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1.
Georgian Med News ; (316-317): 173-178, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34511467

RESUMO

The advantage of polylactide-based implants is their rapid and complete biodegradation, followed by replacement of the defect with bone tissue. The disadvantage of materials with a high biodegradation rate is their low support ability. The admixture of ceramic materials increases the strength of the implants and reduces the rate of biodegradation. 3D printing technology allows you to reduce the negative factors of ceramic impurities through the manufacture of implants of various porosities. Target. Determine the ultimate strength of a composite material based on PLA and TCP, manufactured by 3D printing with different porosity options, depending on the duration of hydration. Were made 9 samples of material with a size of 10x10x10 mm with different porosity 40%, 30%, 20%. Samples of the material were hydrated in saline. Strength tests were carried out on days 2, 10, and 20 after hydration, 3 samples of material of each porosity. All samples were tested for compression. The carried out comparative analysis indicates that the tested samples are statistically significant (at the level of p <0.05) differ from each other depending on the value of porosity at all periods of hydration. Although the average values of the ultimate strength of samples of the same porosity tend to decrease depending on the period of their hydration, these changes do not acquire statistical significance even between the extreme periods of observation. This is confirmed by the values of the indicator of the statistical significance of the differences p equal to 0.07; 0.759 and 0.124 for specimens with porosity of 20%, 30% and 40%, respectively. The tensile strength of samples of material based on polylactide and tricalcium phosphate, made using 3D printing, directly depends on their porosity, the smaller the pore volume, the stronger the samples. The hydration of the samples in saline solution for 20 days does not entail statistically significant changes in their strength regardless of the pore volume, although the average values of the ultimate strength for all tested samples tend to decrease.


Assuntos
Poliésteres , Tecidos Suporte , Fosfatos de Cálcio , Teste de Materiais , Porosidade , Impressão Tridimensional
2.
Chaos ; 31(4): 043110, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34251250

RESUMO

Multiresolution wavelet analysis (MWA) is a powerful data processing tool that provides a characterization of complex signals over multiple time scales. Typically, the standard deviations of wavelet coefficients are computed depending on the resolution level and such quantities are used as measures for diagnosing different types of system behavior. To enhance the capabilities of this tool, we propose a combination of MWA with detrended fluctuation analysis (DFA) of detail wavelet coefficients. We find that such an MWA&DFA approach is capable of revealing the correlation features of wavelet coefficients in independent ranges of scales, which provide more information about the complex organization of datasets compared to variances or similar statistical measures of the standard MWA. Using this approach, we consider changes in the dynamics of coupled chaotic systems caused by transitions between different types of complex oscillations. We also demonstrate the potential of the MWA&DFA method for characterizing different physiological conditions by analyzing the electrical brain activity in mice.


Assuntos
Dinâmica não Linear , Análise de Ondaletas , Animais , Camundongos
3.
Opt Lett ; 46(14): 3360-3363, 2021 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-34264213

RESUMO

In this Letter, optical-to-terahertz (THz) conversion of 800 nm femtosecond laser pulses in large-area bias-free InGaAs emitters based on photo-Dember (PD) and lateral photo-Dember (LPD) effects is experimentally investigated. We use metamorphic buffers to grow sub-micrometer thick InxGa1-xAs layers with indium mole fractions x=0.37, 0.53, and 0.70 on a GaAs substrate. A strong enhancement of THz output energy with an increase of indium content is observed. On the surface of the sample providing the strongest emission (x=0.7), we have fabricated a 1.5cm2 area of asymmetrically shaped metallic grating for LPD emission. This LPD emitter allows achieving high conversion efficiency of 0.24⋅10-3 and a broad generation bandwidth of up to 6 THz. We also demonstrate that there is no significant difference in the conversion efficiency when operating at 1 and 200 kHz repetition rates. Our results show that large-area LPD emitters give a convenient, competitive way to generate intense high-repetition-rate THz pulses.

