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1.
EBioMedicine ; 2019 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-31474552

RESUMO

BACKGROUND: The objective of the current study was to study the molecular mechanism(s) underlying cardiac troponin I autoantibody (cTnIAAb) binding to cardiomyocyte and resultant myocardial damage/dysfunction. METHODS: cTnIAAb was purified from serum of 10 acute myocardial infarction (AMI) patients with left ventricular remodeling. Recombinant human cTnI was used to generate three mouse-derived monoclonal anti-cTnI antibodies (cTnImAb1, cTnImAb2, and cTnImAb3). The target proteins in cardiac myocyte membrane bound to cTnImAb and effect of cTnIAAb and cTnImAb on apoptosis and myocardial function were determined. FINDINGS: We found that cTnIAAb/cTnImAb1 directly bound to the cardiomyocyte membraneα-Enolase (ENO1) and triggered cell apoptosis via increased expression of ENO1 and Bax, decreased expression of Bcl2, subsequently activating Caspase8, Caspase 3, phosphatase and tensin homolog (PTEN) while inhibiting Akt activity. This cTnIAAb-ENO1-PTEN-Akt signaling axis contributed to increased myocardial apoptosis, myocardial collagen deposition, and impaired systolic dysfunction. INTERPRETATION: Results obtained in this study indicate that cTnIAAb is involved in the process of ventricular remodeling after myocardial injury. FUND: The National Natural Science Foundation of China (Grant#: 81260026).

2.
Sci Rep ; 9(1): 11643, 2019 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-31406208

RESUMO

Fifty-two GRAS genes are identified in walnut genome. Based on the evolutionary relationship and motif analysis, the walnut GRAS gene family was divided into eight subfamilies, and the sequence features analysis of JrGRAS proteins showed that the JrGRAS protein sequences were both conserved and altered during the evolutionary process. Gene duplication analysis indicated that seven GRAS genes in walnut have orthologous genes in other species, and five of them occurred duplicated events in walnut genome. Expression pattern analysis of the GRAS family genes in walnut showed that two JrGRAS genes (JrCIGRa-b and JrSCL28a) were differentially expressed between flower bud and leaf bud (p < 0.01), and two JrGRAS genes (JrCIGRa-b and JrSCL13b-d) were differentially expressed between the different development stages of flower buds transition (p < 0.01), besides, three hub genes (JrGAIa, JrSCL3f and JrSHRc) were identified by co-expression analysis, which suggested these GRAS genes may play an important role in regulating the development of apical meristem in walnut. This study laid a foundation for further understanding of the function of GRAS family genes in walnut.

3.
J Colloid Interface Sci ; 553: 549-556, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31234128

RESUMO

The rapid synthesis of nanoscale cyclodextrin metal-organic frameworks (CD-MOFs) was successfully achieved using a simple, environmentally friendly process, which involved seed-mediated crystallization combined with sonication. Short-chain starch nanoparticles isolated from debranched starch were used as seeds to promote the assembly of CD molecules on their surfaces. This process led to the formation of small uniform crystals by increasing orderliness and reducing aggregation. The influence of sonication time on the morphology and dimensions of CD-MOF crystals was investigated. CD-MOFs with a range of mean particle diameters (234-894 nm) could be produced by adjusting the sonication time. Compared to conventional methods, sonication offered a simple and effective means to obtain a high yield and thermal stability of the CD-MOF crystals. Glycyrrhizic acid (GA), a natural triterpene glycoside, is recognized for its potentially beneficial biological activities, such as antibacterial and anti-inflammatory properties. However, it's extremely low water-solubility and loading efficiency currently restrict its application. Fourier transformation infrared (FTIR) analysis provided information about the interactions between GA and CD-MOFs. Analysis of their encapsulation properties showed the potential of the CD-MOF crystals as effective nanocarriers for hydrophobic bioactive agents, such as drugs, vitamins, or nutraceuticals.

