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1.
Vet Ophthalmol ; 23(1): 141-147, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31328856

RESUMO

PURPOSE: To assess outcome of phacoemulsification in cats. METHODS: Records of 71 cats (82 eyes) from five referral centers were reviewed. Groups were divided by cause of cataract (congenital/juvenile [n = 32], traumatic [n = 33], and secondary to uveitis [n = 6]), and group comparisons were performed for the most common complications: postoperative ocular hypertension (POH), uveitis, corneal ulceration, synechia/dyscoria, and posterior capsular opacity (PCO) in three different time periods: immediately postoperatively, at 1-90 days, and at >90 days. RESULTS: Median follow-up was 198 days (interquartile range 64-518 days). The overall visual success rate of the cats with a 12-month follow-up was 92.6% (25/27 eyes). POH occurred in 35/82 (42.6%) eyes. Immediately postoperatively, uveitis was the most common complication in 28/82 eyes (34.1%) followed by corneal ulceration in 22/82 eyes (26.8%). At 1-90 days, uveitis in 41/81 eyes (50.6%) remained the most common complication, followed by synechia/dyscoria in 21/81 eyes (25.9%), corneal ulceration in 16/81 eyes (19.7%), and PCO in 15/81 eyes (18.5%). At >90 days, PCO in 17/47 eyes (36.1%), followed by synechia/dyscoria in 16/47 eyes (34%), was the most common complications. The number of eyes with synechia/dyscoria in the trauma group was higher (13/33 [39.3%]) than in the congenital/juvenile group (5/31 [16.1%]) at 1-90 days (P = .039). No statistical difference was found for the other group comparisons. Three eyes in total were enucleated owing to endophthalmitis, post-traumatic ocular sarcoma, and secondary glaucoma. CONCLUSION: Uveitis in the short-term and PCO and synechia/dyscoria in the long-term were the most common complications following phacoemulsification in cats.

2.
Sci Total Environ ; 690: 388-399, 2019 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-31299572

RESUMO

In this study we reconstruct the long-term exposure of Czech mothers to polychlorinated biphenyls (PCBs) and determine the causes of high contamination of breast milk by indicator PCBs (iPCBs). A data set containing information from more than 1000 primiparous women from the Czech Republic was used, including iPCB concentrations in breast milk, individual physiology and living characteristics. The time series of PCB intakes for the whole period from the beginning of PCB production in 1958 until 2011 were reconstructed. We estimated the individual lifetime exposure of mothers for all iPCBs, i.e. congeners 28, 52, 101, 118, 138, 153 and 180, using a physiologically based pharmacokinetic (PBPK) model. Various model scenarios were investigated to determine the influence of physiology, age at delivery, past dietary exposure, and food composition on concentrations in breast milk for all iPCBs. The highest contributions to the presence of iPCBs in breast milk were observed for food composition. The main factor determining the concentration of higher-chlorinated PCBs (138, 153 and 180) was past exposure. The most important parameter for identification of children's postnatal exposure through breast milk was the time-span from the maximum of the exposure peak to the birth of the child. The current concentrations of iPCBs in breast milk in the Czech population are still high because the maximum of the exposure peak occurred more than 10 years later than in other European countries and was very broad, e.g. covered more than 10 years.


Assuntos
Poluentes Ambientais/metabolismo , Exposição Materna/estatística & dados numéricos , Bifenilos Policlorados/metabolismo , Adulto , República Tcheca , Exposição Dietética/estatística & dados numéricos , Feminino , Humanos , Leite Humano
3.
Drug Metab Rev ; 51(3): 314-329, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31116073

RESUMO

Phthalates are a class of compounds that have been extensively used as plasticizers in different applications. Several phthalates have been recognized as substances of very high concern (SVHCs) in the EU, because of their toxicity for reproduction. However, high amounts of other phthalates are still produced and imported in the European Economic Area. In China and the US, recent studies show increasing concentrations of several phthalates in the air and in human urine, respectively. The understanding of phthalate absorption, distribution, metabolism, and elimination ('pharmacokinetics') in the organism is still limited. Specifically, phthalate partitioning among tissues is insufficiently understood. Here, we estimate partition coefficient (PC) values for different phthalates by using five algorithms and compare them to experimental (in-vivo and in-vitro) PC values. In addition, we review all pharmacokinetic steps for phthalates in human and rat, based on data from 133 peer-reviewed publications. We analyze the factors that determine phthalate partitioning and pharmacokinetics. Four processes are particularly relevant to phthalate distribution: protein binding, ionization, passive partitioning, and metabolism in different tissues. The interplay of these processes needs to be better represented in methods for determining the PC values of phthalates. The hydrophobicity of phthalates affects all pharmacokinetic steps. The exposure route has an influence on specific steps of phthalate pharmacokinetics but generally does not affect the pattern of metabolites in urine. The age of the organism has an influence on phthalate metabolism. More studies on the protein-bound fraction of phthalates in plasma and pharmacokinetic studies following inhalation and dermal exposure are desirable.