4.
Scanning ; 2021: 7626725, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33560277

RESUMO

[This corrects the article DOI: 10.1002/sca.4950190702.].

5.
Khirurgiia (Mosk) ; (11): 134-136, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33210519

RESUMO

Endometriosis is a functioning endometrial tissue outside the inner layer of the uterine wall. Liver endometriosis is one of the rarest forms of atypical endometriosis. In this article, we report a patient with this disease. A 59-year-old patient complained of heaviness and periodic pain in the right hypochondrium for more than a year. Previous contrast-enhanced CT revealed signs of cystic-solid hypovascular mass lesion in the right liver lobe. Histological examination revealed no reliable signs of tumor growth. According to control CT after 8 months, no significant changes were observed. Surgical treatment was indicated and atypical liver resection was performed. Histological examination revealed cystic endometrioid lesion. Liver endometrioma is a rare disease with unclear pathogenesis. Diagnosis is difficult due to uncharacteristic clinical manifestations and no specific markers. Liver endometriosis should be considered in differential diagnosis of liver lesion. Surgical treatment is preferable due to the risk of malignant transformation.


Assuntos
Endometriose , Hepatopatias , Endometriose/diagnóstico por imagem , Endometriose/patologia , Endometriose/cirurgia , Feminino , Hepatectomia , Humanos , Hepatopatias/diagnóstico por imagem , Hepatopatias/patologia , Hepatopatias/cirurgia , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
6.
Chaos ; 30(7): 073138, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32752608

RESUMO

Detrended fluctuation analysis (DFA) is widely used to characterize long-range power-law correlations in complex signals. However, it has restrictions when nonstationarity is not limited only to slow variations in the mean value. To improve the characterization of inhomogeneous datasets, we have proposed the extended DFA (EDFA), which is a modification of the conventional method that evaluates an additional scaling exponent to take into account the features of time-varying nonstationary behavior. Based on EDFA, here, we analyze rat electroencephalograms to identify specific changes in the slow-wave dynamics of brain electrical activity associated with two different conditions, such as the opening of the blood-brain barrier and sleep, which are both characterized by the activation of the brain drainage function. We show that these conditions cause a similar reduction in the scaling exponents of EDFA. Such a similarity may represent an informative marker of fluid homeostasis of the central nervous system.

7.
Khirurgiia (Mosk) ; (7): 25-30, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32736460

RESUMO

OBJECTIVE: To evaluate the effectiveness and safety of aortic valve replacement through upper partial J-shaped sternotomy compared to conventional sternotomy. MATERIAL AND METHODS: There were 240 procedures of isolated aortic valve replacement for the period 2012-2017. According to inclusion criteria, 112 patients were randomized into 2 groups: group I - median sternotomy, group II - upper partial J-shaped sternotomy. Mean age of patients was 56.1±14.3 and 53.1±14.9 years, respectively (p=0.284). Females prevailed in both groups (55.4% vs. 57.1%, p=0.848). Peak pressure gradient on the aortic valve was 106.2±23.9 and 102.8±25.3 mm Hg, respectively (p=0.484). RESULTS: In-hospital mortality was 1.8% (n=1) in group I (p=0.315). Incidence of postoperative complications (complete atrioventricular blockade, ventricular septal defect) was similar (p=1.0). Mean time cross clamping in I and II groups was 65.5±12.5 and 64.7±13.1 min (p=0.729). Mean follow-up period was 31.6 and 33.5 months, respectively. Kaplan-Meier survival rate was 92.6 and 93.0%, respectively (log-rank test=0,767). Freedom from thromboembolic events was 91.7 and 90% (log-rank test=0.213). CONCLUSION. U: Pper partial J-shaped sternotomy is safe and effective for aortic valve surgery and characterized by similar outcomes compared to conventional sternotomy.


