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1.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(10): 1595-1600, 2020 Oct 10.
Artigo em Chinês | MEDLINE | ID: mdl-33297614

RESUMO

Objective: To establish a new model for the prediction of severe outcomes of COVID-19 patients and provide more comprehensive, accurate and timely indicators for the early identification of severe COVID-19 patients. Methods: Based on the patients' admission detection indicators, mild or severe status of COVID-19, and dynamic changes in admission indicators (the differences between indicators of two measurements) and other input variables, XGBoost method was applied to establish a prediction model to evaluate the risk of severe outcomes of the COVID-19 patients after admission. Follow up was done for the selected patients from admission to discharge, and their outcomes were observed to evaluate the predicted results of this model. Results: In the training set of 100 COVID-19 patients, six predictors with higher scores were screened and a prediction model was established. The high-risk range of the predictor variables was calculated as: blood oxygen saturation <94%, peripheral white blood cells count >8.0×10(9), change in systolic blood pressure <-2.5 mmHg, heart rate >90 beats/min, multiple small patchy shadows, age >30 years, and change in heart rate <12.5 beats/min. The prediction sensitivity of the model based on the training set was 61.7%, and the missed diagnosis rate was 38.3%. The prediction sensitivity of the model based on the test set was 75.0%, and the missed diagnosis rate was 25.0%. Conclusions: Compared with the traditional prediction (i.e. using indicators from the first test at admission and the critical admission conditions to assess whether patients are in mild or severe status), the new model's prediction additionally takes into account of the baseline physiological indicators and dynamic changes of COVID-19 patients, so it can predict the risk of severe outcomes in COVID-19 patients more comprehensively and accurately to reduce the missed diagnosis of severe COVID-19.

2.
Zhonghua Yu Fang Yi Xue Za Zhi ; 54(8): 817-821, 2020 Aug 06.
Artigo em Chinês | MEDLINE | ID: mdl-32842308

RESUMO

COVID-19 is a public health emergency currently. In this study, a scale-free network model is established based on the Spring Migration data in 2020.The cities is clustered into three different modules. The epidemic of the cities in the black module was the most serious, followed by the red and the cyan. The black module contains 9 cities in Zhejiang province and 8 cities in Guangdong province, most of them located in the southeast coastal economic belt. These cities should be the key cities for epidemic prevention and control.


Assuntos
Planejamento de Cidades , Infecções por Coronavirus/prevenção & controle , Modelos Biológicos , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , China/epidemiologia , Cidades/epidemiologia , Infecções por Coronavirus/epidemiologia , Humanos , Pneumonia Viral/epidemiologia
3.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(6): 975-980, 2020 Jun 10.
Artigo em Chinês | MEDLINE | ID: mdl-32564570

RESUMO

Shortcomings have been inherited in the traditional influenza early warning system, often expressed through the scope, accuracy on prediction and real-time performance of the monitor related programs. With the new round of scientific and technological revolution and the increasingly maturity of modern information system, related technology on influenza early warning has become the focus of research in this field, based on big data analysis technology. Using the traditional influenza surveillance and early warning system as reference, this paper summarizes the progress of influenza early warning research, based on the Internet, influencing factors, time and space trends, and risk assessment etc., to summarize the trends on the advantages, shortcomings and future development of big data, used in the early warning system on influenza.


Assuntos
Big Data , Influenza Humana/epidemiologia , Vigilância em Saúde Pública/métodos , Previsões , Humanos
4.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(5): 794-798, 2020 May 10.
Artigo em Chinês | MEDLINE | ID: mdl-32447927

RESUMO

Since the implementation of antiretroviral therapy (ART), it has achieved remarkable results in the field of HIV/AIDS treatment. However, when the treatment is applied to the population-level, the actual impact of ART on the HIV epidemic becomes a hot topic in the field. This paper will summarize the research on ART and HIV epidemic in recent years, and discuss the impact of ART on the trend of HIV epidemic, so as to provide scientific support and suggestions for the role of treatment is prevention.


