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1.
ACS Nano ; 14(11): 15227-15240, 2020 11 24.
Artigo em Inglês | MEDLINE | ID: mdl-33174725

RESUMO

We study the nonequilibrium diffusive release of electroneutral molecular cargo encapsulated inside hollow hydrogel nanoparticles. We propose a theoretical model that includes osmotic, steric, and short-range polymer-cargo attractions to determine the effective cargo-hydrogel interaction, ueff*, and the effective diffusion coefficient of the cargo inside the polymer network, Deff*. Using dynamical density functional theory (DDFT), we investigate the scaling of the characteristic release time, τ1/2, with the key parameters involved in the process, namely, ueff*, Deff*, and the swelling ratio. This effort represents a full study of the problem, covering a broad range of cargo sizes and providing predictions for repulsive and attractive polymer shells. Our calculations show that the release time through repulsive polymer networks scales with q2eßueff*/Deff* for ßueff* ≫ 1. In this case, the cargo molecules are excluded from the shell of the hydrogel. For attractive shells, the polymer retains the cargo molecules on its internal surface and its interior, and the release time grows exponentially with the attraction strength. The DDFT calculations are compared to an analytical model for the mean first passage time, which provides an excellent quantitative description of the kinetics for both repulsive and attractive shells without fitting parameters. Finally, we apply the method to reproduce experimental results on the release of paclitaxel from hollow poly(4-vinylpyridine) nanoparticles and find that the slow release of the drug can be explained in terms of the strong binding attraction between the drug and the polymer.

2.
Foodborne Pathog Dis ; 17(12): 739-742, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33112663

RESUMO

Thirty-four Escherichia coli isolates from 91 ready-to-eat lettuce packages, obtained from local supermarkets in Northern California, were genotyped by multilocus sequence typing, tested for susceptibility to antimicrobial agents, and screened for ß-lactamase genes. We found 15 distinct sequence types (STs). Six of these genotypes (ST1198, ST2625, ST2432, ST2819, ST4600, and ST5143) have been reported as pathogens found in human samples. Twenty-six (76%) E. coli isolates were resistant to ampicillin, 17 (50%) to ampicillin/sulbactam, 8 (23%) to cefoxitin, and 7 (20%) to cefuroxime. blaCTX-M was the most prevalent ß-lactamase gene, identified in eight (23%) isolates. We identified a class A broad-spectrum ß-lactamase SED-1 gene, blaSED, reported by others in Citrobacter sedlakii isolated from bile of a patient. This study found that fresh lettuce carries ß-lactam drug-resistant E. coli, which might serve as a reservoir for drug-resistance genes that could potentially be transmitted to pathogens that cause human infections.

3.
PLoS One ; 15(5): e0233138, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32421738

RESUMO

Naringenin is flavonoid mainly found in citrus fruits which has shown several biological properties. In this work, we evaluated the therapeutic potential of the flavonoid Naringenin. Five-month-old B6.MRL-Faslpr/J lupus-prone mice were administered daily orally with Naringenin for seven months. We showed that Naringenin treatment at 50 or 100 mg/kg inhibited the splenomegaly and decreased the levels of anti-nuclear and anti-dsDNA autoantibodies. Furthermore, a reduction in serum concentration of TNF-α, IFN-γ and IL-6 was observed in the mice provided with Naringenin. Interestingly, serum levels of IL-10 increased. Naringenin decreased the frequency and absolute numbers of splenic effector memory T cells. Additionally, in order to be able to evaluate whether Naringenin prevented kidney damage, twelve-week-old MRL/MpJ-Faslpr/J mice, an accelerated lupus model, were orally administered with Naringenin at 100 mg/kg for six weeks. Surprisingly, Naringenin treatment prevented kidney damage and reduced the development of fibrosis similar to cyclophosphamide group. Moreover, Naringenin treatment increased the percentage of regulatory T cells in this aggressive model of lupus. Together, these results suggest a potential ability of Naringenin to reduce the autoimmunity in lupus-prone mice by modulation of T-cell subsets and cytokines profile that mitigate the development of important lupus clinical manifestations.


