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1.
J Photochem Photobiol B ; 205: 111821, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32131044

RESUMO

Iron oxide nanoparticles (Fe2O3NPs) are an interested and attractive area of research as they have numerous effective environmental and biomedical applications. Herein we have reported a simple and eco-benign synthesis Fe2O3NPs using Tamarix aphylla extract. The extract of the Tamarix aphylla acts both as a reducing and capping agent which leads to the fast and successful eco-benign synthesis of Fe2O3NPs.UV/Vis spectroscopy, XRD, EDX, SEM and TEM techniques were used to characterize and explore different features of Fe2O3NPs. UV/Vis studies showed asharppeak at 390 nm due to surface plasmon resonance absorption of Fe2O3NPs. XRD studies indicated that Fe2O3NPs were crystalline in nature. Structural features, elemental composition and geometry of Fe2O3NPswere confirmed by SEM, EDX and TEM. The as synthesized Fe2O3NPs showed efficient efficacy to degrade 100% of Methylene blue (MB) dye by 4 mg/25 ml MB and revealed 90% scavenging of the more stable DPPH free radical(1 mg/ml). Furthermore, Fe2O3NPs showed excellent antimicrobial activity against pathogenic multidrug resistant bacterial strains. The results of the present study explored the potential reducing, capping property of Tamarix aphylla extract, photocatalytic and biomedical applications of eco-benignly synthesized Fe2O3NPs which could be an alternative material for effective remediation of lethal organic pollutants and microbes.

2.
J Clin Invest ; 2020 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-32182225

RESUMO

Plasmacytoid dendritic cells (pDC), the major producers of Type I interferon, are principally recognized as key mediators of antiviral immunity. However, their role in tumor immunity is less clear. Depending on the context, pDC can both promote or suppress antitumor immune responses. In this study, we identified a naturally occurring pDC subset expressing high levels of OX40 (OX40+ pDC) enriched in the tumor microenvironment (TME) of head and neck squamous cell carcinoma. OX40+ pDC were distinguished by a distinct immunostimulatory phenotype, cytolytic function and ability to synergize with conventional dendritic cells (cDC) in generating potent tumor antigen-specific CD8+ T cell responses. Transcriptomically, we found they selectively utilized EIF2 signaling and oxidative phosphorylation pathways. Moreover, depletion of pDC in the murine OX40+ pDC-rich tumor model accelerated tumor growth. Collectively, we present evidence of a pDC subset in the TME that favors antitumor immunity.

3.
Artigo em Inglês | MEDLINE | ID: mdl-32185736

RESUMO

Excess sludge contains a high amount of protein, which can be recovered to prepare protein foaming agents and other products with high added value. Enzymatic hydrolysis (EH) is a promising technology for the recovery of protein from excess sludge, and ultrasound has been identified as a potential method to assist in sludge disintegration. Ultrasonic pretreatment was combined with alkaline protease hydrolysis to extract protein from excess sludge produced by A2/O treatment (S1) and an oxidation ditch treatment (S2), and the extraction effects and changes in sludge dewatering performance were studied. The effects of the six factors ultrasonic power density, ultrasonication time, enzyme dose, pH, hydrolysis temperature and hydrolysis time were analyzed. The results showed that the ultrasound-enhanced enzymatic method could effectively extract sludge protein. Although the extraction efficiencies for the different municipal sludges were different, their extraction conditions were relatively similar. Considering the protein extraction rate and sludge dewatering performance, the selected extraction conditions were as follows: ultrasonic power density, 1 W/mL; ultrasonication time, 20 min; enzyme dose, 3500 U/g; pH 11; hydrolysis temperature, 60 °C; and hydrolysis time, 3 h. Under these conditions, the protein extraction rate (Rp) of S1 and S2 reached 55.9% and 52.3%, respectively. Moreover, the improvement in sludge dewatering performance (Dw) of S1 and S2 was 49.5% and 52.4%, respectively. Comparison of the protein, polypeptide, and amino acid contents obtained from ultrasound-assisted enzymatic hydrolysis (UEH), EH, and ultrasonic hydrolysis (UH) further demonstrated the beneficial effect of ultrasound application on enzymatic hydrolysis.

