Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 168
Filtrar
1.
J Affect Disord ; 298(Pt A): 357-363, 2021 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-34774645

RESUMO

BACKGROUND: Suicide has become a severe public health issue worldwide. Body weight has been put forward as a potentially modifiable element for suicide thought and behavior. However, there are discrepancies across previous studies. Furthermore, the relationships of body weight with suicidal ideation and suicide attempt among low- and middle-income countries (LMICs) remain unclear. Therefore, we addressed this issue among 104,907 adolescents of 12-15 years old in 45 LMICs. METHODS: The present study used data from the Global School-based Student Health Survey (GSHS). Suicidal ideation and suicide attempt during the last year were self-reported. Participants were classified intro underweight, normal weight, overweight and obesity according to their body mass index classification. Multivariable logistic regression and meta-analyses based on country-wise estimates were conducted. RESULTS: The prevalence of suicidal ideation and suicide attempt were 11.8% and 13.0%, respectively. Countrywide meta-analysis demonstrated that overweight and obesity were significantly associated with increased risks of suicidal ideation (For overweight: OR = 1.10; 95% CI = 1.01-1.20; for obesity: OR=1.17; 95%CI: 1.01-1.35) and suicide attempt (For overweight: OR = 1.12; 95% CI = 1.02-1.23; for obesity: OR=1.12; 95%CI: 1.00-1.25). Subgroup analyses showed that the associations between overweight/obesity and suicide attempt were significant for girls but not for boys. LIMITATIONS: The cross-sectional design cannot explore causality; mental health factors were not assessed; suicidal behaviors were self-reported; significant heterogeneity across countries; only students attending school were included. CONCLUSIONS: Overweight/obesity was significantly associated with the risk of suicidal ideation and suicide attempt among adolescents in LMICs.

2.
Bioengineering (Basel) ; 8(11)2021 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-34821728

RESUMO

Stem cells have the capacity to self-renew and differentiate to specialized cells, which are usually sensitive to cryopreservation. Therefore, the cell survival rate of stem cells using common cryopreservation protocol is generally not ideal. High cooling rates are crucial for decreasing the usage of cryoprotectants (CPAs) and promoting the successful vitrification of stem cells. In this study, we adopted liquid helium (LHe) instead of liquid nitrogen (LN2) as the cryogen to achieve high cooling rates for vitrifying stem cells with high viability and complete functions. A numerical model was established to simulate the cooling processes of vitrifying specimens by immersing them in LHe and LN2. The calculated results revealed higher cooling rates when plunging specimens into LHe than into LN2. The high viability of human bone-derived mesenchymal stem cells (hBMSCs) and human embryonic stem cells (hESCs) after vitrifying into LHe also shows the superiority of LHe as the cryogen. Furthermore, considerable cell viability was achieved by vitrification in LHe, even when decreasing the concentrations of CPAs. Additionally, post-vitrification, the cells still maintained high attachment and proliferation efficiency, normal stemness, and multipotential differentiation both for hBMSCs and hESCs. LHe is prospective to be employed as a universal cryogen for vitrification which has a great potential for widespread applications, including bioengineering and clinical medicine.

3.
Artigo em Inglês | MEDLINE | ID: mdl-34783871

RESUMO

The CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6), which binds to the programmed death ligand 1 (PD-L1) and stabilizes the expression of PD-L1 on the cell surface, has been recently discovered as a novel regulator of PD-L1 expression in cancer. PD-L1 is an immune checkpoint inhibitory molecule that can mediate the immune escape of tumor cells in various tumors and has been studied intensively in recent years. In 2017, two articles simultaneously reported that CMTM6 can stabilize the expression of PD-L1 on the plasma membrane and prevent PD-L1 from being degraded by lysosomes; therefore, CMTM6 may play an important role in tumor cell immune escape and immunosuppression. At present, there are few studies on the relationship between the expression of CMTM6 and PD-L1 in different tumors and diseases. These studies together suggested that CMTM6 may be a potential novel immunotherapy target. In this review, we briefly describe the latest research progresses of CMTM6 in various cancers and other diseases.