Assuntos
Valva Aórtica/cirurgia , Doenças das Valvas Cardíacas/cirurgia , Implante de Prótese de Valva Cardíaca/métodos , Esternotomia/métodos , Adulto , Idoso , Feminino , Implante de Prótese de Valva Cardíaca/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos , Estudos Retrospectivos , Resultado do Tratamento
8.
J Phys Chem Lett ; 11(12): 4859-4865, 2020 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-32515198

RESUMO

Supercapacitors based on carbon nanomaterials are attracting much attention because of their high capacitance enabled by large specific surface area. The introduction of heteroatoms such as N or O enhances the specific capacitance of these materials. However, the mechanisms that lead to the increase in the specific capacitance are not yet well-studied. In this Letter, we demonstrate an effective method for modification of the surface of carbon nanowalls (CNWs) using DC plasma in atmospheres of O2, N2, and their mixture. Processing in the plasma leads to the incorporation of ∼4 atom % nitrogen and ∼10 atom % oxygen atoms. Electrochemical measurements reveal that CNWs functionalized with oxygen groups are characterized by higher capacitance. The specific capacitance for samples with oxygen reaches 8.9 F cm-3 at a scan rate of 20 mV s-1. In contrast, the nitrogen-doped samples demonstrate a specific capacitance of 4.4 F cm-3 at the same scan rate. The mechanism of heteroatom incorporation into the carbon lattice is explained using density functional theory calculations.

9.
Kardiologiia ; 60(2): 47-53, 2020 Mar 05.
Artigo em Russo | MEDLINE | ID: mdl-32345198

RESUMO

Objective The search for predictors of severe (>35 %) left atrial (LA) fibrosis in patients (pts) with nonvalvular atrial fibrillation (AF) directed for catheter ablation (CA).Materials and Methods 69 pts with nonvalvular AF (57 paroxismal and 12 persistent) aged from 32 to 69 years (mean age 57.1±8.4, 28 females) were included in the study, among them 59 pts (86 %) with arterial hypertension (AH), 24 (34.8 %) - with AH and CAD. Complete physical study, laboratory tests (including NT-proBNP level), comprehensive echocardiography were performed. As a surrogate substrate of LA fibrosis, the area of low-voltage (<0.5 mV) zones in LA was estimated in the process of voltage electroanatomic mapping, as the first stage of CA. The total square of LA fibrosis in absolute values (Sf, cm2) and in percent of total LA square (Sf%), as well as the degree of fibrosis: degree I - <5 %, II - 5-19 %, III - 20-35 %, IV - >35 % were calculated. Degree IV of fibrosis was considered as severe fibrosis.Results Extent of fibrosis didn't depend on sex, age, body weight, presence of diabetes, CHA2DS2VASc scores, duration of AF history. There was a tendency to smaller Sf in pts with spontaneous termination of AF compared to those who required cardioversion: 7.2 cm2 (4.4; 17.1) and 12.6 cm2 (4.2; 30.5), respectively (p=0.069). Although NT-proBNP level was normal in 62 % of pts (<125 pg / ml), it was higher in Sf% ≥20 % than in Sf% <5 %: 146.0 (48.0; 276.0) and 42.8 (24.2; 91.0) pg / ml, respectively (p=0.0216). The distribution of pts by left ventricular (LV) geometry types was as follows: normal geometry (t.1) - 34, concentric remodeling (t.2) - 16, concentric LV hypertrophy (t.3) - 8, eccentric LV hypertrophy (t.4) - 11. Compared to pts with t. 1 (reference level), pts with t.3 and t.4 had higher LA volume and LV myocardial mass index, and pts with t.4 had larger end-diastolic LV volume and lower LV ejection fraction. Pts with t.4 tended to have higher Sf% than t.1: 31.1 (10.2; 46.2) and 11.2 (5.1; 28.0), respectively (p=0.053). Using logistic regression 3 independent predictors of LA severe fibrosis were detected: type 4 geometry of LV - OR=8.893 (95 % CI 1.150; 68.78), NT-proBNP >128 pg / ml - OR=6.184 (1.01; 37.99), LA volume index >34 ml / m2 - OR=5.92 (1.05; 33.38). According to ROC analysis, the area of the curve AUC = 0.839 (p<0.001), model specificity - 85.1 %, sensitivity - 70.0 %, predictive accuracy - 82.5 %.Conclusion In pts with nonvalvular AF predictors of severe (>35 %) LA fibrosis were LV geometry type in the form of eccentric LV hypertrophy, LA volume index >34 ml / m2 and NT-proBNP >128 pg / ml.