4.
J Hazard Mater ; 392: 122499, 2020 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-32208315

RESUMO

Recently, graphene aerogels (GAs) have attracted considerable research attention in oil/water separation owing to their remarkable properties. However, the serious stacking of graphene oxide nanosheets (GO) would lead to low adsorption capacity and poor recyclability. For the first time, with alkaline ammonium citrate as reducing agent and nitrogen source, the point-to-face contact between magnetic carbon nanospheres (MCNS) and graphene sheets was adopted to effectively inhibit the aggregation of graphene sheets. Nitrogen-doped magnetic carbon nanospheres/graphene composite aerogels (MCNS/NGA) were fabricated under weakly alkaline conditions by one-step hydrothermal in-situ electrostatic self-assembling strategy. The aerogels have low density, super-elasticity (up to 95 % compression), high specific surface area (787.92 m2 g-1) and good magnetic properties. Therefore, they exhibit adsorption capacity in the range of 187-537 g g-1 towards various organic solvents and oils, superior to most reported materials to date. In addition, thanks to their good mechanical properties, excellent thermal stability and flame retardancy, they can be regenerated by squeezing, distillation and combustion. More importantly, magnetic control technology can be adopted to realize oriented adsorption and facilitate recycling of organic solvents and oils in extreme environments.

5.
Artigo em Inglês | MEDLINE | ID: mdl-32117819

RESUMO

Edwardsiella piscicida is found to be an important facultative intracellular pathogen with a broad host range. These organisms can replicate and survive within host macrophages to escape from the subversion of the immune defense. E. piscicida-macrophage interaction is very important in determining the outcome of edwardsiellasis. As an effector protein of E. piscicida T6SS, EvpP has been determined to be a very important virulence factor for E. piscicida, although its precise role in E. piscicida-macrophage interactions is not yet clear. In this study, the roles of EvpP in E. piscicida-macrophage interactions were characterized. Here, we constructed the deletion mutants of evpP (ΔevpP) and complementation (ΔevpP-C) by the allelic exchange method. Compared to wild type strain (WT), ΔevpP was found to be attenuated for growth within macrophages. In line with this observation, we found its survival capacity was lower than WT under oxidative and acid stress in vitro, which simulate conditions encountered in host macrophages. Attenuation of ΔevpP also correlated with enhanced activation of macrophages, as reflected by augmented NO production in ΔevpP-treated macrophages. Moreover, compared to WT, ΔevpP induced markedly increased apoptosis of macrophages, characterized by increased Annexin V binding and the activation of cleaved caspase-3. These findings provided strong evidence that EvpP is involved in the process of E. piscicida-macrophage interactions and is required for its survival and replication in macrophages. Thus, we propose that EvpP might be an important factor that controlling the fate of E. piscicida inside macrophages. To further exploring the underlying mechanism of EvpP action, the cDNA library was constructed from E. piscicida-infected macrophages and a yeast two-hybrid screen was performed to search for cellular proteins interacting with EvpP. Ribosomal protein S5 (RPS5) was identified as a target of EvpP. Furthermore, the interaction was validated with co-immunoprecipitation assay. This result implies that the observed effect of EvpP on macrophages might be related to RPS5-mediated regulation, contributing to a better understanding of the mechanisms of EvpP involved in E. piscicida-macrophage interactions.

6.
Ann Clin Lab Sci ; 50(1): 13-23, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32161008

RESUMO

FZD8, a G protein-coupled receptor protein belonging to the Frizzled family, is considered to play an important role in cancer invasion and metastasis. However, the function of FZD8 in the invasion and metastasis of gastric cancer (GC) has not been elucidated. In this study, we first confirm that FZD8 protein expression was significantly upregulated in gastric cancer tissue and has a potential to be an independent predictor of poor prognosis for patients with GC. In vivo and in vitro evidences were provided that support the idea of FZD8 being able to suppress GC cell invasion and metastasis. Further studies show that FZD8 promotes the markers expression related to invasion and metastasis. FZD8 exerts biological function through the ß-catenin pathway which plays an important role in invasion and metastasis of gastric cancer cells. Finally, FZD8 could activate the ß-catenin pathway and its target gene's expression. In conclusion, our findings show that FZD8 promotes GC invasion and metastasis via the ß-catenin pathway.

