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1.
Environ Monit Assess ; 194(6): 412, 2022 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-35534593

RESUMO

This study uses the daily product data of the concentration of ozone in the atmospheric column (ozone column concentration) collected by the Aura satellite's Ozone Monitoring Instrument (OMI), to evaluate the ozone pollution status of the Fenwei Plain in east-central China, by employing pixel-based spatial analysis, an θslope trend index, a Hurst index, and grey correlation. The following results were found. (1) The spatial distribution of ozone in the atmosphere of the Fenwei Plain was higher in the north and lower in the south, with high values appearing in Jinzhong, Lvliang, and other cities. (2) The changes in ozone column concentration periodically and seasonally in the Fenwei Plain. Seasonally, the ozone column concentration was highest in spring, followed by summer, winter, and autumn. (3) The pixel-based trend change of the ozone slope (θslope) indicated that the ozone concentration in the region was in a downward trend, while the long-term correlation of the time series trend Hurst index found that the region should expect to see a weak rebound in the ozone column concentration in the future, so that routine monitoring should be strengthened. (4) The present study on the factors influencing the ozone concentration found that the concentration is relatively closely related to temperature, air pressure, humidity, grain sowing area, highway mileage, and secondary industry.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Ozônio , Poluentes Atmosféricos/análise , Poluição do Ar/análise , China , Cidades , Monitoramento Ambiental/métodos , Ozônio/análise , Tecnologia de Sensoriamento Remoto , Estações do Ano
2.
EClinicalMedicine ; 46: 101373, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35434582

RESUMO

Background: There are concerns that the use of non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of adverse outcomes among patients with coronavirus COVID-19. This study aimed to synthesize the evidence on associations between the use of NSAIDs and adverse outcomes. Methods: A systematic search of WHO COVID-19 Database, Medline, the Cochrane Library, Web of Science, Embase, China Biology Medicine disc, China National Knowledge Infrastructure, and Wanfang Database for all articles published from January 1, 2020, to November 7, 2021, as well as a supplementary search of Google Scholar. We included all comparative studies that enrolled patients who took NSAIDs during the COVID-19 pandemic. Data extraction and quality assessment of methodology of included studies were completed by two reviewers independently. We conducted a meta-analysis on the main adverse outcomes, as well as selected subgroup analyses stratified by the type of NSAID and population (both positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or not). Findings: Forty comparative studies evaluating 4,867,795 adult cases were identified. Twenty-eight (70%) of the included studies enrolled patients positive to SARS-CoV-2 tests. The use of NSAIDs did not reduce mortality outcomes among people with COVID-19 (number of studies [N] = 29, odds ratio [OR] = 0.93, 95% confidence interval [CI]: 0.75 to 1.14, I2  = 89%). Results suggested that the use of NSAIDs was not significantly associated with higher risk of SARS-CoV-2 infection in patients with or without COVID-19 (N = 10, OR = 0.96, 95% CI: 0.86 to 1.07, I2  = 78%; N = 8, aOR = 1.01, 95% CI: 0.94 to 1.09, I2  = 26%), or an increased probability of intensive care unit (ICU) admission (N = 12, OR = 1.28, 95% CI: 0.94 to 1.75, I2  = 82% ; N = 4, aOR = 0.89, 95% CI: 0.65 to 1.22, I2  = 60%), requiring mechanical ventilation (N = 11, OR = 1.11, 95% CI: 0.79 to 1.54, I2  = 63%; N = 5, aOR = 0.80, 95% CI: 0.52 to 1.24, I2  = 66%), or administration of supplemental oxygen (N = 5, OR = 0.80, 95% CI: 0.52 to 1.24, I2  = 63%; N = 2, aOR = 1.00, 95% CI: 0.89 to 1.12, I2  = 0%). The subgroup analysis revealed that, compared with patients not using any NSAIDs, the use of ibuprofen (N = 5, OR = 1.09, 95% CI: 0.50 to 2.39; N = 4, aOR = 0.95, 95% CI: 0.78 to 1.16) and COX-2 inhibitor (N = 4, OR = 0.62, 95% CI: 0.35 to 1.11; N = 2, aOR = 0.73, 95% CI: 0.45 to 1.18) were not associated with an increased risk of death. Interpretation: Data suggests that NSAIDs such as ibuprofen, aspirin and COX-2 inhibitor, can be used safely among patients positive to SARS-CoV-2. However, for some of the analyses the number of studies were limited and the quality of evidence was overall low, therefore more research is needed to corroborate these findings. Funding: There was no funding source for this study.

