos patológicos. El proceso terapéutico utilizado se basó en la guía de intervención cognitivo comportamental para el manejo de los celos en la relación de pareja. La intervención tuvo una duración de dos meses y se desarrolló en siete sesiones, bajo un diseño AB y con seguimiento a los 6 meses a dos de las consultantes. Los resultados muestran una disminución en el puntaje de la Escala Interpersonal de Celos. Se encontraron diferencias significativas en los resultados globales de la escala en la aplicación pre y pos test (p<,05), así como en la frecuencia de conductas asociadas al problema. Se discuten las bondades y limitaciones de la intervención.


Abstract The aim of this study was to reduce the level of jealousy in six female college students with ages ranging from 18 to 35 years who presented pathological jealousy. The therapeutic process used was based on the cognitive-behavioral intervention guide for jealousy management in couple relationships. Under an AB design, the intervention had a timespan of two months and was developed throughout seven sessions. A follow-up was performed six months later for two of the six subjects. The results show a decrease in Interpersonal Jealousy Scale score and significant differences were found in the global results of the IJS scores in pre- and post-application of the intervention (p<,05). Other differences were seen in the frequency of behavior associated to problematic jealousy. The strengths and limitations of the intervention are discussed.

9.
J Mol Endocrinol ; 56(2): 113-22, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26643909

RESUMO

Increasing thermogenesis in white adipose tissues can be used to treat individuals at high risk for obesity and cardiovascular disease. The objective of this study was to determine the function of EP300-interacting inhibitor of differentiation (EID1), an inhibitor of muscle differentiation, in the induction of beige adipocytes from adipose mesenchymal stem cells (ADMSCs). Subcutaneous adipose tissue was obtained from healthy women undergoing abdominoplasty. ADMSCs were isolated in vitro, grown, and transfected with EID1 or EID1 siRNA, and differentiation was induced after 48 h by administering rosiglitazone. The effects of EID1 expression under the control of the aP2 promoter (aP2-EID1) were also evaluated in mature adipocytes that were differentiated from ADMSCs. Transfection of EID1 into ADMSCs reduced triglyceride accumulation while increasing levels of thermogenic proteins, such as PGC1α, TFAM, and mitochondrial uncoupling protein 1 (UCP1), all of which are markers of energy expenditure and mitochondrial activity. Furthermore, increased expression of the beige phenotype markers CITED1 and CD137 was observed. Transfection of aP2-EID1 transfection induced the conversion of mature white adipocytes to beige adipocytes, as evidenced by increased expression of PGC1α, UCP1, TFAM, and CITED1. These results indicate that EID1 can modulate ADMSCs, inducing a brown/beige lineage. EID1 may also activate beiging in white adipocytes obtained from subcutaneous human adipose tissue.


Assuntos
Adipócitos Brancos/fisiologia , Adipogenia , Células-Tronco Mesenquimais/fisiologia , Proteínas Nucleares/metabolismo , Proteínas Repressoras/metabolismo , Adulto , Proteínas de Ciclo Celular , Células Cultivadas , Feminino , Expressão Gênica , Humanos , Proteínas Nucleares/genética , PPAR gama/fisiologia , Proteínas Repressoras/genética , Gordura Subcutânea/citologia , Adulto Jovem
10.
Rev. colomb. rehabil ; 13|(1): 88-95, 2014. ilus, graf
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-912010

RESUMO

Según la OMS el acceso a los servicios básicos de formación en personas con discapacidad se ve ampliamente limitado, impactando negativamente en los procesos de inclusión laboral. Se propuso el objetivo de identificar la evidencia científica relacionada con el acceso a la forma-ción superior de personas con discapacidad. Se realizó la búsqueda de evidencia en las bases de datos Labordoc, Ebsco, Scielo y Lilacs, a través de los tesauros "Discapacidad", "Competencias laborales", "Profesional", "Formación", "Tecnológico", "Técnico", "Educación superior" "estu-dio"y "Terapia Ocupacional", realizando con estos 10 combinaciones mediante el uso del boléano "AND". Los análisis fueron realizados mediante el establecimiento de frecuencias para variables como país, tipo de estudio, idioma y periodo de publicación. Se encontró un total de 20 artícu-los, en donde la mayor publicación fue Labordoc con el 45%, el periodo de tiempo con más pu-blicaciones es entre 2009-2013 con un 45%, el idioma con más evidencia fue el inglés con el 60%, Brasil y Colombia fueron los países con mayor número de publicaciones, cada uno con un 15%. En el marco legislativo en discapacidad, se hacen evidentes aún las brechas entre la normatividad y la realidad, especialmente en la ejecución e implementación de programas, así como la falta de participación de diversas profesiones, por lo que a partir de este análisis, se hace extensiva la invitación a investigar y publicar artículos con relación a la formación superior desde cada uno de los enfoques de formación.