7.
J Magn Reson Imaging ; 2020 Mar 13.
Artigo em Inglês | MEDLINE | ID: mdl-32167652

RESUMO

BACKGROUND: Approximately one-fourth of all cancer metastases are found in the brain. MRI is the primary technique for detection of brain metastasis, planning of radiotherapy, and the monitoring of treatment response. Progress in tumor treatment now requires detection of new or growing metastases at the small subcentimeter size, when these therapies are most effective. PURPOSE: To develop a deep-learning-based approach for finding brain metastasis on MRI. STUDY TYPE: Retrospective. SEQUENCE: Axial postcontrast 3D T1 -weighted imaging. FIELD STRENGTH: 1.5T and 3T. POPULATION: A total of 361 scans of 121 patients were used to train and test the Faster region-based convolutional neural network (Faster R-CNN): 1565 lesions in 270 scans of 73 patients for training; 488 lesions in 91 scans of 48 patients for testing. From the 48 outputs of Faster R-CNN, 212 lesions in 46 scans of 18 patients were used for training the RUSBoost algorithm (MatLab) and 276 lesions in 45 scans of 30 patients for testing. ASSESSMENT: Two radiologists diagnosed and supervised annotation of metastases on brain MRI as ground truth. This data were used to produce a 2-step pipeline consisting of a Faster R-CNN for detecting abnormal hyperintensity that may represent brain metastasis and a RUSBoost classifier to reduce the number of false-positive foci detected. STATISTICAL TESTS: The performance of the algorithm was evaluated by using sensitivity, false-positive rate, and receiver's operating characteristic (ROC) curves. The detection performance was assessed both per-metastases and per-slice. RESULTS: Testing on held-out brain MRI data demonstrated 96% sensitivity and 20 false-positive metastases per scan. The results showed an 87.1% sensitivity and 0.24 false-positive metastases per slice. The area under the ROC curve was 0.79. CONCLUSION: Our results showed that deep-learning-based computer-aided detection (CAD) had the potential of detecting brain metastases with high sensitivity and reasonable specificity. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY STAGE: 2.

8.
Chemosphere ; 251: 126376, 2020 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-32169694

RESUMO

Highly selective surface molecularly imprinted polymer (SMIP) was prepared on glucose-derived microporous carbon nanospheres (GMCNs) by surface molecular imprinting technology for the removal of phenol from wastewater. GMCNs with rich pore structure and surface oxygenic functional groups were adopted as support materials, on which the active layers were constructed by grafting silane coupling agent 3-(methacryloyloxy) propyltrimethoxysilane. Then with phenol as template molecule, different types and amounts of functional monomer (including methacrylic acid and 4-vinylpyridine (4-VP)) were screened for optimizing imprinting conditions suitable for phenol adsorption, and a series of SMIP was obtained through crosslinking polymerization. The adsorption behaviors of SMIP were evaluated by UV spectrophotometry. The results show that, when 4-VP is used as functional monomer, the resultant 4-VP/SMIP exhibites an excellent adsorption capacity of 85.72 mg g-1. The relative selectivity factor for phenol against hydroquinone, p-nitrophenol and p-tert-butylphenol is 8.38, 7.96 and 6.67, respectively, indicating outstanding adsorption capacity and selectivity of 4-VP/SMIP. The pseudo-second-order model and Langmuir‒Freundlich model fit better than other models for the adsorption of phenol. 4-VP/SMIP is promising for selective removal and enrichment recovery towards phenol in wastewater.

9.
J Neurosurg ; : 1-10, 2020 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-31899871

RESUMO

OBJECTIVE: Cushing's disease (CD) involves brain impairments caused by excessive cortisol. Whether these impairments are reversible in remitted CD after surgery has long been controversial due to a lack of high-quality longitudinal studies. In this study the authors aimed to assess the reversibility of whole-brain changes in remitted CD after transsphenoidal surgery (TSS), and its correlations with clinical and hormonal parameters, in the largest longitudinal study cohort to date for CD patient brain analysis. METHODS: Fifty patients with pathologically diagnosed CD and 36 matched healthy controls (HCs) were enrolled in a tertiary comprehensive hospital and national pituitary disease registry center in China. 3-T MRI studies were analyzed using an artificial intelligence-assisted web-based autosegmentation tool to quantify 3D brain volumes. Clinical parameters as well as levels of serum cortisol, adrenocorticotrophic hormone (ACTH), and 24-hour urinary free cortisol were collected for the correlation analysis. All CD patients underwent TSS and 46 patients achieved remission. All clinical, hormonal, and MRI parameters were reevaluated at the 3-month follow-up after surgery. RESULTS: Widespread brain volume loss was observed in active CD patients compared with HCs, including total gray matter (p = 0.003, with false discovery rate [FDR] correction) and the frontal, parietal, occipital, and temporal lobes; insula; cingulate lobe; and enlargement of lateral and third ventricles (p < 0.05, corrected with FDR). All affected brain regions improved significantly after TSS (p < 0.05, corrected with FDR). In patients with remitted CD, total gray matter and most brain regions (except the frontal and temporal lobes) showed full recovery of volume, with volumes that did not differ from those of HCs (p > 0.05, corrected with FDR). ACTH and serum cortisol changes were negatively correlated with brain volume changes during recovery (p < 0.05). CONCLUSIONS: This study demonstrates the rapid reversal of total gray matter loss in remitted CD. The combination of full recovery areas and partial recovery areas after TSS is consistent with the incomplete recovery of memory and cognitive function observed in CD patients in clinical practice. Correlation analyses suggest that ACTH and serum cortisol levels are reliable serum biomarkers of brain recovery for clinical use after surgery.

10.
Bioresour Technol ; 301: 122762, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31972402

RESUMO

To assess the potential of Chlorella sp. GN1 for producing biodiesel raw materials in flat plate photobioreactors (FPPs) outdoors, we optimized the nitrogen sources and concentrations for the growth of the algae. The effects of different light paths of FPPs on the growth, lipid accumulation, and fatty acids of Chlorella sp. GN1 were also studied. As the light path of the FPPs was reduced, the alga could accumulate lipids rapidly, achieving high lipid content and lipid productivity outdoors. The highest lipid content obtained was 53.5%, when the light path was 5 cm. In addition, the lipid productivity was 66.7 mg L-1 day-1. The main fatty acids were C16/C18, accounting more than 90% of the total fatty acids. Results showed that Chlorella sp. GN1 had the ability to accumulate large quantities of lipids in FPPs outdoors and was a promising microalgal species for biofuel production.


Assuntos
Chlorella , Microalgas , Biocombustíveis , Biomassa , Ácidos Graxos , Luz , Lipídeos , Nitrogênio , Fotobiorreatores
11.
J Agric Food Chem ; 68(5): 1248-1256, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-31927921

RESUMO

Lipophenols are regarded as an emerging source of functional food ingredients. However, little is known about their in vivo digestion, absorption, and metabolism. Thus, the pharmacokinetic characteristics in rat and the gut microbial degradation of tyrosol acyl esters (TYr-Es) with fatty acids of C12:0, C18:0, and C18:2 were investigated for the first time. Major metabolites including tyrosol sulfate and tyrosol glucuronide, rather than the parent compounds, were detected in rat plasma after oral administration of TYr-Es. The increased plasma half-life (T1/2) and mean residence time demonstrated that TYr-Es display a longer duration of action in vivo than TYr, potentially leading to higher oral bioavailability. TYr-Es could be hydrolyzed by the gut microbiota to free TYr, which may result in the appearance of the second absorption peak in pharmacokinetic profiles. Therefore, TYr-Es exhibit improved bioavailability compared to that of TYr because of their prolonged duration of action.


