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1.
Braz. j. med. biol. res ; 48(7): 650-653, 07/2015. graf
Artigo em Inglês | LILACS | ID: lil-751343

RESUMO

As it is a common observation that obesity tends to occur after discontinuation of exercise, we investigated how white adipocytes isolated from the periepididymal fat of animals with interrupted physical training transport and oxidize glucose, and whether these adaptations support the weight regain seen after 4 weeks of physical detraining. Male Wistar rats (45 days old, weighing 200 g) were divided into two groups (n=10): group D (detrained), trained for 8 weeks and detrained for 4 weeks; and group S (sedentary). The physical exercise was carried out on a treadmill for 60 min/day, 5 days/week for 8 weeks, at 50-60% of the maximum running capacity. After the training protocol, adipocytes isolated from the periepididymal adipose tissue were submitted to glucose uptake and oxidation tests. Adipocytes from detrained animals increased their glucose uptake capacity by 18.5% compared with those from sedentary animals (P<0.05). The same cells also showed a greater glucose oxidation capacity in response to insulin stimulation (34.55%) compared with those from the S group (P<0.05). We hypothesize that, owing to the more intense glucose entrance into adipose cells from detrained rats, more substrate became available for triacylglycerol synthesis. Furthermore, this increased glucose oxidation rate allowed an increase in energy supply for triacylglycerol synthesis. Thus, physical detraining might play a role as a possible obesogenic factor for increasing glucose uptake and oxidation by adipocytes.


Assuntos
Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças dos Trabalhadores Agrícolas/induzido quimicamente , Exposição Ocupacional/efeitos adversos , Doença de Parkinson Secundária/induzido quimicamente , Praguicidas/toxicidade , California , Estudos de Casos e Controles , Modelos Estatísticos , Exposição Ocupacional/estatística & dados numéricos , Pontuação de Propensão , Fatores de Risco
2.
Braz J Med Biol Res ; 48(7): 650-3, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26017340

RESUMO

As it is a common observation that obesity tends to occur after discontinuation of exercise, we investigated how white adipocytes isolated from the periepididymal fat of animals with interrupted physical training transport and oxidize glucose, and whether these adaptations support the weight regain seen after 4 weeks of physical detraining. Male Wistar rats (45 days old, weighing 200 g) were divided into two groups (n=10): group D (detrained), trained for 8 weeks and detrained for 4 weeks; and group S (sedentary). The physical exercise was carried out on a treadmill for 60 min/day, 5 days/week for 8 weeks, at 50-60% of the maximum running capacity. After the training protocol, adipocytes isolated from the periepididymal adipose tissue were submitted to glucose uptake and oxidation tests. Adipocytes from detrained animals increased their glucose uptake capacity by 18.5% compared with those from sedentary animals (P<0.05). The same cells also showed a greater glucose oxidation capacity in response to insulin stimulation (34.55%) compared with those from the S group (P<0.05). We hypothesize that, owing to the more intense glucose entrance into adipose cells from detrained rats, more substrate became available for triacylglycerol synthesis. Furthermore, this increased glucose oxidation rate allowed an increase in energy supply for triacylglycerol synthesis. Thus, physical detraining might play a role as a possible obesogenic factor for increasing glucose uptake and oxidation by adipocytes.


Assuntos
Tecido Adiposo Branco/metabolismo , Proteínas Facilitadoras de Transporte de Glucose/metabolismo , Glucose/metabolismo , Condicionamento Físico Animal/fisiologia , Ganho de Peso/fisiologia , Adipócitos/metabolismo , Animais , Dióxido de Carbono/metabolismo , Insulina/metabolismo , Masculino , Oxirredução , Ratos Wistar , Fatores de Tempo
3.
Braz J Med Biol Res ; 47(3): 192-205, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24676492

RESUMO

Numerous studies address the physiology of adipose tissue (AT). The interest surrounding the physiology of AT is primarily the result of the epidemic outburst of obesity in various contemporary societies. Briefly, the two primary metabolic activities of white AT include lipogenesis and lipolysis. Throughout the last two decades, a new model of AT physiology has emerged. Although AT was considered to be primarily an abundant energy source, it is currently considered to be a prolific producer of biologically active substances, and, consequently, is now recognized as an endocrine organ. In addition to leptin, other biologically active substances secreted by AT, generally classified as cytokines, include adiponectin, interleukin-6, tumor necrosis factor-alpha, resistin, vaspin, visfatin, and many others now collectively referred to as adipokines. The secretion of such biologically active substances by AT indicates its importance as a metabolic regulator. Cell turnover of AT has also recently been investigated in terms of its biological role in adipogenesis. Consequently, the objective of this review is to provide a comprehensive critical review of the current literature concerning the metabolic (lipolysis, lipogenesis) and endocrine actions of AT.


Assuntos
Adipócitos/metabolismo , Adipogenia/fisiologia , Tecido Adiposo Branco/fisiologia , Lipólise/fisiologia , Obesidade/fisiopatologia , Adipocinas/metabolismo , Animais , Citocinas/metabolismo , Humanos , Leptina/metabolismo , Camundongos , Nicotinamida Fosforribosiltransferase/metabolismo , Ratos , Resistina/metabolismo , Transdução de Sinais/fisiologia
4.
Braz. j. med. biol. res ; 47(3): 192-205, 03/2014. graf
Artigo em Inglês | LILACS | ID: lil-704621

RESUMO

Numerous studies address the physiology of adipose tissue (AT). The interest surrounding the physiology of AT is primarily the result of the epidemic outburst of obesity in various contemporary societies. Briefly, the two primary metabolic activities of white AT include lipogenesis and lipolysis. Throughout the last two decades, a new model of AT physiology has emerged. Although AT was considered to be primarily an abundant energy source, it is currently considered to be a prolific producer of biologically active substances, and, consequently, is now recognized as an endocrine organ. In addition to leptin, other biologically active substances secreted by AT, generally classified as cytokines, include adiponectin, interleukin-6, tumor necrosis factor-alpha, resistin, vaspin, visfatin, and many others now collectively referred to as adipokines. The secretion of such biologically active substances by AT indicates its importance as a metabolic regulator. Cell turnover of AT has also recently been investigated in terms of its biological role in adipogenesis. Consequently, the objective of this review is to provide a comprehensive critical review of the current literature concerning the metabolic (lipolysis, lipogenesis) and endocrine actions of AT.


Assuntos
Animais , Humanos , Camundongos , Ratos , Adipócitos/metabolismo , Adipogenia/fisiologia , Tecido Adiposo Branco/fisiologia , Lipólise/fisiologia , Obesidade/fisiopatologia , Adipocinas/metabolismo , Citocinas/metabolismo , Leptina/metabolismo , Nicotinamida Fosforribosiltransferase/metabolismo , Resistina/metabolismo , Transdução de Sinais/fisiologia
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