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1.
Cancer Biomark ; 2020 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-32176622

RESUMO

INTRODUCTION: The present study evaluated the effects of the long non-coding RNA (lncRNA) gastric carcinoma high-expressed transcript (GHET1) in cervical carcinoma development. METHODS: The expression levels of GHET1 and PTEN were measured using in situ hybridisation, immunohistochemistry (IHC) and quantitative reverse transcription PCR assay to investigate their correlations. In an in vitro study, the effects of GHET1 knockdown on the biological activities of SiHa and HeLa cells were evaluated by MTT, flow cytometry, transwell and wound-healing assays and relative protein expression was measured using western blotting. In an in vivo experiment, cell apoptosis and relative protein expression were measured in nude mice using TUNEL and IHC assays, respectively. RESULTS: The expression levels of lncRNA GHET1 and PTEN protein differed significantly between cancer and adjacent normal tissues (P< 0.05) and were negatively correlated in the clinical data. In vitro, proliferation rateswere significantly down-regulated in SiHa and HeLa cells. The GHET1 knockdown (si-GHET1) groups showed significantly higher G1 phase and apoptosis rates and significantly suppressed invasion and migration abilities compared with the normal control (NC) group (P< 0.05 for all). The expression levels of PTEN, PI3 K, AKT, P53, matrix metalloproteinase (MMP)-2 and MMP-9 proteins differed significantly between the si-GHET1 and NC groups (P< 0.05 for all). In vitro, the lncRNA group showed significantly suppressed tumour volume and weight, increased cell apoptosis and different relative protein expression levels compared with the NC group (P< 0.05 for all). CONCLUSION: GHET1 knockdown suppressed cervical carcinoma development via the PTEN/PI3 K/AKT signalling pathway.

2.
BMC Cancer ; 19(1): 1122, 2019 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-31744469

RESUMO

BACKGROUND: To assess the efficacy of Nimotuzumab in combination with first-line chemoradiotherapy treatment in Chinese patients with primary III-IVb stage nasopharyngeal carcinoma. METHODS: Patients with primary locoregionally advanced nasopharyngeal carcinoma who were treated with intensity-modulated radiotherapy (IMRT) and concurrent cisplatin-based chemotherapy between January 2008 and December 2013 at a single institution were retrospectively reviewed. Group A received at least 6 doses of Nimotuzumab, while Group B did not receive Nimotuzumab. A propensity score matching method was used to match patients from each group in a 1:3 ratio. RESULTS: In total, 730 eligible patients were propensity matched, with 184 patients in Group A and 546 patients in Group B. Significant differences were not observed in the patient and tumor characteristics between Group A and Group B. At a median follow-up of 74.78 months (range 3.53-117.83 months), locoregional recurrence, distant failure and death were observed in 10.68, 11.10 and 16.03% of all patients, respectively. The estimated 5-year locoregional relapse-free survival, distant metastasis-free survival, progression-free survival and overall survival in the Group A versus Group B were 85.34% versus 89.79% (P = 0.156), 93.09% versus 85.61% (P = 0.012), 79.96% versus 77.99% (P = 0.117) and 88.91% versus 78.30% (P = 0.006), respectively. CONCLUSIONS: This nimotuzumab-containing regimen resulted in improved long-term survival of III-IVb stage NPC patients and warrants further prospective evaluation.

3.
AMB Express ; 9(1): 162, 2019 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-31605263

RESUMO

Exogenous lipids serving as stimulators to improve lycopene production in Blakeslea trispora have been widely reported. However, the selection basis of exogenous lipids and their effects on intracellular lipids are not very clear. In this study, five plant oils with different fatty acid compositions were selected to investigate their effects on lycopene production, fatty acid composition and the desaturation degree of intracellular lipids. Among the oils, soybean oil, with a fatty acid composition similar to that of mycelium, exhibited the best stimulating effect on lycopene formation (improvement of 82.1%). The plant oils enhanced the total content of intracellular lipids and the desaturation degree of reserve lipids due to the alteration of fatty acid composition, especially in neutral lipids. Lycopene production was increased with the improved desaturation degree of intracellular lipids, which may be attributed to the enhancement of storage capacity for lycopene in storage lipid, thus reducing the feedback regulation of free lycopene. In addition, the increase of the desaturation degree of reserve lipids through temperature-changing fermentation also enhanced lycopene production. The present study could serve as a basis for a better understanding of the relationship between the fatty acid composition of reserve lipids and lycopene production.