4.
J Cutan Med Surg ; 23(3): 331, 2019 May/Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31070100
5.
Sci Rep ; 9(1): 7092, 2019 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-31068628

RESUMO

Using paraffin sections, the stages of walnut female flower bud differentiation were divided into the predifferentiation period (F_1), initial differentiation period (F_2) and flower primordium differentiation period (F_3). Leaf buds collected at the same stage as F_2 were designated JRL. Transcriptomic profiling was performed, and a total of 132,154 unigenes were obtained with lengths ranging from 201 bp to 16,831 bp. The analysis of differentially expressed genes (DEGs) showed that there were 597, 784 and 532 DEGs in the three combinations F_1vsF_2, F_1vsF_3, and F_2vsF_3, respectively. The comparison F_2vsJRL showed that 374 DEGs were differentially expressed between female buds and leaf buds. Thirty-one DEGs related to flowering time were further used to construct coexpression networks, and CRY2 and NF-YA were identified as core DEGs in flowering time regulation. Eighteen DEGs related to flowering time were subjected to real-time quantitative analysis. Our work provides a foundation for further research on the walnut floral transition and provides new resources for future research on walnut biology and biotechnology.

6.
Behav Brain Res ; 367: 194-200, 2019 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-30953658

RESUMO

Subarachnoid hemorrhage (SAH) may lead to brain atrophy and cognitive dysfunction. This study aimed to compare the efficacy of nimodipine and deferoxamine on these sequelae of SAH. A rat model of SAH was established by the double-hemorrhage method. These rats were injected with saline (intraperitoneal, IP), nimodipine (IP), or deferoxamine (IP and intranasal) every 12 h for 5 days after SAH. The MRI scanning, including magnetic resonance angiography, diffusion tensor imaging, T2-weighted imaging, was performed to detect the brain structure. The levels of iron metabolism-related proteins were examined by Western blot analysis. The Morris water maze (MWM) test was used to assess the cognitive function. Then, then neurons in the cortex and hippocampus were counted on hematoxylin and eosin-stained brain sections. Significant cerebral vasospasm (CVS) was found in the saline and deferoxamine groups, but not in the nimodipine group. Cerebral peduncle injury was detected in the saline and nimodipine groups, but not significantly in the deferoxamine group. Compared with nimodipine, deferoxamine reduced transferrin (Tf), Tf receptor, and ferritin levels after SAH. The MWM performances were significantly worse in the saline and nimodipine groups than that in the deferoxamine group. Brain atrophy and neuronal losses were more significant in the saline and nimodipine groups than in the deferoxamine group. Nimodipine significantly ameliorated CVS, but it did not improve the late changes in brain structure and cognitive function. Deferoxamine effectively reduced neuronal cell death and ameliorated cognitive function after SAH.

7.
J Agric Food Chem ; 67(14): 3966-3980, 2019 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-30888158

RESUMO

Most conventional synthetic hydrogels suffer from poor mechanical properties; despite recent significant progress in fabricating tough hydrogels, it is still a challenge to simultaneously realize high stretchability, self-recovery, and self-healing capability in a hydrogel. In this work, a new type of starch/PVA/borax hybrid dual cross-linked (DC) hydrogel was synthesized by a one-pot method. The as-prepared DC hydrogels exhibited mechanical properties of remarkable extensibility (ca. 2485%), excellent toughness (ca. 290.5 kJ m-3), high compression strength (ca. 547.8 kPa), rapid recoverability (81.9% energy recovery after 30 min), and free-shapeable behavior. More impressively, the DC gels sustained approximately 300 times their own weight and exhibited an outstanding self-healing capability at room temperature both in air and underwater. Furthermore, the adsorption amount of methylene blue onto the anionic DC gel (144.68 mg/g) was much higher than that of corn starch gel. Consequently, the eco-friendly, stable, and biodegradable hydrogels will have a great potential application in removing anionic dyes from the wastewater produced by agriculture and industry.


