Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 16 de 16
Filtrar
Mais filtros










Tipo de estudo
Intervalo de ano de publicação
1.
Anaesthesia ; 75(1): 21-26, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31236918

RESUMO

Previous studies on the safety of peri-operative transoesophageal echocardiography seem to suggest a low rate of associated morbidity and mortality. That said, there has been a paucity of prospective multicentre studies in this important area of clinical practice. We carried out a one-year prospective study in 2017, co-ordinated by the Association of Cardiothoracic Anaesthesia and Critical Care, to determine the rate and severity of complications associated with peri-operative transoesophageal echocardiography in anaesthetised cardiology and cardiac surgical patients. With the help of clinicians from 28 centres across the UK and Ireland, we recorded the total number of examinations conducted in anaesthetised patients during the study period. All major complications at each centre were prospectively reported and recorded. Of the 22,314 examinations, there were 17 patients diagnosed with a major complication which caused either palatal injury or gastro-oesophageal disruption. This corresponds to an incidence of 0.08% (95%CI 0.05-0.13%) or approximately 1:1300 examinations. There were seven deaths reported during the study period which were directly attributed to these complications, corresponding to an incidence of 0.03% (95%CI 0.01-0.07%) or approximately 1:3000. These figures are higher than previously reported and suggest a high probability of death following the development of a complication (~40%). Most complications occurred in patients without known risk factors for transoesophageal echocardiography associated gastro-oesophageal injury. We suggest clinicians and departments review their procedural guidelines, especially in relation to probe insertion techniques, together with the information communicated to patients when the risks and benefits of such examinations are discussed.


Assuntos
Anestesia em Procedimentos Cardíacos , Procedimentos Cirúrgicos Cardíacos , Ecocardiografia Transesofagiana/efeitos adversos , Auditoria Médica/estatística & dados numéricos , Assistência Perioperatória/efeitos adversos , Idoso , Ecocardiografia Transesofagiana/estatística & dados numéricos , Feminino , Humanos , Irlanda , Masculino , Assistência Perioperatória/métodos , Assistência Perioperatória/estatística & dados numéricos , Estudos Prospectivos , Fatores de Risco , Índice de Gravidade de Doença , Sociedades Médicas , Reino Unido
2.
J Photochem Photobiol B ; 201: 111667, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31683167

RESUMO

Titanium dioxide nanoparticles (TiO2-NPs) were synthesized using the aqueous leaf extract of Aloe barbadensis as a reducing and fabricating agent. The biosynthesis of the TiO2-NPs was initially confirmed by UV-vis spectroscopy. Based on the HRTEM and FESEM analysis, the biosynthesized NPs were found to be polydispersed and predominantly spherical in shape, with an average size of ~20 nm. A sharp and strong characteristic peaks of titanium (Ti) and oxygen (O) observed in the EDS pattern confirmed the synthesis of the TiO2-NPs. The FTIR spectroscopy suggested the presence of terpenoids, flavonoids and proteins which might be responsible for the biosynthesis and fabrication of the TiO2-NPs. The crystalline nature of the synthesized TiO2-NPs constituting of a mixture of brookite, anatase, and rutile phases was indicated by the XRD pattern. The spectral window around 180-1000 cm-1 covered the high-frequency Raman spectra of the TiO2-NPs. The Raman vibrational spectrum showed four Eg modes centered at 197.84, 399.24, 514.50, and 641.58 cm-1 representing the anatase phase of TiO2-NPs. The strongest and broadened peak of anatase was observed at the frequency of 641.58 cm-1. The metabolic activity of P. aeruginosa exposed to the MIC of TiO2-NPs was measured based on the reduction of tetrazolium salt by the dehydrogenase enzyme, produced by the metabolically active bacterial cells. The reduction in TTC was evident from the appearance of a red colored formazan in the solution. A noticeable suppression in the cell viability by 30.76 ±â€¯3.96% of P. aeruginosa in the biofilm mode was found in presence of TiO2-NPs. Furthermore, the Minimum Inhibitory Concentration (MIC) of TiO2-NPs exhibited profound antibiofilm activity against P. aeruginosa by effectively preventing the adherence of the planktonic cells to the substratum. Thus, these NPs may be employed in controlling bacterial infections associated with biofilm.