According to WHO access to basic training in people with disabilities is greatly limited negative impact on the processes of labor inclusion. To identify the scientific evidence related the access to higher education for people with disabilities. The search for evidence on the basis of Labor-doc , Ebsco , Lilacs and SciELO data was conducted through thesauri "Disability" , "Skills ", " Professional ", " Training ", " Technology ", " Technical " "Higher Education " and " Occupa-tional Therapy" , performing with these 10 combinations using the boolean "AND". Analyses were performed by setting frequencies for variables such as country, study type , language and publication period . A total of 20 items , where most public Labordoc with 45% , was found the time most published between 2009-2013 is 45% , most evidently language was English with 60 % , Brazil and Colombia were the countries with the highest number of publications , each with 15% . Despite major advances in the legislative framework on disability, are evident even gaps between norms and reality, especially in the execution and implementation of programs and the lack of participation of various professions , so from this analysis is extended the invitation to research and publish articles regarding the top from each training approaches training.


Assuntos
Humanos , Terapia Ocupacional , Pessoas com Deficiência , Educação , Pesquisa
11.
Arch Argent Pediatr ; 111(3): 202-5, 2013 Jun.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-23732345

RESUMO

Invasive pneumococcal diseases are the main cause of morbidity and mortality in children. In the Hospital "Prof. Dr. Juan P. Garrahan", between October 1st , 2008 and September 30th, 2011 all invasive pneumococcal diseases with positive blood cultures were retrospectively studied before the implementation of the universal immunization schedule with the 13-valent pneumococcal conjugate vaccine. A total of 124 patients were identified, and their mean age was 48.3 months (range: 1-216). In this population, 58.9% (n: 73) were OVER 2 years old and 89% (n: 65) of them had an underlying disease. The most frequent clinical presentation was pneumonia. The most frequent S. pneumoniae serotypes identified were: 14 (22.5%, n: 25), 6 (14.4%, n: 16), 19 (8.1%, n: 9), 23 (7.2%, n: 8), 1 (6.3%, n: 7), 5 (4.5%, n: 5), and 7 (7.2%, n: 8). Of the S. pneumoniae serotypes in this series, 82.2% is included in the 13-valent pneumococcal conjugate vaccine. Continuous epidemiological surveillance is essential to further identify the epidemiology and study the evolution of invasive pneumococcal disease in Argentina.


Assuntos
Infecções Pneumocócicas/diagnóstico , Infecções Pneumocócicas/microbiologia , Streptococcus pneumoniae/classificação , Adolescente , Criança , Pré-Escolar , Feminino , Hospitais Pediátricos , Humanos , Lactente , Masculino , Vacinas Pneumocócicas , Estudos Retrospectivos , Sorotipagem , Centros de Atenção Terciária , Vacinas Conjugadas
12.
Arch. argent. pediatr ; 111(3): 202-205, jun. 2013. graf, tab
Artigo em Espanhol | LILACS | ID: lil-694626

RESUMO

Las enfermedades invasivas por neumococo constituyen la principal causa de morbimortalidad en los niños. En el Hospital "Prof. Dr. Juan P. Garrahan" se estudiaron retrospectivamente todas las infecciones invasivas por neumococo con hemocultivos positivos entre el 1 de octubre de 2008 y el 30 de septiembre de 2011, antes de la vacunación universal con la vacuna conjugada de 13 serotipos. Se identificaron 124 pacientes, con una media de edad de 48,3 meses (r: 1-216). El 58,9% de la población era mayor de 2 años (n: 73) y el 89% (n: 65) de ellos tenían una enfermedad de base. La principal forma de presentación fue la neumonía. Los serotipos de S. pneumoniae más frecuentes fueron: 14 (22,5%, n: 25), 6 (14,4%, n: 16), 19 (8,1%, n: 9), 23 (7,2%, n: 8), 1 (6,3%, n: 7), 5 (4,5%, n: 5) y 7 (7,2%, n: 8). El 82,8% de los serotipos de S. pneumoniae de esta serie están incluidos en la vacuna conjugada de 13 serotipos. Es esencial mantener la vigilancia epidemiológica para identificar la evolución y epidemiología de la enfermedad invasiva por neumococo en la Argentina.