3.
Water Res ; 216: 118290, 2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-35306460

RESUMO

Flow-electrode capacitive deionization (FCDI) is viewed as a potential alternative to the current state-of-the-art electrodriven technology for the desalination of brackish water. However, the key shortcoming of the FCDI is still the discontinuous nature of the electrode conductive network, resulting in low electron transport efficiency and ion adsorption capacity. Here, a novel magnetic field-assisted FCDI system (termed magnetic FCDI) is proposed to enhance brackish water desalination, simply by using magnetic activated carbon (MAC) as flow electrodes. The results show that the assistance from the magnetic field enables a 78.9% - 205% enhancement in the average salt removal rate (ASRR) compared with that in the absence of a magnetic field, which benefits from the artificial manipulation of the flow electrode transport behavior. In long-term tests, the stable desalination performance of magnetic FCDI was also demonstrated with a stable ASRR of 0.70 µmol cm-2 min-1 and energy-normalized removed salt (ENRS) of 8.77 µmol J-1. In addition, magnetic field also enables the regeneration of the electrode particles from the concentrated electrolyte. In summary, the findings indicate that the magnetic FCDI is an energy-efficient and operation convenient technology for brackish water desalination.


Assuntos
Purificação da Água , Adsorção , Eletrodos , Campos Magnéticos , Águas Salinas , Cloreto de Sódio , Cloreto de Sódio na Dieta
4.
Foods ; 11(6)2022 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-35327274

RESUMO

The application of ß-glucosidase from non-Saccharomyces yeasts to improve wine aroma has been widely explored. However, few enzymes are active under the severe conditions of wine aging (high ethanol concentration, low temperature, and low pH). Therefore, the application of ß-glucosidase in wine aging needs further research. In this study, the ß-glucosidases Mg-ßgl and Hu-ßgl extracted from Meyerozyma guilliermondii NM218 and Hanseniaspora uvarum BF345 were purified and used in young Chardonnay wines aged for 50 days. The enzyme activity of the two enzymes was measured. The effects of the two enzymes and a commercial ß-glucosidase (An-ßgl) on the volatile composition and sensory quality of the wine were also determined. The results showed that Mg-ßgl and Hu-ßgl had high specific activity of 1.95 U/mg and 2.11 U/mg, respectively, maintaining the activity of 70-80% at 20 °C, pH of 3.0-4.0, and 15% ethanol, corresponding to wine aging conditions. Analysis of volatiles with GC-MS showed a 65-70% increase in total terpenoids and new detection of C13-norisoprenoids when the wines were treated with the three ß-glucosidases. In addition, wines treated with Mg-ßgl and Hu-ßgl had more hexanol, phenylethanol, ethyl octanoate, ethyl heptanoate, and ethyl caprate than wines treated without and with An-ßgl. In sensory analysis, the judges showed a greater preference for Hu-ßgl-treated wines, to which they attributed pleasant sweet, floral, honey, pomelo, and banana aromas. The results of this study not only offer a way to improve flavor complexity in wine but also provide a reference for the use of other edible sources of ß-glucosidase in wine aging.

5.
Front Plant Sci ; 13: 835943, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35251107

RESUMO

Impatiens is one of the most species-rich genera of angiosperms, with more than 1,000 species distributed in Eurasia and Africa. Previous studies have shown that seeds of Impatiens display enormous morphological diversity, and seed micromorphology may contribute to the classification of those species. However, the micromorphological seed coat characteristics of Impatiens seeds have not been systematically studied. In this study, we examined 117 Impatiens seeds from two subgenera and seven sections, and analyzed the seed characters of shape, primary ornamentation, secondary ornamentation, anticlinal cell wall, and periclinal cell wall. We discovered that, according to the different shapes of ornamentation, seed coat can be divided into three types, viz, reticulate type, protrusive type, appendicular type, and that they can be further subdivided into 10 subtypes. In addition, the characteristics of seed coat ornamentation with taxonomic significance in this genus are discussed. We reconstructed the ancestral states of the above seed characters of the Impatiens using the maximum likelihood approach based on the reconstructed phylogenetic framework. The seed character reconstruction showed that the seed shape, primary ornamentation, and anticlinal cell wall could be identified as unambiguous, while other characters were ambiguous in the last common ancestor of Impatiens. Reconstruction of important seed morphological characters showed that the secondary ornamentation possesses high plasticity, and the primary ornamentation has high homology. In addition, we inferred the evolutionary trends of seed ornamentation and found that the seed coat ornamentation of Impatiens experienced a complex evolutionary process from a reticulate type into more complex types. We also discussed the relationship between seed coat diversity vs. environmental adaptation and seed dispersal in Impatiens.