Assuntos
Aloe/química , Biofilmes/efeitos dos fármacos , Nanopartículas Metálicas/toxicidade , Pseudomonas aeruginosa/fisiologia , Titânio/química , Aloe/metabolismo , Química Verde , Nanopartículas Metálicas/química , Testes de Sensibilidade Microbiana , Tamanho da Partícula , Extratos Vegetais/química , Folhas de Planta/química , Folhas de Planta/metabolismo
3.
J Nanosci Nanotechnol ; 19(6): 3511-3518, 2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-30744779

RESUMO

Unadulterated and scorch stage In2SnO3 nanopowder is effectively arranged with the doping proportion of 80-20% (In2O3-Sn) by simple sol-gel combustion direction. The material is characterized by XRD measurements and their geometrical parameters are compared with calculated values. The FT-IR and NMR spectra are recorded in both bulk and nanophase and FT-Raman spectrum is recorded in bulk phase and the fundamental frequencies are assigned. The optimized parameters and the frequencies are calculated using HF and DFT (B3LYP, B3PW91 and MPW1PW91) theory in bulk phase of In2SnO3 and are compared with its nanophase. The vibrational frequency pattern in nanophase gets realigned and the frequencies are shifted up and down little bit to the region of spectra when compared with bulk phase. The UV-visible spectrum is simulated and analyzed. The frontier molecular orbital analysis has been carried out and the values of the HOMO-LUMO bandgap (Kubo gap) explore the optical and electronic characteristics of the In2SnO3. Structural studies by XRD showed the crystallite sizes of the particles. The atomic arrangement in the grain boundary seems to be somewhat different from regular periodic arrangement whereas inside the grain there is a good periodic arrangement of atoms. Above 10 mol% Sn ions, 15 mol% Sn ions, 20 mol% Sn ions to 50 mol% Sn ions form correlated clusters, 20 mol% Sn ions which lead to broadening. These EPR spectra were formed to contain two different components, one from the single isolated ions and the other from the clusters. The transition is observed for different composition increase with decreasing grain size.

4.
J Nanosci Nanotechnol ; 19(7): 4026-4032, 2019 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-30764965

RESUMO

Research on CdSe/ZnS core-shell quantum dots (QDs) was synthesized by a chemical route using bio-conjugated organic amino acid (L-Cysteine). The structural, morphological, and optical properties of the nanocrystal powder samples were analyzed using various characterization techniques. The diameter of the resulting QDs was about 3 nm with uniform size distribution. The optical properties QDs exhibited an absorption and emission peak at 515 and 525 nm respectively, at room temperature. The QDs through emission in the spectral range at 516-535 nm is special for their application in green LEDs and white-light generation. The high optical properties performance of the QDs nanocomposites gained indicates that the materials are promising for (LED) applications.

5.
J Epidemiol Community Health ; 51(4): 443-8, 1997 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9328555

RESUMO

STUDY OBJECTIVES: To assess the poliomyelitis trend, including study of the epidemiological features, and to correlate this with the immunisation coverage of infants. DESIGN: Three annual lameness surveys in children aged 0-60 months employing cluster sampling methods and a series of five cross sectional surveys of immunisation coverage in children aged 12-23 months of age were undertaken. SETTING: Pondicherry, India, 1988-92. SUBJECTS: More than 10,000 children in the age group of 0-60 months took part in the three annual lameness surveys and samples of 210 children aged 12-23 months were covered each year in immunisation coverage surveys. MEASUREMENTS AND MAIN RESULTS: Altogether 50 of 11,461, 24 of 10,093, and 17 of 11,218 children surveyed during 1989, 1990, and 1991 respectively had become lame as a result of poliomyelitis, giving prevalences of 4.4, 2.4, and 1.5 per 1000 children for the three surveys. The corrected prevalences of poliomyelitis were 5.9, 3.2, and 2.0 per 1000 children during 1989, 1990, and 1991 respectively. The proportion of cases aged up to 36 months fell from 48% in 1989 to 12.5% in 1990 and 6% in 1991. The age at onset was less than 1 year in most. The median age at onset was 10.7 months. About 54% of the affected children had received three doses of oral poliomyelitis vaccine (OPV) before the onset of paralysis. In 1988 immunisation coverage for the third dose of OPV was 91% and in 1992 it was 97.6%. The drop out rate for the first versus the third dose of OPV fell from 6.3 in 1988 to 1.9% in 1992. CONCLUSION: Three successive annual lameness surveys showed that poliomyelitis was declining between 1989 and 1991. Five immunisation coverage surveys conducted from 1988 to 1992 showed high initial coverage followed by an improvement in the form of almost universal coverage for OPV.