Assuntos
Citocinas/imunologia , Flavanonas/farmacologia , Memória Imunológica/efeitos dos fármacos , Nefrite Lúpica/tratamento farmacológico , Linfócitos T Reguladores/imunologia , Animais , Modelos Animais de Doenças , Nefrite Lúpica/imunologia , Nefrite Lúpica/patologia , Masculino , Camundongos , Linfócitos T Reguladores/patologia
4.
J Ren Nutr ; 30(3): 223-231, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31607549

RESUMO

OBJECTIVE: The aim of this study was to evaluate the interaction between diet quality and interleukin (IL)-6 genotypes and its association with metabolic and renal function parameters in Mexican patients with type 2 diabetes mellitus (T2DM). DESIGN AND METHODS: Using an analytical cross-sectional design, 219 patients with T2DM (92 men; age 62 ± 10 years) were evaluated for selected metabolic and renal function parameters. Diet quality according to the Healthy Eating Index was evaluated and classified as good diet or poor diet in all patients. IL-6 serum concentrations and genotypes and haplotypes for IL6-597G > A (rs180097), -572G > C (rs180096), and -174G > C (rs180095) polymorphisms were determined. RESULTS: Eighty-two percent of patients reported having a poor diet. Carriers of alleles -572C and -174C showed higher high-density lipoprotein cholesterol levels (44 ± 12 vs. 40 ± 9 mg/dL; P = .01) and lower total cholesterol levels (184 ± 33 vs. 197 ± 42 mg/dL; P = .03) than did those homozygous for G/G. Neither IL6 genotypes nor haplotypes were significantly associated with serum concentrations of IL-6. Some significant interactions between IL6 genotypes/haplotypes and diet quality were associated with body mass index, waist circumference, high-density lipoprotein cholesterol levels, and estimated glomerular filtration rate. CONCLUSIONS: Interactions between diet quality and IL6 genotypes/haplotypes were associated with the main metabolic and renal function parameters in Mexican patients with T2DM. It will be important to consider genetic profiles in designing dietary portfolios and nutritional interventions for the management of such patients.

5.
Opt Express ; 27(18): 25228-25240, 2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31510398

RESUMO

We present spatially-resolved observations of orbital angular momentum (OAM) conservation, via a Laguerre-Gauss (LG) basis decomposition, of spatially-entangled photon pairs produced in type-I collinear spontaneous parametric downconversion (SPDC). These results were obtained with a novel detection system for OAM-entangled photon pairs that combines a projective measurement for the signal photon to a specific value of the azimuthal index ls, with a spatially-resolved measurement for the idler photon using an intensified charge coupled (ICCD) camera. In combination with far-field diffraction of the idler photon through a triangular aperture, we are able to obtain: i) the spatial structure of the heralded idler photon, as governed by the user-selected topological charge of the signal photon; ii) the OAM spectrum; and iii) the topological charge (both magnitude and sign) for the heralded idler photon.

6.
Artigo em Inglês | MEDLINE | ID: mdl-31205733

RESUMO

Background: Colostrum is the primary source of maternal immunoglobulin A (IgA) for the newborn. IgA participates in protection and regulation mechanisms of the immune response at the neonate's mucosa. Several studies have evaluated infectious diseases and vaccine protocols effects during pregnancy on maternal milk IgA levels, with the aim to understand lactation protecting effect on newborn. However, most of their results demonstrated that there were no differences in the total IgA levels. In humans, IgA has two subclasses (IgA1 and IgA2), they have an anatomical distribution among mucosal compartments, their levels vary after antigen stimulation and are also seen to describe differential affinities in colostrum. Although there are differences between IgA subclasses in several compartments, these studies have excluded specific colostrum IgA1 and IgA2 determination. Methods: We analyzed data from 900 women in Mexico City. With Pearson correlation, we compared the number of infectious episodes during their pregnancy that was associated with mucosal compartments (skin, respiratory and gastrointestinal tracts) and colostrum IgA subclasses. Results: We show a correlation between increased colostrum IgA1 levels and the number of infectious episodes at respiratory tract and the skin. In contrast, infections at the gastrointestinal tract correlated with increased IgA2 amounts. Conclusions: Infections present during pregnancy at certain mucosal site increase specific IgA subclasses levels in human colostrum. These results will help in understanding infections and immunizations effects on maternal IgA at the mammary gland, and their impact on the development and protection of the newborn.

