Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 7 de 7
Filtrar
Mais filtros










Intervalo de ano de publicação
1.
Braz. j. biol ; 82: e238673, 2022. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1153461

RESUMO

Abstract Coccidiosis remains one of the major problems in poultry all over the world. Very limited data on anticoccidial drugs in wild pigeons is available. The current study was aimed to understand the comparative efficacy of sulfadimidine, amprolium and triquen in wild pigeons of Dir district, Pakistan suffering from coccidiosis. The faecal matter of wild pigeons were purchased from the local market for coccidian infection. Results revealed that 88.8% (16/18) were found infected with Eimeria spp. Three positive groups were treated with sulfadimidine (0.2mg/L), amprolium (25mg/L) and triquen. Sulfadimidine was most effective (45%) followed by amprolium (44.6%) while triquen (24.0%) showed less effectiveness against coccidiosis in pigeons. Number of oocysts were 79, 81 and 80 before treatment and 60, 44 and 44 after treatment with sulfadimidine, amprolium and triquen respectively. This study showed that sulphadimidine, amprolium and triquen could not significantly reduce the coccidiosis in pigeons. Further studies are required to clear the mechanism of anti-coccidial drugs in wild pigeons.


Resumo A coccidiose continua sendo um dos maiores problemas em aves de todo o mundo. Dados muito limitados sobre drogas anticoccidiais em pombos selvagens estão disponíveis. O presente estudo teve como objetivo compreender a eficácia comparativa da sulfadimidina, amprólio e triquenho em pombos selvagens do distrito de Dir, no Paquistão, que sofrem de coccidiose. A matéria fecal dos pombos selvagens foi comprada no mercado local para infecção por coccídios. Os resultados revelaram que 88,8% (16/18) foram encontrados infectados com Eimeria spp. Três grupos positivos foram tratados com sulfadimidina (0,2mg / L), amprólio (25mg / L) e triquenho. A sulfadimidina foi mais eficaz (45%), seguida pelo amprólio (44,6%), enquanto o triquenho (24,0%) apresentou menor efetividade contra a coccidiose em pombos. O número de oocistos foram 79, 81 e 80 antes do tratamento e 60, 44 e 44 após o tratamento com sulfadimidina, amprólio e triquenho, respectivamente. Este estudo mostrou que sulphadimidine, amprolium e triquen não poderiam reduzir significativamente a coccidiose em pombos. Mais estudos são necessários para limpar o mecanismo de drogas anticoccidiais em pombos selvagens.

2.
Braz J Biol ; 82: e238673, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33729384

RESUMO

Coccidiosis remains one of the major problems in poultry all over the world. Very limited data on anticoccidial drugs in wild pigeons is available. The current study was aimed to understand the comparative efficacy of sulfadimidine, amprolium and triquen in wild pigeons of Dir district, Pakistan suffering from coccidiosis. The faecal matter of wild pigeons were purchased from the local market for coccidian infection. Results revealed that 88.8% (16/18) were found infected with Eimeria spp. Three positive groups were treated with sulfadimidine (0.2mg/L), amprolium (25mg/L) and triquen. Sulfadimidine was most effective (45%) followed by amprolium (44.6%) while triquen (24.0%) showed less effectiveness against coccidiosis in pigeons. Number of oocysts were 79, 81 and 80 before treatment and 60, 44 and 44 after treatment with sulfadimidine, amprolium and triquen respectively. This study showed that sulphadimidine, amprolium and triquen could not significantly reduce the coccidiosis in pigeons. Further studies are required to clear the mechanism of anti-coccidial drugs in wild pigeons.


Assuntos
Amprólio , Coccidiose , Animais , Galinhas , Coccidiose/tratamento farmacológico , Coccidiose/veterinária , Columbidae , Paquistão , Sulfametazina
3.
Physiol Res ; 68(6): 939-945, 2019 12 30.
Artigo em Inglês | MEDLINE | ID: mdl-31647300

RESUMO

To compare serum adiponectin changes across the menstrual cycle between normal weight and overweight/obese young women and its correlation with serum estradiol. Young women (n=56) with regular menstrual cycle had been grouped according to their BMI into normal weight group (n=26) and overweight /obese group (n=30). Blood samples were drawn during early follicular (FP), pre-ovulatory (OP) and luteal phases (LP) of menstrual cycle for serum adiponectin and estradiol levels determination using enzyme-linked immunosorbent assay. Adiponectin serum level showed a significant decreasing pattern across the phases of menstrual cycle in normal weight group. This pattern was absent in the overweight/obese group. In addition, serum adiponectin was lower in overweight/obese group compared to normal weight subjects through all phases of menstrual cycle. No correlation was found between adiponectin and estradiol levels in both groups. A significant variation of serum adiponectin level was detected across the menstrual cycle in females with normal weight. In comparison, overweight/obese group showed a relatively stable adiponectin level throughout the cycle. This lack of adiponectin variation might be added to the complex mechanisms lies behind obesity-related female infertility.