4.
Mol Cancer Ther ; 18(12): 2433-2445, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31527225

RESUMO

The transcription factor SOX18, which was initially discovered as an activator of genetic transcription during embryogenesis, is now implicated in many diseases, including cancer, and is associated with the malignant tumor phenotype, angiogenesis, and lymphangiogenesis. However, the role of SOX18 in clear cell renal cell carcinoma (ccRCC) is not well understood. In the current study, SOX18 expression was evaluated in a 250 case-cohort of primary ccRCC tissues that included 103 cases of matched normal kidney tissues and 21 cases of metastatic tissues. Functional and mechanistic analyses were performed in cells that had SOX18 either overexpressed or silenced to evaluate the effects of SOX18 on cell function, the cellular response to cabozantinib, and SOX18-mediated molecular mechanisms. Our data revealed that upregulation and nuclear translocation of SOX18 promoted ccRCC carcinogenesis and metastasis. Elevated SOX18 expression was associated with advanced pathologic grades and TNM stages, as well as poor patient survival. SOX18 also regulated the cell cycle and the epithelial-mesenchymal transition to promote the malignant phenotype in ccRCC cells. The activation of EGF/EGFR and HGF/c-MET signaling in vitro and in vivo was induced by SOX18. Moreover, SOX18 activation bypassed the inhibitory effects of cabozantinib on cell proliferation, migration, and invasion. In conclusion, our data indicate that SOX18 may be a promising therapeutic target for ccRCC treatment.

5.
Cancer Cell ; 36(4): 431-443.e5, 2019 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-31543464

RESUMO

BCR-ABL1 point mutation-mediated resistance to tyrosine kinase inhibitor (TKI) therapy in Philadelphia chromosome-positive (Ph+) leukemia is effectively managed with several approved drugs, including ponatinib for BCR-ABL1T315I-mutant disease. However, therapy options are limited for patients with leukemic clones bearing multiple BCR-ABL1 mutations. Asciminib, an allosteric inhibitor targeting the myristoyl-binding pocket of BCR-ABL1, is active against most single mutants but ineffective against all tested compound mutants. We demonstrate that combining asciminib with ATP site TKIs enhances target inhibition and suppression of resistant outgrowth in Ph+ clinical isolates and cell lines. Inclusion of asciminib restores ponatinib's effectiveness against currently untreatable compound mutants at clinically achievable concentrations. Our findings support combining asciminib with ponatinib as a treatment strategy for this molecularly defined group of patients.

6.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 31(3): 269-274, 2019 Aug 28.
Artigo em Chinês | MEDLINE | ID: mdl-31544405

RESUMO

OBJECTIVE: To explore the spatial-temporal clustering distribution of schistosomiasis transmission risk in Yunnan Province from 2004 to 2015, so as to provide scientific evidence for the future schistosomiasis control and consolidation of the control achievements. METHODS: All data pertaining to endemic situation of human and bovine schistosomiasis and snail survey at a township level in Yunnan Province from 2004 to 2015 were collected. A descriptive epidemiological method and Joinpoint model were used to describe the changing trends of Schistosoma japonicum infections in humans, bovine and snails, and the hotspots and clusters of schistosomiasis transmission risk were identified using spatial autocorrelation analysis, hotspots analysis and retrospective space-time scan statistic in Yunnan Province from 2004 to 2015. RESULTS: The prevalence of S. japonicum infections appeared a continuous decline in humans, bovine and snails in Yunnan Province from 2004 to 2015, and the estimated number of schistosomiasis cases reduced from 43 056 in 2004 to 756 in 2015, with a decline rate of 98.24%. There were no acute cases since 2008 and no infected snails since 2014 in Yunnan Province. There were significant differences in the changing trends of human and bovine S. japonicum infections in Yunnan Province between 2012 and 2015 and between 2013 and 2015, respectively using the Joinpoint model (P < 0.05). In addition, there was a spatial autocorrelation in human S. japonicum infections in Yunnan Province from 2004 to 2013 (P < 0.01), and the hotspots areas for human S. japonicum infections were mainly distributed in some townships from Dali City, Weishan County and Eryuan County. Retrospective spatial-temporal scanning revealed that S. japonicum human, bovine and snail infections were clustered in 23, 15, 4 townships from Dali City, Weishan County, Eryuan County, Nanjian County and Heqing County, respectively, with relative risks of 6.25 to 28.75 (P < 0.01), which was almost consistent with the cluster areas detected by hotspots analysis. CONCLUSIONS: The endemic situation of schistosomiasis significantly reduced in Yunnan Province from 2004 to 2015; however, there is still a risk of schistosomiasis transmission. The monitoring and control of schistosomiasis should be intensified in the future in Yunnan Province.