Assuntos
Antirretrovirais/uso terapêutico , Epidemias , Infecções por HIV/tratamento farmacológico , Surtos de Doenças , Humanos
5.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(4): 480-484, 2020 Apr 10.
Artigo em Chinês | MEDLINE | ID: mdl-32129581

RESUMO

Since December 2019, the outbreak of COVID-19 in Wuhan has spread rapidly due to population movement during the Spring Festival holidays. Since January 23rd, 2020, the strategies of containment and contact tracing followed by quarantine and isolation has been implemented extensively in mainland China, and the rates of detection and confirmation have been continuously increased, which have effectively suppressed the rapid spread of the epidemic. In the early stage of the outbreak of COVID-19, it is of great practical significance to analyze the transmission risk of the epidemic and evaluate the effectiveness and timeliness of prevention and control strategies by using mathematical models and combining with a small amount of real-time updated multi-source data. On the basis of our previous research, we systematically introduce how to establish the transmission dynamic models in line with current Chinese prevention and control strategies step by step, according to the different epidemic stages and the improvement of the data. By summarized our modelling and assessing ideas, the model formulations vary from autonomous to non-autonomous dynamic systems, the risk assessment index changes from the basic regeneration number to the effective regeneration number, and the epidemic development and assessment evolve from the early SEIHR transmission model-based dynamics to the recent dynamics which are mainly associated with the variation of the isolated and suspected population sizes.


Assuntos
Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/prevenção & controle , Modelos Estatísticos , Pandemias/prevenção & controle , Pneumonia Viral/epidemiologia , Pneumonia Viral/prevenção & controle , Betacoronavirus , China/epidemiologia , Infecções por Coronavirus/transmissão , Humanos , Pneumonia Viral/transmissão , Medição de Risco
6.
Phys Rev Lett ; 124(2): 023603, 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-32004058

RESUMO

Exploring the properties and applications of topological quantum states is essential to better understand topological matter. Here, we theoretically study a quasi-one-dimensional topological atom array. In the low-energy regime, the atom array is equivalent to a topological superatom. Driving the superatom in a cavity, we study the interaction between light and topological quantum states. We find that the edge states exhibit topology-protected quantum coherence, which can be characterized from the photon transmission. This quantum coherence helps us to find a superradiance-subradiance transition, and we also study its finite-size scaling behavior. The superradiance-subradiance transition also exists in symmetry-breaking systems. More importantly, it is shown that the quantum coherence of the subradiant edge state is robust to random noises, allowing the superatom to work as a topologically protected quantum memory. We suggest a relevant experiment with three-dimensional circuit QED. Our study may have applications in quantum computation and quantum optics based on topological edge states.

7.
Sci Rep ; 8(1): 10033, 2018 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-29968751

RESUMO

We report development and microwave characterization of rf SQUID (Superconducting QUantum Interference Device) qubits, consisting of an aluminium-based Josephson junction embedded in a superconducting loop patterned from a thin film of TiN with high kinetic inductance. Here we demonstrate that the systems can offer small physical size, high anharmonicity, and small scatter of device parameters. The work constitutes a non-tunable prototype realization of an rf SQUID qubit built on the kinetic inductance of a superconducting nanowire, proposed in Phys. Rev. Lett. 104, 027002 (2010). The hybrid devices can be utilized as tools to shed further light onto the origin of film dissipation and decoherence in phase-slip nanowire qubits, patterned entirely from disordered superconducting films.

