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1.
Bull Cancer ; 106(11): 1039-1049, 2019 Nov.
Artigo em Francês | MEDLINE | ID: mdl-31570215

RESUMO

Return to work is a public health priority which led the French Health Authority to publish recommendations about "return to work and health: prevention of exclusion from work". The aim of this article is to present a literature review of return to work after cancer. Studies about medium-term and long-term effects of cancer are sparse. They suggest worker durable effects. Factors associated with return to work are linked to the patient characteristics, to characteristics of the illness and the treatment, to the workplace and to the help provided to the patient during the return to work process. A specific plan for returning to work in 3 phases (situation comprehension, identification of negative and positive factors for returning to work, implementation of measures concerning the patient, the workplace and the coordination between return to work actors) should be built for each patient, involving the worker, the occupational practitioner, the general and specialist practitioners.


Assuntos
Neoplasias , Retorno ao Trabalho , Fatores Etários , Guias como Assunto , Humanos , Fatores Sexuais , Fatores Socioeconômicos , Avaliação da Capacidade de Trabalho , Local de Trabalho
2.
BMC Public Health ; 17(1): 191, 2017 02 14.
Artigo em Inglês | MEDLINE | ID: mdl-28193266

RESUMO

BACKGROUND: The aim of this work was to establish recommendations for the medical follow-up of workers currently or previously exposed to lung carcinogens. METHODS: A critical synthesis of the literature was conducted. Occupational lung carcinogenic substances were listed and classified according to their level of lung cancer risk. A targeted screening protocol was defined. RESULTS: A clinical trial, National Lung Screnning Trial (NLST), showed the efficacy of chest CAT scan (CT) screening for populations of smokers aged 55-74 years with over 30 pack-years of exposure who had stopped smoking for less than 15 years. To propose screening in accordance with NLST criteria, and to account for occupational risk factors, screening among smokers and former smokers needs to consider the types of occupational exposure for which the risk level is at least equivalent to the risk of the subjects included in the NLST. The working group proposes an algorithm that estimates the relative risk of each occupational lung carcinogen, taking into account exposure to tobacco, based on available data from the literature. CONCLUSION: Given the lack of data on bronchopulmonary cancer (BPC) screening in occupationally exposed workers, the working group proposed implementing a screening experiment for bronchopulmonary cancer in subjects occupationally exposed or having been occupationally exposed to lung carcinogens who are confirmed as having high risk factors for BPC. A specific algorithm is proposed to determine the level of risk of BPC, taking into account the different occupational lung carcinogens and tobacco smoking at the individual level.


Assuntos
Carcinógenos/toxicidade , Neoplasias Pulmonares/epidemiologia , Doenças Profissionais/epidemiologia , Exposição Ocupacional/efeitos adversos , Idoso , Detecção Precoce de Câncer , Medicina Baseada em Evidências , Feminino , Seguimentos , França/epidemiologia , Humanos , Neoplasias Pulmonares/induzido quimicamente , Neoplasias Pulmonares/prevenção & controle , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/induzido quimicamente , Doenças Profissionais/prevenção & controle , Exposição Ocupacional/prevenção & controle , Fatores de Risco , Fumar/efeitos adversos
3.
Hum Vaccin ; 5(5): 341-6, 2009 May.
Artigo em Inglês | MEDLINE | ID: mdl-19221513

RESUMO

In this sero-epidemiological study, we investigated humoral immunity to three vaccine-preventable diseases--tetanus, diphtheria and pertussis--among 331 adults (aged 18-60 years) attending vaccination centres for travellers and who had been vaccinated according to national recommendations in France. Serological results showed that the percentage of subjects with antibodies to diphtheria and tetanus decreases with age. Results also confirmed surveillance data on vaccination in France, with 7.6% of the study population (13.4% of those aged 18-29 years) having recently acquired a pertussis infection. These results confirm the importance of following French recommendations for regular boosters for tetanus and diphtheria among adults. They also indicate the need for better implementation of the current recommendations for pertussis-vaccine boosters in adults.


Assuntos
Anticorpos Antibacterianos/sangue , Vacina contra Difteria, Tétano e Coqueluche/imunologia , Adolescente , Adulto , Fatores Etários , Difteria/imunologia , Feminino , França , Humanos , Imunização Secundária , Masculino , Pessoa de Meia-Idade , Estudos Soroepidemiológicos , Tétano/imunologia , Coqueluche/epidemiologia , Coqueluche/imunologia , Adulto Jovem
4.
AIDS Res Hum Retroviruses ; 24(11): 1445-8, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19000023

RESUMO

Long-term persistence of HIV vaccine-induced seropositivity in uninfected HIV vaccine recipients remains unknown. The duration of HIV humoral-induced responses was assessed in 72 volunteers who had received rgp160 and/or HIV recombinant canarypox virus constructs able to induce immune responses detectable using standard serological tests. Among the 43 rgp160 recipients, 94% and 83% remained HIV seropositive after 5 and 8 years of follow-up, respectively, while all the 29 volunteers who had received canarypox constructs alone were seronegative after 5 years. Because rgp160 induces long-term persistence (>8 years) of vaccine-induced HIV seropositivity, volunteers should be offered long-term follow-up to monitor their serological evolution.