Assuntos
Esquistossomose Japônica , Esquistossomose , Animais , Bovinos , China , Humanos , Estudos Retrospectivos , Fatores de Risco , Esquistossomose/epidemiologia , Esquistossomose/prevenção & controle , Esquistossomose/transmissão , Caramujos , Análise Espaço-Temporal
7.
Life Sci ; 232: 116614, 2019 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-31260682

RESUMO

AIMS: SRY-box 18 (SOX18) is a transcription factor known for its role in regulating cell differentiation and lymphatic and blood vessel development. It has been reported that SOX18 was involved in various diseases, including cancer. This study aimed to explore the significance and biological function of SOX18 in bladder cancer (BCa). MATERIALS AND METHODS: SOX18 expression in BCa and normal tissues was analyzed by immunohistochemistry, and SOX18 expression in BCa cell lines was quantified by western blotting and quantitative real-time PCR. The role of SOX18 on the proliferation, migration and invasion of BCa cells was explored by CCK-8 and transwell invasion assays in vitro. Cell cycle was measured by flow cytometry assays. Western blotting and qRT-PCR were performed to investigate the potential mechanisms by which SOX18 leads to tumor progression. KEY FINDINGS: SOX18 was significantly upregulated in BCa and its expression was associated with clinical features of patients with BCa. Our data demonstrated that SOX18 promoted cell proliferation via accelerating cell cycle and by regulating c-Myc and Cyclin D1, promoted cell invasion via upregulation of MMP-7. Moreover, phosphorylation of c-Met and Akt regulated by SOX18 was identified to be involved in the process of cell migration and invasion, indicating the vital role of SOX18 in the metastasis of BCa. SIGNIFICANCE: Our data demonstrated a cancer-promoting effect of SOX18 in BCa, revealed the potential mechanisms of SOX18 in mediating cellular functions, and indicated that SOX18 may serve as a promising progression and prognostic biomarker and a therapeutic target for BCa.


Assuntos
Fatores de Transcrição SOXF/metabolismo , Neoplasias da Bexiga Urinária/metabolismo , Idoso , Idoso de 80 Anos ou mais , Animais , Linhagem Celular Tumoral , Movimento Celular/fisiologia , Proliferação de Células/fisiologia , Ciclina D1/metabolismo , Feminino , Fase G1/fisiologia , Xenoenxertos , Humanos , Masculino , Metaloproteinase 7 da Matriz/metabolismo , Camundongos , Camundongos Nus , Pessoa de Meia-Idade , Invasividade Neoplásica , Proteínas Proto-Oncogênicas c-myc/metabolismo , Fase S/fisiologia , Fatores de Transcrição SOXF/biossíntese , Fatores de Transcrição SOXF/genética , Transcriptoma/genética , Neoplasias da Bexiga Urinária/genética , Neoplasias da Bexiga Urinária/patologia
8.
Radiat Prot Dosimetry ; 183(4): 417-421, 2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-30169836