Assuntos
Poliomielite/epidemiologia , Fatores Etários , Serviços de Saúde da Criança , Pré-Escolar , Estudos Transversais , Humanos , Índia/epidemiologia , Lactente , Paralisia/epidemiologia , Poliomielite/prevenção & controle , Vacinação
6.
J Epidemiol Community Health ; 47(3): 210-4, 1993 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-8350034

RESUMO

STUDY OBJECTIVES: To assess the amount of poliomyelitis and its epidemiological features including risk factors. DESIGN: This was a retrospective study of cases of paralytic poliomyelitis among children 0-6 years of age. SETTING: Pondicherry, India, 1983-89. SUBJECTS: A total of 47,960 children aged less than 6 years. MEASUREMENTS AND MAIN RESULTS: In 1989, 469 field workers undertook a door to door survey of children 0-6 years old to identify those with limb paralysis. This was followed by clinical examination to establish the cause, supplemented by case notes held by the Child Development Services. Altogether 203 cases of limb paralysis were identified, 188 of which were judged a result of paralytic poliomyelitis. The prevalence of poliomyelitis in 1989 was 3.9/1000 among children below 6 years of age. There was a male preponderance with a male:female ratio of 1.4:1. The prevalence was least in infants (1/1000) and highest in children aged 2 to 3 years (6.4/1000). The age at onset was less than 12 months in 42% of cases and less than 3 years in 98%. The median age at onset was 13.4 months. Time series analysis showed a high occurrence of cases from May to September between 1983 and 1989. The legs were affected in 97%. About 41% of children had received three doses of oral polio vaccine. There was a history of intramuscular injection, possibly provoking a paralytic attack, in 54% of cases. CONCLUSION: This retrospective community study involving the staff of the Integrated Child Development Services provided valid data about poliomyelitis with little additional cost and minimum training. Because the study covered a whole population of children under 6 years, rather than a sample, the data will help in monitoring and surveillance of poliomyelitis and also in planning strategies for effective control.


Assuntos
Poliomielite/epidemiologia , Fatores Etários , Criança , Pré-Escolar , Feminino , Humanos , Incidência , Índia/epidemiologia , Lactente , Masculino , Prevalência , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo
7.
World Health Forum ; 14(2): 188-90, 1993.
Artigo em Inglês | MEDLINE | ID: mdl-8185770

RESUMO

This article outlines the features of community postings for medical students in their second clinical year at the Jawaharlal Institute of Postgraduate Medical Education and Research, in Pondicherry, India. Their exposure to the realities of preventive and social medicine in the field clearly helps them to cope with what would otherwise be only theoretical knowledge.


Assuntos
Estágio Clínico , Medicina Comunitária/educação , Países em Desenvolvimento , Currículo , Humanos , Índia , Saúde da População Rural
13.
Indian Pediatr ; 29(11): 1379-84, 1992 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-1294492

RESUMO

Infant mortality rate is one of the 12 global indicators for monitoring Health for All. Reliable data on infant mortality are not available for the majority of developing countries including India. To plan strategies for bringing down the rate and, later, to evaluate them, 'Cause Specific Rates' would be necessary. Pondicherry has achieved low rates of infant mortality. A study was conducted in the Anganwadis of Pondicherry to determine the causes of infant deaths. The 8185 children born between 1-4-1987 and 31-3-1988 in Pondicherry formed the study group. The Anganwadi workers collected information on the cause of death for the 222 children dying within the first year. The infant mortality rate was 27.1 per 1000 live births. Acute respiratory infections and diarrheal diseases accounted for 45% of the deaths.


Assuntos
Causas de Morte , Mortalidade Infantil , Estudos de Coortes , Feminino , Humanos , Índia/epidemiologia , Lactente , Recém-Nascido , Masculino , Fatores Socioeconômicos
14.
Int J Gynaecol Obstet ; 33(1): 1-5, 1990 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-1974525

RESUMO

Intrauterine growth retardation (IUGR) is one of the major causes of perinatal mortality in countries like India. Fundal height traditionally measured in relation to umbilicus and xiphisternum is of little value in predicting the fetal growth. Some workers have found that symphysis fundal height (SFH) measurements could be useful in screening pregnancies for growth retardation. A prospective study was taken up in 109 pregnant women attending the antenatal clinic of our Institution. Serial measurements of SFH, abdominal girth, double abdominal wall thickness (DAWT) and maternal weight gain were recorded. SFH measurements obtained were arranged on the basis of 10th, 50th and 90th percentile and represented graphically. Statistical analysis showed that the coefficient of variation was smallest for SFH as compared to abdominal girth and maternal weight gain. The babies (single born) delivered were between 2600 g and 3700 g irrespective of whether the maternal weight gain was 143 g/week or 424 g/week. The abdominal wall thickness had no influence on the measurement of SFH. An attempt was made to develop a nomogram of SFH for our population. This is a simple, reliable and inexpensive method in the screening of pregnancies for IUGR.


Assuntos
Desenvolvimento Embrionário e Fetal , Retardo do Crescimento Fetal/diagnóstico , Feto/anatomia & histologia , Ultrassonografia , Feminino , Retardo do Crescimento Fetal/epidemiologia , Idade Gestacional , Humanos , Índia/epidemiologia , Gravidez , Estudos Prospectivos , Valores de Referência
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA