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1.
Chem Rec ; 2020 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-32319734

RESUMO

In this mini-review, we highlighted the recent progresses in the controlled synthesis of metal sulfides hollow nanostructures via hard template technique. After a brief introduction about the formation mechanism of the inorganic hollow nanostructures via hard template technique, the discussions primarily focused on the emerging development of metal sulfides hollow nanostructures. Various synthetic strategies were summarized concerning the use of the hard template engaged strategies to fabricate various metal sulfides hollow nanostructures, such as hydrothermal method, solvothermal method, ion-exchange, sulfidation or calcination etc. Finally, the perspectives and summaries have been presented to demonstrate that a facile synthetic technique would be widely used to fabricate metal sulfides hollow nanostructures with multi-shells and components.

2.
Biomaterials ; 237: 119835, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32035321

RESUMO

Hollow nanostructures have been evoked considerable attention owing to their intriguing hollow interior for important and potential applications in drug delivery, lithium battery, catalysis and etc. Herein, Bi2S3 hollow microspheres with rod-based urchin-like nanostructures (denoted as U-BSHM) were synthesized through a facile and rapid ion exchanging method using a particular hard template. The growth mechanism of the U-BSHM has been investigated and illustrated by the morphological evolution of the different samples at early stages. The obtained U-BSHM exhibited strong and wide UV-vis-NIR absorption ability and outstanding photothermal conversion efficiency. Thus, the U-BSHM can be used as spatio-temporal precisely controlled carrier by loading the mixture of 1-tetradecanol (phase change material, PCM) with melting point around 38 °C and hydrophilic chemotherapeutic doxorubicin hydrochloride (denoted as DOX) into the hollow interior to form (PCM + DOX)@Bi2S3 nanocomposites (denoted as PD@BS) for photoacoustic (PA) imaging and chemo-photothermal therapy of the tumors. When exposed to 808 nm near infrared light (NIR) laser irradiation, this nanocomposites could elevate the temperature of the surroundings by absorption and conversion of the NIR photons into heat energy, which inducing the triggered release of DOX from the hollow interior once the temperature reach up to the melting point of PCM. The killing efficiency of the chemo-photothermal therapy was systematically validated both in vitro and in vivo. In the meanwhile, the implanted tumor was completely restrained through PA imaging and combined therapies. Therefore, this kind of urchin-like hollow nanostructures would be used as important candidates for the multimodal bioimaging and therapy of tumors.

3.
ACS Nano ; 14(2): 2126-2136, 2020 02 25.
Artigo em Inglês | MEDLINE | ID: mdl-32027121

RESUMO

Similar to translated thermal ablative techniques in clinic, the occurrence of cellular necrosis during tumor photothermal therapy (PTT) would induce inflammatory responses that are detrimental to therapeutic outcomes. Inspired by the well-known colorimetric Folin-Ciocalteu assay, monodispersed and renal-clearable tungsten (W)-based polyoxometalate nanoclusters (W-POM NCs, average diameter of around 2.0 nm) were successfully obtained here through a facile redox reaction with natural gallic acid in alkaline aqueous solution. Apart from excellent stability in the form of freeze-dried powder, the as-prepared W-POM NCs occupied considerable biocompatibility toward normal cells/tissues both in vitro and in vivo, since no obvious toxicities were observed by treating female Balb/c mice with concentrated W-POM NCs during the 30 day post-treatment period. More importantly, W-POM NCs exhibited not only considerable near-infrared (NIR) light absorption (coloration effect originated from the existence of electron-trapped W5+) for efficient PTT but also impressive anti-inflammatory ability (eliminating inflammation-related reactive oxygen species by the oxidation of W5+ into W6+ state) to achieve better therapeutic outcomes. Thus, our study pioneers the application of POMs for non-inflammatory PTT with expected safety and efficiency.