Assuntos
Ácidos Ftálicos/farmacocinética , Animais , Humanos , Ácidos Ftálicos/química , Plastificantes/química , Plastificantes/farmacocinética , Ratos , Distribuição Tecidual
4.
Environ Res ; 172: 216-230, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30818231

RESUMO

Given the opportunities provided by internal dosimetry modelling in the interpretation of human biomonitoring (HBM) data, the assessment of the links between exposure to chemicals and observed HBM data can be effectively supported by PBTK modelling. This paper gives a comprehensive review of available human PBTK models for compounds selected as a priority by the European Human Biomonitoring Initiative (HBM4EU). We highlight their advantages and deficiencies and suggest steps for advanced internal dose modelling. The review of the available PBTK models highlighted the conceptual differences between older models compared to the ones developed recently, reflecting commensurate differences in research questions. Due to the lack of coordinated strategies for deriving useful biomonitoring data for toxicokinetic properties, significant problems in model parameterisation still remain; these are further increased by the lack of human toxicokinetic data due to ethics issues. Finally, questions arise as well as to the extent they are really representative of interindividual variability. QSARs for toxicokinetic properties is a complementary approach for PBTK model parameterisation, especially for data poor chemicals. This approach could be expanded to model chemico-biological interactions such as intestinal absorption and renal clearance; this could serve the development of more complex generic PBTK models that could be applied to newly derived chemicals. Another gap identified is the framework for mixture interaction terms among compounds that could eventually interact in metabolism. From the review it was concluded that efforts should be shifted toward the development of generic multi-compartmental and multi-route models, supported by targeted biomonitoring coupled with parameterisation by both QSAR approach and experimental (in-vivo and in-vitro) data for newly developed and data poor compounds.


Assuntos
Modelos Biológicos , Toxicocinética , Humanos , Relação Quantitativa Estrutura-Atividade
5.
Vet Ophthalmol ; 22(5): 591-599, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30706615

RESUMO

OBJECTIVE: To describe the visual outcome following phacoemulsification in English Cocker Spaniels (ECS) affected by cataracts and suspected progressive retinal atrophy (PRA). ANIMALS STUDIED: Fifty-four client-owned dogs. PROCEDURES: A multicenter, retrospective study was performed including ECS with suspected PRA which underwent phacoemulsification. PRA was suspected on ophthalmic examination before and after surgery, and/or after electroretinography (ERG) was performed. Visual outcome was assessed by menace response per eye at seven time periods post-surgery (P1= 25-90 days, P2 = 91-180 days, P3 = 181-364 days, P4 = 365-549 days, P5 = 550-729 days, P6 = 730-1094 days, and P7 ≥ 1095 days). Descriptive statistics were performed. Generalized estimating equations were used to identify predictors associated with vision after surgery. Odds ratio and confidence intervals were reported. Significance was set at P < 0.05. Owners were invited to participate in a questionnaire. RESULTS: Phacoemulsification was performed in 85 eyes. Median age at surgery was 9.09 years (min. 2.17 years, max. 13.49 years). At all re-examinations, up to and including P5, significantly more eyes were visual than before surgery (P ≤ 0.003). Odds for vision were significantly increased for eyes that underwent surgery. Electroretinograms were performed in 75/85 eyes that underwent surgery, demonstrating low b-wave amplitudes. There was no significant effect of the age, gender, vision before surgery, presence of dazzle reflex, cataract stage or abnormality on gonioscopy on visual outcome. The questionnaire response rate was 48.2%. Most participants (92.5%) felt that cataract surgery led to improvement of the dog's quality of life. CONCLUSIONS: English Cocker Spaniels with suspected PRA may benefit from phacoemulsification with vision up to 2 years following surgery.