8.
J Endocrinol Invest ; 41(4): 403-409, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28884301

RESUMO

OBJECTIVE: To identify the clinical and pathological predictors of central lymph node metastasis (CLNM) in patients with clinically lymph node-negative papillary thyroid microcarcinoma (PTMC). MATERIALS AND METHODS: Data pertaining to 541 clinically lymph node-negative PTMC patients who underwent thyroid surgery at the Shanghai General Hospital between January 2010 and December 2013 were retrospectively analyzed. According to histopathological evidence of central lymph node involvement, patients were divided into central lymph node metastasis (CLNM)-positive and CLNM-negative groups; risk factors for CLNM were identified statistically. RESULTS: LNM was found in 148 (27.4%) patients. Gender (P = 0.002), age (P < 0.001), tumor size (P < 0.001), multifocality (P < 0.001), and extrathyroidal extension (P < 0.001) were significantly different between CLNM-positive and CLNM-negative groups. On multivariate analyses, male sex (odds ratio [OR] = 2.656), age <45 years (OR = 4.184), tumor size >0.575 cm (OR = 2.105), gross extrathyroidal extension (OR = 14.605) and multifocality (OR = 2.084) were independent risk factors for CLNM. Among patients who did not have any of these five risk factors, only 3.9% were found to have CLNM. CONCLUSIONS: A relatively high prevalence of CLNM was observed in patients with clinically lymph node-negative PTMC. CLNM was associated with male sex, younger age, larger tumor size, extrathyroidal extension and multifocal PTMC.


Assuntos
Carcinoma Papilar/secundário , Linfonodos/patologia , Neoplasias da Glândula Tireoide/secundário , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Carcinoma Papilar/epidemiologia , Carcinoma Papilar/cirurgia , Estudos de Casos e Controles , China/epidemiologia , Seguimentos , Humanos , Linfonodos/cirurgia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Estudos Retrospectivos , Fatores de Risco , Fatores Sexuais , Neoplasias da Glândula Tireoide/epidemiologia , Neoplasias da Glândula Tireoide/cirurgia , Adulto Jovem
9.
Oncogene ; 36(13): 1779-1792, 2017 03 30.
Artigo em Inglês | MEDLINE | ID: mdl-27641329

RESUMO

We previously demonstrated that fermitin family member 1 (FERMT1) was significantly overexpressed in colon cancer (CC) and associated with poor metastasis-free survival. This study aimed to investigate the precise role of FERMT1 in CC metastasis and the mechanism by which FERMT1 is involved in the epithelial-mesenchymal transition (EMT). Correlations between FERMT1 and EMT markers (E-cadherin, Slug, N-cadherin and ß-catenin) were examined via immunohistochemistry in a cohort of CC tissues and adjacent normal colon mucosae. A series of in vitro and in vivo assays were performed to elucidate the function of FERMT1 in CC metastasis and underlying mechanisms. The upregulated expression of FERMT1 in CC tissues correlated positively with that of Slug, N-cadherin and ß-catenin, but correlated inversely with E-cadherin expression. Altered FERMT1 expression led to marked changes in the proliferation, migration, invasion and EMT markers of CC cells both in vitro and in vivo. Investigations of underlying mechanisms found that FERMT1 interacted directly with ß-catenin and activated the Wnt/ß-catenin signaling pathway by decreasing the phosphorylation level of ß-catenin, enhancing ß-catenin nuclear translocation and increasing the transcriptional activity of ß-catenin/TCF/LEF. Activation of the Wnt/ß-catenin pathway by CHIR99021 reversed the effect of FERMT1 knockdown, whereas inhibition of the Wnt/ß-catenin pathway by XAV939 impaired the effect of FERMT1 overexpression on EMT and cell motility. In conclusion, findings of this study suggest that FERMT1 activates the ß-catenin transcriptional activity to promote EMT in CC metastasis.


Assuntos
Neoplasias do Colo/genética , Neoplasias do Colo/patologia , Transição Epitelial-Mesenquimal/genética , Regulação Neoplásica da Expressão Gênica , Proteínas de Membrana/genética , Proteínas de Neoplasias/genética , Transcrição Genética , beta Catenina/genética , Biomarcadores , Caderinas/metabolismo , Linhagem Celular Tumoral , Movimento Celular/genética , Proliferação de Células/genética , Neoplasias do Colo/metabolismo , Feminino , Glicogênio Sintase Quinase 3 beta/metabolismo , Humanos , Mucosa Intestinal/metabolismo , Mucosa Intestinal/patologia , Masculino , Proteínas de Membrana/metabolismo , Gradação de Tumores , Metástase Neoplásica , Proteínas de Neoplasias/metabolismo , Estadiamento de Neoplasias , Proteínas Proto-Oncogênicas c-akt/metabolismo , Carga Tumoral , Via de Sinalização Wnt , beta Catenina/metabolismo
10.
Nat Commun ; 7: 12588, 2016 08 22.
Artigo em Inglês | MEDLINE | ID: mdl-27545689