Assuntos
Hidrogéis/química , Boratos/química , Reagentes para Ligações Cruzadas/química , Hidrogéis/síntese química , Extratos Vegetais/química , Álcool de Polivinil/química , Amido/química , Resistência à Tração , Zea mays/química
9.
J Phys Chem Lett ; 10(6): 1259-1263, 2019 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-30811200

RESUMO

Intersystem crossing in conjugated organic molecules is most conveniently viewed from pure electronic perspectives; yet, vibrational displacements may often drive these transitions. We investigate an alkyl-substituted thienylene-vinylene dimer (dTV) displaying efficient triplet formation. Steady-state electronic and Raman spectra display large Stokes shifts (∼4000 cm-1) involving high-frequency skeletal symmetric stretching modes (∼900-1600 cm-1) in addition to large displacements of low-frequency torsional motions (∼300-340 cm-1). Transient absorption spectroscopy reveals the emergence of distorted singlet (S1) and triplet signatures following initial vibrational relaxation dynamics that dominate spectral dynamics on time scales > 100 ps, with the latter persisting on time scales up to ca. 7 µs. Potential energy surfaces calculated along the dominant displaced out-of-plane torsional mode reveal shallow energy barriers for entering the triplet manifold from S1. We propose that dTV is a good model system for understanding vibrational contributions to intersystem crossing events in related polymer systems.

10.
J Coll Physicians Surg Pak ; 29(1): 12-15, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30630561

RESUMO

OBJECTIVE: To investigate the effects of sustained inhalation of sevoflurane on cognitive function and the expression of oxidative stress response proteins such as NADPH oxidase subunits NOX2 and NOX4 in elderly patients undergoing radical surgery for lung cancer. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, China, from February 2016 to October 2017. METHODOLOGY: Elderly patients who underwent radical surgery for lung cancer were divided into the sevoflurane group and the propofol group, with 52 cases in each group. Sustained inhalation of sevoflurane and propofol was administered to maintain anesthesia in the respective groups. Cognitive function and lung function parameters were compared between the two groups. Serum S100 β levels and expression of NOX2 and NOX4 proteins in peripheral blood mononuclear cells of the two groups were determined. RESULTS: At 24 hours after surgery, the lung function indices of the sevoflurane group such as FEV1, FVC and VC were higher than those of the propofol group (p<0.001, p=0.008 and p=0.002, respectively). At the end of the surgery and at 24 hours after surgery, the MMSE scores of the sevoflurane group were higher than the propofol group (all p<0.001). S100 levels were lower than the propofol group (p=0.003 and p<0.001, respectively). Levels of NADPH oxidase subunits NOX2 and NOX4 proteins in peripheral blood mononuclear cells of the sevoflurane group were lower than the propofol group (p=0.033, p<0.001, p<0.001and p<0.001, respectively). CONCLUSION: Compared with intravenous anesthesia with propofol, general anesthesia with sevoflurane inhalation has little effect on the short-term cognitive function in elderly patients undergoing radical surgery for lung cancer, and can effectively improve lung function. The mechanism may be related to the reduction of the expression of NOX2 and NOX4 proteins.


Assuntos
Anestésicos/administração & dosagem , Cognição/efeitos dos fármacos , Neoplasias Pulmonares/sangue , Pulmão/fisiologia , NADPH Oxidase 2/efeitos dos fármacos , NADPH Oxidase 4/efeitos dos fármacos , Propofol/farmacologia , Sevoflurano/farmacologia , Administração por Inalação , Idoso , Anestésicos/efeitos adversos , Anestésicos Inalatórios , Anestésicos Intravenosos , China , Cognição/fisiologia , Feminino , Humanos , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Masculino , Pessoa de Meia-Idade , Estresse Oxidativo/efeitos dos fármacos , Complicações Pós-Operatórias , Propofol/administração & dosagem , Subunidade beta da Proteína Ligante de Cálcio S100 , Sevoflurano/administração & dosagem
11.
Sci Rep ; 9(1): 388, 2019 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-30675014

RESUMO

We demonstrate for the first time the direct stereolithographic 3D printing of an extrinsically self-healing composite, comprised of commercial photocurable resin modified with anisole and PMMA-filled microcapsules. The composites demonstrate solvent-welding based autonomous self-healing to afford 87% recovery of the initial critical toughness. This work illustrates the potential of stereolithographic printing to fabricate self-healing composites with user-defined structures, avoiding the need for extensive rheological optimization of printing inks, like in direct-write 3D printing. Importantly, this work also demonstrates the inclusion of microcapsules into 3D printing resins to incorporate additional functionality into printed composites, which could be adapted for applications beyond self-healing materials.