7.
Sci Rep ; 9(1): 8954, 2019 06 20.
Artigo em Inglês | MEDLINE | ID: mdl-31222097

RESUMO

Optical-coherence tomography (OCT) is a technique that employs light in order to measure the internal structure of semitransparent, e.g. biological, samples. It is based on the interference pattern of low-coherence light. Quantum-OCT (QOCT), instead, employs the correlation properties of entangled photon pairs, for example, generated by the process of spontaneous parametric downconversion (SPDC). The usual QOCT scheme uses photon pairs characterised by a joint-spectral amplitude with strict spectral anti-correlations. It has been shown that, in contrast with its classical counterpart, QOCT provides resolution enhancement and dispersion cancellation. In this paper, we revisit the theory of QOCT and extend the theoretical model so as to include photon pairs with arbitrary spectral correlations. We present experimental results that complement the theory and explain the physical underpinnings appearing in the interference pattern. In our experiment, we utilize a pump for the SPDC process ranging from continuous wave to pulsed in the femtosecond regime, and show that cross-correlation interference effects appearing for each pair of layers may be directly suppressed for a sufficiently large pump bandwidth. Our results provide insights and strategies that could guide practical implementations of QOCT.

8.
J Ren Nutr ; 29(5): 370-376, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-30679077

RESUMO

OBJECTIVE: Obesity is clearly associated to kidney disease in adult population; however, there is scarce evidence in children and adolescents. The aim was to compare frequency of renal damage according to the presence of overweight-obesity in children and adolescents, as well as to compare nutritional and biochemical risk factors, according to the presence of kidney alterations. METHODS: Cross-sectional study; 172 children and adolescents, 6-16 years old, without malnutrition, diabetes mellitus, hypertension and independent comorbid conditions associated to obesity or kidney disease, as well as transitory causes of microalbuminuria (MA) from a Primary Health-Care Unit were included. Clinical, biochemical, anthropometric and dietetic evaluations were measured in all subjects; subsequently they were classified as normal weight, overweight and obesity groups according to sex- and age-adjusted body mass index (BMI). Glomerular filtration rate (GFR, estimated by Schwartz equation) and albuminuria (albumin/creatinine ratio) were determined. Presence of kidney alterations was measured as decreased GFR (<90 mL/min/1.73m2), hyperfiltration (>170 mL/min/1.73m2) and MA (30-300 mg/g). RESULTS: Compared with controls, subjects with overweight-obesity had significantly (P<.05) abdominal obesity (0 vs 69%), hypertension (19 vs 26%), hypertriglyceridemia (11 vs 47%), high low-density lipoprotein cholesterol (2 vs 8%) and low high-density lipoprotein cholesterol (HDL-cholesterol; 2 vs 28%), hyperuricemia (11 vs 28%) and hyperinsulinemia (8 vs 70%). Hyperfiltration and MA were present in 5 and 4 subjects with overweight/obesity, respectively, whereas decreased GFR was present in only 1 subject with obesity. Normal weight subjects had no kidney alterations. In multivariate analysis, kidney alterations were significantly predicted by higher BMI and lower HDL-cholesterol. CONCLUSIONS: Kidney alterations were observed only in subjects with overweight (3.6%) and obesity (9.9%), who additionally, displayed cardiometabolic and kidney disease risk factors more frequently than normal weight subjects.


Assuntos
Nefropatias/epidemiologia , Sobrepeso/epidemiologia , Obesidade Pediátrica/epidemiologia , Atenção Primária à Saúde , Adolescente , Albuminúria/epidemiologia , Índice de Massa Corporal , Criança , Estudos Transversais , Feminino , Taxa de Filtração Glomerular , Humanos , Peso Corporal Ideal , Rim/patologia , Masculino , Fatores de Risco
9.
J Ren Nutr ; 29(2): 143-148, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30322787