4.
Front Oncol ; 11: 683007, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34671548

RESUMO

Background: Primary central nervous system lymphoma (PCNSL) is characterized by a lack of specificity and poor prognosis. Further understanding of the tumor heterogeneity and molecular phenotype of PCNSL is of great significance for improving the diagnosis and treatment of this disease. Methods: To explore the distinct phenotypic states of PCNSL, transcriptome-wide single-cell RNA sequencing was performed on 34,851 PCNSL cells from patients. The cell types, heterogeneity, and gene subset enrichment of PCNSL were identified. A comparison of the PCNSL cells with 21,250 normal human fetal brain (nHFB) cells was further analyzed to reveal the differences between PCNSL and normal sample. Results: Six cell populations were mainly identified in the PCNSL tissue, including four types of immune cells-B cell, T cell, macrophage and dendritic cell-and two types of stromal cells: oligodendrocyte and meningeal cell. There are significant cellular interactions between B cells and several other cells. Three subpopulations of B cells indicating diffident functions were identified, as well as a small number of plasma cells. Different subtypes of T cells and dendritic cells also showed significant heterogeneity. It should be noted that, compared with normal, the gene expression and immune function of macrophages in PCNSL were significantly downregulated, which may be another important feature of PCNSL in addition to B cell lesions and may be a potential target for PCNSL therapy.

5.
Artigo em Inglês | MEDLINE | ID: mdl-34583911

RESUMO

Mammalian target of rapamycin (mTOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant (LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival (RFS) in hepatocellular carcinoma (HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specific for the first 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefits for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data. Trial register: Trial registered at http://www.chictr.org.cn: ChiCTR2100042869.

6.
Clin Lab ; 67(9)2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34542971

RESUMO

BACKGROUND: The aim was to probe the association of pleural effusion with lung infection in patients with liver transplantation and to provide a theoretical foundation for preventing, diagnosing, and remedying pulmonary complications after liver transplantation. METHODS: Our team harvested clinical data of patients undergoing orthotopic allogeneic liver transplantation complicated with pleural effusion after surgery in our institution from May 2018 to July 2019. Based on whether puncture drainage was needed, patients were allocated to either control group or observation group. The differences in pleural effusion depth, lung function, lung infection, serum inflammatory factor levels and 6-month survival before and after surgery were compared. Finally, ROC curves were constructed for dissecting the correlation of pleural effusion with lung infection. RESULTS: On day 3 after surgery, (1) pleural effusion depth of the observation group was 5.70 ± 1.20 cm, which was saliently greater than that of control group (p < 0.05); (2) in comparison to control group, lung function indexes FVC, FEV1.0, MVV, and PaO2 of observation group declined (all p < 0.05); (3) sputum culture evinced that the lung infection rates of the control group and observation group were 17.24% and 71.70%, respectively, and the observation group harbored brilliantly higher infection rate (p < 0.05); (4) in comparison to the control group, IL-6, IL-8, and TNF-α in observation group were increased (p < 0.05); (5) AUC of pleural effusion depth and lung infection was 0.849, 0.805, and 0.853, respectively on days 1, 2, and 3 after surgery. CONCLUSIONS: A positive correlation existed between pleural effusion and lung infection after liver transplantation. When patients have persistent pleural effusion, the incidence of lung infection should be prevented and reduced.


Assuntos
Transplante de Fígado , Derrame Pleural , Pneumonia , Drenagem , Humanos , Transplante de Fígado/efeitos adversos , Pulmão , Derrame Pleural/diagnóstico , Derrame Pleural/etiologia
7.
Ecotoxicol Environ Saf ; 223: 112606, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34365211

RESUMO

Heavy metal(loid) contamination represents an immense challenge in sustainable agriculture. Arsenic, in particular, poses a great risk to the quality of agricultural products (e.g., rice grain). The sulfur amendment is recommended as an effective practice to remediate heavy metal(loid)-polluted soil, given its function in enhancing crop production and alleviating heavy metal(loid) accumulation in the plant. This study aims to investigate the roles of sulfur fertilizer on arsenic accumulation in rice and to explore the key mechanisms. In this study, Elemental sulfur (ES) and gypsum sulfur (GS) were chosen as sulfur fertilizers, with different application rates (0, 0.15, and 0.30 g S kg-1 soil). The results showed that ES and GS treatment significantly increased rice grain yield by 46.6-59.7% and significantly reduced the rice grain arsenic content by more than 39.1%. The sulfur treatment decreased soil pe + pH values. ES treatment increased the availability of arsenic in the bulk soil, whereas GS showed little effect. Sulfur application promoted the formation of iron and manganese plaques, which could suppress the migration of arsenic from soil to rice root. In addition, the sulfur treatment decreased the arsenic that migrating from rice roots to grains by 33.3-66.7%. This study indicates that sulfur application could increase arsenic availability in paddy soil; however, it can inhibit arsenic accumulation in rice grains via increasing the root plaques content and inhibiting the translocation of arsenic from roots to grains.