Assuntos
Ésteres/farmacocinética , Álcool Feniletílico/análogos & derivados , Animais , Disponibilidade Biológica , Ésteres/química , Ácidos Graxos/sangue , Ácidos Graxos/química , Cinética , Masculino , Álcool Feniletílico/química , Álcool Feniletílico/farmacocinética , Plasma/química , Ratos , Ratos Sprague-Dawley
12.
Chem Soc Rev ; 49(3): 865-907, 2020 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-31957756

RESUMO

Supramolecular chemistry is a central topic in modern chemistry. It touches on many traditional disciplines, such as organic chemistry, inorganic chemistry, physical chemistry, materials chemistry, environmental chemistry, and biological chemistry. Supramolecular hosts, inter alia macrocyclic hosts, play critical roles in supramolecular chemistry. Calix[4]pyrroles, non-aromatic tetrapyrrolic macrocycles defined by sp3 hybridized meso bridges, have proved to be versatile receptors for neutral species, anions, and cations, as well as ion pairs. Compared to the parent system, octamethylcalix[4]pyrrole and its derivatives bearing simple appended functionalities, strapped calix[4]pyrroles typically display enhanced binding affinities and selectivities. In this review, we summarize advances in the design and synthesis of strapped calix[4]pyrroles, as well as their broad utility in molecular recognition, supramolecular extraction, separation technology, ion transport, and as agents capable of inhibiting cancer cell proliferation. Future challenges within this sub-field are also discussed.


Assuntos
Calixarenos/química , Calixarenos/metabolismo , Porfirinas/química , Porfirinas/metabolismo , Ânions/química , Apoptose , Cátions/química , Permeabilidade da Membrana Celular , Cristalização , Modelos Moleculares , Estrutura Molecular , Compostos Orgânicos/química , Relação Estrutura-Atividade , Termodinâmica
13.
Cancer Med ; 9(2): 562-574, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31789464

RESUMO

BACKGROUND: To estimate easily assessed preoperative factors for predicting 90-day mortality in patients with a pancreatic head adenocarcinoma (PHA) receiving a pancreaticoduodenectomy. METHODS: We analyzed data from the Taiwan Cancer Registry Database of patients with a PHA who received a pancreaticoduodenectomy. Basic demographic characteristics, including gender and age, were categorized. The selection of preoperative comorbidities was based on the preoperative American Society of Anesthesiologists score and Charlson comorbidity index. RESULTS: We enrolled 8490 patients with a PHA who received a pancreaticoduodenectomy without distant metastasis. Currently, a pancreaticoduodenectomy for a PHA achieves an overall 90-day mortality rate of 8.39%. Univariate and multivariate Cox regression analyses indicated that an older age (65-74 and ≥75 years) and specific comorbidities (chronic obstructive pulmonary disease, chronic kidney disease, dementia, and sepsis) were significant independent prognostic factors for predicting 90-day mortality after a pancreaticoduodenectomy. After adjustment, the adjusted hazard ratios (aHRs) (95% confidence intervals [CIs]) of subjects with middle and high comorbidity scores for 90-day mortality in 65 to 74-year-old patients were 1.36 (1.05-1.75) and 2.25 (1.03-4.90), respectively, compared to subjects with low comorbidity scores. The aHRs (95% CIs) of subjects with middle and high comorbidity scores for 90-day mortality in ≥75-year-old patients were 1.35 (1.07-1.78) and 2.07 (1.19-3.62), respectively, compared to those with low comorbidity scores. CONCLUSIONS: Elderly patients with a PHA and moderate or high comorbidity scores have an increased risk of 90-day mortality after a pancreaticoduodenectomy.

14.
J Reconstr Microsurg ; 36(2): 151-156, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31645075

RESUMO

BACKGROUND: After mastectomy and breast reconstruction, many patients experience upper extremity complications, such as pain, restriction in motion, and lymphedema. Despite an aesthetically satisfactory outcome, these occurrences can diminish a patient's postoperative quality of life. Several studies have investigated the causes and incidence of these complications. However, there is currently a paucity of data comparing postoperative upper extremity function according to reconstruction technique. METHODS: A review was performed of patients enrolled in a physical therapy (PT) program after mastectomy and immediate breast reconstruction. PT initial encounter evaluations were used to gather data on patients' postoperative upper extremity function. Hospital records were used to gather surgical and demographic data. For each patient, data were collected for each upper extremity that was ipsilateral to a reconstructed breast. Data were then compared between patients who underwent implant-based versus autologous deep inferior epigastric perforator flap reconstruction. RESULTS: A total of 72 patients were identified, including 39 autologous and 33 implant-based reconstruction cases. Proportions of patients who underwent sentinel lymph node biopsies and axillary lymph node dissections were similar between the two groups. The autologous-based reconstruction patients had significantly higher arm pain at rest (p = 0.004) and with activity (p = 0.031) compared with implant patients. Shoulder range of motion and manual muscle test results were similar between groups, with the exception of elbow flexion, which was weaker in implant patients (p = 0.030). Implant patients were also more likely to report "severe difficulty" or "inability" to perform activities of daily living (p = 0.022). Edema/swelling, axillary cording, and lymphedema girth measurements were similar between the two groups. CONCLUSION: Different techniques of breast reconstruction can result in different postoperative upper extremity complications. These data show specific areas where postoperative care and PT can be customized according to reconstruction type. Investigation is currently underway to determine the effect of PT on upper extremity function in these patients.