4.
Langmuir ; 36(6): 1523-1529, 2020 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-31995982

RESUMO

Hollow nanostructures of metal sulfides have gained tremendous attention in catalysis, biomedicine, and energy storage and conversion owing to their intriguing structural features and fascinating physicochemical properties. Here, we reported a hard template-engaged cation exchange method to fabricate a family of binary or ternary metal sulfide (CuS, Ag2S, Bi2S3, CuxBi1-xS, ZnxCo1-xS, ZnxCd1-xS, ZnxNi1-xS, and ZnxMn1-xS) hollow microspheres via adjusting the reaction kinetic parameters including solvent and temperature in the presence of unique ZnS composite microspheres. Particularly, the shell layer thickness of metal sulfide hollow microspheres could be modulated by manipulating the reaction temperature during the cation exchanging procedure. Meanwhile, the desired elementary composition of ternary metal sulfide hollow microspheres could be achieved by varying the mole ratio and species of the metal source. This synthetic strategy could be extended to rationally design and construct other metal sulfide hollow nanostructures and provide a deep insight into the nucleation and growth process of the metal sulfide hollow microspheres with well-controlled composition and microstructures.

5.
Chem Rec ; 20(1): 2-9, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30946531

RESUMO

It's of great importance for construction of upconversion nanoparticles (UCNPs)/semiconductor heterostructures activated by near infrared light, which have gained worldwide research interests owing to important applications in photocatalysis, solar cells, nanomedicine, and etc. In this review, we highlight the synthetic strategies developed to fabricate upconversion nanoparticles based heterostructures, such as chemical epitaxial growth method, electrospinning technique, self-assembly method, hydrothermal method, and etc. Numerous examples are given concerning the use of the strategies to fabricate various microstructures/nanostructures incorporated with UCNPs and semiconductors materials. The latest advances and perspectives in the synthetic strategies and preparation of this kind of composite nanostructures are made.

6.
Ther Clin Risk Manag ; 15: 803-810, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31417267

RESUMO

Purpose: This study aimed to evaluate Atorvastatin (ATO)-associated hepatotoxicity using prescription sequence symmetry analysis (PSSA), based on a health insurance database of a Chinese population living in Jiangsu Province, China. Methods: Patients prescribed ATO and hepatoprotective drugs in 2017 were identified, and the run-in period was determined based on the "waiting-time" distribution. Adjusted sequence ratio (ASR) and 95% confidence interval (95% CI) were calculated to estimate the risk of ATO-associated hepatotoxicity under different time intervals or based on gender and age stratification. Results: A total of 2,549 patients, with 1,518 filling the ATO prescription first and 1,031 filling the ATO prescription second, were analyzed. After setting the run-in period as 30 days and the time interval as 15, 30, 60, 90, 120, and 180 days, the ASRs were 1.492 (95% CI: 1.367-1.652), 1.399 (95% CI: 1.308-1.508), 1.280 (95% CI: 1.213-1.357), 1.292 (95% CI: 1.234-1.356), 1.278 (95% CI: 1.226-1.336), and 1.274 (95% CI: 1.229-1.323), respectively. No significant difference was observed between different genders and ages (χ2=0.161, P=0.688; χ2=1.565, P=0.211, respectively). Conclusion: This is the first study conducted in a real-world setting to evaluate the relationship between ATO and hepatotoxicity using the PSSA in a Chinese population. We found a 1.3- to 1.5-fold increase in risk of hepatotoxicity following ATO, with the greater risk occurring within the first 30 days of treatment.

7.
ACS Nano ; 13(9): 10074-10084, 2019 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-31430428

RESUMO

An in situ forming hydrogel has emerged as a promising wound dressing recently. As physically cross-linked hydrogels are normally unstable, most in situ forming hydrogels are chemically cross-linked. However, big concerns have remained regarding the slow gelation and the potential toxicity of residual functional groups from cross-linkers or the polymer matrix. Herein, we report a sprayable in situ forming hydrogel composed of poly(N-isopropylacrylamide166-co-n-butyl acrylate9)-poly(ethylene glycol)-poly(N-isopropylacrylamide166-co-n-butyl acrylate9) copolymer (P(NIPAM166-co-nBA9)-PEG-P(NIPAM166-co-nBA9), denoted as PEP) and silver-nanoparticles-decorated reduced graphene oxide nanosheets (Ag@rGO, denoted as AG) in response to skin temperature. This thermoresponsive hydrogel exhibits intriguing sol-gel irreversibility at low temperatures for the stable dressing of a wound, which is attributed to the inorganic/polymeric dual network and abundant coordination interactions between Ag@rGO nanosheets and PNIPAM. The biocompatibility and antibacterial ability against methicillin-resistant Staphylococcus aureus (MRSA) of this PEP-AG hydrogel wound dressing are confirmed in vitro and in vivo, which could transparently promote the healing of a MRSA-infected skin defect.