Assuntos
Arsênio , Oryza , Poluentes do Solo , Arsênio/análise , Cádmio/análise , Sulfato de Cálcio , Fertilizantes , Solo , Poluentes do Solo/análise , Enxofre
8.
Int J Pharm ; 607: 120967, 2021 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-34352336

RESUMO

The cutaneous biodistribution method (CBM) yields a high-resolution quantitative profile of drug deposition as a function of skin depth. However, it provides limited details about drug spatial distribution or penetration pathways. Mass spectrometry imaging (MSI) can complement the detailed quantitative data generated by CBM studies. The objectives of this work were to use desorption electrospray ionization (DESI)-MSI to (i) investigate the spatial cutaneous distributions of a topically applied drug and excipient and relate them to skin structures and (ii) image endogenous skin components and combine these results to gain insight into drug penetration routes. Porcine skin was used to compare two bioequivalent creams of econazole nitrate (ECZ) and a micelle formulation based on D-α-tocopheryl succinate polyethylene glycol 1000 (TPGS). DESI-MSI successfully imaged the cutaneous spatial distribution of ECZ and TPGS in 40 µm-thick horizontal sections and vertical cross-sections of the skin. Interestingly, clinically bioequivalent formulations did not appear to exhibit the same molecular distribution of ECZ in XY-horizontal sections. DESI-MSI also enabled visualization of TPGS (m/z 772.4706), mainly in the upper epidermis (≤80 µm). In conclusion, through co-localization of drugs and excipients with endogenous elements of the skin, DESI-MSI could further our understanding of the cutaneous penetration pathways of xenobiotics.


Assuntos
Espectrometria de Massas por Ionização por Electrospray , Xenobióticos , Animais , Lipídeos , Pele , Suínos , Distribuição Tecidual
9.
Biomacromolecules ; 2021 Aug 11.
Artigo em Inglês | MEDLINE | ID: mdl-34378928

RESUMO

The cryopreservation (CP) of cell/tissue is indispensable in medical science. However, the formation of ice during cooling and ice recrystallization/growth in time of thawing present significant risk of cell/tissue damage upon analysis of CP process. Herein, the natural and biocompatible silk fibroin (SF) with regular hydrophobic and hydrophilic domains, were first employed as a cryoprotectant (CPA), to the CP of human bone-derived mesenchymal stem cells (hBMSCs), which has been routinely cyropreserved for cell-based therapies. Addtion of SF can regulate the formation of ice crystals during cooling process because of its strong hydration ability in the comparation to the cryopreservation medium (CM) without SF. Moreover, the devitrification-induced recrystallization/growth of ice during the thawing process is suppressed. Most importantly, the addition of 10 mg mL-1 SF can achieve 81.28% cell viability of cryopreserved hBMSCs as similar as those with the addition of 180 mg mL-1 Ficoll 70 (commercial CPA), and the functions of the cryopreserved hBMSCs are maintained as good as that of the fresh ones. This work is not only significant for meeting the ever-increasing demand of cell therapy, but also trailblazing for designing materials in controlling ice formation and growth during the CP of other cells and tissues.

10.
J Org Chem ; 86(17): 11998-12007, 2021 09 03.
Artigo em Inglês | MEDLINE | ID: mdl-34404211

RESUMO

A visible-light photoredox-catalyzed sulfonyl lactonization of unsaturated carboxylic acids with sulfonyl chlorides is described. This reaction features good functional group tolerance and a broad substrate scope, providing a simple and efficient protocol to access a wide range of sulfonyl lactones in high to excellent yields. Preliminary mechanistic investigations suggested that a free-radical pathway should be involved in the process.


