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1.
Ter Arkh ; 91(8): 118-126, 2019 Aug 15.
Artigo em Russo | MEDLINE | ID: mdl-32598763

RESUMO

In the article the problem of the combined use of clopidogrel and various proton pump inhibitors (PPIs) in terms of cardiovascular complications risk and stent thrombosis is considered. The results of meta - analyses and a systematic reviews affecting this issue are represented in detail. The inter - drug interactions mechanisms of various PPIs with clopidogrel based on the characteristics of the metabolism in the liver cytochromes system are discussed. The authors conducted a search, systematization and analysis of studies regarding the association between cardiovascular risk and combined use of individual medications from PPI class with clopidogrel, and these results are presented in the review. Currently available data do not allow to answer the question about the differences between individual PPIs in their impact on the risk of adverse cardiovascular events due to the small number of such studies, design heterogeneity, differences in the inclusion criteria and end points as well as in the rate of administration of individual PPIs.


Assuntos
Doenças Cardiovasculares , Clopidogrel , Interações Medicamentosas , Inibidores da Agregação Plaquetária , Inibidores da Bomba de Prótons , Doenças Cardiovasculares/induzido quimicamente , Clopidogrel/efeitos adversos , Quimioterapia Combinada , Humanos , Inibidores da Agregação Plaquetária/efeitos adversos , Inibidores da Bomba de Prótons/efeitos adversos , Ticlopidina , Resultado do Tratamento
2.
Kardiologiia ; 57(11): 68-75, 2017 Nov.
Artigo em Russo | MEDLINE | ID: mdl-29276920

RESUMO

The article is devoted to the modern state of the problem of blood pressure variability (BPV). Along with discussion of classification and methods of diagnosis it contains data on prognostic value of visit-to-visit BPV. We have also reviewed effect on BPV of various regimens of antihypertensive therapy and presented evidence base supporting ability of amlodipine/perindopril fixed dose combination to lower visit-to-visit BPV.


Assuntos
Hipertensão , Anlodipino , Anti-Hipertensivos , Pressão Sanguínea , Determinação da Pressão Arterial , Combinação de Medicamentos , Humanos , Perindopril
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