RESUMO

OBJECTIVE: Pica could be strongly implicated in nutritional status of patients on dialysis; however, very scarce data are currently available. The objective of this study was to evaluate the prevalence of pica and its association with nutritional status in dialysis patients. DESIGN AND METHODS: This is a cross-sectional study in a tertiary care teaching hospital. Four-hundred patients on dialysis, without previous pica diagnosis or transplant, pregnancy, mental illness, or infection, were included in the study. Pica, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, was classified as no pica, ice pica, or hard pica. Dialysis Malnutrition Score, 24-hour dietary recall, and biochemical measurements were obtained from patients. As part of statistical analysis, point prevalence and 95% confidence interval of pica were calculated. Comparisons between groups were performed by means of analysis of variance, Kruskal-Wallis test, χ2, or Fisher exact tests, as appropriate. A multivariate analysis was performed by multinomial logistic regression. RESULTS: Prevalence of pica was 42% (ice pica, 46%; soil, 29%; two substances, 14%; red brick, 5%; paper, 3%; soap, 2%; and cattle pasture, 1%). Comparing patients with pica (hard pica and ice pica) versus no pica, subjects with pica were of younger age (25 ± 7, 27 ± 9, 30 ± 11 years, respectively), were more frequently educated <9 years (57%, 46%, 30%, respectively), and had longer dialysis duration (36 ± 19, 32 ± 18, 27 ± 16 months, respectively). Patients with pica achieved the recommended calorie and macronutrients intake target less frequently than those without pica (40-64% vs. 66-77%, P <.05). Malnutrition was present in 74% of the whole sample: (1) 67% in no pica group, (2) 80% in ice pica group, and (3) 89% in hard pica group (P = .001). In the multivariate analysis (R2, 0.27; P < .0001), malnutrition, C-reactive protein, and lower educational level significantly predicted both ice and hard pica. CONCLUSIONS: A worse nutritional status was observed in patients with pica, who additionally were younger, had lower educational level, longer dialysis duration, and worse macronutrient intake routine than patients without pica. Malnutrition, C-reactive protein, and lower educational level significantly predicted both ice and hard pica.


Assuntos
Falência Renal Crônica/terapia , Estado Nutricional , Pica/epidemiologia , Diálise Renal , Adolescente , Adulto , Fatores Etários , Proteína C-Reativa/análise , Estudos Transversais , Escolaridade , Ingestão de Energia , Feminino , Humanos , Gelo , Falência Renal Crônica/fisiopatologia , Masculino , Desnutrição/epidemiologia , Nutrientes/administração & dosagem , Solo , Adulto Jovem
10.
CienciaUAT ; 13(1): 35-49, jul.-dic. 2018. tab, graf
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1001737

RESUMO

RESUMEN En los últimos años, la brecha digital ha recibido especial atención de investigadores y organismos internacionales, ya que genera desigualdades digitales que impactan el desarrollo social y la educación. El modelo de la accesibilidad en etapas a la tecnología (AET), propuesto por Van Dijk, ha venido consolidándose en un marco teórico evolutivo, encaminado a explicar la penetración social de las tecnologías de la información y las comunicaciones (TIC). Además, define una parte importante del segmento de la teoría de los recursos y la apropiación tecnológica (TRA). El objetivo de este trabajo fue evaluar el nivel de infraestructura digital en las primarias del estado de Tamaulipas, el grado de conocimiento y el uso que le dan a las TIC los alumnos de este sector, a través del modelo de (AET). Esta investigación fue empírica y descriptiva, con diseño no experimental. La información analizada proviene de una muestra de 213 estudiantes de 167 instituciones del estado, a quienes se les aplicó un cuestionario utilizado por la Comisión Económica para América Latina y el Caribe y la Organización de las Naciones Unidas (CEPAL-ONU). En las pruebas estadísticas de regresión, se evidenciaron enlaces causales significativos (P < 0.05), entre las variables motivación, acceso, capacidades y uso de las TIC. El nivel de capacidades fue una influencia significativa en el nivel de uso de estas tecnologías; la relación causal Motivación x Acceso reveló una beta negativa, dado que la falta de acceso, por carecer de infraestructura de las TIC o por subemplearla en un proceso de capacitación discontinuo o inexistente, afecta la apropiación de estas tecnologías por los alumnos.