Assuntos
Cloretos , Lactonas , Ácidos Carboxílicos , Catálise , Luz
11.
Risk Manag Healthc Policy ; 14: 3037-3056, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34321939

RESUMO

Objective: Sufficient amounts of basic medical materials and high-end medical equipment are required for epidemics. This study aims to investigate and determine the key risks and main factors influencing China's high-end medical equipment innovations using a SWOT (Strengths, Weaknesses, Opportunities, Threats) matrix. Then, on the basis of findings and relevant literature concerning the development of China's high-end medical equipment in recent years, especially during the COVID-19 period, we put forward strategies for the development of and innovations in high-end medical equipment for China, based on an analytic network process ANP-SWOT model. Methods: In this study, a comprehensive ANP-SWOT analysis model was selected to examine the current state of development of the high-end medical equipment innovation industry in China. First, a SWOT model was used to comprehensively analyze the internal and external factors influencing the development of the industry. Then, an ANP network structure was designed to accurately reflect the relationships among the influencing factors. Subsequently, weights for the influencing factors were determined according to the importance of the factors, and alternative choices for China's strategy for high-end medical equipment innovation were presented. Results: The results revealed that the essential features of the best strategy for the innovation and development of China's high-end medical equipment industry were as follows: first, speeding up the construction and improvement of a technological innovation system that is enterprise-dominated, market-oriented, and involves joint industry-university research; second, a greater focus on increasing the financial support for research and development and industrialization; and third, strong government support through taxes, medical insurance, promotion of talent, and appropriate land usage. Conclusion: Strong governmental support through taxes, medical insurance, promotion of talent, and land usage is required to ensure rapid development of the high-end medical equipment industry in China.

12.
Trends Biotechnol ; 2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34238601

RESUMO

Cryopreservation can help to meet the demand for biosamples of high medical value. However, it remains difficult to effectively cryopreserve some sensitive cells, tissues, and reproductive organs. A coordinated effort from the perspective of the whole frozen biological system is necessary to advance cryopreservation technology. Animals that survive in cold temperatures, such as hibernators and cold-tolerant insects, offer excellent natural models. Their anti-cold strategies, such as programmed suppression of metabolism and the synthesis of cryoprotectants (CPAs), warrant systematic study. Furthermore, the discovery and synthesis of metabolism-regulating and cryoprotective biomaterials, combined with biotechnological breakthroughs, can also promote the development of cryopreservation. Further advances in the quality and duration of biosample storage inspired by nature will promote the application of cryopreserved biosamples in clinical therapy.

13.
J Org Chem ; 86(15): 10580-10590, 2021 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-34314188

RESUMO

A copper-catalyzed intermolecular electrophilic amination of benzamides with O-benzoyl hydroxylamines was achieved with the assistance of an 8-aminoquinolyl group. With this protocol, good compatibility was observed for a variety of aryl amides and heteroaryl amides, and excellent tolerance with various functional groups was achieved. Significantly, the monoaminated product was overwhelmingly delivered under the simple reaction conditions. Preliminary mechanistic investigations suggested that a radical pathway should be excluded and C-H activation be potentially the rate-determining step.

14.
Appl Opt ; 60(17): 5056-5065, 2021 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-34143071

RESUMO

Combined with computed tomography (CT), the laser absorption spectroscopy technique is used to measure the two-dimensional distribution information of the flow field. The CT method needs an "integral parameter" as a known quantity. The integrated absorbance satisfies the criterion in the laser absorption spectral measurement. The direct absorption spectroscopy method directly measures the integrated absorbance. However, fitting the absorbance curve is difficult due to the distorted baseline in harsh environments. By contrast, the wavelength modulation spectroscopy (WMS) method has satisfactory noise rejection capability. The difficulty that introduces WMS method to measure the non-uniform flow distribution is the integrated absorbance cannot be written in a mathematical expression. Previous efforts focused on solving the average temperature, concentration, and pressure and recalculating the integrated absorbance. This paper aims to develop an integrated absorbance measurement based on the calibration-free WMS method for non-uniform flow, which is called the calibration-free WMS-A method. First, the relationship between the transmissivity and integrated absorbance was established. Then, integrated absorbance was written into the WMS harmonic signals and solved by comparing the measured and simulated signals. The systematic comparison between the WMS-A and the previous WMS method showed the effectivity of the WMS-A method for non-uniform flow measurement. The reliable integrated absorbance can considerably improve the two-dimensional reconstruction quality.