RESUMO

This study aims to estimate the effective doses of dental X-ray devices under common scanning protocols. After putting TLDs in the Alderson Radiation Therapy Phantom, we exposed the phantom under common scanning protocols of three dental X-ray devices, namely CBCT, dental panoramic machine and intraoral round cone device. Then effective doses were calculated using the measured absorbed doses of organs and tissues. Tissue weighting factors recommended by the ICRP were adopted in the calculation. Effective doses under common scanning protocols of three Dental X-ray devices were obtained. The effective dose of dental CT was 0.20 mSv, and that of dental panoramic machine and intraoral radiography were 0.013 and 0.0050 mSv, respectively. The tissue absorbed doses of dental CT scan were 0.63 mGy of brain, 7.7 mGy of salivary glands, 8.7 mGy of thyroid and 4.0 mGy of the lens of the eye. The tissue absorbed doses from dental panoramic machine are 0.62 mGy of salivary glands and 0.25 mGy of thyroid. And finally the tissue absorbed dose of intraoral radiography was 0.80 mGy of salivary gland. Among the three dental X-ray devices studied, dental CBCT scan can cause much higher effective dose than the other two. Brain, salivary glands, thyroid and the lens of the eye are tissues receiving relatively higher absorbed doses.


Assuntos
Imagens de Fantasmas , Radiografia Dentária/instrumentação , Radiografia Dentária/estatística & dados numéricos , Tomografia Computadorizada por Raios X/métodos , Humanos , Cristalino/efeitos da radiação , Masculino , Radiografia Dentária/métodos , Glândulas Salivares/efeitos da radiação , Dosimetria Termoluminescente , Glândula Tireoide/efeitos da radiação
9.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 30(5): 578-580, 2018 Aug 08.
Artigo em Chinês | MEDLINE | ID: mdl-30567037

RESUMO

The study analyzes the strengths, weaknesses, opportunities and threats (SWOT) of the informatization of parasitic disease prevention and control in China, and puts forward the development strategies, in order to provide the reference for accelerating the informatization of parasitic disease prevention and control.


Assuntos
Disseminação de Informação , Doenças Parasitárias , China , Assistência à Saúde , Humanos , Doenças Parasitárias/prevenção & controle
10.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 30(3): 282-288, 2018 Jun 08.
Artigo em Chinês | MEDLINE | ID: mdl-30019555

RESUMO

OBJECTIVE: To understand the epidemiological characteristics of death cases of echinococcosis in China from 2008 to 2016, so as to provide an important reference for the prevention and control of echinococcosis. METHODS: The death information registration and management system data were selected to analyze the epidemiological characteristics of the death cases of echinococcosis. The data were analyzed by SPSS 21.0 and the map was drawn by ArcGIS 10.1 software. RESULTS: From 2008 to 2016, a total of 367 death cases of echinococcosis were reported in China, and the number of deaths in turn was 33, 30, 21, 32, 35, 54, 55, and 81 in each year, with an annual average crude mortality of 129.29 /105. The average age of death was (56 ± 18) years; the sex ratio of male to female was 100∶94. There was no statistical difference between the male and female death cases (χ2 = 0.33, P > 0.05).The death cases of echinococcosis were mainly distributed in endemic areas of Qinghai, Sichuan, Ningxia, Xinjiang, Gansu, Inner Mongolia, Yunnan and non-endemic areas of Heilongjiang, Jiangsu, Henan and Shandong. The death cases in the first eleven provinces accounted for 87.5% (321/367) of the total death cases, among which the highest proportions of the nationality, occupation, educational level, highest diagnostic units, and the place of death were Han (52.0%, 191/367), farmer (46.6%, 171/367), junior high school or below (57.2%, 210/367), provincial or three-level hospitals (46.6%, 171/367), and at home (59.9%, 220/367). CONCLUSIONS: Since 2014, the death cases of echinococcosis in China have been increasing year by year, indicating that the prevention and treatment of echinococcosis is still very serious. The causes for the rise of the fatality rate remain to be further studied.


Assuntos
Equinococose , Adulto , Idoso , China/epidemiologia , Equinococose/epidemiologia , Equinococose/mortalidade , Equinococose/prevenção & controle , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Fatores de Risco
11.
Gene ; 668: 166-173, 2018 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-29783073

RESUMO

The Yangtze River delta white goat is the only goat breed that produces high-quality brush hair, which is specifically used in top-grade writing brushes. Previous studies have indicated that the CMTM3 and DUSP1 genes are involved in the growth and cycle of high-quality brush hair, and these genes are thought to be involved in the formation of high-quality brush hair traits. In this study, we investigated the relationship between methylation of CMTM3 and DUSP1 and such traits. The results indicated that the relative expression levels of the CMTM3 and DUSP1 genes were higher in non-high-quality brush hair than in high-quality brush hair. Furthermore, the CpG sites of the DUSP1 gene were not methylated, and the methylation level of CMTM3 was negatively correlated with the gene expression level. We believe that the DUSP1 gene regulates the formation of high-quality brush hair by non-methylated, and that methylation of the CMTM3 gene results in a decrease in its expression, causing an increase in the activity of the androgen receptor and the level of androgen. This high androgen level promotes the growth of high-quality brush hair. These study results provide a theoretical basis for further elucidating the molecular mechanism of the formation of high-quality brush hair characteristics, and provide scientific reference for the molecular breeding of high-quality brush hair.