Assuntos
Doenças do Cão/cirurgia , Facoemulsificação/veterinária , Degeneração Retiniana/veterinária , Animais , Catarata/veterinária , Extração de Catarata/veterinária , Cães , Feminino , Masculino , Degeneração Retiniana/cirurgia , Estudos Retrospectivos , Resultado do Tratamento , Visão Ocular
6.
Rev. argent. cardiol ; 86(6): 20-26, dic. 2018. graf
Artigo em Espanhol | LILACS-Express | ID: biblio-1003233

RESUMO

RESUMEN Introducción: La fracción de eyección es un parámetro débil para evaluar la función ventricular en la hipertrofia ventricular. Es de fundamental importancia analizar aspectos de la mecánica ventricular que podrían diferenciar una amiloidosis cardiaca de una miocardiopatía hipertrófica. Objetivo: Comparar el comportamiento del strain longitudinal y otros parámetros de la mecánica ventricular entre pacientes con miocardiopatía hipertrófica y amiloidosis cardíaca ambos con fracción de eyección conservada. Material y métodos: Estudio comparativo, prospectivo realizado en 15 pacientes con amiloidosis cardíaca (Grupo G 1) y 15 pacientes con miocardiopatía hipertrófica (G 2), ambos con fracción de eyección conservada (> 50%). Fueron analizados con ecocardiografía por seguimiento de marcas (speckle tracking), parámetros de strain y rotacionales del VI. El strain longitudinal se obtuvo a partir de planos apicales de 4, 3 y 2 cámaras. El strain circunferencial y la rotación ventricular a partir de planos transversales del VI. Se calculó el giro: suma de rotación apical y basal (°), torsión (giro / distancia base-ápex del VI (°/cm)) y los nuevos parámetros: producto de deformación (multiplicación entre el strain longitudinal global y el strain circunferencial apical); índice de deformación (°/%): (giro / strain longitudinal) y el cociente fracción de eyección / strain longitudinal global Resultados: Los pacientes con amiloidosis cardíaca presentaron valores significativamente menores de fracción de eyección (58,08% ± 6,16 vs. 67,15% ± 8,09; p = 0,012) y de strain longitudinal global (-12,61% ± 4,32 vs. -17,15% ± 3,95; p = 0,008) a expensas de los segmentos basales. No se constataron diferencias significativas con el giro, la torsión, el strain circunferencial y el radial. El producto entre strain longitudinal y el circunferencial apical resultó disminuido mientras que el cociente fracción de eyección / strain longitudinal global se encontró aumentado de manera significativa en los pacientes con amiloidosis. Conclusiones: El producto strain longitudinal x strain circunferencial apical y el cociente fracción de eyección / strain longitudinal global son parámetros útiles que permiten diferenciar pacientes con amiloidosis cardíaca de pacientes con miocardiopatía hipertrófica.


ABSTRACT Background: Ejection fraction is a poor parameter to assess left ventricular function in ventricular hypertrophy. It is highly important to analyze aspectis of ventricular mechanics that could differentiate cardiac amyloidosis from hypertrophic car-diomyopathy. Objective: The aim of this study was to compare longitudinal strain and other ventricular mechanical parameters between patientis with hypertrophic cardiomyopathy and cardiac amyloidosis, both with preserved ejection fraction. Methods: A comparative, prospective study was conducted in 15 patientis with cardiac amyloidosis Group (G) 1 and 15 pa-tientis with hypertrophic cardiomyopathy (G2), both presenting preserved ejection fraction (>50%). Patientis were analyzed with speckle tracking echocardiography and strain and left ventricular (LV) rotational parameters. Longitudinal strain was obtained from apical 4-, 3- and 2-chamber planes. Circumferential strain and ventricular rotation were obtained from LV transverse planes. Twist: algebraic sum of apical and basal rotation (°), torsion [twist/LV base-apex distance (º/cm)] and the new parameters: deformation product (global longitudinal strain × apical circumferential strain); deformation index: twist/ longitudinal strain (°/%) and ejection fraction/global longitudinal strain ratio were calculated. Resultis: Patientis with cardiac amyloidosis presented significantly lower ejection fraction (58.08%±6.16 vs. 67.15%±8.09; p=0.012) and global longitudinal strain values (-12.61%±4.32 vs. -17.15%±3.95; p=0.008) at the expense of basal segmentis. No significant differences were found for twist, torsion, and circumferential and radial strain. The product between longitudinal strain and apical circumferential strain decreased, while the ejection fraction/global longitudinal strain ratio was significantly increased in patientis with cardiac amyloidosis. Conclusions: The product of longitudinal strain × apical circumferential strain and the ejection fraction/global longitudinal strain ratio are useful parameters that allow differentiating cardiac amyloidosis from hypertrophic cardiomyopathy patientis.