Invasive pneumococcal diseases are the main cause of morbidity and mortality in children. In the Hospital "Prof. Dr. Juan P. Garrahan", between October 1st , 2008 and September 30th, 2011 all invasive pneumococcal diseases with positive blood cultures were retrospectively studied before the implementation of the universal immunization schedule with the 13-valent pneumococcal conjugate vaccine. A total of 124 patients were identified, and their mean age was 48.3 months (range: 1-216). In this population, 58.9% (n: 73) were OVER 2 years old and 89% (n: 65) of them had an underlying disease. The most frequent clinical presentation was pneumonia. The most frequent S. pneumoniae serotypes identified were: 14 (22.5%, n: 25), 6 (14.4%, n: 16), 19 (8.1%, n: 9), 23 (7.2%, n: 8), 1 (6.3%, n: 7), 5 (4.5%, n: 5), and 7 (7.2%, n: 8). Of the S. pneumoniae serotypes in this series, 82.2% is included in the 13-valent pneumococcal conjugate vaccine. Continuous epidemiological surveillance is essential to further identify the epidemiology and study the evolution of invasive pneumococcal disease in Argentina.


Assuntos
Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Infecções Pneumocócicas/diagnóstico , Infecções Pneumocócicas/microbiologia , Streptococcus pneumoniae/classificação , Hospitais Pediátricos , Vacinas Pneumocócicas , Estudos Retrospectivos , Sorotipagem , Centros de Atenção Terciária , Vacinas Conjugadas
13.
Arch. argent. pediatr ; 111(3): 202-205, jun. 2013. graf, tab
Artigo em Espanhol | BINACIS | ID: bin-130945

RESUMO

Las enfermedades invasivas por neumococo constituyen la principal causa de morbimortalidad en los niños. En el Hospital "Prof. Dr. Juan P. Garrahan" se estudiaron retrospectivamente todas las infecciones invasivas por neumococo con hemocultivos positivos entre el 1 de octubre de 2008 y el 30 de septiembre de 2011, antes de la vacunación universal con la vacuna conjugada de 13 serotipos. Se identificaron 124 pacientes, con una media de edad de 48,3 meses (r: 1-216). El 58,9% de la población era mayor de 2 años (n: 73) y el 89% (n: 65) de ellos tenían una enfermedad de base. La principal forma de presentación fue la neumonía. Los serotipos de S. pneumoniae más frecuentes fueron: 14 (22,5%, n: 25), 6 (14,4%, n: 16), 19 (8,1%, n: 9), 23 (7,2%, n: 8), 1 (6,3%, n: 7), 5 (4,5%, n: 5) y 7 (7,2%, n: 8). El 82,8% de los serotipos de S. pneumoniae de esta serie están incluidos en la vacuna conjugada de 13 serotipos. Es esencial mantener la vigilancia epidemiológica para identificar la evolución y epidemiología de la enfermedad invasiva por neumococo en la Argentina.(AU)


Invasive pneumococcal diseases are the main cause of morbidity and mortality in children. In the Hospital "Prof. Dr. Juan P. Garrahan", between October 1st , 2008 and September 30th, 2011 all invasive pneumococcal diseases with positive blood cultures were retrospectively studied before the implementation of the universal immunization schedule with the 13-valent pneumococcal conjugate vaccine. A total of 124 patients were identified, and their mean age was 48.3 months (range: 1-216). In this population, 58.9% (n: 73) were OVER 2 years old and 89% (n: 65) of them had an underlying disease. The most frequent clinical presentation was pneumonia. The most frequent S. pneumoniae serotypes identified were: 14 (22.5%, n: 25), 6 (14.4%, n: 16), 19 (8.1%, n: 9), 23 (7.2%, n: 8), 1 (6.3%, n: 7), 5 (4.5%, n: 5), and 7 (7.2%, n: 8). Of the S. pneumoniae serotypes in this series, 82.2% is included in the 13-valent pneumococcal conjugate vaccine. Continuous epidemiological surveillance is essential to further identify the epidemiology and study the evolution of invasive pneumococcal disease in Argentina.(AU)


Assuntos
Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Infecções Pneumocócicas/diagnóstico , Infecções Pneumocócicas/microbiologia , Streptococcus pneumoniae/classificação , Hospitais Pediátricos , Vacinas Pneumocócicas , Estudos Retrospectivos , Sorotipagem , Centros de Atenção Terciária , Vacinas Conjugadas
14.
Arch. argent. pediatr ; 111(3): 202-205, jun. 2013. tab, graf
Artigo em Espanhol | LILACS | ID: lil-748661