6.
BMC Med Educ ; 22(1): 154, 2022 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-35255878

RESUMO

BACKGROUND: Undergraduate medical (UM) students faced the difficulties inherent in medical careers due to the coronavirus (COVID-19) outbreak. Thus, imperative containment measures might affect UM students' career intentions. Information on the factors that may be associated with these students' career change intentions is limited. METHODS: We conducted a cross-sectional survey in August 2020 to investigate the impact of the COVID-19 pandemic on career intention and the associated factors in UM students. Univariate analyses and logistic regression analysis were performed to identify said factors. RESULTS: A total of 2040 medical students from the Hubei University of Medicine were surveyed. Univariate analyses showed that grade, attitude towards healthcare, and the degree of the COVID-19 pandemic's impact on the students' lives were associated with changes in career choice (P<0.05). Logistic regression analysis showed that Grade 2, Grade 5, attitude towards a medical career, and having relatives with a medical background were associated with changes in career choice. The degree of the COVID-19 pandemic's impact was a common and significant factor associated with career preference, career perspective, and ideal workplace. CONCLUSIONS: Changes in career intentions were particularly influenced by grade, attitude towards being a health worker, and the degree of COVID-19's impact on the participants' lives. Treating large-scale public health emergencies rationally, setting up correct views of occupation choice, and building reasonable career planning may reduce the loss of medical talent.


Assuntos
COVID-19 , Estudantes de Medicina , COVID-19/epidemiologia , Escolha da Profissão , Estudos Transversais , Humanos , Intenção , Ocupações , Pandemias , SARS-CoV-2 , Inquéritos e Questionários
7.
Mar Drugs ; 20(3)2022 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-35323477

RESUMO

One new depsidone derivative, aspergillusidone H (3), along with seven known biosynthetically related chlorinated polyketides, were obtained from the Beibu Gulf coral-derived fungus Aspergillus unguis GXIMD 02505. Their structures were determined by comprehensive physicochemical and spectroscopic data interpretation. Notably, the X-ray crystal structure of 2 and the previously unknown absolute configuration of 8, assigned by ECD calculations, are described here for the first time. Compounds 1-5, 7 and 8 exhibited inhibition of lipopolysaccharide (LPS)-induced NF-κB in RAW 264.7 macrophages at 20 µM. In addition, the two potent inhibitors (2 and 7) dose-dependently suppressed RANKL-induced osteoclast differentiation without any evidence of cytotoxicity in bone marrow macrophages cells (BMMs). This is the first report of osteoclastogenesis inhibitory activity for the metabolites of these kinds. Besides, compounds 1, 2, 4, and 6-8 showed inhibitory activity against marine biofilm-forming bacteria, methicillin-resistant Staphylococcus aureus, Microbulbifer variabilis, Marinobacterium jannaschii, and Vibrio pelagius, with their MIC values ranging from 2 to 64 µg/mL. These findings provide a basis for further development of chlorinated polyketides as potential inhibitors of osteoclast differentiation and/or for use as anti-fouling agents.


Assuntos
Antozoários/microbiologia , Antibacterianos , Aspergillus/química , Produtos Biológicos , Osteogênese/efeitos dos fármacos , Policetídeos , Animais , Antibacterianos/química , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Bactérias/efeitos dos fármacos , Bactérias/crescimento & desenvolvimento , Produtos Biológicos/química , Produtos Biológicos/isolamento & purificação , Produtos Biológicos/farmacologia , Células Cultivadas , Lipopolissacarídeos/farmacologia , Macrófagos/citologia , Macrófagos/efeitos dos fármacos , Camundongos , Estrutura Molecular , NF-kappa B/metabolismo , Oceanos e Mares , Policetídeos/química , Policetídeos/isolamento & purificação , Policetídeos/farmacologia , Ligante RANK
8.
Eur J Pediatr ; 181(5): 2135-2146, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35192051