8.
Chem Sci ; 10(21): 5435-5443, 2019 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-31293725

RESUMO

A common issue of functional nanoagents for potential clinical translation is whether they are biodegradable or renal clearable. Previous studies have widely explored noble metal nanoparticles (Au and Pd) as the first generation of photothermal nanoagents for cancer therapy, but all of the reported noble metal nanoparticles are non-degradable. On the other hand, rhenium (Re), one of the noble and precious metals with a high atomic number (Z = 75), has been mainly utilized as a jet superalloy or chemical catalyst, but the biological characteristics and activity of Re nanoparticles have never been evaluated until now. To address these issues, here we report a simple and scalable liquid-reduction strategy to synthesize PEGylated Re nanoclusters, which exhibit intrinsically high photothermal conversion efficacy (33.0%) and high X-ray attenuation (21.2 HU mL mg-1), resulting in excellent photothermal ablation (100% tumor elimination) and higher CT enhancement (15.9 HU mL mg-1 for commercial iopromide in clinics). Impressively, biocompatible Re nanoclusters can degrade into renal clearable ReO4 - ions after exposure to H2O2, and thus achieve much higher renal clearance efficiency than conventional gold nanoparticles. This work reveals the potential of theranostic application of metallic Re nanoclusters with both biodegradation and renal clearance properties and provides insights into the design of degradable metallic platforms with high clinical prospects.

9.
Inorg Chem ; 58(16): 10620-10624, 2019 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-31347837

RESUMO

An organic ligand-free solution method is developed for preparing homogeneous core-shell quantum-dot (QD)-modified pure Cs4PbBr6 microcrystals on a large scale (∼12 g) at room temperature. The ligand-free Cs4PbBr6 microcrystals show a high green photoluminescence quantum yield of 76% with 360 nm of excitation light, which is attributed to their unique microarchitecture, with several features including quantum confinement of the outer QDs, stability of the inner Cs4PbBr6 microcrystals, improved light trapping, and interfacial recombination. UV-vis-near-IR and photoluminescence analyses provide valued evidence to support the ligand-free Cs4PbBr6 with synergy between the QDs and microcrystals.

10.
J Colloid Interface Sci ; 546: 303-311, 2019 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-30927594

RESUMO

Rational design of photocatalysts with heterostructure is of scientific and technological interest for taking full advantage use of solar energy. Here we demonstrate a facile method to fabricate Zn0.5Cd0.5S/Bi2S3 composite nanospheres, in which Bi2S3 nanorods grown on the surface of Zn0.5Cd0.5S nanospheres. The as-prepared Zn0.5Cd0.5S@ZnS core-shell nanospheres play a vital role in formation of the Zn0.5Cd0.5S@Bi2S3 composite nanospheres. The Zn0.5Cd0.5S/Bi2S3 composites show both excellent photocatalysis and photothermal effect. Nanorods-like Bi2S3 show wide optical absorption from visible to near infrared light and photocurrent response, which enable enhanced full spectrum absorption of the heterostructured photocatalyst and photocurrent for overall photocatalytic performance. Additionally, Bi2S3 nanorods with photothermal effect would synergistically increase the temperature of the micro-environment around the catalysts of ZnxCd1-xS. Thus, the Zn0.5Cd0.5S/Bi2S3 composites exhibit a little better photocatalytic activity than that of pure Zn0.5Cd0.5S. The present study provides a promising strategy for the rational design of efficient sulfide semiconductor heterojunction catalysts for making the utmost of solar fuels in dealing with organic pollutants from wastewater.