RESUMO

Las enfermedades invasivas por neumococo constituyen la principal causa de morbimortalidad en los niños. En el Hospital "Prof. Dr. Juan P. Garrahan" se estudiaron retrospectivamente todas las infecciones invasivas por neumococo con hemocultivos positivos entre el 1 de octubre de 2008 y el 30 de septiembre de 2011, antes de la vacunación universal con la vacuna conjugada de 13 serotipos. Se identificaron 124 pacientes, con una media de edad de 48,3 meses (r: 1-216). El 58,9% de la población era mayor de 2 años (n: 73) y el 89% (n: 65) de ellos tenían una enfermedad de base. La principal forma de presentación fue la neumonía. Los serotipos de S. pneumoniae más frecuentes fueron: 14 (22,5%, n: 25), 6 (14,4%, n: 16), 19 (8,1%, n: 9), 23 (7,2%, n: 8), 1 (6,3%, n: 7), 5 (4,5%, n: 5) y 7 (7,2%, n: 8). El 82,8% de los serotipos de S. pneumoniae de esta serie están incluidos en la vacuna conjugada de 13 serotipos. Es esencial mantener la vigilancia epidemiológica para identificar la evolución y epidemiología de la enfermedad invasiva por neumococo en la Argentina...


Assuntos
Humanos , Bacteriemia , Infecções Pneumocócicas , Pneumonia , Streptococcus pneumoniae
15.
Arch. argent. pediatr ; 111(3): 202-5, 2013 Jun.
Artigo em Espanhol | BINACIS | ID: bin-133107

RESUMO

Invasive pneumococcal diseases are the main cause of morbidity and mortality in children. In the Hospital "Prof. Dr. Juan P. Garrahan", between October 1st , 2008 and September 30th, 2011 all invasive pneumococcal diseases with positive blood cultures were retrospectively studied before the implementation of the universal immunization schedule with the 13-valent pneumococcal conjugate vaccine. A total of 124 patients were identified, and their mean age was 48.3 months (range: 1-216). In this population, 58.9


(n: 73) were OVER 2 years old and 89


(n: 65) of them had an underlying disease. The most frequent clinical presentation was pneumonia. The most frequent S. pneumoniae serotypes identified were: 14 (22.5


, n: 25), 6 (14.4


, n: 16), 19 (8.1


, n: 9), 23 (7.2


, n: 8), 1 (6.3


, n: 7), 5 (4.5


, n: 5), and 7 (7.2


, n: 8). Of the S. pneumoniae serotypes in this series, 82.2


is included in the 13-valent pneumococcal conjugate vaccine. Continuous epidemiological surveillance is essential to further identify the epidemiology and study the evolution of invasive pneumococcal disease in Argentina.


Assuntos
Infecções Pneumocócicas/diagnóstico , Infecções Pneumocócicas/microbiologia , Streptococcus pneumoniae/classificação , Adolescente , Criança , Pré-Escolar , Feminino , Hospitais Pediátricos , Humanos , Lactente , Masculino , Vacinas Pneumocócicas , Estudos Retrospectivos , Sorotipagem , Centros de Atenção Terciária , Vacinas Conjugadas
17.
J Pediatr Hematol Oncol ; 33(1): e5-8, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21178704

RESUMO

BACKGROUND: The impact of the novel 2009 influenza A (H1N1) (2009 H1N1) virus in children with malignant diseases under therapy is not well known. OBJECTIVE: To analyze the clinical features and outcome in children with anticancer therapy infected with the 2009 H1N1 virus. PATIENTS AND METHODS: Descriptive, case-control study. Between May and July 2009, 24 cases of 2009 (H1N1) virus infections in children with malignant diseases were registered and 48 control cases of similar patients infected with common influenza A virus (IA) diagnosed between 2006 and 2008 were selected. RESULTS: Median age for cases was 72 months and for controls was 83 months (P ≥ 0.05). Children with IA showed neutropenia more frequently (52% vs. 17%), longer period of time with illness before diagnosis (3 d vs. 1.7 d), higher rate of earlier medical consultation (69% vs. 25%), and more antibiotic therapy courses (54% vs. 4%; P ≤ 0.05) than patients with 2009 H1N1 virus. Children infected with this virus presented hypoxemia more frequently (42% vs. 8%) and higher rates of intensive care unit hospitalizations (29% vs. 2%; P ≤ 0.05). Three children with 2009 H1N1 virus and 1 in the control group died. CONCLUSIONS: Children infected with 2009 H1N1 virus presented more morbidity and mortality than patients infected with seasonal IA virus.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Vírus da Influenza A Subtipo H1N1 , Influenza Humana/complicações , Neoplasias/complicações , Neoplasias/tratamento farmacológico , Adolescente , Antibacterianos/uso terapêutico , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , Humanos , Hipóxia/tratamento farmacológico , Lactente , Recém-Nascido , Influenza Humana/mortalidade , Influenza Humana/virologia , Masculino , Neoplasias/mortalidade , Neoplasias/virologia , Resultado do Tratamento
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