RESUMO

The purpose of this systematic review is to evaluate the efficacy and safety of using potential drugs: remdesivir and glucocorticoid in treating children and adolescents with COVID-19 and intravenous immunoglobulin (IVIG) in treating MIS-C. We searched seven databases, three preprint platform, ClinicalTrials.gov, and Google from December 1, 2019, to August 5, 2021, to collect evidence of remdesivir, glucocorticoid, and IVIG which were used in children and adolescents with COVID-19 or MIS-C. A total of nine cohort studies and one case series study were included in this systematic review. In terms of remdesivir, the meta-analysis of single-arm cohort studies have shown that after the treatment, 54.7% (95%CI, 10.3 to 99.1%) experienced adverse events, 5.6% (95%CI, 1.2 to 10.1%) died, and 27.0% (95%CI, 0 to 73.0%) needed extracorporeal membrane oxygenation or invasive mechanical ventilation. As for glucocorticoids, the results of the meta-analysis showed that the fixed-effect summary odds ratio for the association with mortality was 2.79 (95%CI, 0.13 to 60.87), and the mechanical ventilation rate was 3.12 (95%CI, 0.80 to 12.08) for glucocorticoids compared with the control group. In terms of IVIG, most of the included cohort studies showed that for MIS-C patients with more severe clinical symptoms, IVIG combined with methylprednisolone could achieve better clinical efficacy than IVIG alone. CONCLUSIONS: Overall, the current evidence in the included studies is insignificant and of low quality. It is recommended to conduct high-quality randomized controlled trials of remdesivir, glucocorticoids, and IVIG in children and adolescents with COVID-19 or MIS-C to provide substantial evidence for the development of guidelines. WHAT IS KNOWN: • The efficacy and safety of using potential drugs such as remdesivir, glucocorticoid, and intravenous immunoglobulin (IVIG) in treating children and adolescents with COVID-19/MIS-C are unclear. WHAT IS NEW: • Overall, the current evidence cannot adequately demonstrate the effectiveness and safety of using remdesivir, glucocorticoids, and IVIG in treating children and adolescents with COVID-19 or MIS-C. • We are calling for the publication of high-quality clinical trials and provide substantial evidence for the development of guidelines.


Assuntos
COVID-19 , Adolescente , COVID-19/complicações , COVID-19/tratamento farmacológico , Criança , Glucocorticoides/uso terapêutico , Humanos , Imunoglobulinas Intravenosas/efeitos adversos , Respiração Artificial , Síndrome de Resposta Inflamatória Sistêmica
9.
J Autism Dev Disord ; 2022 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-35129796

RESUMO

Previous studies have shown reduced attention to the eyes in individuals with autism spectrum disorder (ASD). However, most eye-tracking evidence regarding this impairment has been derived from passive viewing tasks. Here, we compared the passive viewing of faces with an active task involving face identification with morphing faces. While typical controls prioritized the eyes over other facial features regardless of viewing condition, autistic children exhibited reduced eye-looking in passive viewing, but displayed increased attention allocation to the eyes when instructed to identify faces. The proportional eye-looking in ASD during facial recognition was negatively related to the autism symptoms severity. These findings provide evidence regarding the specific situations in which diminished eye-looking may rise in young ASD children.

10.
Theriogenology ; 180: 176-188, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-34990963

RESUMO

Inducing maturation of the ovaries to enable the production of good-quality eggs is critical for the successful artificial breeding of Anguilla japonica. During the spawning season, however, the ovaries of A. japonica have been found to develop into asynchronous clutches, impeding the success of artificial breeding on a commercial scale. The dynamic molecular regulation of follicular development in the same individual was assessed by transcriptome analysis of the five stages of follicles, the pre-vitellogenic, early vitellogenic, midvitellogenic, late vitellogenic, and migratory nucleus stages in artificial maturing A. japonica. Comparisons across these developmental stages identified a total of 19,298 differentially expressed transcripts (DETs). Short time-series expression miner analysis across these DETs revealed four significant expression profiles. Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses found that some of the significantly enriched biological processes and metabolic pathways included those related to steroid hormone biosynthesis (cyp11a1, cyp17a1, cyp17a2, hsd17b1, and hsd17b12), cargo receptor activity (vtgr and vldlr), meiosis and ovulation (pgrs and mPRγ), hydration (cts and aqp1), and egg coat formation (zp). These genes and pathways were associated with serum 17ß-estradiol concentrations and morphological changes. The levels of hsd17b12 and mPRγ mRNAs were much higher during the migratory nucleus stage, suggesting their respective involvement in the biosynthesis and functional pathway of the maturation-inducing steroid 17α,20ß-dihydroxy-4-pregnen-3-one. The gene subtypes aqp1b and ctsd may regulate water influx into oocytes and yolk protein proteolysis, respectively. To our knowledge, the present study is the first to describe combined transcriptome profiling of asynchronously developing follicles in the same individual. The findings suggest that steroid hormone synthesis and nutrient absorption in follicular somatic cells play important roles during follicular development and maturation, despite the same external physiological surroundings.