11.
Langmuir ; 35(2): 489-494, 2019 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-30561206

RESUMO

Monodisperse sub-10 nm core-shell nanocrystals have been extensively studied owing to their important applications in catalysis, bioimaging, nanomedicine, and so on. In this work, an amorphous shell component crystallization strategy has been proposed to prepare high quality sub-10 nm NaYF4:Yb/Er@NaGdF4 core-shell nanocrystals successfully via a sequential growth process. The dynamic light scattering technique has been used to investigate the secondary nucleation and growth process forming the core-shell nanocrystals. The size and morphology evolution of the core-shell nanocrystals reveals that the secondary nucleation of the shell component is unavoidable after hot-injecting the shell precursor at high temperatures, which was followed by dissolution and recrystallization (an Ostwald ripening process) to partially produce the core-shell nanocrystals. The present study demonstrates that the size of seed nanocrystals and the injection temperature of the shell component precursor play a vital role in the formation of core-shell nanostructures completely. This work will provide an alternative strategy for precisely controlling the fabrication of sub-10 nm core-shell nanostructures for various applications.

12.
J Mater Chem B ; 7(1): 143-149, 2019 01 07.
Artigo em Inglês | MEDLINE | ID: mdl-32254958

RESUMO

To overcome the unfavorable effects of the hydrophobicity of drugs and cancer resistance, mesoporous NiS2 nanospheres (mNiS2 NSs) have been successfully developed here to package hydrophobic camptothecin (CPT) and realize the synergistic photothermal-chemotherapy of cancer. The mNiS2 NSs which were prepared through a facile solvothermal method here exhibited not only considerable near-infrared (NIR) absorption and good photothermal conversion efficiency as high as 44.6%, but also achieved a NIR light induced CPT release property which were both beneficial for improving the cancer cell-killing efficacy. After a short period of NIR light illumination, a significant intensified cell killing efficacy was observed when 4T1 or HepG2 cancer cells were incubated with CPT@mNiS2 NSs. Thus, mNiS2 NSs have been demonstrated here to have potential as a novel NIR light-responsive hydrophobic drug delivery nanoplatform for realizing synergistic cancer treatment.


Assuntos
Antineoplásicos/uso terapêutico , Terapia Combinada/métodos , Sistemas de Liberação de Medicamentos/métodos , Nanosferas/uso terapêutico , Neoplasias/tratamento farmacológico , Animais , Camptotecina/administração & dosagem , Sobrevivência Celular/efeitos dos fármacos , Liberação Controlada de Fármacos , Tratamento Farmacológico/métodos , Células Hep G2 , Células Endoteliais da Veia Umbilical Humana , Humanos , Níquel/química , Fototerapia/métodos
13.
Infect Genet Evol ; 66: 217-221, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30316884

RESUMO

OBJECTIVE: Anti-tuberculosis drug-induced hepatotoxicity (ATDH) is related to hepatotoxic intermediaries, which are detoxified by glutathione S-transferases (GSTs). GSTM1 and GSTT1 are regulated by nuclear factor erythroid 2-related factor 2 (Nrf2) signalling pathway, and the BTB domain and CNC homologue 1 (Bach1) could compete with Nrf2 for binding to the DNA. Thus, bach1 may indirectly affect GSTs expression. The present study aimed to examine the role of tagSNPs in BACH1 in a Chinese population-based cohort. METHODS: A nested case-control study was conducted. Each ATDH case was matched with two controls by age, gender, treatment history, etc. Seven tagSNPs were detected and analysed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using a conditional logistic regression model. RESULTS: A total of 290 ATDH cases and 580 controls were included in the present study. Patients carrying GG genotype of rs372883 were at a lower risk of ATDH than with AA genotype (OR = 0.553, 95%CI: 0.357-0.857, P = .008), and significant differences were also found under recessive model (P = .021) and additive model (P = .009). Similar results were also found in the polymorphism of rs1153285 (AA vs. GG, OR = 0.574, 95%CI: 0.360-0.914, P = .019), and under its recessive model (P = .033) and additive model (P = .026). Two haplotypes of A-G-T and C-T-G were identified to be associated with ATDH development. Further subgroup analysis also suggested significant association between BACH1 polymorphisms and ATDH among certain and probable hepatotoxicity cases. CONCLUSIONS: This is the first study to explore the relationship between tagSNPs of BACH1 and ATDH in a Chinese cohort. Based on this cohort, genetic polymorphisms of BACH1 may be associated with susceptibility to ATDH in the Chinese population.