7.
Cardiovasc Ultrasound ; 16(1): 16, 2018 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-30223828

RESUMO

BACKGROUND: Left ventricular ejection fraction (LVEF) results from the combined action of longitudinal and circumferential contraction, radial thickening, and basal and apical rotation. The study of these parameters together may lead to an accurate assessment of the cardiac function. METHODS: Ninety healthy volunteers, categorized by gender and age (≤ 55 and >  55 years), were evaluated using two-dimensional speckle tracking echocardiography. Transversal views of the left ventricle (LV) were obtained to calculate circumferential strain and left ventricular twist, while three apical views were obtained to determine longitudinal strain (LS) and mitral annular plane systolic excursion (MAPSE). We established the integral myocardial function of the LV according to: 1. The Combined Deformation Parameter (CDP), which includes Deformation Product (DP) - Twist x LS (° x %) - and Deformation Index (DefI) -Twist / LS (° / %)-; and 2. the Torsion Index (TorI): Twist / MAPSE (° / cm). RESULTS: The mean age of our patients was 50.3 ± 11.1 years. CDP did not vary with gender or age. The average DP was - 432 ± 172 ° x %, and the average DefI was - 0.96 ± 0.36 ° / %. DP provides information about myocardial function (normal, pseudonormal, depressed), and the DefI quotient indicates which component (s) is/are affected in cases of abnormality. TorI was higher in volunteers over 55 years (16.5 ± 15.2 vs 13.1 ± 5.0 °/cm, p = 0.003), but did not vary with gender. CONCLUSIONS: The proposed parameters integrate values of twisting and longitudinal shortening. They allow a complete physiological assessment of cardiac systolic function, and could be used for the early detection and characterization of its alteration.


Assuntos
Ecocardiografia/métodos , Ventrículos do Coração/diagnóstico por imagem , Volume Sistólico/fisiologia , Função Ventricular Esquerda/fisiologia , Feminino , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Sístole
8.
J Cardiovasc Dev Dis ; 5(3)2018 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-30096870

RESUMO

BACKGROUND: According to the ventricular myocardial band model, the diastolic isovolumetric period is a contraction phenomenon. Our objective was to employ speckle-tracking echocardiography (STE) to analyze myocardial deformation of the left ventricle (LV) and to confirm if it supports the myocardial band model. METHODS: This was a prospective observational study in which 90 healthy volunteers were recruited. We evaluated different types of postsystolic shortening (PSS) from an LV longitudinal strain study. Duration of latest deformation (LD) was calculated as the time from the start of the QRS complex of the ECG to the latest longitudinal deformation peak in the 18 segments of the LV. RESULTS: The mean age of our subjects was 50.3 ± 11.1 years. PSS was observed in 48.4% of the 1620 LV segments studied (19.8%, 13.5%, and 15.1% in the basal, medial, and apical regions, respectively). PSS was more frequent in the basal, medial septal, and apical anteroseptal segments (>50%). LD peaked in the interventricular septum and in the basal segments of the LV. CONCLUSIONS: The pattern of PSS and LD revealed by STE suggests there is contraction in the postsystolic phase of the cardiac cycle. The anatomical location of the segments in which this contraction is most frequently observed corresponds to the main path of the ascending component of the myocardial band. This contraction can be attributed to the protodiastolic untwisting of the LV.