Assuntos
Anguilla , Anguilla/genética , Animais , Feminino , Perfilação da Expressão Gênica/veterinária , Oócitos , Folículo Ovariano , Ovário , Transcriptoma , Vitelogênese/genética
11.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 53(1): 166-170, 2022 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-35048619

RESUMO

OBJECTIVE: To explore the effects of interventional therapy with bronchoscopy in children with acquired subglottic stenosis (SGS). METHODS: The clinical data of ten pediatric inpatients with acquired SGS who were admitted to Children's Hospital of Chongqing Medical University, as well as their follow-up information obtained 1 week, 1 month, 3 months and 6 months after the procedure was done.were retrospectively analyzed to examine the effect of interventional bronchoscopic therapies, including balloon dilatation, holmium laser, and cryotherapy, in pediatric patients with acquired SGS. RESULTS: Among the 10 patients with acquired SGS, there were 5 boys and 5 girls aged between 1 month and 6 years and 5 months, with a median age of 11 months and 1 day. Among the 5 patients with acute acquired SGS, two were treated with balloon dilatation only, with one cured and one showing clinical improvement, while three received comprehensive interventional therapy combining balloon dilatation, holmium laser, and cryotherapy, with two cured and one showing improvement. Among the 5 patients with chronic acquired SGS, four cases were cured with comprehensive interventional therapy, while one case suffered from aggravated upper airway obstruction 4 + hours after balloon dilatation. The patient was subsequently put on invasive mechanical ventilation for 4 days, but was unable to be extubated. The parents signed do-not-resuscitate order and the patient died afterwards. Bronchoscopy performed 1 week, 1 month and 3 months after the procedure was done showed that the SGS was improved to varying degrees. CONCLUSION: Bronchoscopy intervention is an effective therapy for acquired SGS in children.


Assuntos
Laringoestenose , Broncoscopia , Criança , Endoscopia , Feminino , Humanos , Lactente , Laringoestenose/etiologia , Laringoestenose/terapia , Masculino , Estudos Retrospectivos , Resultado do Tratamento
12.
Comput Math Methods Med ; 2022: 2021613, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35069777

RESUMO

BACKGROUND: Hepatocellular carcinoma (HCC) is predominant among all types of primary liver cancers characterised by high morbidity and mortality. Genes in the mediator complex (MED) family are engaged in the tumour-immune microenvironment and function as regulatory hubs mediating carcinogenesis and progression across diverse cancer types. Whereas research studies have been conducted to examine the mechanisms in several cancers, studies that systematically focused on the therapeutic and prognostic values of MED in patients with HCC are limited. METHODS: The online databases ONCOMINE, GEPIA, UALCAN, GeneMANIA, cBioPortal, OmicStudio, STING, Metascape, and TIMER were used in this study. RESULTS: The transcriptional levels of all members of the MED family in HCC presented an aberrant high expression pattern. Significant correlations were found between the MED1, MED6, MED8, MED10, MED12, MED15, MED17, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, and MED27 expression levels and the pathological stage in the patients with HCC. The patients with high expression levels of MED6, MED8, MED10, MED17, MED19, MED20, MED21, MED22, MED24, and MED25 were significantly associated with poor prognosis. Functional enrichment analysis revealed that the members of the MED family were mainly enriched in the nucleobase-containing compound catabolic process, regulation of chromosome organisation, and transcriptional regulation by TP53. Significant correlations were found between the MED6, MED8, MED10, MED17, MED19, MED20, MED21, MED22, MED24, and MED25 expression levels and all types of immune cells (B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells). B cells and MED8 were independent predictors of overall survival. We found significant correlations between the somatic copy number alterations of the MED6, MED8, MED10, MED20, MED21, MED22, MED24, and MED25 molecules and the abundance of immune infiltrates. CONCLUSIONS: Our study delineated a thorough landscape to investigate the therapeutic and prognostic potentials of the MED family for HCC cases, which yielded promising results for the development of immunotherapeutic drugs and construction of a prognostic stratification model.