12.
J Agric Food Chem ; 67(1): 391-398, 2019 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-30532967

RESUMO

In this study, a novel emulsion stabilized by nano-cyclodextrin-based metal-organic frameworks and glycyrrhizic acid (CD-MOF/GA) was successfully fabricated, exhibiting long-term storage stability. The characterization and mechanisms for the emulsion formation with CD-MOF/GA were studied. The phase change of the emulsions from sol to gel could be controlled using different oil fractions and mass ratios of CD-MOF and GA. The rheological results showed that the emulsions were transformed from liquid emulsions to emulsion gels when the oil fractions were higher than 0.3 and the mass ratio of CD-MOF and GA was 1:3. The low-field nuclear magnetic resonance results revealed that the T22 relaxation time of emulsions decreased from 403.702 to 231.013 ms when the oil fractions increased from 0.1 to 0.6, indicating that movable water was converted to constructal water. The emulsions showed good stability, even in high-alkaline pH and high-temperature conditions.


Assuntos
Ciclodextrinas/química , Ácido Glicirrízico/química , Estruturas Metalorgânicas/química , Nanocompostos/química , Emulsões/química , Géis/química , Temperatura Alta , Concentração de Íons de Hidrogênio , Reologia
13.
BMC Plant Biol ; 18(1): 255, 2018 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-30352551

RESUMO

BACKGROUND: The eukaryotic transcription factor NF-Y (which consists of NF-YA, NF-YB and NF-YC subunits) is involved in many important plant development processes. There are many reports about the NF-Y family in Arabidopsis and other plant species. However, there are no reports about the NF-Y family in walnut (Juglans regia L.). RESULTS: Thirty-three walnut NF-Y genes (JrNF-Ys) were identified and mapped on the walnut genome. The JrNF-Y gene family consisted of 17 NF-YA genes, 9 NF-YB genes, and 7 NF-YC genes. The structural features of the JrNF-Y genes were investigated by comparing their evolutionary relationship and motif distributions. The comparisons indicated the NF-Y gene structure was both conserved and altered during evolution. Functional prediction and protein interaction analysis were performed by comparing the JrNF-Y protein structure with that in Arabidopsis. Two differentially expressed JrNF-Y genes were identified. Their expression was compared with that of three JrCOs and two JrFTs using quantitative real-time PCR (qPCR). The results revealed that the expression of JrCO2 was positively correlated with the expression of JrNF-YA11 and JrNF-YA12. In contrast, JrNF-CO1 and JrNF-YA12 were negatively correlated. CONCLUSIONS: Thirty-three JrNF-Ys were identified and their evolutionary, structure, biological function and expression pattern were analyzed. Two of the JrNF-Ys were screened out, their expression was differentially expressed in different development periods of female flower buds, and in different tissues (female flower buds and leaf buds). Based on prediction and experimental data, JrNF-Ys may be involved in flowering regulation by co-regulate the expression of flowering genes with other transcription factors (TFs). The results of this study may make contribution to the further investigation of JrNF-Y family.


Assuntos
Fator de Ligação a CCAAT/genética , Juglans/genética , Proteínas de Plantas/genética , Fator de Ligação a CCAAT/metabolismo , Flores/genética , Regulação da Expressão Gênica de Plantas , Genoma de Planta , Filogenia , Folhas de Planta/genética , Proteínas de Plantas/metabolismo , Mapas de Interação de Proteínas
14.
ACS Appl Mater Interfaces ; 10(43): 37470-37477, 2018 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-30272433

RESUMO

For solar-driven macroscopic motions, we assert that there is a local heating that facilitates large-scale deformations in anisotropic morphologic materials caused by thermal gradients. This report specifically identifies the fate of heat generation in photonastic materials and demonstrates how heat can perform work following excitation of a nonisomerizing dye. Utilizing the electrospinning technique, we have created a series of anisotropic nanofibrous polymer mats that comprise nonisomerizing dyes. Polymers are chosen because of their relative glass transition temperatures, elastic moduli, and melting temperatures. Light irradiation of these polymer mats with an excitation wavelength matching the absorption characteristics of the dye leads to macroscopic deformation of the mat. Analysis of still images extracted from digital videos provides plots of angular displacement vs power. The data were analyzed in terms of a photothermal model. Analyses of scanning electron microscopy micrographs for all samples are consistent to local melting in low Tg polymers and softening in high Tg polymers. Dynamic mechanical analysis allowed for quantification of the modulus change under a given light fluence. We employ these data to calculate a energy conversion efficiency. These efficiencies for the polymer mats are compared to other nonmuscular systems, including a few natural, biological samples.