9.
Open Vet J ; 8(2): 144-148, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29765868

RESUMO

The purpose was to describe a case of retrobulbar steatitis and meningitis in a cat caused by otitis media, otitis interna and an inflammatory polyp in the middle ear. Investigations included ophthalmic and neurological examinations, haematology and biochemistry, magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis and aerobic, anaerobic bacterial and fungal culture of material from the middle ear. A 6-year-old female neutered domestic-short-haired cat presented with right-sided exophthalmos and resistance to retropulsion. Anisocoria, reduced corneal sensation and oculocephalic movements and low Schirmer tear test (STT1) were found. An MRI revealed the right external ear canal and tympanic bulla to be fluid filled with presence of a thickened contrast-enhancing mucosa. Contrast enhancement extended into the calvarium, as marked thickening and contrast enhancement of the pachymeninges, and further rostrally through the right orbital fissure into the orbit. The retrobulbar tissues were swollen, resulting in mild exophthalmos. Enrichment culture of material from the middle ear revealed Klebsiella pneumonia susceptible to marbofloxacin. The cat underwent a total ear canal ablation with removal of the cartilaginous cuff at the external auditory meatus and local debridement and curettage. A polypoid structure was removed from the middle ear. No bulla osteotomy was performed. Horner's syndrome was present immediately following surgery. The cat received a course of systemic dexamethasone (1mg/cat SID/3 weeks) tapered off and marbofloxacin (2mg/kg SID/2 weeks). Follow up at 120 days showed no recurrence of the symptoms. The Horner's syndrome and low STT1 had resolved and returned to normal values respectively. This case highlights the importance of MRI in the investigation of retrobulbar diseases. MRI is a useful tool for the evaluation of the extent of the lesion and the appearance of adjacent structures in which additional potentially life-threatening abnormalities, such as meningitis, can be seen.

10.
Eur Heart J Case Rep ; 2(4): yty105, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31020181

RESUMO

Background: Pulmonary artery aneurysms (PAAs) are rare and they are infrequently diagnosed due to the non-specificity of their symptoms. However, their related complications, mainly described in patients with pulmonary hypertension (PH), are associated with significant morbidity and mortality. Case summary: We report the case of a 64-year-old woman previously operated on for pulmonary valve stenosis, who presented with rapid worsening of dyspnoea and sudden onset of chest pain. Physical examination did not show heart failure symptoms, and an echocardiogram showed significant but not severe pulmonary regurgitation with preserved right and left ventricular function. Estimated pulmonary artery (PA) pressure was normal. As myocardial ischaemia was suspected the patient underwent a coronary computed tomography angiography that showed compression of the left main coronary artery by a large PAA. Early diagnosis led to surgery that solved her symptoms. Discussion: Comprehensive medical evaluation of symptomatic patients with PA dilatation, even in the absence of PH, is key to rule out the possibility of serious complications as soon as possible.

11.
J Cardiovasc Electrophysiol ; 28(10): 1169-1178, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28675508

RESUMO

INTRODUCTION: Risk stratification for ventricular arrhythmias in patients with ischemic cardiomyopathy needs to be improved. Coronary chronic total occlusions in an infarct-related artery (IRA-CTOs) have been associated with an increased arrhythmic risk. This study aimed to evaluate the association between IRA-CTOs and appropriate implantable cardioverter-defibrillator (ICD) therapies. METHODS AND RESULTS: Observational cohort study that included 342 patients with ischemic cardiomyopathy, an ICD implanted for primary or secondary prevention, and a coronary angiography performed shortly before ICD implantation. The ICD was implanted for primary prevention in 163 patients (48%). IRA-CTO was found in 161 patients (47%). During a median follow-up of 33 months, 41% of patients experienced at least one appropriate ICD therapy. Patients with IRA-CTO had higher proportions of appropriate ICD therapies (57% vs. 26%, P < 0.001) and appropriate ICD shocks (40% vs. 17%, P < 0.001). At multivariate Cox regression, IRA-CTO was the only variable that consistently resulted as independent predictor of appropriate ICD therapies and shocks both in the global population of the study (HR 2.3, P < 0.001 and HR 3, P < 0.001, respectively) and when analyzing separately patients with primary or secondary prevention ICD. CONCLUSIONS: IRA-CTO is an independent predictor of appropriate ICD therapies, including appropriate ICD shocks. This association is consistent across all the subgroups analyzed. Patients with IRA-CTO have a very high risk of appropriate ICD therapies. These findings may help improving risk stratification as well as the management of ventricular arrhythmias in patients with ischemic cardiomyopathy.