Assuntos
Antituberculosos/efeitos adversos , Fatores de Transcrição de Zíper de Leucina Básica/genética , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Predisposição Genética para Doença , Polimorfismo de Nucleotídeo Único , Adulto , Idoso , Alelos , Grupo com Ancestrais do Continente Asiático/genética , Biomarcadores , Estudos de Casos e Controles , Doença Hepática Induzida por Substâncias e Drogas/diagnóstico , China , Estudos de Coortes , Feminino , Genótipo , Haplótipos , Humanos , Masculino , Pessoa de Meia-Idade
14.
Langmuir ; 34(31): 9264-9271, 2018 08 07.
Artigo em Inglês | MEDLINE | ID: mdl-30005165

RESUMO

Magnetically recyclable photocatalyst has drawn considerable research interest because of its importance in practical applications. Herein, we demonstrate a facile hydrothermal process to fabricate magnetic core-shell microspheres of Fe3O4@Zn xCd1- xS, successfully using Fe3O4@ZnS core-shell microspheres as sacrificed templates. The as-prepared magnetically recyclable photocatalysts show efficient photochemical reduction of Cr(VI) under irradiation of visible light. The photochemical reduction mechanism has been studied to illustrate the reduction-oxidation ability of the photogenerated electrons (e-) and holes (h+), which play an important role in the reduction of Cr(VI) to Cr(III) and oxidation of organic dyes. The as-prepared Fe3O4@Zn0.55Cd0.45S core-shell microspheres show good chemical stability and only a slight decrease in the photocatalytic activity after four recycles. In particular, the as-prepared photocatalysts could be easily recycled and reused by an external magnetic field. Therefore, this work would provide a facile chemical approach for controlled synthesis of magnetic nanostructures combined with alloyed semiconductor photocatalysts for wastewater treatment.

15.
Biomaterials ; 170: 147-155, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29674231

RESUMO

Controlling poly(ethylene glycol) (PEG) shielding/deshielding at the desired site of action exhibits great advantages for nanocarrier-based on-demand drug delivery in vivo. However, the current PEG deshielding strategies were mainly designed for anticancer drug delivery; even so, their applications are also limited by tumor heterogeneity. As a proof-of-concept, we explored a photoinduced PEG deshielding nanocarrier TK-NPCe6&PTX to circumvent the aforementioned challenge. The TK-NPCe6&PTX encapsulating chlorin e6 (Ce6) and paclitaxel (PTX) was self-assembled from an innovative thioketal (TK) linkage-bridged diblock copolymer of PEG with poly(d,l-lactic acid) (PEG-TK-PLA). We demonstrated that the high PEGylation of TK-NPCe6&PTX in blood helps the nanocarrier efficiently avoid rapid clearance and consequently prolongs its circulation time. At the desired site (tumor), 660-nm red light irradiation led to ROS generation in situ, which readily cleaved the TK linkage, resulting in PEG deshielding. Such photoinduced PEG deshielding at the desired site significantly enhances the cellular uptake of the nanocarriers, achieving on-demand drug delivery and superior therapeutic efficacy. More importantly, this strategy of photoinducing PEG deshielding of nanocarriers could potentially extend to a variety of therapeutic agents beyond anticancer drugs for on-demand delivery.


Assuntos
Portadores de Fármacos/química , Sistemas de Liberação de Medicamentos , Luz , Nanopartículas/química , Polietilenoglicóis/química , Espécies Reativas de Oxigênio/metabolismo , Animais , Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Feminino , Humanos , Camundongos Nus , Porfirinas/química , Espectroscopia de Prótons por Ressonância Magnética
16.
Biomaterials ; 158: 74-85, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29304404