15.
Plant J ; 2018 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-30375131

RESUMO

Epicuticular waxes provide a hydrophobic barrier that protects land plants from environmental stresses. To elucidate the molecular functions of maize glossy mutants that reduce accumulation of epicuticular waxes, eight non-allelic glossy mutants were subjected to transcriptomic comparisons with their respective wild-type siblings. Transcriptomic comparisons identified 2,279 differential expression (DE) genes. Other glossy genes tended to be down-regulated in glossy mutants; in contrast stress-responsive pathways were induced in mutants. Gene co-expression network (GCN) analysis found that glossy genes were clustered, suggestive of co-regulation. Genes potentially regulating the accumulation of glossy gene transcripts were identified via a pathway level co-expression (PLC) analysis. Expression data from diverse organs showed that maize glossy genes are generally active in young leaves, silks and tassels, while largely inactive in seeds and roots. Through reverse genetics, a DE gene homologous to Arabidopsis CER8 and co-expressed with known glossy genes was confirmed to participate in epicuticular wax accumulation. A GCN data informed forward genetics approach enabled the cloning of the gl14 gene, which encodes a putative membrane-associated protein. Our results deepen understanding of the transcriptional regulation of the genes involved in the accumulation of epicuticular wax, and provide two maize glossy genes and a number of candidate genes for further characterization. This article is protected by copyright. All rights reserved.

16.
Chem Commun (Camb) ; 54(89): 12654-12657, 2018 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-30357151

RESUMO

We report the synthesis, characterization, and gas adsorption analyses of a new charge-separated metal-organic framework (MOF), UNM-1 (C52H16BCuF16N4), possessing diamondoid structures, assembled from an anionic tetrahedral borate ligand and cationic Cu(i) metal ion. The resulting MOF structure displays four-fold interpenetration, resulting in high environmental stability, and at the same time possesses relatively large surface area (SABET = 621 m2 g-1) due to the absence of free ions. Gas adsorption measurements revealed temperature-dependent CO2 adsorption/desorption hysteresis and large CO2/N2 ideal selectivities up to ca. 99 at 313 K and 1 bar, suggesting potential applications of this type of charge-separated MOFs in flue gas treatment and CO2 sequestration.

17.
J Agric Food Chem ; 66(35): 9326-9334, 2018 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-30111089

RESUMO

Biopolymer-based nanohydrogels have great potential for various applications, including in food, nutraceutical, and pharmaceutical industries. Herein, starch nanohydrogels were prepared for the first time via reverse emulsification coupled with internal gelation. The effects of starch type (normal corn, potato, and pea starches), amylose content, and gelation time on the structural, morphological, and physicochemical properties of starch nanohydrogels were investigated. The diameter of starch nanohydrogel particles was around 100 nm after 12 h of retrogradation time. The relative crystallinity and thermal properties of starch nanohydrogels increased gradually with an increasing amylose content and gelation time. The swelling behavior of starch nanohydrogels was dependent upon the amylose content, and the swelling ratios were between 2.0 and 14.0, with the pea starch nanogels exhibiting the lowest values and the potato starch nanogels exhibiting the highest values.