Assuntos
Apêndice Atrial , Fibrilação Atrial , Ablação por Cateter , Adulto , Idoso , Feminino , Fibrose , Átrios do Coração , Humanos , Masculino , Pessoa de Meia-Idade
10.
J Phys Condens Matter ; 32(24): 245001, 2020 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-32079003

RESUMO

The size, form and distribution function of catalyst particles define the quality of synthesized arrays of carbon nanotubes. In this work, we study the kinetics of catalyst particle formation from the thin nickel film (9 nm) deposited on the silicon substrate (SiO2/Si) with a buffer layer of niobium nitride at the temperature of 880 °C. In the experiment, we have obtained the time dependences of the average radius, average height and concentration of nickel particles. The experimental data are satisfactorily described by simulations based on the wetting transition theory. Comparison of the simulation results and experimental data allows us to estimate the effective interaction potential between the nickel film and buffer layer of niobium nitride. Besides, we have estimated the viscosity of the nickel confirming an undercooled liquid state of the nanosized nickel film at the temperature of 880 °C.

11.
Urologiia ; (5): 105-108, 2019 Dec.
Artigo em Russo | MEDLINE | ID: mdl-31808641

RESUMO

A description of specific features of CT-MRI in rare patient with perirenal non-Hodgkins lymphoma is presented in the article. CT scan was used to determine the accumulation of contrast medium and pathological vessels along the right kidneys border. Diffusion weighted MRI revealed the low values of the measured diffusion coefficient (MDC) and high accumulation index of the paramagnetic in the tumor tissue (0.59-0.62). The specific features of perirenal non-Hodgkins lymphoma on CT/MRI, an evaluation of the tumors volume and stage, and signs of malignancy are described.


Assuntos
Imagem de Difusão por Ressonância Magnética/métodos , Neoplasias Renais/diagnóstico por imagem , Linfoma não Hodgkin/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Meios de Contraste , Humanos
12.
Angiol Sosud Khir ; 25(3): 95-100, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31503252

RESUMO

The purpose of our investigation was to evaluate the immediate and intermediate results of staged operations of carotid endarterectomy and coronary artery bypass grafting in patients with multifocal atherosclerosis. We analysed a total of 475 operations. Of these, 371 (78.1%) patients underwent staged interventions (stage 1 - carotid endarterectomy, stage 2 - coronary artery bypass grafting). No neurological complications were observed after stage 1. Five (1.3%) patients developed cardiac arrhythmia in the form of atrial fibrillation, 7 (1.9%) were found to have transient neuropathy of cranial nerves. There were no lethal outcomes. Stage 2 was carried out 16±13 days after carotid endarterectomy. Of complications encountered, mention should be made of perioperative myocardial infarction in 1 (0.3%) patient, with 2 (0.6%) patients requiring emergency coronary bypass angiography. Newly onset atrial fibrillation was registered in 71 (19.1%) patients, haemorrhage followed by resternotomy in 6 (1.6%), and purulent wound complications in 4 (1.1%) patients. Death occurred in 1 (0.3%) patient. We also analysed the mid-term postoperative results (up to 32 months). The coverage amounted to 151 patients. The incidence rate of major adverse cardiac and cerebrovascular events (MACCE) was 6% (myocardial infarction - 2, acute cerebral ischaemia - 1, repeat myocardial revascularization - 5, lethal outcome - 1). Based on the obtained findings it may be concluded that staged operations on the carotid basin and coronary arteries by the number of complications are comparable to those after isolated coronary artery bypass grafting.