RESUMO

There is a great demand to develop high-relaxivity nanoscale contrast agents for magnetic resonance (MR) angiography with high resolution. However, there should be more focus on stability, ion leakage and excretion pathway of the intravenously injected nanoparticles, which are closely related to their clinic potentials. Herein, uniform ultrasmall-sized NaGdF4 nanocrystal (sub-10 nm) was synthesized using a facile high temperature organic solution method, and the nanocrystals were modified by a ligand-exchange approach using PEG-PAA di-block copolymer. The PEG-PAA modified NaGdF4 nanocrystal (denoted as ppNaGdF4 nanocrystal) exhibited a high r1 relaxivity which was twice of commercially used gadopentetate dimeglumine (Gd-DTPA) injection. MR angiography on rabbit using ppNaGdF4 nanocrystal at a low dose showed enhanced vascular details and long circulation time. Lyophilized powder of ppNaGdF4 nanocrystals have been successfully prepared without aggregation or reduction of MR performance, indicating the stability and an effective way to store this nanoscale contrast agent. No haemolysis was induced by ppNaGdF4 nanocrystal, and an extremely low leakage of gadolinium ions was confirmed. Furthermore, efficient renal excretion was one of the clearance pathways of ppNaGdF4 nanocrystal according to both the time dependent distribution data in blood and tissues and MR images. The in vivo toxicity evaluation further validated the great potential as a clinical agent for blood pool imaging.


Assuntos
Meios de Contraste , Gadolínio , Angiografia por Ressonância Magnética/métodos , Nanopartículas , Animais , Meios de Contraste/química , Gadolínio/administração & dosagem , Gadolínio/química , Humanos , Rim/diagnóstico por imagem , Rim/metabolismo , Teste de Materiais , Nanopartículas/química , Coelhos
17.
Biomater Sci ; 5(12): 2403-2415, 2017 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-29072715

RESUMO

It is a significant challenge to develop nanoscale magnetic resonance imaging (MRI) contrast agents with high performance of relaxation. In this work, Gd3+-doped CaF2-based core-shell nanoparticles (CaF2:Yb,Er@CaF2:Gd) of sub-10 nm size were controllably synthesized by a facile sequential growth method. The as-prepared hydrophilic CaF2:Yb,Er@CaF2:Gd nanoparticles modified using PEG-PAA di-block copolymer benefited from the presence of Gd only in the outer CaF2 layer of the nanoparticles, which exhibited r1 as high as 21.86 mM-1 s-1 under 3.0 T, seven times as high as that of commercially used gadopentetate dimeglumine (Gd-DTPA). Low cytotoxicity, no hemolysis phenomenon and no potential gadolinium ion leakage phenomenon of the hydrophilic CaF2:Yb,Er@CaF2:Gd nanoparticles have been observed and confirmed. Clear vascular details can be observed in magnetic resonance angiography and obvious MR signal of 4T1 tumor area could be significantly improved by intravenous injection of the hydrophilic CaF2:Yb,Er@CaF2:Gd nanoparticles at a low dosage in mice. A series of in vivo biological safety evaluations confirmed the good biocompatibility of the hydrophilic CaF2:Yb,Er@CaF2:Gd nanoparticles, which might be employed in clinical blood pool imaging and tumor diagnosis as a safe and efficient MRI probe.


Assuntos
Angiografia por Ressonância Magnética/métodos , Nanopartículas/química , Neoplasias/diagnóstico por imagem , Neoplasias/diagnóstico , Animais , Meios de Contraste/química , Meios de Contraste/uso terapêutico , Gadolínio/química , Gadolínio/uso terapêutico , Células HeLa , Humanos , Imagem por Ressonância Magnética/métodos , Camundongos , Nanopartículas/uso terapêutico , Neoplasias/patologia , Itérbio/química , Itérbio/uso terapêutico
18.
Nanoscale ; 9(38): 14512-14519, 2017 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-28930346