Assuntos
Emulsificantes/química , Nanoestruturas/química , Extratos Vegetais/química , Amido/química , Varredura Diferencial de Calorimetria , Cristalografia por Raios X , Géis/química , Solanum tuberosum/química , Difração de Raios X , Zea mays/química
18.
Phys Chem Chem Phys ; 20(34): 22159-22167, 2018 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-30116824

RESUMO

We investigate a class of non-emissive conjugated polymers with very short excited state lifetimes believed to undergo singlet fission and relaxation to mid-gap forbidden excited states. Poly(3-decylthieneylenvinylene) (P3DTV) and its heavy atom analog, poly(3-decylseleneylenvinylene) (P3DSV), are strongly aggregating conjugated polymers that experience large excited state displacements along multiple vibrational modes. We demonstrate this Franck-Condon vibrational activity effectively disperses excitation energy into multiple non-radiative channels that can be explained using a simple, two-state potential energy surface model. Resonance Raman spectroscopy is sensitive to early Franck-Condon vibrational activity and we observe rich harmonic progressions involving multiple high frequency CC backbone symmetric stretching motions (∼1000-1600 cm-1) in both systems reflecting mode-specific excited state geometrical displacements. Transient absorption spectra confirm that efficient non-radiative processes dominate excited state relaxation dynamics which are confined to π-stacked aggregated chains. Surprisingly, we found little influence of the heteroatom consistent with efficient vibrational energy dissipation. Our results highlight the importance of aggregation and multi-dimensional Franck-Condon vibrational dynamics on the ability to harvest excitons, which are not usually considered in materials design and optimization schemes.

19.
J Agric Food Chem ; 66(37): 9785-9793, 2018 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-30153014

RESUMO

In this study, the nano- and microsized cyclodextrin-based metal-organic frameworks (CD-MOFs) were successfully conducted using short-chain starch nanoparticles as seeds through the seed-mediated method. The morphology, size, crystal structure, thermal, and N2 adsorption properties of CD-MOFs prepared at different time intervals were investigated. The scanning electron microscopy results showed that the size variation from nanometer to millimeter could be controlled by crystal growth time. The CD-MOFs based on short-chain starch nanoparticle had higher crystallinity and N2 uptake, thus indicating that the method of seed-mediated was more facile and efficient than the previous approach. Resveratrol (Res) is a natural polyphenol compound that has anticancer and antimicrobial activities against several pathogens. However, this compound suffers from poor stability. trans-Res rapidly isomerizes when exposed under ultraviolet or visible light. The results showed that the stability of Res was substantially enhanced by its encapsulation in CD-MOF crystals.


Assuntos
Ciclodextrinas/química , Portadores de Fármacos/química , Estruturas Metalorgânicas/química , Nanopartículas/química , Amido/química , Cristalização , Portadores de Fármacos/síntese química , Química Verde , Isomerismo , Cinética , Estruturas Metalorgânicas/síntese química , Tamanho da Partícula , Resveratrol , Estilbenos/química
20.
J Telemed Telecare ; : 1357633X18792805, 2018 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-30153767

RESUMO

Introduction Telehealth intervention has been proposed as a sustainable and innovative intervention approach to Parkinson's disease (PD) patients, but there are still conflicting results in the literature about its effect. This study aimed to evaluate the efficacy of telehealth intervention for PD patients. Methods PubMed, EMBASE, CENTRAL and China National Knowledge Infrastructure (CNKI) were searched from the inception to June 2018 for randomized controlled trials (RCTs) and cohort studies, without language restrictions. When feasible, data were statistically pooled for meta-analysis using Review Manager 5.3. Otherwise, narrative summaries were used. Results Twenty-one studies were included. With respect to PD severity, compared with usual care, telehealth intervention was beneficial in lowering motor impairment of PD patients significantly (mean difference (MD) = -2.27, 95% confidence interval (95% CI) -4.25 to -0.29, p = 0.02), rather than mental status (MD = -0.98, 95% CI -2.61 to 0.65, p = 0.24), activities of daily living (MD = -1.51, 95% CI -4.91 to 1.89, p = 0.38) and motor complications (MD = -0.36, 95% CI -1.31 to 0.59, p = 0.46). Telehealth intervention did not lead to significant reduction in quality of life (standardized mean difference (SMD) = 0.04, 95% CI -0.20 to 0.28, p = 0.76), depression (SMD = -0.12, 95% CI -0.37 to 0.13, p = 0.34), cognition (MD = 0.37, 95% CI -0.34 to 1.09, p = 0.31) and balance (MD = 0.09, 95% CI -2.49 to 2.66, p = 0.95). Discussion Telehealth intervention is an effective option for individuals with PD to improve their motor impairment. Further well-designed studies are warranted to confirm our findings.

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