Assuntos
Oclusão Coronária/etiologia , Oclusão Coronária/terapia , Desfibriladores Implantáveis , Infarto do Miocárdio/complicações , Infarto do Miocárdio/prevenção & controle , Idoso , Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/tratamento farmacológico , Estudos de Coortes , Angiografia Coronária , Oclusão Coronária/mortalidade , Desfibriladores Implantáveis/efeitos adversos , Feminino , Seguimentos , Transplante de Coração/estatística & dados numéricos , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/mortalidade , Isquemia Miocárdica/diagnóstico , Isquemia Miocárdica/fisiopatologia , Valor Preditivo dos Testes , Prevenção Primária , Estudos Retrospectivos , Medição de Risco , Prevenção Secundária , Taquicardia Ventricular/fisiopatologia , Taquicardia Ventricular/terapia , Resultado do Tratamento , Fibrilação Ventricular/fisiopatologia , Fibrilação Ventricular/terapia
12.
Chemosphere ; 178: 424-431, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28342374

RESUMO

The aim of the current study was to describe the fate of ingested α-hexabromocyclododecane (α-HBCDD) in fast-growing (FG) and slow-growing (SG) broilers, through an exposure to a dietary concentration of 50 ng α-HBCDD g-1 feed during 42 and 84 days, respectively. Depuration parameters were assessed in SG broilers successively exposed during 42 days and depurated during 42 days. At market age, SG broilers had ingested 42% more feed than FG broilers, while their body weight gain per g of feed ingested was 34% lower. No isomerization of α- to ß- or γ-HBCDD forms occurred, while OH-HBCDD was identified as a product of α-HBCDD metabolism. Irrespective of the strain, abdominal fat displayed the highest α-HBCDD concentration on a lipid weight basis, followed leg muscles and then breast muscle, liver and plasma. The accumulation ratios of α-HBCDD were slightly higher in SG (6.7, 2.1, 2.6 and 9.9 in leg muscles, breast muscle, liver and abdominal fat, respectively) than in FG broilers (5.2, 2.2, 1.1 and 8.4, respectively). The elimination half-lives in SG broilers were 20, 12 and 19 d in leg muscles, breast muscle and abdominal fat, respectively, to which dilution through growth contributed for around 50%. The overall assimilation efficiency of α-HBCDD was estimated at 58 and 50% in FG and SG broilers, respectively, while 22 and 17% of α-HBCDD ingested were estimated to be eliminated in excreta as metabolites.


Assuntos
Galinhas/crescimento & desenvolvimento , Galinhas/metabolismo , Retardadores de Chama/metabolismo , Hidrocarbonetos Bromados/metabolismo , Animais , Peso Corporal , Dieta , Masculino , Distribuição Tecidual
13.
Int J Health Plann Manage ; 32(4): 653-659, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27139300

RESUMO

The aim is to analyze whether time to surgery (TtoS) in hip fracture patients is associated with longer than expected length of stay (LofS) and whether there is any particular group in which this is especially relevant. We developed an observational study in Madrid, Spain. From 771 patients admitted to the orthopedic ward, we selected 723 with surgical delay ≤7 days. Age was characterized as younger (<81), elderly (81-90), very elderly (>90). Modified Barthel Index was classified as very dependent (<41), moderately dependent (41-80), independent (>80). RESULTS: Median (IQR) TtoS was 3 (1-4) days; LofS 12 (7-15). Mean age was 84.3 years, 78.4% were women. TtoS was associated with LofS, which increased by 1.80 days (95% CI, 1.50-2.10) per delayed day (p<0.001). After adjustment for age, sex, functional status, we found an increase of 1.75 days (1.46-2.04) per day (p<0.001). We did not find effect of age or sex. Functional status had a higher effect in moderately dependent patients 2.25 days (1.78-2.72) than in very dependent or independent patients, 1.33 (0.37-2.30) and 1.50 days (1.09-1.91) respectively (p 0.012). As conclusion we could affirm that increasing TtoS leads to longer than expected LofS in hip fracture patients, particularly moderately dependent patients. Copyright © 2016 John Wiley & Sons, Ltd.


Assuntos
Fraturas do Quadril/cirurgia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Tempo de Internação/estatística & dados numéricos , Masculino , Estudos Prospectivos , Espanha , Tempo para o Tratamento/estatística & dados numéricos
15.
Front Pediatr ; 4: 42, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27200323