Assuntos
Estenose das Carótidas , Ponte de Artéria Coronária , Doença da Artéria Coronariana , Endarterectomia das Carótidas , Doença da Artéria Coronariana/terapia , Humanos , Complicações Pós-Operatórias , Estudos Retrospectivos , Taxa de Sobrevida
13.
Mol Biol (Mosk) ; 53(3): 513-523, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31184617

RESUMO

The effects of modified deoxyuridine triphosphates (mod-dUTPs) with different substituents at the C5 position of the pyrimidine cycle on the kinetics of PCR with Taq and Vent (exo-) DNA polymerases are studied. Substituents in mod-dUTP include carboxamide group and groups that are part of the side chains of alanine, valine, leucine, phenylalanine, tryptophan, or tyrosine. For each mod-dUTP, the yields of the target product are measured with the full substitution of dTTP. A fragment of bacterial DNA with a certain nucleotide sequence and a synthetic combinatorial DNA library of random nucleotide sequences are used as templates for amplification. For each mod-dUTP-template-polymerase combination, the correlation between the amplification efficiencies and yields of the target product are investigated. PCR product accumulation curves are influenced by both the template used and the presence of a modified substrate. The catalytic activity of Taq polymerase is higher when mod-dUTPs with short aliphatic substituents are used and decreases when the derivatives with long aliphatic, phenyl, and indole substituents are utilized. Vent (exo-) polymerase is less sensitive to the chemical structure of mod-dUTP. The dynamic measuring of DNA accumulation may be useful for optimizing the temperature-time PCR profiles individually for each of the mod-dUTP. The derivatives may be used in combination with Vent (exo-) polymerase to obtain modified DNA sequences for the method of selection of modified aptamers (mod-SELEX).


Assuntos
DNA Polimerase Dirigida por DNA/metabolismo , DNA/biossíntese , DNA/química , Reação em Cadeia da Polimerase em Tempo Real , Biblioteca Gênica , Cinética , Técnica de Seleção de Aptâmeros
14.
Sud Med Ekspert ; 61(3): 11-14, 2018.
Artigo em Russo | MEDLINE | ID: mdl-29863713

RESUMO

The objective of the present study was to identify the clinical and pathomorphological changes in the internal organs for the elucidation of the cause of death associated with various forms of alcoholic intoxication (chronic alcoholic intoxication, poisoning with surrogate alcohols, etc.). The analysis of the clinical conditions resulting from alcohol abuse has demonstrated that the principal pathology underlying the fatal outcome is complemented by a variety of non-lethal somatic disorders aggravating the patients' condition and enhancing its severity. The clinicians are known to give more attention to the accompanying somatic complications than to the cause underlying the main pathology (alcoholism). Such attitude in the absence of the adequate treatment of the alcohol dependency is neither clinically efficient nor economically appropriate. Poisoning with surrogate alcohols is characterized by the pulmonary-cerebral variant of tanatogenesis in the combination with hypercoagulation and the erosive processes in the gastrointestinal tract whereas death from alcoholic intoxication is usually associated with heart tanatogenesis.


