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2.
Chem Commun (Camb) ; 56(6): 956-959, 2020 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-31858094

RESUMO

On-resin intramolecular native chemical ligation (NCL) assisted by N-ethylcysteine using Fmoc/SPPS to obtain cyclic peptides is described. N-terminal cysteine-containing peptides were subjected to NCL conditions leading to cyclization-cleavage reactions and consecutive S → N shift, rendering cyclic peptides in good yields and purities. The compounds were evaluated against P. falciparum 3D7.


Assuntos
Peptídeos Cíclicos/síntese química , Compostos de Sulfidrila/química , Cisteína/análogos & derivados , Cisteína/química , Estrutura Molecular , Peptídeos Cíclicos/química , Resinas Sintéticas/química
3.
Eur J Orthod ; 35(5): 568-76, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22898749

RESUMO

The purpose of this study was to measure the efficacy of anchorage control between differential moments mechanics and temporary anchorage devices in a clinical trial. Forty-six patients requiring extraction of maxillary first premolars were allocated into 2 treatment groups. The differential moments group (G1) received a nickel titanium (NiTi) intrusion arch and a 150g NiTi closing coil spring for separate canine retraction, followed by a continuous mushroom loop archwire for the retraction of the incisors. The TAD group (G2) received one miniscrew placed between maxillary second premolars and first molars with a 150 g NiTi closing coil spring connecting the miniscrew to a hook placed in the archwire between the lateral incisor and canine. Lateral cephalograms were taken before (T1) and after incisor retraction (T2). The ratio of molar protraction to incisor retraction was calculated and intragroup and intergroup changes in upper lip, maxillary incisor and molar position were analyzed by paired and independent t-tests. Twenty-eight patients were analyzed after 18 patients did not receive the intervention, were lost to follow-up, or discontinued treatment. The ratio of molar protraction to incisor retraction in G1 was 0.44 and in G2 was -0.11, which was significantly different. There was a statistically significant change in upper lip from T1 to T2 but no difference between the two groups. Moreover, there was a significant distal molar tipping and lingual incisor tipping in G2. There is a significant difference in the amount of anchorage control using differential moments mechanics compared to TADs. Although statistically significant retraction of upper lip was observed in both groups, there was no significant difference between the two groups.


Assuntos
Parafusos Ósseos , Procedimentos de Ancoragem Ortodôntica , Técnicas de Movimentação Dentária , Adulto , Dente Pré-Molar/cirurgia , Cefalometria , Feminino , Humanos , Incisivo/cirurgia , Masculino , Maxila/cirurgia , Dente Molar/cirurgia , Níquel , Estudos Prospectivos , Titânio , Adulto Jovem
5.
CES odontol ; 13(2): 20-24, jul.-dic. 2000. graf
Artigo em Espanhol | LILACS | ID: lil-472856

RESUMO

El objetivo del estudio fue establecer el efecto de la procaína infiltrada en el tiempo de cicatrización de las lesiones recurrentes del herpes simple labial. Se incluyeron 30 pacientes, 20 mujeres y 30 hombres. Todos presentaban lesiones establecidas de herpes labial (estado vesicular) con máximo dos días de evolución y 22 presentaron haber presentado lesiones recurrentes previas. Los pacientes fueron evaluados clínicamente y la información referente a la historia y evolución de las lesiones fue registrada en un formulario. Las lesiones se infiltraron con 1.8 ml de procaína al 1 por ciento y se hizo un seguimiento cada 24 horas hasta la cicatrización de las mismas. Esta información fue comparada con el comportamiento clínico y tiempo de cicatrización habitual de las lesiones relatado por los pacientes, además con la comparación de con los resultados de otros estudios los cuales evalúan diferentes agentes terapéuticos para las lesiones recurrentes del herpes labial.


Assuntos
Herpes Labial , Herpes Simples , Procaína , Cicatrização , Odontologia
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