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1.
Am J Clin Hypn ; 62(1-2): 118-137, 2020 Jul - Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31265368

RESUMO

Over the years, the field of hypnosis has often given more attention to the state and procedural factors of hypnosis than the relational ones. In an attempt to address this imbalance, the 60th annual meeting of the American Society of Clinical Hypnosis (ASCH) had as its theme "Hypnosis and the Treatment Relationship." A centerpiece of this meeting was a collegial discussion among a panel of psychologists with expertise in relational hypnotherapy. The panel addressed several pertinent questions: (1) What are the healing qualities of relationship in psychotherapy? (2) What makes hypnosis relational in nature? (3) How do relational factors of hypnosis resemble healthy attachment processes and recapitulate stalled developmental maturation? (4) How does relationally informed hypnotherapy influence and strengthen the relationship, process, and outcome of psychotherapy? This article summarizes the factors that led to the creation of this panel; provides an edited transcript of this panel discussion, along with additional commentary on several key points raised; and concludes with a summary of the main themes and recommendations for further clinical practice and study.

2.
Am J Clin Hypn ; 62(1-2): 95-117, 2020 Jul - Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31265370

RESUMO

This article explores how hypnotic strategies can be used within a polyvagal science framework to help create more secure attachment within the therapeutic relationship, as well as within the client in terms of ego-state relationships. Principles of safety and connection are emphasized, along with specific strategies to access the attachment circuits of the ventral vagal system, including the necessity of being present with the client without agenda. Uses of hypnosis related to safety and connection and methods to work with the center core self to facilitate empowerment, self-cohesion, and conflict-free experience are also reviewed. From an ego-state therapy perspective, a discussion of hypnosomatic approaches to connect with preverbal, nonverbal, and somatic aspects of self to accomplish developmental repair and facilitate secure attachment is also offered, along with case examples. A three-step model, which attempts to integrate polyvagal, somatic, and hypnotic approaches, is offered by the author to help structure corrective experiences for clients with trauma.

3.
Proc Natl Acad Sci U S A ; 113(38): 10631-6, 2016 09 20.
Artigo em Inglês | MEDLINE | ID: mdl-27582468

RESUMO

DNMT3a is a de novo DNA methyltransferase expressed robustly after T-cell activation that regulates plasticity of CD4(+) T-cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8(+) T-cell effector and memory fate decisions. Whereas effector function of DNMT3a knockout T cells is normal, they develop more memory precursor and fewer terminal effector cells in a T-cell intrinsic manner compared with wild-type animals. Rather than increasing plasticity of differentiated effector CD8(+) T cells, loss of DNMT3a biases differentiation of early effector cells into memory precursor cells. This is attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8(+) T cells. These data identify DNMT3a as a crucial regulator of CD8(+) early effector cell differentiation and effector versus memory fate decisions.


Assuntos
DNA (Citosina-5-)-Metiltransferases/genética , Fator 1-alfa Nuclear de Hepatócito/genética , Memória Imunológica/genética , Fator 1 de Transcrição de Linfócitos T/genética , Animais , Linfócitos T CD8-Positivos/imunologia , Diferenciação Celular/genética , Linhagem da Célula/genética , Linhagem da Célula/imunologia , Metilação de DNA/genética , Metilação de DNA/imunologia , Ativação Linfocitária/imunologia , Camundongos , Regiões Promotoras Genéticas
4.
J Appl Meas ; 16(4): 401-15, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26771568

RESUMO

Research in teacher self-efficacy has a long history that can be traced back to Bandura (1986) and has been shown to be linked to teacher performance. This article presents evidence for teacher self-efficacy in urban schools, a construct that is separate from but related to the more general construct of teacher self-efficacy. An instrument was developed and validated by a team of university faculty, urban teachers, and school administrators. The Teachers' Sense of Efficacy in Urban Schools (SEUS) is a 15-item instrument designed to address factors that are important for success in teaching in an urban environment, including working effectively with English language learners, students with disabilities, economically disadvantaged students, cultural diversity, literacy, technology, differentiation, and assessment data. The present study analyzes SEUS on multiple levels, using the Rasch partial credit model.


Assuntos
Autoeficácia , Estudantes , Logro , Criança , Docentes , Humanos , Instituições Acadêmicas , Ensino , População Urbana
5.
Front Genet ; 4: 83, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23720669

RESUMO

Interest in extracellular RNA (exRNA) has intensified as evidence accumulates that these molecules may be useful as indicators of a wide variety of biological conditions. To establish specific exRNA molecules as clinically relevant biomarkers, reproducible recovery from biological samples and reliable measurements of the isolated RNA are paramount. Toward these ends, careful and rigorous comparisons of technical procedures are needed at all steps from sample handling to RNA isolation to RNA measurement protocols. In the investigations described in this methods paper, RT-qPCR was used to examine the apparent recovery of specific endogenous miRNAs and a spiked-in synthetic RNA from blood plasma samples. RNA was isolated using several widely used RNA isolation kits, with or without the addition of glycogen as a carrier. Kits examined included total RNA isolation systems that have been commercially available for several years and commonly adapted for extraction of biofluid RNA, as well as more recently introduced biofluids-specific RNA methods. Our conclusions include the following: some RNA isolation methods appear to be superior to others for the recovery of RNA from biological fluids; addition of a carrier molecule seems to be beneficial for some but not all isolation methods; and quantitative recovery of RNA is observed from increasing volumes of cerebrospinal fluid.