RESUMO

PURPOSE: To correlate sonographic renal parenchymal measurements among patients with ureteropelvic junction obstruction (UPJO) labeled society of fetal urology (SFU) hydronephrosis grades 1-4 and to examine whether sonographic renal parenchymal measurements could be used to differentiate conservative vs. surgical management. MATERIALS AND METHODS: Retrospective chart review and sonographic renal parenchymal measurements (renal length, medullary pyramid thickness, and renal parenchymal thickness) were performed in patients with SFU grades 1-4 hydronephrosis secondary to UPJO managed between 2009 and 2014. Exclusion criteria included other concomitant genitourinary pathology or incomplete follow-up. Anterior-posterior renal pelvic diameter (APRPD) and radionuclide renography were also evaluated when available. RESULTS: One hundred four patients with UPJO underwent 244 renal and bladder ultrasound (1,464 sonographic renal parenchymal measurements in 488 kidneys). Medullary pyramid thickness and renal parenchymal thickness progressively decreased from SFU grades 1-4 (p < 0.05). A similar trend was appreciated when comparing SFU grades 1 and 2 vs. 3 and 4, as well as SFU grades 3 vs. 4 (p < 0.05). SFU grade 3 and 4 patients who underwent pyeloplasty had longer renal length in comparison to those who were managed conservatively (p < 0.02). CONCLUSION: This is the first study that evaluates these objective, quantifiable sonographic renal parenchymal measurements in children with unilateral UPJO. These sonographic renal parenchymal measurements correlate closely with worsening of hydronephrosis graded by the SFU and APRPD classification systems. Prospective studies are needed to elucidate the role of sonographic renal parenchymal measurements in the management of children with UPJO.

16.
J Agric Food Chem ; 64(10): 2112-9, 2016 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-26889954

RESUMO

The aim of the current study was to describe the fate of ingested α-hexabromocyclododecane (α-HBCDD) in laying hens. Individuals were exposed to two dietary concentrations of α-HBCDD (50 and 5 ng g(-1) feed) for 18 or 11 weeks followed by a 7-week decontamination period. The results show that no isomerization of α- to ß- or γ-HBCDD forms occurred, whereas OH-HBCDD was identified as a product of α-HBCDD metabolism. Irrespective of the level of feed contamination, estimates of steady-state accumulation ratios were 5.2, 3.6, and 9.2 and half-lives were estimated at 17.4, 22.8, and 35.3 days in egg yolk, liver tissue, and abdominal fat, respectively. The steady-state carry-over rate to eggs was 22.9%. Thus, α-HBCDD ingested by laying hens is readily transferred to eggs and significantly accumulates in adipose tissue.


Assuntos
Galinhas/metabolismo , Ovos/análise , Hidrocarbonetos Bromados/metabolismo , Ração Animal/análise , Animais , Gema de Ovo/química , Gema de Ovo/metabolismo , Feminino , Contaminação de Alimentos/análise , Hidrocarbonetos Bromados/análise , Distribuição Tecidual
17.
ACS Appl Mater Interfaces ; 8(3): 1913-21, 2016 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-26730704

RESUMO

The nanocarrier capabilities of atomically smooth two-dimensional sheets of a biantennary oligoglycine peptide C8H16(-CH2-NH-Gly5)2 (also called tectomers) are demonstrated. We show that the pH-controlled, rapid, and reversible assembly and disassembly of oligoglycine can be effectively used for controlled loading and release of the anticancer drug and fluorescent probe coralyne. The calculated partition coefficient in water is of the same order of magnitude or higher when compared to other nanocarriers such as liposomes and micelles, signifying the tectomer's impressive loading capabilities. Moreover, the loading of guest molecules in tectomers facilitates the protection from rapid photochemically induced degradation. Such efficient, pH-sensitive, stable, and biocompatible nanocarriers are extremely attractive for biosensing, therapeutic, and theranostic applications. Additionally, our results suggest that these planar self-assembled materials can also act as phase-transfer vehicles for hydrophobic cargoes further broadening their biomedical and technological applications.


Assuntos
Portadores de Fármacos/química , Nanopartículas/química , Peptídeos/química , Alcaloides de Berberina/farmacologia , Liberação Controlada de Fármacos , Concentração de Íons de Hidrogênio , Microscopia Confocal , Nanopartículas/ultraestrutura , Solubilidade , Soluções , Espectrometria de Fluorescência , Espectrofotometria Ultravioleta , beta Caroteno/farmacologia
19.
Nutr Hosp ; 31(5): 1996-2005, 2015 May 01.
Artigo em Espanhol | MEDLINE | ID: mdl-25929367