15.
Plant Biotechnol J ; 18(1): 45-56, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31116473

RESUMO

The base-editing technique using CRISPR/nCas9 (Cas9 nickase) or dCas9 (deactivated Cas9) fused with cytidine deaminase is a powerful tool to create point mutations. In this study, a novel G. hirsutum-Base Editor 3 (GhBE3) base-editing system has been developed to create single-base mutations in the allotetraploid genome of cotton (Gossypium hirsutum). A cytidine deaminase sequence (APOBEC) fused with nCas9 and uracil glycosylase inhibitor (UGI) was inserted into our CRISPR/Cas9 plasmid (pRGEB32-GhU6.7). Three target sites were chosen for two target genes, GhCLA and GhPEBP, to test the efficiency and accuracy of GhBE3. The editing efficiency ranged from 26.67 to 57.78% at the three target sites. Targeted deep sequencing revealed that the C→T substitution efficiency within an 'editing window', approximately six-nucleotide windows of -17 to -12 bp from the PAM sequence, was up to 18.63% of the total sequences. The 27 most likely off-target sites predicted by CRISPR-P and Cas-OFFinder tools were analysed by targeted deep sequencing, and it was found that rare C→T substitutions (average < 0.1%) were detected in the editing windows of these sites. Furthermore, whole-genome sequencing analyses on two GhCLA-edited and one wild-type plants with about 100× depth showed that no bona fide off-target mutations were detectable from 1500 predicted potential off-target sites across the genome. In addition, the edited bases were inherited to T1 progeny. These results demonstrate that GhBE3 has high specificity and accuracy for the generation of targeted point mutations in allotetraploid cotton.

16.
Food Chem ; 311: 125900, 2020 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-31780223

RESUMO

Nucleotide degradation in fish is an important biochemical change after death, which is closely related to freshness and sensory quality. However, except ATP-relative nucleotides, it remains unclear about changes in other nucleotide metabolites during postmortem stage. In this study, a strategy for the simultaneous quantification of 28 nucleobases, nucleosides, and nucleotides using hydrophilic interaction chromatography coupled with tandem mass spectrometry (HILIC-MS/MS) with positive/negative ion switching was developed. This method showed good linearity, precision, repeatability, and recovery. Furthermore, it was successfully applied to monitor the postmortem nucleotide degradation of turbot mince during chill (4 °C) and partial freezing (-3 °C) storage for 168 h. It was noted that the patterns of the changes in nucleotide metabolites differed considerably depending on the storage temperature. Meanwhile, the different pathway and speed of nucleotide catabolism in turbot mince was summarized based on the quantification data.

17.
Clin Imaging ; 59(2): 154-156, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31821972

RESUMO

Computed tomography of the chest may be occasionally performed with the arm in mid extended position, in patients unable to fully raise their arms overhead. In such patients, a combination of beam hardening, incomplete projection and subtle motion artifacts may result in an appearance of diffuse cortical thickening and irregularity of the humerus. We describe this appearance as the 'hazy humerus artifact'. Radiologists must be aware of this appearance in order to avoid a misdiagnosis. The artifact can be minimized by having the arm positioned non-parallel to the plane of the gantry.