Assuntos
Intoxicação Alcoólica , Encéfalo/patologia , Etanol , Trato Gastrointestinal/patologia , Pulmão/patologia , Intoxicação Alcoólica/etiologia , Intoxicação Alcoólica/mortalidade , Intoxicação Alcoólica/patologia , Causas de Morte , Etanol/química , Etanol/toxicidade , Patologia Legal/métodos , Humanos
15.
Chaos ; 28(1): 013124, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29390623

RESUMO

The scaling properties of complex processes may be highly influenced by the presence of various artifacts in experimental recordings. Their removal produces changes in the singularity spectra and the Hölder exponents as compared with the original artifacts-free data, and these changes are significantly different for positively correlated and anti-correlated signals. While signals with power-law correlations are nearly insensitive to the loss of significant parts of data, the removal of fragments of anti-correlated signals is more crucial for further data analysis. In this work, we study the ability of characterizing scaling features of chaotic and stochastic processes with distinct correlation properties using a wavelet-based multifractal analysis, and discuss differences between the effect of missed data for synchronous and asynchronous oscillatory regimes. We show that even an extreme data loss allows characterizing physiological processes such as the cerebral blood flow dynamics.

16.
Klin Lab Diagn ; 63(12): 788-792, 2018.
Artigo em Russo | MEDLINE | ID: mdl-30785695

RESUMO

The work describes the development of a reagent kit for high-performance HLA-typing using the Illumina MiSeq System platform. The developed reagent kit contains all the necessary components for target enrichment of five HLA genes, preparation of libraries, and software for automatic data analysis. The reagent kit verified on a 93 DNA samples with known genotypes. During the verification, the sensitivity and specificity of the reagent kit for each of the HLA loci were determined - for A and B they were 1.0 and 1.0, respectively, for the C-1.0 and 0.99 locus, for the DRB1 locus 0.98 and 0.99, for the DQB1 locus 0.98 and 0.93.


Assuntos
Teste de Histocompatibilidade , Kit de Reagentes para Diagnóstico/normas , Células-Tronco/classificação , Alelos , Genótipo , Humanos
17.
Khirurgiia (Mosk) ; (12): 41-45, 2017.
Artigo em Russo | MEDLINE | ID: mdl-29286029

RESUMO

AIM: To justify ligation of vascular branches of anterior pancreateroduodenal arterial arch or gastroduodenal artery prior to bifurcation. MATERIAL AND METHODS: This method was tested on sufficient clinical material: 147 patients with recurrent chronic pancreatitis. The interventions are presented by Frey, Beger procedures and its Berne variant. RESULTS: Comparative analysis showed reliable advantages of vascular ligation during pancreatectomy.


Assuntos
Perda Sanguínea Cirúrgica/prevenção & controle , Duodeno , Hemostasia Cirúrgica/métodos , Pâncreas , Pancreaticoduodenectomia , Pancreatite Crônica , Procedimentos Cirúrgicos Vasculares , Adulto , Duodeno/irrigação sanguínea , Duodeno/patologia , Duodeno/cirurgia , Feminino , Humanos , Ligadura/métodos , Masculino , Pessoa de Meia-Idade , Avaliação de Processos e Resultados em Cuidados de Saúde , Pâncreas/irrigação sanguínea , Pâncreas/patologia , Pâncreas/cirurgia , Pancreaticoduodenectomia/efeitos adversos , Pancreaticoduodenectomia/métodos , Pancreatite Crônica/diagnóstico , Pancreatite Crônica/patologia , Pancreatite Crônica/fisiopatologia , Pancreatite Crônica/cirurgia , Fluxo Sanguíneo Regional , Procedimentos Cirúrgicos Vasculares/métodos
18.
Angiol Sosud Khir ; 23(2): 142-147, 2017.
Artigo em Russo | MEDLINE | ID: mdl-28594808