Assuntos
Vacinas contra a AIDS/imunologia , Anticorpos Anti-HIV/sangue , Adulto , Feminino , Seguimentos , Soropositividade para HIV/imunologia , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Tempo , Vacinas Sintéticas/imunologia
5.
Vaccine ; 26(21): 2657-66, 2008 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-18068876

RESUMO

One goal of HIV vaccination is to achieve high mucosal levels of specific secretory IgA (SIgA). In order to elicit specific SIgA antibodies against human immunodeficiency virus type-1 (HIV-1), a vaccine must be administered by the mucosal route, to the nasal or vaginal mucosa for example. We report here the results of the first phase I, randomized, open-label trial designed to assess the mucosal tolerability and immunogenicity of a candidate vaccine (recombinant protein HIV-1 gp160MN/LAI with or without DC-Chol adjuvant) administered by the nasal or vaginal route. Thirty-four female volunteers with a mean age of 46 years were vaccinated. There were 465 adverse events, of which 65 were considered related to the vaccine. No severe adverse events were related to the vaccine, and no difference in terms of tolerability was observed between the sites of vaccination or between the vaccine formulations. None of the volunteers reported that study participation affected their intimate or broader social relationships. No anti-gp160 activity was found between week 4 and week 48 in serum, saliva, or cervicovaginal and nasal secretions. These results show that a mucosal HIV vaccine can be well tolerated when administered by the nasal or vaginal route.


Assuntos
Vacinas contra a AIDS/efeitos adversos , Vacinas contra a AIDS/imunologia , Administração Intranasal , Administração Intravaginal , Proteína gp160 do Envelope de HIV/imunologia , Infecções por HIV/prevenção & controle , Vacinas contra a AIDS/administração & dosagem , Adjuvantes Imunológicos/administração & dosagem , Adulto , Colo do Útero/imunologia , Colesterol/administração & dosagem , Colesterol/análogos & derivados , Feminino , Anticorpos Anti-HIV/análise , Anticorpos Anti-HIV/sangue , Proteína gp160 do Envelope de HIV/genética , Humanos , Imunoglobulina A/análise , Imunoglobulina A/sangue , Pessoa de Meia-Idade , Mucosa Nasal/imunologia , Proteínas Recombinantes/genética , Proteínas Recombinantes/imunologia , Saliva/imunologia
8.
Therapie ; 60(3): 209-14, 2005.
Artigo em Francês | MEDLINE | ID: mdl-16128261

RESUMO

Pharmacoepidemiological studies are essential in the post-licensing surveillance of vaccines in order to evaluate the potential benefits and risks of vaccines used in common practice. Surveillance is required to detect rare or unanticipated vaccine adverse events and to ensure confidence in vaccination. Epidemiological studies provide data on the long-term protection conferred by vaccination, and the incidence and associated mortality of, and population susceptibility to, diseases preventable by vaccine. These studies also allow verification of the compatibility between strains contained in the vaccine as well as circulating strains.


Assuntos
Licenciamento em Medicina , Vigilância de Produtos Comercializados , Vacinas/normas , Fatores Epidemiológicos , Humanos , Vacinas/efeitos adversos , Vacinas/uso terapêutico
9.
Virology ; 316(2): 290-301, 2003 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-14644611

RESUMO

Rectal infection of macaques by SIV is a model for rectal HIV transmission. We focus here on the digestive tract during days 7-14 of primary rectal infection by SIV in 15 rhesus macaques. Surprisingly, we did not detect productively infected cells in the rectosigmoid colon at early stages of viral dissemination. This strongly suggests that there is no massive viral amplification in the rectosigmoid colon prior to viral dissemination. As dissemination proceeds, productively infected T cells are observed in the rectosigmoid colon and small intestine, with rectosigmoid colon showing the heaviest viral load. Lymphoid follicles are infected prior to lamina propria at both sites. When viral dissemination is widespread, inflammatory infiltrates are visible in the rectosigmoid colon, but not in the small intestine. An important decrease in CD4(+) T cells is then observed in the lamina propria of the rectosigmoid colon only.


Assuntos
Linfócitos T CD4-Positivos/imunologia , Colo Sigmoide/virologia , Mucosa Intestinal/virologia , Reto/virologia , Síndrome de Imunodeficiência Adquirida dos Símios/virologia , Replicação Viral , Animais , Hibridização In Situ , Linfonodos/virologia , Macaca mulatta , Masculino , Síndrome de Imunodeficiência Adquirida dos Símios/imunologia
10.
AIDS Res Hum Retroviruses ; 18(13): 977-81, 2002 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-12230940

RESUMO

We report here the gene for DC-SIGN from Chinese rhesus macaques. DC-SIGN is a C-type lectin expressed by dendritic cells (DCs). It is involved in the interaction of DCs with T cells, and in transmission to T cells of HIV-1 and SIV. Alternative splicing in human DC-SIGN yields A and B isoforms of the protein. The overall organization of the rhesus macaque gene is similar to that of the human gene. Translation of B isoforms cannot occur because of a point substitution. The coding sequence shows that we have cloned a fourth allele for rhesus macaque DC-SIGN. This allele shows high homology to the other rhesus macaque alleles. However, at the protein level, the homology is highest with the pigtail macaque protein. This suggests a convergent evolution of DC-SIGN in macaques living in China. The importance of DC-SIGN variability in the immune response remains to be investigated.


Assuntos
Moléculas de Adesão Celular/genética , Lectinas Tipo C/genética , Macaca mulatta , Receptores de Superfície Celular/genética , Alelos , Sequência de Aminoácidos , Substituição de Aminoácidos , Animais , China , Humanos , Dados de Sequência Molecular , Isoformas de Proteínas , Análise de Sequência de DNA
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