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Photodiagnosis Photodyn Ther ; 19: 170-174, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28619615


INTRODUCTION: The aim of the present study was to evaluate, in vitro, the influence of the addition of chlorhexidine to photosensitiser in the antimicrobial activity of photodynamic therapy in root canals infected by Enterococcus faecalis. METHODS: The root canals of 50 single-rooted human extracted teeth were enlarged up to a file F3 of Pro-Taper system, autoclaved, inoculated with Enterococcus faecalis and incubated for 14days. The samples were divided into five groups (n=10) according to the protocol of decontamination: G1 (control group) - no procedure was performed; G2-photosensitiser (0.01% methylene blue); G3-2% chlorhexidine gel; G4-photodynamic therapy; and G5-photodynamic therapy with photosensitiser modified by chlorhexidine. Microbiological test (CFU counting) was performed to evaluate the effectiveness of proposed treatments. Data were subjected to one-way ANOVA followed by post-hoc Tukey test (α=0.05). RESULTS: Group 3 (CHX) showed the lowest mean contamination (2.03 log10 CFU/mL), being statistically different from all other all groups (p<0.05). There was no statistically significant difference between groups 4 (PDT) and 5 (PDT+CHX) (p<0.05), being more effectives against E. faecalis when compared to groups 1 (NT) and 2 (MB), and less effective when compared to group 2 (CHX). CONCLUSIONS: The addition of chlorhexidine to photosensitiser did not result in a better decontamination potential of photodynamic therapy alone over root canals infected by E. faecalis.

Anti-Infecciosos/farmacologia , Clorexidina/farmacologia , Enterococcus faecalis/efeitos dos fármacos , Azul de Metileno/farmacologia , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/farmacologia , Anti-Infecciosos/administração & dosagem , Clorexidina/administração & dosagem , Cavidade Pulpar/microbiologia , Humanos , Azul de Metileno/administração & dosagem , Fármacos Fotossensibilizantes/administração & dosagem , Irrigantes do Canal Radicular/uso terapêutico , Preparo de Canal Radicular/métodos , Células-Tronco
Photodiagnosis Photodyn Ther ; 17: 216-220, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28065860


INTRODUCTION: The aim of the present study was to evaluate the influence of ultrasonic activation (US) of the final irrigant in the removal of the photosensitizer from root canal walls after photodynamic therapy. METHODS: The root canals of 60 single-rooted bovine extracted teeth were filled with 0.01% methylene blue and submitted to photodynamic therapy for 90s. After that, the roots were divided into six groups (n=10) according to the final irrigation protocol: distilled water (DW), DW+US, 17% EDTA, QMix, EDTA+US, and QMix+US. Then, the samples were submitted to scanning electron microscopy where a scoring system was used to evaluate the images and effectiveness of proposed treatments in the cervical, middle and apical regions of the root canals. The data were statistically analyzed by the Kruskal-Wallis and Mann-Whitney U tests for intergroup comparisons as well as the Wilcoxon and Friedman tests for intragroup comparisons at 5% of significance. RESULTS: The 17% EDTA+US and QMix+US treatments were most effective in the removal of the photosensitizer in all regions of the root canal; the difference was statistically significant when compared to all other groups (p<0.05). There were no significant differences in the intragroup analysis comparing the effectiveness in the different regions of the same group (p<0.05). CONCLUSIONS: US can aid 17% EDTA and QMix in removing the photosensitizer after photodynamic therapy and contributes to cleaning root canal walls.

Cavidade Pulpar , Azul de Metileno/efeitos adversos , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/efeitos adversos , Irrigantes do Canal Radicular/farmacologia , Ultrassom/métodos , Animais , Biguanidas/administração & dosagem , Bovinos , Ácido Edético/administração & dosagem , Azul de Metileno/uso terapêutico , Microscopia Eletrônica de Varredura , Fotoquimioterapia/efeitos adversos , Fármacos Fotossensibilizantes/uso terapêutico , Polímeros/administração & dosagem , Água/administração & dosagem