Assuntos
Metilação de DNA , Fosfatase 1 de Especificidade Dupla/genética , Cabras/genética , Cabelo/metabolismo , Proteínas com Domínio MARVEL/genética , Regiões Promotoras Genéticas , Androgênios/sangue , Animais , Sítios de Ligação , Ilhas de CpG , Expressão Gênica , Cabras/sangue , Cabras/metabolismo , Masculino , Fatores de Transcrição/metabolismo
12.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 30(2): 211-214, 2018 Apr 17.
Artigo em Chinês | MEDLINE | ID: mdl-29770669

RESUMO

A taeniasis/cysticercosis information management system was designed to achieve the dynamic monitoring of the epidemic situation of taeniasis/cysticercosis and improve the intelligence level of disease information management. The system includes three layer structures (application layer, technical core layer, and data storage layer) and designs a datum transmission and remote communication system of traffic information tube in Browser/Server architecture. The system is believed to promote disease datum collection. Additionally, the system may provide the standardized data for convenience of datum analysis.


Assuntos
Cisticercose/epidemiologia , Estudos Epidemiológicos , Inquéritos e Questionários , Teníase/epidemiologia , Epidemias
13.
Nanotechnology ; 29(14): 144001, 2018 Apr 06.
Artigo em Inglês | MEDLINE | ID: mdl-29376835

RESUMO

The optical absorption of graphene-molybdenum disulfide photovoltaic cells (GM-PVc) in wedge-shaped metal-mirror microcavities (w-MMCs) combined with a spectrum-splitting structure was studied. Results showed that the combination of spectrum-splitting structure and w-MMC can enable the light absorption of GM-PVcs to reach about 65% in the broad spectrum. The influence of processing errors on the absorption of GM-PVcs in w-MMCs was 3-14 times lower than that of GM-PVcs in wedge photonic crystal microcavities. The light absorption of GM-PVcs reached 60% in the broad spectrum, even with the processing errors. The proposed structure is easy to implement and may have potentially important applications in the development of ultra-thin and high-efficiency solar cells and optoelectronic devices.

14.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 30(6): 601-604, 2018 Dec 25.
Artigo em Chinês | MEDLINE | ID: mdl-30891967

RESUMO

The Three-year Tough Action Plan for Endemic Diseases Control (2018-2020), which was formulated by 10 ministries of China, was issued on November 29, 2018. Schistosomiasis control is an important part of this plan, and the implementation of the plan provides an important basis for the health poverty alleviation and the fight against schistosomiasis in China. This paper describes the objective and principle of the plan and proposes "six actions" and supporting measures to implement the three-year tough action targeting schistosomiasis, with aims to guide the scientific implementation of the three-year tough action against schistosomiasis and facilitate the progress towards schistosomiasis elimination in China.


Assuntos
Erradicação de Doenças , Doenças Endêmicas , Esquistossomose , Animais , China , Doenças Endêmicas/prevenção & controle , Humanos , Pobreza , Esquistossomose/prevenção & controle
15.
Med Sci Monit ; 23: 4454-4461, 2017 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-28916736