ABSTRACT In the last years, the digital divide has received special attention of investigators and international organizations, since it generates digital inequality that impacts social development and education. The model of accessibility in stages to the Technology (AET), proposed by Van Dijk, has been consolidated as an evolutionary theoretical framework, which aims to explain the social penetration of Information and Communication Technologies (ICT). In addition, it defines an important part of the segment of the theory of resources and the appropriation of technology (ART). The objective of this work was to employ the accessibility model in stages to Technology (AET) to assess three aspects of the digital divide in primary schools of Tamaulipas: the level of digital infrastructure, the degree of knowledge, and the use given to ICT by students at this level. This research was empirical and descriptive, with a non-experimental design. The analyzed information was obtained from a sample of 213 students of 167 institutions in the State, who were administered a questionnaire used by the Economic Commission for Latin America and the Caribbean and the Organization of the United Nations (ECLAC-UN). Regression analysis tests showed significant causal links (P < 0.05) between the variable motivation, access to ICT infrastructure, level of skills and level of use of ICT. The level of capacities was a significant influence on the level of use of these technologies, the causal relation Motivation x Access revealed a negative Beta that affects the appropriation of these technologies by students due to two main factors: a lack of access to ICT infrastructure, or lack of its effective use; and a discontinuous or non-existent training process.

11.
Eur J Immunol ; 48(11): 1851-1860, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30289564

RESUMO

A novel cell population denominated IFN-γ-producing killer dendritic cells (IKDCs) have been recently described. These cells are lymphocytes lacking B- or T- receptors, but they can be identified by the presence of B220+ CD38+ CD49b+ and low CD11c, among other cell surface markers. The main characteristics of IKDCs are the production of IFN-γ and the ability to spontaneously kill tumor cells. We found that this population increases in B6.MLR-Faslpr /J mice. Interestingly, IKDCs increase with age and are more abundant in mice older than 6 months onward. To analyze whether these cells have any role in the induction of the lupus-like phenotype in the B6.MLR-Faslpr /J mice, IKDCs were purified and transferred into 6-month-old B6.MRL-Faslpr /J mice, then the presence of anti-nuclear antibodies (ANAS) and anti-dsDNA antibodies were analyzed 2 and 4 months after the transfer. The results showed a reduction in the levels of these autoantibodies and increased survival of these mice, indicating that these cells may have a regulatory function. In vitro assays demonstrated that IKDCs reduced the proliferation of both autoreactive B and T cells, suggesting that these may be the mechanisms used by these cells to ameliorate the lupus-like phenotype in the B6.MRL-Faslpr /J mice.


Assuntos
Células Dendríticas/imunologia , Interferon gama/imunologia , Células Matadoras Naturais/imunologia , Lúpus Eritematoso Sistêmico/imunologia , Animais , Anticorpos Antinucleares/imunologia , Autoanticorpos/imunologia , Linfócitos B/imunologia , Proliferação de Células/fisiologia , Feminino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos MRL lpr , Linfócitos T/imunologia
13.
Rev Esp Enferm Dig ; 110(9): 598, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29931984

RESUMO

Hepatic mucinous cystic neoplasms represent a challenging pathology due to their very low frequency, insidious presentation and unclear demography due to the limited cases reported to date. Surgical treatment is mandatory when possible to prevent recurrence and malignant transformation. The case presented herein has a peculiarity, mainly an increased level of CA 19-9 which has not been previously reported.


Assuntos
Neoplasias do Sistema Biliar/patologia , Cistadenoma Mucinoso/patologia , Neoplasias Hepáticas/patologia , Adulto , Neoplasias do Sistema Biliar/diagnóstico por imagem , Neoplasias do Sistema Biliar/cirurgia , Cistadenoma Mucinoso/diagnóstico por imagem , Cistadenoma Mucinoso/cirurgia , Feminino , Hepatectomia , Humanos , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Hepáticas/cirurgia , Tomografia Computadorizada por Raios X
14.
Arch Med Res ; 49(7): 451-455, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30718148

RESUMO

INTRODUCTION: Diabetic nephropathy is a leading cause of chronic kidney disease (CKD). In diabetes, changes in serum levels of both soluble alpha Klotho (sKL) and fibroblast growth factor 23 (FGF-23) have been associated with CKD progression. OBJECTIVE: To evaluate the associations of circulating levels of sKL and FGF-23 with the presence of early nephropathy (EN) in diabetic patients. METHODS: A cross-sectional study in 136 Mexicans with type 2 diabetes mellitus (T2DM). Early nephropathy was defined as an estimated glomerular filtration rate (≥60 ml/min) and urinary albumin excretion (≥30 mg/g). Serum concentrations of sKL and FGF-23 were measured using ELISA. Associations were evaluated with multiple logistic regression. RESULTS: Fifty-two subjects had EN. Median values of sKL and FGF-23 for all individuals were 244 pg/mL (interquartile range [IQR]: 201-402) and 92 pg/mL (IQR: 39-507), respectively. A positive correlation was found between levels of sKL and FGF-23 (r = 0.38; p <0.001). FGF-23 levels correlated negatively with angiotensin-II receptor blocker therapy (ARB, r = 0.24; p <0.01). Subjects without EN were younger (59 vs. 63 years old, p = 0.02). Elevated concentrations of FGF-23 were negatively associated with EN (Odds Ratio [ORadjusted] = 0.29, 95% Confidence Interval [95% CI] = 0.13, 0.65). CONCLUSIONS: In Mexican diabetic patients, serum levels of FGF-23 were positively correlated with sKL but negatively correlated with ARB therapy. In addition, a higher concentration of FGF-23 reduced the odds of early nephropathy in patients with T2DM.