RESUMO

Developing a facile and reliable method for the fabrication of transition metal chalcogenides is a vital and endless pursuit of scientific and technological disciplines. In this work, we develop a one-pot solution approach to obtain copper selenide nanostructures with different morphologies and crystal structures (Cu2Se nanoparticles, CuSe nanoplates and CuSe2 nanosheets). In comparison to previously reported methods, our method did not use expensive and very toxic raw materials. After detailed studies of reaction conditions, including temperature, reaction time, and feeding amount of surfactants and precursors, we found that the feeding ratio of precursors played a key role in the crystal structures and morphologies of the final products. Moreover, as a proof-of-concept study, the potential applications of the as-prepared copper selenide nanostructures in the photocatalytic discoloration of aqueous methylene blue (MB) under visible light irradiation and near-infrared (NIR) light induced photothermal therapy for cancer treatment were investigated. Encouraged by their strong photocatalytic activities and high photothermal conversion efficiencies (calculated to be 51.0%, 49.5% and 48.9% for Cu2Se nanoparticles, CuSe nanoplates and CuSe2 nanosheets, respectively), we believe that copper selenide nanostructures fabricated from the one-pot solution approach developed in this work would be promising candidates for a wide variety of emerging applications.


Assuntos
Cobre , Nanopartículas Metálicas , Fototerapia , Compostos de Selênio , Células HeLa , Células Endoteliais da Veia Umbilical Humana , Humanos , Luz , Nanoestruturas , Temperatura
19.
Theranostics ; 7(5): 1290-1302, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28435466

RESUMO

Imaging-guided cancer therapy, which integrates diagnostic and therapeutic functionalities into a single system, holds great promise to enhance the accuracy of diagnosis and improve the efficacy of therapy. Specifically, for photodynamic therapy (PDT), it is highly desirable to precisely focus laser light onto the tumor areas to generate reactive oxygen species (ROS) that are cytotoxic tumor cells and avoid light-associated side effects. Herein, a distinct three-layer nanostructured particle with tumor acidity-responsiveness (S-NP) that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates Gd3+ is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT. We show clear evidence that the outer PEG layer significantly prolongs circulation time, and the inner poly(ε-caprolactone) (PCL) core can physically encapsulate Ce6. More interestingly, the middle layer of the S-NP, acting as a molecular fence to keep Ce6 in the circulation system, was dismantled by the slightly acidic tumor microenvironment. Afterwards, the PEG shell is deshielded from the S-NP at the tumor tissue, resulting in improved cell uptake, enlarged MR signal intensity, rapid release of Ce6 within tumor cells, and elevated PDT efficacy. Our results suggest that tumor-acidity-responsive nanoparticles with fine design could serve as a theranostic platform with great potential in imaging-guided PDT treatment of cancer.


Assuntos
Antineoplásicos/farmacocinética , Imagem por Ressonância Magnética , Neoplasias/diagnóstico , Neoplasias/tratamento farmacológico , Imagem Óptica , Fotoquimioterapia/métodos , Porfirinas/farmacocinética , Ácidos , Antineoplásicos/administração & dosagem , Linhagem Celular Tumoral , Gadolínio/administração & dosagem , Gadolínio/farmacocinética , Humanos , Concentração de Íons de Hidrogênio , Nanopartículas/administração & dosagem , Porfirinas/administração & dosagem
20.
Biomaterials ; 133: 165-175, 2017 07.
Artigo em Inglês | MEDLINE | ID: mdl-28437627

RESUMO

Nanoparticles simultaneously integrated the photosensitizers and diagnostic agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). However, the diagnostic sensitivity and therapeutic efficacy of nanoparticles as well as the heterogeneity of tumors pose tremendous challenges for clinical imaging-guided PDT treatment. Herein, a polymeric nanoparticle with tumor acidity (pHe)-activatable TAT targeting ligand that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates contrast agent Gd3+ is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT. We show clear evidence that the resulting nanoparticle DATAT-NP [its TAT lysine residues' amines was modified by 2,3-dimethylmaleic anhydride (DA)] efficiently avoids the rapid clearance by reticuloendothelial system (RES) by masking of the TAT peptide, resulting in the significantly prolonged circulation time in the blood. Once accumulating in the tumor tissues, DATAT-NP is reactivated by tumor acidity to promote cellular uptake, resulting in enlarged fluorescence/MR imaging signal intensity and elevated in vivo PDT therapeutic effect. This concept provides new avenues to design tumor acidity-activatable targeted nanoparticles for imaging-guided cancer therapy.


Assuntos
Imagem por Ressonância Magnética/métodos , Nanomedicina/métodos , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/química , Produtos do Gene tat do Vírus da Imunodeficiência Humana/química , Linhagem Celular Tumoral , Humanos
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