Assuntos
Adiponectina/sangue , Peso Corporal Ideal/fisiologia , Ciclo Menstrual/sangue , Sobrepeso/sangue , Adolescente , Adulto , Biomarcadores/sangue , Estudos de Coortes , Feminino , Humanos , Obesidade/sangue , Obesidade/diagnóstico , Sobrepeso/diagnóstico , Estudos Prospectivos , Adulto Jovem
4.
Physiol Res ; 67(5): 787-793, 2018 11 14.
Artigo em Inglês | MEDLINE | ID: mdl-30044107

RESUMO

Present study aimed to explore the levels and correlation of oxidative stress biomarkers with anthropometry in a population of young Saudi females. One hundred six normotensives, non-diabetic Saudi females, with minimally active lifestyle, based on their body mass index (BMI) were divided as; normal-weight (NW; n=52), overweight (OW; n=24) and obese (OB; n=30). Anthropometric measurements [BMI, Waist Circumference (WC), Waist-Hip Ratio (WHR), Body Density (BD), Body Adiposity Index (BAI), % Body fat] and oxidative stress biomarkers; Thiobarbituric acid reactive substances (TBARS), 8-hydroxy-2-deoxyguanosine (8-OH-2dG: indicative of DNA/RNA damage), Superoxide dismutase, Serum total antioxidant capacity) were recorded. There was statistically significant higher 8-OH-2dG (pg/ml) in OB compared to NW (800.63+/-6.19 vs. 780.22+/-3.34; p=0.007), as determined by one-way ANOVA and Tukey post hoc test. 8-OH-2dG was significantly and positively associated with BMI (r=0.286, p=0.004), WC (r=0.280, p=0.005), BAI (r=0.26, p=0.008), and % body fat (r=0.27, p=0.006). There may be significantly increased DNA damage in normoglycemic, normotensive obese adolescent females. This can be linked to the amount of adipose tissue in the body as depicted by strong positive association between DNA damage and BMI, WC, BAI, and % body fat.


Assuntos
Antropometria , Antioxidantes/metabolismo , Obesidade/sangue , Oxidantes/sangue , Estresse Oxidativo/fisiologia , Circunferência da Cintura/fisiologia , Adiposidade/fisiologia , Antropometria/métodos , Estudos Transversais , Dano ao DNA/fisiologia , Feminino , Humanos , Obesidade/diagnóstico , Obesidade/epidemiologia , Arábia Saudita/epidemiologia , Relação Cintura-Quadril/métodos , Adulto Jovem
5.
Neth J Med ; 73(4): 175-8, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25968289

RESUMO

OBJECTIVE: A rise in oestrogen in the preovulatory phase produces a GnRH-induced luteinising hormone surge. Oestrogen receptors are not found on GnRH neurons but these are present on kisspeptin neurons. That led us to hypothesise that serum kisspeptin levels may vary during various phases of the menstrual cycle in relation to serum oestradiol. METHODS: Thirty female students, 18-25 years old, Saudi nationality, with a regular menstrual cycle, were recruited from various health colleges of the University of Dammam, Saudi Arabia. Three blood samples per volunteer were collected at three different times: the early follicular, preovulatory and luteal phase. Serum kisspeptin and oestradiol were measured using ELISA kits. Comparison between individual subjects during the various phases was done by one-way, repeated-measures ANOVA. To discover which specific means differed, Bonferroni post hoc test was applied. Pearsons correlation was used to find out the relationship. RESULTS: There was a statistically significant increase (p < 0.001) in serum kisspeptin levels from the early follicular to the preovulatory phase (264.11±28.42 vs. 472.46±17.82 nmol/l respectively), and from the preovulatory to the luteal phase (472.46±17.82 vs. 724.79±36.85 nmol/l respectively). Oestradiol levels also increased significantly (p = 0.006) from the early follicular to the preovulatory phase (45.85±5.34 vs. 79.07±7.45 pg/ml respectively), Pearsons correlation revealed a statistically insignificant correlation between kisspeptin and oestradiol in all three phases. CONCLUSION: Endogenous kisspeptin secretion seems to vary across the different phases of the menstrual cycle and is not related to serum oestradiol.


Assuntos
Estradiol/sangue , Fase Folicular/sangue , Kisspeptinas/sangue , Fase Luteal/sangue , Adolescente , Adulto , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Ciclo Menstrual/sangue , Adulto Jovem
6.
Ann Oncol ; 14(9): 1430-7, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12954584

RESUMO

BACKGROUND: Pegylated liposomal doxorubicin (Doxil) has been reported to cause immediate hypersensitivity reactions (HSRs) that cannot be explained as IgE-mediated (type I) allergy. Previous in vitro and animal studies indicated that activation of the complement (C) system might play a causal role in the process, a proposal that has not been tested in humans to date. PATIENTS AND METHODS: Patients with solid tumors (n = 29) treated for the first time with Doxil were evaluated for HSRs and concurrent C activation. HSRs were classified from mild to severe, while C activation was estimated by serial measurement of plasma C terminal complex (SC5b-9) levels. Increases in SC5b-9 were compared in patients with or without reactions, and were correlated with Doxil dose rate. RESULTS: Moderate to severe HSRs occurred in 45% of patients. Plasma SC5b-9 at 10 min after infusion was significantly elevated in 92% of reactor patients versus 56% in the non-reactor group, and the rise was greater in reactors than in non-reactors. We found significant association between C activation and HSRs, both showing direct correlation with the initial Doxil dose rate. CONCLUSIONS: C activation may play a key role in HSRs to Doxil. However, low-level C activation does not necessarily entail clinical symptoms, highlighting the probable involvement of further, as yet unidentified, amplification factors.


Assuntos
Antibióticos Antineoplásicos/efeitos adversos , Ativação do Complemento/efeitos dos fármacos , Doxorrubicina/efeitos adversos , Hipersensibilidade a Drogas/imunologia , Hipersensibilidade Imediata/imunologia , Adulto , Idoso , Relação Dose-Resposta a Droga , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/tratamento farmacológico
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...