RESUMO

An on-demand single-photon source is a key element in a series of prospective quantum technologies and applications. Here we demonstrate the operation of a tuneable on-demand microwave photon source based on a fully controllable superconducting artificial atom strongly coupled to an open-ended transmission line. The atom emits a photon upon excitation by a short microwave π-pulse applied through a control line. The intrinsically limited device efficiency is estimated to be in the range 65-80% in a wide frequency range from 7.75 to 10.5 GHz continuously tuned by an external magnetic field. The actual demonstrated efficiency is also affected by the excited state preparation, which is about 90% in our experiments. The single-photon generation from the single-photon source is additionally confirmed by anti-bunching in the second-order correlation function. The source may have important applications in quantum communication, quantum information processing and sensing.

11.
Zhonghua Liu Xing Bing Xue Za Zhi ; 37(5): 653-7, 2016 May.
Artigo em Chinês | MEDLINE | ID: mdl-27188356

RESUMO

OBJECTIVE: To investigate the infection status of HCV in remunerated blood donors and risk factors in Jiangsu province. METHODS: A Cross-sectional study was conducted among people aged >50 years. Questionnaires were used to collect the information about their demographic characteristics and risk behaviors, and venous blood samples were collected from them to detect HCV anti-body, HCV-RNA and other biochemical indicators. EpiData and Stata were used for data entry and statistical analysis. RESULTS: The overall HCV sero-prevalence rates were 22.55% and 61.05% among remunerated blood donors. Data from multiple stepwise regression analysis showed that alanine aminotransferase(ALT)(adjusted OR=1.38, 95%CI: 1.18-1.62)and aspartate aminotransferase(AST)(adjusted OR=1.30, 95%CI: 1.10-1.54)were associated with the outcomes of HCV infection, and fasting plasma glucose(adjusted OR=1.17, 95%CI: 1.01-1.35)were associated with HCV RNA viral loads. CONCLUSION: The prevalence of HCV infection in remunerated blood donors was high, clinical ALT, AST and fasting plasma glucose levels were associated with the risk for HCV infection and HCV RNA viral load.


Assuntos
Alanina Transaminase/sangue , Doadores de Sangue/estatística & dados numéricos , Anticorpos Anti-Hepatite C/sangue , Hepatite C/sangue , Adolescente , Adulto , China/epidemiologia , Estudos Transversais , Feminino , Hepatite C/diagnóstico , Hepatite C/prevenção & controle , Hepatite C/transmissão , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Análise de Regressão , Fatores de Risco , Estudos Soroepidemiológicos , Inquéritos e Questionários , Adulto Jovem
15.
Phys Rev Lett ; 115(22): 223603, 2015 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-26650305

RESUMO

A single superconducting artificial atom can be used for coupling electromagnetic fields up to the single-photon level due to an easily achieved strong coupling regime. Bringing a pair of harmonic oscillators into resonance with the transitions of a three-level atom converts atomic spontaneous processes into correlated emission dynamics. We present the experimental demonstration of two-mode correlated emission lasing in harmonic oscillators coupled via a fully controllable three-level superconducting quantum system (artificial atom). The correlation of emissions with two different colors reveals itself as equally narrowed linewidths and quenching of their mutual phase diffusion. The mutual linewidth is more than 4 orders of magnitude narrower than the Schawlow-Townes limit. The interference between the different color lasing fields demonstrates that the two-mode fields are strongly correlated.