RESUMO

INTRODUCTION: Overweight and obesity has high prevalence in children and adolescents in Spain. OBJECTIVE: To determine the degree of influence of four modifiable factors (dietary habits, physical activity, sedentary and sleep) jointly on the weight status of a group of school children and adolescents in Madrid. METHODS: 189 schoolchildren aged 6 to 16 years, who underwent an anthropometric study. To exercise the IPAQ questionnaire was used, establishing a minimum of one hour of exercise a day, as a recommendation, and two hours per day in case of sedentary, which took into account the hours of computer, consoles and TV. Sleep quality was assessed by collecting sleeping hours weekdays and weekend nap. Stating that school children should sleep 10 hours a day. The KIDMED Index was used for the diet quality, the score can be accessed from 0-12 and classified into 3 categories, it was regrouped for statistical measure. The first two results (0-7) as "Bad adherence" and ≥ 8 value as "Good adherence". RESULTS: 27.6% of students had excess weight. CONCLUSION: No significant differences were reported analyzing the four factors studied versus weight status among those who keep recommendations and excess weight, either individually or multifactor analysis was observed.


Assuntos
Peso Corporal/fisiologia , Hábitos , Estilo de Vida , Adolescente , Criança , Dieta , Exercício , Feminino , Humanos , Masculino , Comportamento Sedentário , Espanha/epidemiologia , Inquéritos e Questionários
20.
Nutr. hosp ; 31(5): 1996-2005, mayo 2015. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-140364

RESUMO

Introducción: El sobrepeso y la obesidad alcanzan una alta prevalencia entre niños y adolescentes en España. Objetivo: Conocer el grado de influencia de cuatro factores modificables (hábitos alimentarios, práctica de actividad física, sedentarismo y horas de sueño) de forma conjunta sobre el estado ponderal de un colectivo de niños en edad escolar y adolescentes de Madrid. Metodología: 189 escolares, de 6 a 16 años, a los que se les realizó un estudio antropométrico. Para el ejercicio físico se usó el cuestionario IPAQ modificado, estableciéndose un mínimo de una hora de ejercicio al día, como recomendación, y de dos horas al día en el caso del sedentarismo, donde se tuvieron en cuenta las horas de ordenador, consolas y televisión. La calidad del sueño se valoró recogiendo las horas de sueño entre semana, siesta y fin de semana. Estableciendo que los niños en edad escolar deben dormir 10 horas al día. Para la dieta, se utilizó el Índice KidMed, la puntuación que se puede alcanzar de 0 a 12 y se clasifica en 3 categorías, se reagrupo para nuestra medida estadística. Los dos primeros resultados (0-7) como 'no cumple la adherencia' y ≥ 8 valor como 'si cumple la adherencia'. Resultados: El 27,6% de los estudiantes tenían exceso ponderal. Conclusión: No se observaron diferencias significativas al analizar los cuatro factores estudiados frente al estado ponderal, entre los aquellos que cumplían o no cumplían las recomendaciones y el exceso de peso, ni de forma individual ni multifactorialmente (AU)


Introduction: Overweight and obesity has high prevalence in children and adolescents in Spain. Objective: To determine the degree of influence of four modifiable factors (dietary habits, physical activity, sedentary and sleep) jointly on the weight status of a group of school children and adolescents in Madrid. Methods: 189 schoolchildren aged 6 to 16 years, who underwent an anthropometric study. To exercise the IPAQ questionnaire was used, establishing a minimum of one hour of exercise a day, as a recommendation, and two hours per day in case of sedentary, which took into account the hours of computer, consoles and TV. Sleep quality was assessed by collecting sleeping hours weekdays and weekend nap. Stating that school children should sleep 10 hours a day. The KIDMED Index was used for the diet quality, the score can be accessed from 0-12 and classified into 3 categories, it was regrouped for statistical measure. The first two results (0-7) as 'Bad adherence' and ≥ 8 value as 'Good adherence'. Results: 27.6% of students had excess weight. Conclusion: No significant differences were reported analyzing the four factors studied versus weight status among those who keep recommendations and excess weight, either individually or multifactor analysis was observed (AU)


Assuntos
Humanos , Comportamento Alimentar , Crescimento/fisiologia , Estatura-Idade , Alimentos Integrais , Obesidade Pediátrica/epidemiologia , Sobrepeso/epidemiologia , Desenvolvimento Infantil/fisiologia , Insuficiência de Crescimento/epidemiologia , Dieta Mediterrânea/estatística & dados numéricos , Atividade Motora/fisiologia , Comportamento Sedentário
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