15.
World J Clin Cases ; 9(15): 3765-3772, 2021 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-34046481

RESUMO

BACKGROUND: Liver transplantation (LT) is the most effective treatment strategy for advanced liver diseases. With the increasing survival rate and prolonged survival time, the postoperative long-term complications of LT recipients are becoming an important concern. Among them, the newly developed cancer after LT is the second complication and cause of LT-related death after cardiovascular disease. At present, few papers have reported multiple primary carcinomas (MPCs) after LT. Herein, we retrospectively analyzed an MPC case with gastric cancer and lung cancer after LT. CASE SUMMARY: Herein, we retrospectively analyzed an MPC case with de novo gastric cancer and lung cancer after LT with no obvious complaints. Forty-one months after LT, the patient underwent radical distal gastrectomy (Billroth II) for intramucosal signet ring cell carcinoma, and then thoracoscopic wedge resection of the right lower lobe of the right lung and localized lymph node dissection 2 mo later. Therefore, paying attention to follow-up in LT recipients with early detection and intervention of de novo MPCs is the key to improving the survival rate and quality of life of LT recipients. CONCLUSION: De novo MPCs after LT are rare, and the prognosis is poorer. However, early detection and related intervention can significantly improve the prognosis of patients. Therefore, we recommend that liver transplant recipients should be followed and screened for newly developed malignant tumors to improve the survival rate and quality of life.

16.
Neurol Sci ; 2021 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-34052937

RESUMO

OBJECTIVE: Bipolar disorder (BD) may be associated with an increased risk of stroke, but to date, the results of the studies are still controversial. This study aimed to assess the association of BD with stroke incidence and mortality by a meta-analysis. METHOD: PubMed, EMBASE, the Cochrane library databases, and Web of Science databases were searched from inception to July 2020. We regarded stroke as a composite endpoint. The pooled hazard ratio (HRs) of 95% confidence interval (Cls) was calculated. Subgroup and sensitivity analyses were performed to assess the potential sources of heterogeneity of the pooled estimation. RESULTS: A total of 7 studies involving a total of 13,305,007 participants were included in this meta-analysis. Pooled analysis showed participants with BD experienced a significantly increased risk of both stroke incidence (combined HR, 1.43; 95% CI, 1.24-1.66; p = 0.000) and stroke mortality (combined HR, 1.54; 95% CI, 1.09-2.18; p = 0.013) compared to participants without BD. In addition, the pooled estimate of multivariate HRs of stroke incidence and mortality were 1.35 (95% CI: 1.26-1.45); 2.30 ( 95% CI: 1.37-3.85) among men and 1.43 (95% CI:1.27-1.60); 2.08 (95% CI:1.60-2.71) among women respectively. CONCLUSIONS: This meta-analysis suggests that BD may modestly increase the risk of both stroke incidence and mortality. Extensive clinical observational studies should be conducted in the future to explore whether BD is a potentially modifiable risk factor for stroke.

17.
Nanoscale ; 13(19): 8817-8836, 2021 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-33960346

RESUMO

Transcatheter arterial chemoembolization (TACE) has become one of the preferred choices for advanced liver cancer patients. Current clinically used microsphere embolic agents, such as PVA, gelatin, and alginate microspheres, have limited therapeutic efficacy and lack the function of real-time imaging. In this work, we fabricated magnetic liquid metal nanoparticle (Fe@EGaIn NP) loaded calcium alginate (CA) microspheres (denoted as Fe@EGaIn/CA microspheres), which integrate CT/MR dual-modality imaging and photothermal/photodynamic functions of the Fe@EGaIn NP core, as well as embolization and drug-loading functions of CA microspheres. Namely, such nano-in-micro spheres can be used as fully flexible theranostic agents to achieve smart-chemoembolization. It has been confirmed by in vitro and in vivo experiments that Fe@EGaIn/CA microspheres have advantageous morphology, favorable biocompatibility, splendid versatility, and advanced embolic efficacy. Benefiting from these properties, excellent therapeutic efficiency was achieved with a tumor growth-inhibiting value of 100% in tumor-bearing rabbits. As a novel microsphere embolic agent with promising therapeutic efficacy and diagnostic capability, Fe@EGaIn/CA microspheres have shown potential applications in clinical transcatheter arterial chemoembolization. And the preparation strategy presented here provides a generalized paradigm for achieving multifunctional and fully flexible theranostics.


