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Nanoscale ; 10(38): 18398-18406, 2018 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-30256373

RESUMO

Iron oxide nanomaterials have been intensively investigated over the past few decades as magnetic resonance imaging (MRI) contrast agents (CAs) due to their favorable magnetism and excellent biocompatibility. However, commercial iron-oxide-nanoparticle-based CAs suffer from low T2 relaxivity, which significantly limits their applications in the biomedical field. Herein, we report a new type of iron oxide nanoplate (IOP) with an interesting twinning plane, which is fabricated via seed growth. Compared with the conventional iron oxide (IO) spherical nanoparticles, iron oxide twin nanoplates (IOP-13) have a larger effective radius, higher saturation magnetization, and greater anisotropy, resulting in their superior T2 relaxivity of 571.21 mM-1 s-1 at 0.5 T, which is about six times higher than that of commercial IO nanoparticles. In vivo MR imaging demonstrated that IOP-13 could be used for liver imaging and liver tumor diagnosis with high sensitivity and accuracy, revealing the great potential of IOP-13 as a next-generation CA. This work provides a novel strategy of structure tuning to devise high-performance T2 contrast agents, which expands the applications of iron oxide nanoparticles in biology and materials.


Assuntos
Meios de Contraste/química , Compostos Férricos/química , Imagem por Ressonância Magnética/métodos , Nanopartículas Metálicas/química , Animais , Linhagem Celular Tumoral , Meios de Contraste/administração & dosagem , Meios de Contraste/síntese química , Humanos , Neoplasias Hepáticas Experimentais/diagnóstico por imagem , Neoplasias Hepáticas Experimentais/patologia , Nanopartículas Metálicas/administração & dosagem , Nanopartículas Metálicas/ultraestrutura , Camundongos Endogâmicos BALB C , Sensibilidade e Especificidade , Testes de Toxicidade Aguda
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