16.
Genet Mol Res ; 14(4): 14882-92, 2015 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-26600549

RESUMO

Grain size is an important trait that directly influences the yield of rice. Validation and evaluation of grain genes is important in rice genetic studies and for breeding. In a population of 240 recombinant inbred lines (RILs) derived from a cross between an extra-large grain japonica variety TD70 and a small grain indica variety Kasalath, we mapped 19 QTLs controlling grain traits. These QTLs included six cloned grain genes, namely, GW2, GS3, qSW5, qGL3, GS5, and GW8. All of the alleles with the optimal effects on grain size came from TD70, the variety with extra-large grains. To verify these gene loci, we cloned and sequenced GW2, GS3, GW5 (qSW5), qGL3, GS5, GW8, and TGW6 in TD70 and Kasalath, and found several functional polymorphisms in the sequences of the genes. New functional markers for the cloned genes were designed to identify parents and RILs. The contributions of these polymorphisms to the improvement in rice grain size traits were evaluated. Our results indicate that at least six functional polymorphisms have additive effects on grain shape and that one non-functional polymorphism in TGW6 affects grain shape in TD70. The newly designed markers will be useful in further studies to identify functional grain genes. Our findings provide insight into the control of grain size in rice, and they will be of value for improving rice grain yield.


Assuntos
Grão Comestível/genética , Oryza/genética , Proteínas de Plantas/genética , Locos de Características Quantitativas/genética , Alelos , Cruzamento , Mapeamento Cromossômico , Cromossomos de Plantas/genética , Clonagem Molecular , Oryza/crescimento & desenvolvimento , Fenótipo , Sementes/genética , Análise de Sequência de DNA
17.
Epidemiol Infect ; 143(13): 2827-36, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25600557

RESUMO

Limited information is available on the prevalence of hepatitis C virus (HCV) in the general population in China. A community-based epidemiological study was conducted in three counties in eastern China. A total of 149 175 individuals were investigated in 60 communities in three counties in Jiangsu province, eastern China, of whom 1175 subjects [0·79%, 95% confidence interval (CI) 0·74-0·83] were HCV antibody positive. The prevalence was low in children (0·09%, 95% CI 0·04-0·17), but increased progressively from adolescents (0·20%, 95% CI 0·15-0·28) to adults aged ⩾21 years (95% CI 0·15-1·64). Women had a higher prevalence of HCV infection than men in most age groups. In a multilevel regression analysis, age, sex, education, occupation, blood transfusion [odds ratio (OR) 2·91, 95% CI 1·09-5·37], invasive testing (OR 1·28, 95% CI 1·14-1·61), and dental therapy (OR 2·27, 95% CI 1·41-3·42) were associated with HCV infection. In conclusion, although the prevalence of HCV in this population was lower than reported from national levels, the total reservoir of infection is significant and warrants public health measures, such as health education to limit the magnitude of the problem.


Assuntos
Hepatite C/epidemiologia , Adolescente , Adulto , Idoso , Criança , China/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco
18.
Sci Rep ; 4: 7289, 2014 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-25487352

RESUMO

Three-wave mixing in second-order nonlinear optical processes cannot occur in atomic systems due to the electric-dipole selection rules. In contrast, we demonstrate that second-order nonlinear processes can occur in a superconducting quantum circuit (i.e., a superconducting artificial atom) when the inversion symmetry of the potential energy is broken by simply changing the applied magnetic flux. In particular, we show that difference- and sum-frequencies (and second harmonics) can be generated in the microwave regime in a controllable manner by using a single three-level superconducting flux quantum circuit (SFQC). For our proposed parameters, the frequency tunability of this circuit can be achieved in the range of about 17 GHz for the sum-frequency generation, and around 42 GHz (or 26 GHz) for the difference-frequency generation. Our proposal provides a simple method to generate second-order nonlinear processes within current experimental parameters of SFQCs.