6.
Am J Clin Hypn ; 56(1): 23-38, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24660337

RESUMO

Ego state therapy has often been cited as an effective treatment to help repair fragmentation related to posttraumatic stress and dissociative disorders. This article explores how specialized work with ego states can help to clarify and strengthen internal and external boundaries, create greater boundary flexibility, and contribute to containment and self-regulation. Applications of direct and indirect hypnosis to repair boundary issues through ego state therapy are emphasized, and clinical case examples are used to illustrate results.


Assuntos
Ego , Hipnose/métodos , Transtornos Mentais/terapia , Psicoterapia Psicodinâmica/métodos , Adulto , Feminino , Humanos , Masculino , Transtornos Mentais/psicologia , Pessoa de Meia-Idade , Resultado do Tratamento
7.
J Sex Res ; 47(1): 1-11, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19381998

RESUMO

Structural equation modelling was used to assess the strengths of the links between sexual satisfaction and self-reported (a) relationship well-being, (b) mental health, and (c) physical health for women in same-sex (i.e., homosexual, n = 114) versus mixed-sex (i.e., heterosexual, n = 208) relationships. Participants came from a large-scale Internet study. Sexual satisfaction was found to be an extremely strong predictor of relational well-being, a strong predictor of mental health, and a weak to moderately strong predictor of physical health. A two-group comparison model indicated that the strength of these links was the same, regardless of whether the women were in a sexual relationship with a man or with another woman.


Assuntos
Heterossexualidade/psicologia , Homossexualidade Feminina/psicologia , Satisfação Pessoal , Qualidade de Vida/psicologia , Comportamento Sexual/psicologia , Adolescente , Adulto , Feminino , Nível de Saúde , Humanos , Internet , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Inquéritos e Questionários , Adulto Jovem
8.
Nucleic Acids Res ; 33(15): 4965-77, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16284197

RESUMO

An algorithm is presented for the generation of sets of non-interacting DNA sequences, employing existing thermodynamic models for the prediction of duplex stabilities and secondary structures. A DNA 'word' structure is employed in which individual DNA 'words' of a given length (e.g. 12mer and 16mer) may be concatenated into longer sequences (e.g. four tandem words and six tandem words). This approach, where multiple word variants are used at each tandem word position, allows very large sets of non-interacting DNA strands to be assembled from combinations of the individual words. Word sets were generated and their figures of merit are compared to sets as described previously in the literature (e.g. 4, 8, 12, 15 and 16mer). The predicted hybridization behavior was experimentally verified on selected members of the sets using standard UV hyperchromism measurements of duplex melting temperatures (T(m)s). Additional experimental validation was obtained by using the sequences in formulating and solving a small example of a DNA computing problem.


Assuntos
Algoritmos , DNA/química , Análise de Sequência de DNA/métodos , Termodinâmica , Sequência de Bases , Biologia Computacional/métodos , Citosina/química , Guanina/química , Conformação de Ácido Nucleico , Desnaturação de Ácido Nucleico , Ácidos Nucleicos Heteroduplexes/química , Hibridização de Ácido Nucleico , Temperatura Ambiente
9.
Am J Clin Hypn ; 47(1): 3-12, 2004 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15376604

RESUMO

Many patients with posttraumatic fragmentation demonstrate a positive response to the corrective possibilities provided through Ego-State Therapy. However, full resolution of presenting symptoms may not occur for individuals with significant childhood histories of parental abuse and neglect without opposite sex, as well as same sex, re-nurturing interventions. This presentation emphasizes the use of maternal re-nurturing methods with men who struggle with the effects of significant attachment deficits in early life. Case examples feature male patients with long-term difficulties in their adult relationships with women that had proved refractory to other therapy methods. Following Ego-State Therapy interventions with maternal symbolic figures, however, these problems improved dramatically. Therapeutic implications for cross-gender re-nurturing with patients who report different types of maternal attachment trauma are explored and discussed.


Assuntos
Maus-Tratos Infantis/terapia , Ego , Hipnose/métodos , Relações Mãe-Filho , Psicoterapia/métodos , Transtorno Reativo de Vinculação na Infância/terapia , Transtornos de Estresse Pós-Traumáticos/terapia , Adolescente , Adulto , Criança , Maus-Tratos Infantis/psicologia , Terapia Combinada , Identidade de Gênero , Humanos , Masculino , Poder Familiar/psicologia , Transtorno Reativo de Vinculação na Infância/psicologia , Transtornos de Estresse Pós-Traumáticos/psicologia , Sugestão
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