RESUMO

BACKGROUND UCA1 is a long non-coding RNA that has been found to be aberrantly upregulated in various cancers. The aim of this study was to determine the expression level and function of UCA1 in medulloblastoma, the most common malignant brain tumor during childhood. MATERIAL AND METHODS Real-time PCR was used to detect the expression of UCA1 in medulloblastoma specimens and cell lines. Lentiviral-mediated expression of a short hairpin RNA (shRNA) targeting UCA1 or a negative control shRNA was also achieved with the medulloblastoma cell line, Daoy. Cell proliferation and cell cycle progression were subsequently characterized with cell counting kit (CCK)-8 and flow cytometry. Cell migration was examined in wound healing and Transwell migration assays. RESULTS Levels of UCA1 mRNA were higher in the medulloblastoma specimens (p<0.05) and cell lines (p<0.05) compared to the corresponding nontumor adjacent tissue specimens and a glioblastoma cell line, respectively. For the Daoy cells with silenced UCA1, their proliferation was reduced by 30% compared to the Daoy cells expressing a negative control shRNA (p=0.017). Cell cycle arrest in the G0/G1 phase, resulting in a decreased number of cells in the S phase, as well as reduced cell migration in both wound scratch healing (p=0.001) and Transwell migration assays (p=0.021) were also observed for the Daoy cells with silenced UCA1. CONCLUSIONS UCA1 was highly expressed in part of medulloblastoma specimens and cell lines examined. In addition, knockdown of UCA1 significantly inhibited the proliferation and migration of medulloblastoma cells in vitro.


Assuntos
Neoplasias Cerebelares/genética , Neoplasias Cerebelares/metabolismo , Meduloblastoma/genética , Meduloblastoma/metabolismo , RNA Longo não Codificante/biossíntese , RNA Longo não Codificante/genética , Adulto , Apoptose/genética , Biomarcadores Tumorais/biossíntese , Biomarcadores Tumorais/genética , Linhagem Celular Tumoral , Movimento Celular/genética , Proliferação de Células/genética , Criança , Pré-Escolar , Feminino , Humanos , Masculino , RNA Longo não Codificante/metabolismo , RNA Mensageiro/genética , RNA Interferente Pequeno/genética , Regulação para Cima
16.
J Pediatr Orthop B ; 26(2): 152-158, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27258359

RESUMO

Reverse flow sural flap (RFSF) and vacuum sealing drainage (VSD) have been used to cover soft tissue defects in the heels of children in medical emergency settings. We report a retrospective case series, including a total of 19 children with soft tissue defects in heels resulting from spokes injury. In six patients, soft tissue defects in the heel were covered with RFSF. Further, in 13 patients, the defects were covered with VSD, in seven patients defects were repaired using free skin, and in six patients defects were repaired using RFSF after VSD. All wounds in the donor and recipient areas healed by first intention, and all free skins or island flaps completely survived; the color and luster on reconstructed areas were perfect. Patients were followed up for about 3-30 months, without osteomyelitis and infection in the heel, and the functions of the heel were satisfactory. RFSF and VSD were both advantageous, and were ideal for covering heel defects in children in emergency settings.


Assuntos
Medicina de Emergência/métodos , Calcanhar/lesões , Calcanhar/cirurgia , Lesões dos Tecidos Moles/cirurgia , Criança , Pré-Escolar , Cor , Drenagem , Serviço Hospitalar de Emergência , Feminino , Humanos , Traumatismos da Perna/cirurgia , Masculino , Osteomielite/complicações , Procedimentos Cirúrgicos Reconstrutivos/métodos , Estudos Retrospectivos , Transplante de Pele , Retalhos Cirúrgicos , Fatores de Tempo , Resultado do Tratamento , Vácuo
17.
Bull Environ Contam Toxicol ; 98(2): 162-166, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27999881

RESUMO

Concentrations of total mercury (T-Hg) and methylmercury (MeHg) in a wetland food chain were determined at Majuan Island of the Sanjiang Plain in China. Four tissues (muscle, liver, kidney and brain) of three waterbird species (great cormorant, grey heron and great egret), muscle tissues of fish (grass carp, crucian carp and longnose gudgeon), insects (predacious diving beetle), aquatic plants (ditch reed) and soil were analyzed. The mean concentrations of T-Hg were 0.392 ± 0.237 mg/kg for tissues of all juveniles, 1.999 ± 2.053 mg/kg for great cormorant adults, and 0.029 ± 0.019 mg/kg for fish muscle, respectively. While the relative contents of T-Hg of insects, plants and sediments were 0.012 ± 0.002, 0.006 ± 0.001 and 0.020 ± 0.002 mg/kg, respectively. Bioaccumulation of Hg along the wetland food chain may be able to show the current situation of Hg contamination in remote regions of East Asia.