19.
Transplant Proc ; 46(5): 1448-52, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24935312

RESUMO

BACKGROUND: Acinetobacter baumannii (Ab) has become an important pathogenic bacterium with specific epidemic features in the intensive care unit. We explored the epidemiology of multidrug-resistant Ab infections among liver transplant recipients at the Liver Transplantation Center, 1st Affiliated Hospital of Shanghai Jiao Tong University. METHODS: Seventeen multidrug-resistant Ab strains were isolated from the sputum and bronchoalveolar lavage fluid specimens of 249 liver transplant recipients from January 2007 to December 2009. The drug resistance and minimum inhibitory concentration (MIC) for the 17 Ab strains were determined. The Ab strains were genotyped with the use of repetitive element-based polymerase chain reaction. The risk factors were also characterized by single-factor and multifactor analysis to the clinical data of the 249 liver transplant recipients. RESULTS: The drug sensitivity results showed that the 17 Ab strains isolated displayed 100% drug resistance rate to aminoglycosides (gentamicin), quinolones (ciprofloxacin), penicillins (piperacillin), cephalosporins (ceftazidime, cefotaxime, and cefepime), and carbapenems (imipenem and meropenem). The 17 Ab strains could be divided into 3 genotypes: 1, 1, and 15 strains for types A, C, and B, respectively. Fungal culture positivity after operation (odds ratio [OR], 5.470) and tracheal intubation twice (OR, 11.538) were the independent risk factors for multidrug-resistant Ab strain infection. CONCLUSIONS: Type B multidrug-resistant Ab strains are prevalent in the liver transplantation center, and they could be transmitted clonally. Liver transplant recipients with postoperational fungal culture positivity and tracheal intubation twice are prone to multidrug-resistant Ab infections. Therefore, a high degree of vigilance should be paid to those recipients to avoid nosocomial Ab infections.


Assuntos
Infecções por Acinetobacter/etiologia , Acinetobacter baumannii/isolamento & purificação , Antibacterianos/uso terapêutico , Farmacorresistência Bacteriana Múltipla , Transplante de Fígado/efeitos adversos , Infecções por Acinetobacter/tratamento farmacológico , Acinetobacter baumannii/efeitos dos fármacos , Acinetobacter baumannii/genética , Antibacterianos/farmacologia , Sequência de Bases , Primers do DNA , DNA Bacteriano/isolamento & purificação , Feminino , Genes Bacterianos , Humanos , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase
20.
Clin Radiol ; 69(2): 163-71, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24268513

RESUMO

AIM: To investigate the diagnostic accuracy of dual-source computed tomography (DSCT) coronary angiography with and without the application of a ß-blocker. MATERIALS AND METHODS: An exact binomial rendition of the bivariate mixed-effects regression model was used to synthesize diagnostic test data. RESULTS: The pooled sensitivity at the patient level was 0.98 [95% confidence intervals (CI): 0.97-0.99], and specificity 0.88 (95% CI: 0.84-0.91). The results showed that without heart rate control, the sensitivity and specificity at the patient level did not decrease (p = 0.27 and 0.56, respectively). At the artery level, no significant differences in sensitivity and specificity for studies with and without heart rate control were detected (p = 0.04 and 0.05, respectively). At the segment level, the specificity decreased without heart rate control (p = 0.03), whereas the sensitivity was not influenced (p = 0.63). The median radiation exposure was 2.6 mSv, with 1.6 mSv and 8 mSv for heart rate-controlled studies and uncontrolled studies, respectively. CONCLUSIONS: DSCT coronary angiography without heart rate control has a similar excellent diagnostic performance at the patient level as that of heart rate control groups. However, controlling for heart rate to decrease radiation and to provide effective information for selecting the therapeutic strategy and risk stratification is recommended.


Assuntos
Angiografia Coronária/métodos , Doença da Artéria Coronariana/diagnóstico por imagem , Frequência Cardíaca/fisiologia , Tomografia Computadorizada por Raios X/métodos , Antagonistas Adrenérgicos beta/administração & dosagem , Humanos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
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