Assuntos
Biomarcadores Tumorais/genética , Carcinoma Hepatocelular/genética , Neoplasias Hepáticas/genética , Complexo Mediador/genética , Biomarcadores Tumorais/imunologia , Carcinoma Hepatocelular/imunologia , Biologia Computacional , Bases de Dados Genéticas , Perfilação da Expressão Gênica/estatística & dados numéricos , Regulação Neoplásica da Expressão Gênica , Redes Reguladoras de Genes , Humanos , Estimativa de Kaplan-Meier , Neoplasias Hepáticas/imunologia , Complexo Mediador/imunologia , Família Multigênica , Prognóstico , Mapas de Interação de Proteínas/genética , Mapas de Interação de Proteínas/imunologia , Microambiente Tumoral/genética , Microambiente Tumoral/imunologia
13.
J Pept Sci ; 28(5): e3381, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-34811838

RESUMO

The reversible and dynamic post-translational modifications (PTMs) of histones in eukaryotic chromatin are intimately connected to cell development and gene function, and abnormal regulation of PTMs can result in cancer and neurodegenerative diseases. Specific combinations of these modifications are mediated by a series of chromatin proteins that write, erase, and read the "histone codes," but mechanistic studies of the precise biochemical and structural relationships between different sets of modifications and their effects on chromatin function constitute a unique challenge to canonical biochemical approaches. In the past decade, the development and application of chemical methods for investigating histone PTM crosstalks has received considerable attention in the field of chemical biology. In this review, taking the functional crosstalk between H2B ubiquitylation at Lys120 (H2BK120ub) and H3 methylation at Lys79 (H3K79me) as a typical example, we survey recent developments of different chemical methods, in particular, protein synthetic chemistry and protein-based chemical probes, for studying the mechanism of the functional crosstalks of histone PTMs.


Assuntos
Histonas , Processamento de Proteína Pós-Traducional , Cromatina/genética , Histonas/química , Metilação , Ubiquitinação
14.
Plant Divers ; 43(5): 409-419, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34816066

RESUMO

Corallorhiza sinensis, a new species of mycoheterotrophic orchid from western Sichuan, China, is described and illustrated based on molecular and morphological evidence. It is morphologically similar to Corallorhiza trifida, but can be distinguished by bigger flowers, both sepals and petals with 3 veins, and longer lateral lobes of lip. To distinguish the new Corallorhiza species and explore its phylogenetic position within subtribe Calypsoinae, this study employed sequences of the nuclear ribosomal DNA (nrDNA) and whole plastome assembled from the genome skimming approach. The plastome is 148,124 bp in length, including a pair of inverted repeats (IRs) of 26,165 bp, a large single-copy region (LSC) of 82,207 bp, and a small single-copy region (SSC) of 13,587 bp. Further, phylogenetic analyses were performed using nrDNA sequence and 79 coding sequences (CDSs) from 26 complete plastomes of subtribe Calypsoinae. The phylogenetic tree based on nrDNA sequence suggested that Corallorhiza is a monophyletic group, and strongly support C. sinensis as sister to the rest species of Corallorhiza. The plastid tree showed that 10 Corallorhiza species grouped into two clades and C. sinensis is most closely related to the North American C. striata and C. bentleyi instead of Oreorchis foliosa and O . angustata in the same clade. The plastid tree and nrDNA tree indicate Oreorchis is a paraphyletic. Although the topological conflicts are displayed between plastome and nrDNA phylogenies of C. sinensis, it is still the most closely related to Corallorhiza. Comparative analysis showed that C. sinensis populations are characteristic of the intermediate morphological traits between Corallorhiza and Oreorchis. The finding of this new species from China shed new light on the phylogeny of Oreorchis and Corallorhiza.

15.
Plants (Basel) ; 10(9)2021 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-34579345

RESUMO

Impatiens longiaristata (Balsaminaceae), a new species from western Sichuan Province in China, is described and illustrated here based on morphological and molecular data. It is similar to I. longiloba and I. siculifer, but differs in its lower sepal with a long arista at the apex of the mouth, spur curved downward or circinate, and lower petal that is oblong-elliptic and two times longer than the upper petal. Molecular analysis confirmed its placement in sect. Racemosae. Simultaneously, during the inspection of the protologues and type specimens of allied species, it was found that the types of two names from this section were syntypes based on Article 9.6 of the International Code of Nomenclature for algae, fungi, and plants (Shenzhen Code). According to Articles 8.1, 9.3, and Recommendations 9A.1, 9A.2, and 9A.3, the lectotypes of these two names are here designated.