Assuntos
Carcinoma Hepatocelular , Quimioembolização Terapêutica , Neoplasias Hepáticas , Animais , Carcinoma Hepatocelular/diagnóstico por imagem , Carcinoma Hepatocelular/tratamento farmacológico , Humanos , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Hepáticas/tratamento farmacológico , Fenômenos Magnéticos , Microesferas , Medicina de Precisão , Coelhos
18.
J Org Chem ; 86(12): 8437-8447, 2021 Jun 18.
Artigo em Inglês | MEDLINE | ID: mdl-34042441

RESUMO

An efficient transition-metal-free decarboxylative cyclization of N-arylacrylamides with 2,2-difluoro-2-(phenylthio)acetic acid for the construction of thiodifluoroindoleone derivatives is described. This strategy features stable and readily available substrates, mild reaction conditions, and transition-metal-free catalysts. Notably, this protocol has successfully applied to synthesis of gem-difluoroalkenes, which exist in numerous biologically active compounds.

19.
Nano Lett ; 21(11): 4868-4877, 2021 06 09.
Artigo em Inglês | MEDLINE | ID: mdl-33819045

RESUMO

Ice nucleators are of crucial and important implications in various fields including chemistry, climate, agriculture, and cryobiology. However, the complicated extract and biocompatibility of ice nucleators remain unresolved, and the mechanism of ice nucleation remains largely unknown. Herein, we show that natural nanocrystalline cellulose materials possess special properties to enhance ice nucleation and facilitate needle-like ice crystal growth. We reveal the molecular level mechanism that the efficient exposure of cellulose hydroxyl groups on (-110) surface leads to faster nucleation of water. We further design chitosan-decorated cellulose nanocrystals to accomplish molecular cryoablation in CD 44 high-expression cells; the cell viability shows more than ∼10 times decrease compared to cryoablation alone and does not show evident systematic toxicity. Collectively, our findings also offer improved knowledge in molecular level ice nucleation, which may benefit multiple research communities and disciplines.


Assuntos
Gelo , Nanopartículas , Celulose , Cristalização , Congelamento , Terapia de Alvo Molecular
20.
Minerva Surg ; 2021 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-33890441

RESUMO

BACKGROUND: To probe the association of pleural effusion with lung infection of patients with liver transplantation, and to provide a theoretical foundation for preventing, diagnosing and remedying pulmonary complications after liver transplantation. METHODS: Our team harvested clinical data of patients undergoing orthotopic allogeneic liver transplantation complicated with pleural effusion after surgery in our institution from May 2018 to July 2019. Based on whether puncture drainage was needed, patients were allocated to either control group or observation group. The differences in pleural effusion depth, lung function, lung infection, serum inflammatory factor levels and 6-month survival before and after surgery were compared. Finally, ROC curves were constructed for dissecting the correlation of pleural effusion with lung infection. RESULTS: On day 3 after surgery, (1) pleural effusion depth of the observation group was (5.70±1.20) cm, which was saliently greater than that of control group (P<0.05); (2) in comparison to control group, lung function indexes FVC, FEV1.0, MVV and PaO2 of observation group declined (all P<0.05); (3) sputum culture evinced that the lung infection rates of control group and observation group were 17.24% and 71.70% separately, and observation group harbored brilliantly higher infection rate (P<0.05); (4) in comparison to control group, IL-6, IL-8, TNF-α contents in observation group augmented (P<0.05); (5) AUC of pleural effusion depth and lung infection was 0.849, 0.805 and 0.853 separately on days 1, 2, 3 after surgery. CONCLUSIONS: A positive correlation is existed between pleural effusion and lung infection after liver transplantation. When patients have persistent pleural effusion, the incidence of lung infection should be prevented and reduced.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...