18.
Catheter Cardiovasc Interv ; 95(2): 206-215, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30990245

RESUMO

OBJECTIVES: The aim of the present report was to compare 2-year safety outcomes of two biodegradable polymer (BP) sirolimus-eluting stents (SESs) with different drug eluting and polymer absorption kinetics in a subgroup of complex patients and lesions. BACKGROUND: The previously published PANDA III study showed the BuMA BP SES, with faster drug elution and polymer absorption, was non-inferior to the Excel SES in target lesion failure (TLF). METHODS: In PANDA III trial, patients who fulfilled one or more of the following criteria were included: Small vessel disease (reference vessel diameter ≤ 2.5 mm); long lesion (lesion length ≥ 20 mm); chronic total occlusion lesion; and diabetic patients. RESULTS: Among 2,348 patients randomly assigned to treatment with BuMA (n = 1,174) or Excel SES (n = 1,174) in the PANDA III study, 858 in the BuMA group and 855 in the Excel group satisfied the inclusion criteria. At 2-year follow-up, the incidence of definite/probable stent thrombosis (ST) was significantly lower with BuMA SES as compared with Excel SES (0.7% vs. 1.9%, p = 0.03). This difference was mainly caused by decreased subacute stent thrombosis rate (0% vs. 0.6%, p = 0.03). In patients who did not fulfill the complex patient and lesion criteria, there were no between-group difference in ST (0.7% vs. 0%, p = 0.50). Myocardial infarction and TLF rates were similar (5.7% vs. 6.0%, p = 0.79 and 8.8% vs. 7.5%, p = 0.34, respectively), whereas patient-oriented composite endpoint was higher with BuMA SES mainly due to high risk of revascularization (15.6% vs. 11.4%, p = 0.01; 8.4% vs. 4.6%, p < 0.01). CONCLUSIONS: Two-year subgroup analysis of the all-comer PANDA III trial revealed the increased safety benefit of the BuMA SES is more prominently seen in complex patient and lesion population. CLINICAL TRIAL: ClinicalTrial.gov, Identifier-NCT02017275.

19.
Chemosphere ; 238: 124693, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31524627

RESUMO

In this work, self-assembled gels were prepared with exfoliated montmorillonite and chitosan (EMCG) as the adsorbent for removing methyl orange (MO) from water in absence and presence of methylene blue (MB). Several techniques including scanning electron microscope (SEM), zeta potential, fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) were used for the characterization of the EMCG before and after removal of MO. The EMCG performed well in the removal of MO attributing to the electrostatic attraction, cation exchange and hydrogen bond. The adsorption behaviors were followed pseudo-second-order and Langmuir isotherm. More surprisingly, the maximum adsorption capacity of MO was obviously enhanced in the presence of MB that it increased from 545 mg g-1 (absence of MB) to 1060 mg g-1 with the shielding effect of MB on EMCG which allowed MO and MB to alternately arrange at the adsorption sites. This finding of the synergistic effect between the two dyes on the proposed composite opens up new vistas to imagine the enhanced purification of the wastewater with multiple dyes co-existed using the multifunctional adsorbents.


Assuntos
Compostos Azo/análise , Bentonita/química , Quitosana/química , Azul de Metileno/química , Poluentes Químicos da Água/análise , Purificação da Água/métodos , Adsorção , Compostos Azo/química , Corantes/química , Géis , Espectroscopia Fotoeletrônica , Espectroscopia de Infravermelho com Transformada de Fourier , Águas Residuárias/química , Poluentes Químicos da Água/química
20.
Crit Rev Biotechnol ; 40(1): 99-118, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31690134

RESUMO

The importance of highly efficient wastewater treatment is evident from aggravated water crises. With the development of green technology, wastewater treatment is required in an eco-friendly manner. Biotechnology is a promising solution to address this problem, including treatment and monitoring processes. The main directions and differences in biotreatment process are related to the surrounding environmental conditions, biological processes, and the type of microorganisms. It is significant to find suitable biotreatment methods to meet the specific requirements for practical situations. In this review, we first provide a comprehensive overview of optimized biotreatment processes for treating wastewater during different conditions. Both the advantages and disadvantages of these biotechnologies are discussed at length, along with their application scope. Then, we elaborated on recent developments of advanced biosensors (i.e. optical, electrochemical, and other biosensors) for monitoring processes. Finally, we discuss the limitations and perspectives of biological methods and biosensors applied in wastewater treatment. Overall, this review aims to project a rapid developmental path showing a broad vision of recent biotechnologies, applications, challenges, and opportunities for scholars in biotechnological fields for "green" wastewater treatment.

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