Assuntos
Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/patologia , Nefropatias Diabéticas/sangue , Fatores de Crescimento de Fibroblastos/sangue , Glucuronidase/sangue , Insuficiência Renal Crônica/patologia , Idoso , Estudos Transversais , Nefropatias Diabéticas/patologia , Progressão da Doença , Feminino , Taxa de Filtração Glomerular/fisiologia , Humanos , Masculino , México , Pessoa de Meia-Idade
16.
J Biophotonics ; 10(5): 674-682, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-27273138

RESUMO

The potential use of Gold Nanoparticles (GNPs) as contrast agents for clinical intracoronary frequency domain Optical Coherence Tomography (OCT) is here explored. The OCT contrast enhancement caused by GNPs of different sizes and morphologies has been systematically investigated and correlated with their optical properties. Among the different GNPs commercially available with plasmon resonances close to the operating wavelength of intracoronary OCT (1.3 µm), Gold Nanoshells (GNSs) have provided the best OCT contrast due to their largest scattering cross section at this wavelength. Clinical intracoronary OCT catheters are here demonstrated to be capable of three dimensional visualization and real-time tracking of individual GNSs. Results here included open an avenue to novel application of intravascular clinical OCT in combination with GNPs, such as real time evaluation of intravascular obstructions or pressure gradients.


Assuntos
Vasos Coronários/diagnóstico por imagem , Ouro/análise , Nanopartículas Metálicas/análise , Tomografia de Coerência Óptica , Meios de Contraste/análise , Humanos
17.
Rev Med Inst Mex Seguro Soc ; 55(Suppl 2): S124-32, 2017.
Artigo em Espanhol | MEDLINE | ID: mdl-29697222

RESUMO

In Mexico, as in other parts of the world, end-stage renal disease (ESRD) constitutes a public health problem associated with high morbidity, mortality, costs and a diminished quality of life. The Instituto Mexicano del Seguro Social (IMSS) attends to, approximately, 73% of the Mexican population requiring dialysis or transplant. In 2014, the treatment of ESRD represented 15% of the total annual expenditure of IMSS major program (Disease and Maternity Security), i.e. approximately $13 250 million Mexican pesos (MP); this expense was invested in only 0.8% of patients (those with ERSD). There are few economic evaluation studies showing the real cost of kidney replacement therapies from institution's perspective. In order to reduce the global cost of ESRD, it is necessary to implement appropriate strategies of prevention, diagnosis and treatment to reduce incidence and progression of chronic kidney disease; to intensify research studies for a better understanding of etiological factors, mechanism of kidney damage progression and identification of new therapeutic agents; to create a national kidney disease registry, and to incorporate the economic evaluation methodology in the decision-making, in order to identify improved cost-benefit or cost-effective strategies.


Assuntos
Efeitos Psicossociais da Doença , Custos de Cuidados de Saúde/estatística & dados numéricos , Insuficiência Renal Crônica/economia , Academias e Institutos , Humanos , México/epidemiologia , Insuficiência Renal Crônica/diagnóstico , Insuficiência Renal Crônica/epidemiologia , Insuficiência Renal Crônica/terapia , Previdência Social
18.
Rev Med Inst Mex Seguro Soc ; 55(Suppl 2): S134-42, 2017.
Artigo em Espanhol | MEDLINE | ID: mdl-29697223