Assuntos
Monitoramento Ambiental , Cadeia Alimentar , Mercúrio/metabolismo , Compostos de Metilmercúrio/metabolismo , Poluentes Químicos da Água/metabolismo , Áreas Alagadas , Animais , Aves/metabolismo , China , Ecossistema , Peixes/metabolismo , Insetos/metabolismo , Mercúrio/análise , Compostos de Metilmercúrio/análise , Poluentes Químicos da Água/análise
18.
Artigo em Chinês | MEDLINE | ID: mdl-29536699

RESUMO

Mosquito is a vector of many infectious diseases, and it is recognized a leading killer of human in the world. After the Belt and Road Initiative launches, more are countries involved and the international communication and cooperation are significantly growing in China. Therefore, the risk of imported infectious diseases is increasing as well, some mosquito-borne diseases which have been well controlled or seldom seen in China, will be more risky to cause locally transmission from imported cases and become the threat to people's health in China. This paper reviews the risk of major imported mosquito borne-diseases to China, and discusses the control strategy as well, so as to provide the suggestion for entry-exit inspection and control of imported mosquito-borne diseases in China.


Assuntos
Controle de Doenças Transmissíveis , Doenças Transmissíveis , Culicidae , Mosquitos Vetores , Animais , China , Humanos
19.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 29(3): 324-328, 2017 Jun 08.
Artigo em Chinês | MEDLINE | ID: mdl-29469523

RESUMO

OBJECTIVE: To report the integrated progress of the hydatid disease information management system, and to provide the reference for further system improvements by analysis of results on simulation test feedback. METHODS: The work of institutional code matching by collecting fundamental and integrated information of the system in epidemic areas of hydatid disease was carried out, and professional control agencies were selected to carry out the simulation test. RESULTS: The results of agencies code matching at stage indicated the average completion rate was 94.30% on administrative agencies, 69.94% on registered professional agencies and 56.40% on professional institutions matching related to hydatid disease prevention and control implements in seven provinces (autonomous regions) and Xinjiang Production and Construction Corps. Meanwhile, the response rate of open-ended proposals was 93.33% on fifteen feedbacks, and the statistics showed 21.43% believed the system was low fluency, 64.29% considered the system was inconvenience for data inputs and 42.86% considered it would be improved on system statistics functions, of which 27.78% were provincial users, 22.22% were the city users and 50.00% were the county users. CONCLUSIONS: The hydatid disease prevention information management system meets the fundamental needs of the majority agencies in hyperendemic areas of echinococcosis, it needs to develop the further test with more agencies joining after the work of the institutional code matching completion and the system service improvement in the next stage.


Assuntos
Equinococose/prevenção & controle , Sistemas de Informação em Saúde , Integração de Sistemas , China , Cidades , Simulação por Computador , Epidemias , Humanos
20.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 28(6): 624-629, 2016 Dec 07.
Artigo em Chinês | MEDLINE | ID: mdl-29469250

RESUMO

OBJECTIVE: To investigate the tempo-spatial patterns of schistosomiasis in Jiangling County, Hubei Province, so as to identify the risk areas and provide the scientific evidence in following intervention plans for marshland epidemic areas in the stage of transmission control. METHODS: The schistosomiasis epidemiological data in Jiangling County from 2009 to 2013 together with the related geographical information were collected and analyzed. The tempo-spatial distribution patterns were analyzed by the spatial autocorrelation analysis and spatial clustering analysis. RESULTS: The human infection rate was decreased from 2.15% in 2009 to 0.63% in 2013, which was the historically low level. The results of tempo-spatial analysis showed that there were spatial clustering effects in human schistosomiasis infection for each of the years. The values of spatial autocorrelation index Moran's I were statistically significant. Eighteen and thirty-five clusters were detected by using SatScan and FlexScan software, respectively. CONCLUSIONS: From 2009 to 2013, the schistosomiasis endemic situation in Jiangling County presented a decline trend and reached the historical low level. The identified spatial clustering areas should be targeted as the prioritized areas for schistosomiasis control.


Assuntos
Esquistossomose/epidemiologia , Análise Espaço-Temporal , China , Análise por Conglomerados , Epidemias , Geografia , Humanos , Esquistossomose/prevenção & controle , Áreas Alagadas
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