RESUMO

The study was aimed at revealing risk factors for progression of atherosclerosis in the shunted coronary artery in the remote period following coronary artery bypass grafting. Our prospective study included a total of 292 patients having endured coronary artery bypass grafting. All patients were divided in two groups depending on the type of the bypass grafts used: either autoarterial shunts (Group 1) or autovenous grafts (Group 2). We thus assessed a total of 516 autoarterial grafts and 257 autovenous grafts, as well as the coronary arteries shunted thereby. The long-term results were evaluated by means of coronaroshuntography performed not earlier than 12 months after surgery. The average duration of follow up amounted to 53.4±26.5 months. Analysing the cumulative risk for progression of atherosclerosis in the arteries shunted demonstrated that for autoarterial grafts the rate of the development of proximal stenosis of the coronary artery (CA) shunted was lower compared with autovenous grafts (p≤0.001). The Cox regression model showed that an autovein used as a graft increased the risk for the development of occlusion of the shunted CA by 43% from the baseline each postoperative month. The presence of proximal stenosis of the shunted coronary artery amounting to or exceeding 90% increases the risk of occlusion by 68% per month. Also, for the patients with the SYNTAX scoring ≥ 32 points the risk of coronary artery occlusion increases 2.2-fold each month after the operation. Such factors as the patient's gender, the diameter of the shunted artery, diabetes mellitus, tobacco smoking, multifocal atherosclerosis by the findings of the study exerted no influence on the progression of proximal stenosis of the shunted coronary artery.


Assuntos
Ponte de Artéria Coronária , Doença da Artéria Coronariana , Reestenose Coronária , Vasos Coronários , Efeitos Adversos de Longa Duração , Angiografia Coronária/métodos , Ponte de Artéria Coronária/efeitos adversos , Ponte de Artéria Coronária/métodos , Doença da Artéria Coronariana/diagnóstico , Doença da Artéria Coronariana/epidemiologia , Doença da Artéria Coronariana/cirurgia , Reestenose Coronária/diagnóstico , Reestenose Coronária/epidemiologia , Vasos Coronários/diagnóstico por imagem , Vasos Coronários/patologia , Progressão da Doença , Feminino , Humanos , Efeitos Adversos de Longa Duração/diagnóstico , Efeitos Adversos de Longa Duração/epidemiologia , Masculino , Pessoa de Meia-Idade , Avaliação de Processos e Resultados em Cuidados de Saúde , Período Pós-Operatório , Fatores de Risco , Federação Russa/epidemiologia , Fatores de Tempo , Grau de Desobstrução Vascular
19.
Klin Lab Diagn ; 62(5): 305-309, 2017.
Artigo em Russo | MEDLINE | ID: mdl-31509662

RESUMO

The mucoviscidosis is one of frequent monogenic diseases. In Russia, in case of mucoviscidosis carrying out of DNA-diagnostic is optional. However, its application permits shortening time of diagnosing, increasing efficiency of of therapeutic treatment and preventing secondary manifestation of disease in family. The DNA-diagnostic using panels on frequent mutations in gene CFTR is recommended in cases of uncertain clinical picture and under borderline values of specific laboratory indices. In Russia, application of such panels permit detecting up to 90% of pathological alleles in gene CFTR. To detect more rare alleles the Sanger sequencing is traditionally applied. Lately, highly productive sequencing techniques became available to detect rare mutations. The actual article presents evaluation of efficiency of application of test-system based on technology of target sequencing for detecting mutations unidentified at primary DNA-diagnostic. Besides, in two patients with mucoviscidosis the application of highly productive sequencing techniques permitted to identify previously unknown nonsense mutations Q1038X (c.3112C>T) и W1310X (c.3930G>A).

20.
Anesteziol Reanimatol ; 62(1): 32-35, 2017 Jan.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-29932577

RESUMO

Realising for thefirst time in Russia the transportation of a patient with critical respiratory failure in conditions of EC-MO-therapy, the authors have accumulated great experience of its application at the stage of inter-hospital evacuation. This category ofpatients previously considered non-transportable by the severity of their condition. Having conducted a retrospective analysis of clinical experience in the use of high-tech medical care method, the authors received a zero mortality and questioned the possible new criteria and recommendations in assessing risk of death in patients with life-threatening conditions at the stage of inter-hospital transportation.


Assuntos
Oxigenação por Membrana Extracorpórea/métodos , Insuficiência Respiratória/terapia , Transporte de Pacientes/métodos , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Federação Russa , Adulto Jovem
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