RESUMO

Multidisciplinary attention models include the joined and coordinated participation of different professionals within the health team (physicians, nurses, social workers, dietitians, physical trainers, among others). A multidisciplinary approach facilitates and improves management of patients from early chronic kidney disease (CKD) in the primary health-care setting. This approach is a strategy for improving comprehensive care, initiating and maintaining healthy behaviors, promoting teamwork, eliminating barriers to achieve goals and improving the processes of care. A multidisciplinary intervention may include educational processes guided by health professional, use of self-help groups and the development of a CKD management plan. The complex and fragmented care management of patients with CKD, associated with poor outcome, enhances the importance of implementing a multidisciplinary approach in the management of this disease from the early stages. Multidisciplinary strategies should focus on the needs of patients and should be adapted to the resources and health systems; its systematic implementation can help to improve patient care and prevent/slow the progression of CKD.


Assuntos
Assistência à Saúde/métodos , Assistência à Saúde/organização & administração , Gerenciamento Clínico , Equipe de Assistência ao Paciente/organização & administração , Atenção Primária à Saúde/métodos , Atenção Primária à Saúde/organização & administração , Insuficiência Renal Crônica/terapia , Humanos
19.
Rev Med Inst Mex Seguro Soc ; 55(Suppl 2): S167-74, 2017.
Artigo em Espanhol | MEDLINE | ID: mdl-29697238

RESUMO

In Mexico, there is a high prevalence of early nephropathy that usually goes unnoticed and may in part be due to the acquisition of "moderns" negative habits a lifestyle from an early age like physical inactivity, unhealthy diet, smoking and alcohol intake abuse associated with the increasing prevalence of overweight and obesity, diabetes and hypertension, leading causes of chronic kidney disease (CKD) in Mexico. These behaviors are difficult to control by medical intervention alone and may be associated with lack of resources of patients to perform self-care activities and the health care-model predominant in México also may be insufficient to generate healthy behaviors. To improve the care of patients from early stages of CKD, is necessary to implement multidisciplinary strategies to empower the patient and develop their self-efficacy to carry out self-care actions to manage their disease, control risk factors, promotion of healthy habits and modify risk behaviors. Promoting self-care is an area of opportunity with potential benefits to reduce the progression of kidney damage and complications. The aim of this article is to review the main multidisciplinary strategies to promote self-care in patients with early nephropathy in primary health-care.


Assuntos
Promoção da Saúde/métodos , Atenção Primária à Saúde/métodos , Insuficiência Renal Crônica/terapia , Autocuidado/métodos , Progressão da Doença , Comportamentos Relacionados com a Saúde , Humanos , México , Insuficiência Renal Crônica/psicologia
20.
REMHU ; 24(47): 153-174, maio/ago. 2016. ilus
Artigo em Espanhol | Index Psicologia - Periódicos técnico-científicos | ID: psi-70058

RESUMO

Se analiza la migración calificada desde un prisma analítico que hasta ahora había sido esencialmente ignorado en la literatura especializada: la profunda reestructuración que experimentan los sistemas de innovación en el marco de la globalización neoliberal y bajo la batuta de Estados Unidos. Además de dilucidar las principales transformaciones que acusan los sistemas de innovación a nivel mundial, se examina el incremento explosivo que han tenido las patentes en el curso de las últimas dos décadas, el cual ha venido acompañado de una creciente participación de científicos y tecnólogos proveniente de países periféricos y emergentes. A partir de esta mirada analítica y tomando como referente el caso de la migración calificada mexicana, se aportan algunos elementos tendientes a desentrañar las nuevas modalidades de intercambio desigual que emergen en el horizonte Norte-Sur y que tienen como trasfondo una mercantilización y apropiación privada sin precedentes del conocimiento, en tanto bien común intangible.(AU)


Skilled migration is analyzed through an analytical framework that so far has been essentially ignored in the specialized literature on the subject: the deep restructuration process to which innovation systems have been subjected under the context of neoliberal globalization and the leadership of the United States. Besides unraveling the main transformations undertaken by innovation systems worldwide, the explosive growth of patents that has taken place during the last two decades is analyzed. This trend has been accompanied by an increasing participation of scientists and technicians from peripheral and emerging countries. From this particular analytical lens and taking as a reference the Mexican case, several elements aimed at disentangling the new modalities of unequal exchange that have emerged along the North-South divide are provided. At the background of this embryonic trend underlies an unprecedented commodification and appropriation of knowledge, as an intangible common good.(AU)

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