16.
Environ Sci Technol ; 55(19): 13286-13296, 2021 10 05.
Artigo em Inglês | MEDLINE | ID: mdl-34529405

RESUMO

The stack configuration in flow-electrode capacitive deionization (FCDI) has been verified to be an attractive and feasible strategy for scaling up the desalination process. However, challenges still exist when attempting to simultaneously improve the desalination scale and the cell configuration. Here, we describe a novel stack FCDI configuration (termed a gradient FCDI system) based on a membrane-current collector assembly, in which the charge neutralization enables the in situ regeneration of the flow electrodes in the single cycle operation, thereby realizing a considerable increase in the desalinating performance. By evaluating standardized metrics such as the salt rejection, productivity (P), average salt removal rate (ASRR), energy-normalized removed salt (ENRS), and TEE, the results indicated that the gradient FCDI system could be a performance-stable and energy-efficient alternative for scale-up desalination. Under optimal operating conditions (carbon content = 10 wt %, feed salinity = 3000 mg L-1, cell voltage = 1.2 V, and productivity = 56.7 L m-2 h-1), the robust desalination performance (ASRR = 1.07 µmol cm-2 min-1) and energy consumption (ENRS = 7.8 µmol J-1) of the FCDI system with a desalination unit number of four were verified at long-term operation. In summary, the stacked gradient FCDI system and its operation mode described here may be an innovative and promising strategy capable of enlarging the scale of desalination while realizing performance improvement and device simplification.


Assuntos
Purificação da Água , Adsorção , Eletrodos , Salinidade , Cloreto de Sódio
17.
Plants (Basel) ; 10(8)2021 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-34451742

RESUMO

Impatiens longshanensis (The LSID for the name Impatiens longshanensis is: 77219154-1) sp. nov. and I. lihengiana (The LSID for the name I. lihengiana is: 77219153-1) sp. nov., from Hunan, China, are described and illustrated here. The molecular phylogenetic study suggests that I. longshanensis and I. lihengiana should be placed in the I. sect. Impatiens. A detailed description, diagnostic characters between the two new species and allied species, pollen and seed morphology, and color photographs are provided. In addition, based on wide sampling, we found that the longifilamenta group, an endemic group to China, whose members have basal lobes of lateral united petals with long filamentous hairs, shows significant morphological variability. In this paper, we discuss the taxonomic significance of morphological characteristics within this group. Based on a literature review and observation of living materials in the field, an updated identification key for this group is also proposed.

18.
Water Res ; 202: 117423, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34284122

RESUMO

Phosphorus (P) extraction from human urine is a potential strategy to address global resource shortage, but few approaches are able to obtain high-quality liquid P products. In this study, we introduced an innovative flow-electrode capacitive deionization (FCDI) system, also called ion-capture electrochemical system (ICES), for selectively extracting P and N (i.e., urea) from fresh human urine simply by integrating a liquid membrane chamber (LMC) using a pair of anion exchange membrane (AEM). In the charging process, negatively charged P ions (i.e., HPO42- and H2PO4-) can be captured by acidic extraction solutions (e.g., solutions of HCl, HNO3 and H2SO4) on their way to the anode chamber, leading to the conversion of P ions to uncharged H3PO4, while other undesired ions such as Cl- and SO42- are expelled. Simultaneously, uncharged urea molecules remain in the urine effluent with the removal of salt. Thus, high-purity phosphoric acid and urea solutions can be obtained in the LMC and spacer chambers, respectively. The purification of P in an acidic environment is ascribed largely to the competitive migration and protonation of ions. The latter contributes ~27% for the selective capture of P. Under the optimal operating conditions (i.e., ratio of the urine volume to the HCl volume = 7:3, initial pH of the extraction solution = 1.43, current density = 20 A/m2 and threshold pH ~ 2.0), satisfactory recovery performance (811 mg/L P with 73.85% purity and 8.3 g/L urea-N with 81.4% extraction efficiency) and desalination efficiency (91.1%) were obtained after 37.5 h of continuous operation. Our results reveal a promising strategy for improving in selective separation and continuous operation via adjustments to the cell configuration, initiating a new research dimension toward selective ion separation and high-quality P recovery.


