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Pharmacol Res Perspect ; 9(1): e00705, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33421347


Drug-drug interaction (DDI) is a common clinical problem that has occurred as a result of the concomitant use of multiple drugs. DDI may occur in patients under treatment with medications used for coronavirus disease 2019 (COVID-19; i.e., chloroquine, lopinavir/ritonavir, ribavirin, tocilizumab, and remdesivir) and increase the risk of serious adverse reactions such as QT-prolongation, retinopathy, increased risk of infection, and hepatotoxicity. This review focuses on summarizing DDIs for candidate medications used for COVID-19 in order to minimize the adverse reactions.

Antivirais/uso terapêutico , /tratamento farmacológico , Animais , Anticorpos Monoclonais Humanizados/uso terapêutico , Cloroquina/uso terapêutico , Interações Medicamentosas , Humanos , Lopinavir/uso terapêutico , Ribavirina/uso terapêutico , Ritonavir/uso terapêutico
Bioanalysis ; 11(23): 2189-2205, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31724438


Verapamil (VER) is a calcium channel blocker that is widely used to treat various cardiovascular diseases and is also effective in migraine prophylaxis. As the therapeutic range of VER is very narrow and toxicity can occur in patients after oral administration, therapeutic drug monitoring is recommended to optimize pharmacotherapy. The choice of an appropriate bioanalytical method for therapeutic drug monitoring of VER in the biological samples is a very important step in achieving fast and reliable results. This review focuses on the various analytical methods reported between 1976 and 2019 for the determination of VER in different biological samples and pharmaceutical dosage forms along with their methodological limitations. This review provides an overview for pharmaceutical industry researchers, clinicians and clinical chemists.

Bloqueadores dos Canais de Cálcio/análise , Verapamil/análise , Administração Oral , Testes Respiratórios , Bloqueadores dos Canais de Cálcio/efeitos adversos , Bloqueadores dos Canais de Cálcio/uso terapêutico , Doenças Cardiovasculares/tratamento farmacológico , Indústria Farmacêutica , Humanos , Estrutura Molecular , Verapamil/efeitos adversos , Verapamil/uso terapêutico