Assuntos
Fósforo , Purificação da Água , Adsorção , Eletrodos , Humanos , Ureia
19.
Int Immunopharmacol ; 94: 107491, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33770552

RESUMO

Pristimerin (Pris), which is a natural triterpenoid compound extracted from the Celastraceae plant, has an effect on intestinal inflammation, but its mechanism needs further study. Human genome-wide analysis found that the expression of microRNA-155 in the blood and colon tissue of patients with IBD was increased. Therefore, we studied the effect of Pris on a model of DSS-induced colitis in mice and investigated whether Pris inhibited the expression of microRNA-155. We obtained a mouse model of acute experimental colitis by allowing the mice to drink a 3% by mass DSS solution freely for 7 days. Pris solutions at different concentrations were injected via the abdomen to simulate the therapeutic effect of Pris on colitis. The body weight and faeces were measured and recorded daily. The mice were sacrificed by the cervical dislocation method after the experiment, and the colon length and histological changes, as well as the changes in Nrf2 in the colon tissue, were measured. The activities of the antioxidant enzymes GSH, GSH-Px and SOD were examined. The expression levels of microRNA-155, IL-1ß, IL-6, IL-17, and TNF-α in the colon were detected by RT-PCR technology, and the expression of NF-κB p65 in the colon was detected by western blotting. Our study shows that Pris can reduce the DAI score, obviously alleviate weight loss, and decrease the colon pathological tissue damage caused by DSS. Pris can inhibit the increase in microRNA-155 expression induced by DSS-induced colitis. Our study has shown that Pris may reduce DSS-induced colitis in mice by inhibiting the expression of microRNA-155, and further inhibition of the inflammatory response and oxidative stress occurred.


Assuntos
Anti-Inflamatórios/uso terapêutico , Colite/tratamento farmacológico , MicroRNAs/antagonistas & inibidores , Triterpenos Pentacíclicos/uso terapêutico , Animais , Anti-Inflamatórios/farmacologia , Colite/induzido quimicamente , Colite/imunologia , Colite/patologia , Colo/efeitos dos fármacos , Colo/patologia , Citocinas/genética , Citocinas/imunologia , Sulfato de Dextrana , Células HT29 , Humanos , Masculino , Camundongos Endogâmicos C57BL , MicroRNAs/imunologia , Estresse Oxidativo/efeitos dos fármacos , Triterpenos Pentacíclicos/farmacologia
20.
Environ Sci Pollut Res Int ; 28(22): 28571-28584, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33544344

RESUMO

Permeable pavement is an effective means for stormwater runoff control and pollutant removal. However, relatively few studies have examined the characteristics of permeable brick and corresponding permeable pavement system (PPS). In this work, the permeable pavement systems consisted of surface permeable brick layer (concrete or ceramic) with structural layer (including a cement mortar layer, a permeable concrete layer, and a gravel layers) were selected as typical cases to assess their permeability and runoff pollutant removal performance by laboratory experiments. The results indicated that PPS had obvious outflow hysteresis effect. The PPS with ceramic brick layer reached the saturation flow rate earlier and showed larger outflow rate than that with concrete brick layer. Both types of PPSs had a relatively high efficiency (83.8-95.2%) in removing suspended solids (SS) in stormwater runoff mainly due to the interception and filtration of the surface brick layer, whereas the structural layer of the PPS played a vital role in the removal of total phosphorus (TP). The percentage of total nitrogen (TN) removal efficiency via ceramic brick layer accounted for via corresponding PPS was obviously larger than that of concrete brick layer. The PPS also displayed a certain chemical oxygen demand (COD) removal ability: around 14.0-27.0% for concrete type and 20.9-28.9% for ceramic type. Subsequently, a multi-objective evaluation model was implemented based on the analytic hierarchy process (AHP) method to identify the optimal scheme in relation to four indices: permeability, environmental benefit, compressive strength, and comprehensive economic cost. The results showed, insofar, the ceramic PPS is preferred with a better economic performance. Our study attempts to select optimal designs of PPS and provides insight into the permeable capacity and the efficiency of pollutant removal in PPS.


Assuntos
Poluentes Ambientais , Poluentes Químicos da Água , Permeabilidade , Fósforo , Chuva , Movimentos da Água , Poluentes Químicos da Água/análise
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