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1.
BMC Ecol Evol ; 21(1): 47, 2021 Mar 20.
Artigo em Inglês | MEDLINE | ID: mdl-33743581

RESUMO

BACKGROUND: Sexual dimorphism is widespread in insects. The certain specialized structures may be used as weapons in male-male combats or as ornaments to enhance mating opportunities. RESULTS: We report striking swollen first tarsal segments in two families, four genera and six species of scorpionflies from the Middle Jurassic Yanliao Biota of Northeastern China. Swollen tarsal segments are restricted to male specimens and to hind leg tarsi. The geometric morphometric analyses reveal that the degree of swelling within the orthophlebiid species possessing swollen first metatarsal segments is species-specific, which can be used as a diagnostic character for taxonomic and phylogenetic studies. CONCLUSIONS: The new findings indicate that swollen first metatarsal segments are relatively common in the family Orthophlebiidae during the Middle Jurassic. The tarsal swellings are considered to be sexually dimorphic, potentially associated with sexually display by males and/or camouflage of a "nuptial gift" in the mating process.

2.
Soc Indic Res ; : 1-36, 2021 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-33716383

RESUMO

This paper innovatively expands China's human development index under the background of development concept in the new era, constructs the index system of China's human development index (CHDI) with four core dimensions of "life span, education, income and sustainable development" and measures the human development level of 31 provinces and the whole country from 1990 to 2017. Using the method of exploratory spatial data analysis (ESDA), this paper studies the spatiotemporal evolution characteristics of CHDI in 31 provinces from 1990 to 2017 and discusses the mechanism of CHDI in China. The results show that: ① CHDI in eastern China is obviously ahead of other regions and there is a big gap in human development among different regions. CHDI of 31 provinces had positive spatial correlation, showing significant spatial aggregation effect. ② In addition to its own influencing factors, the CHDI of a province is also affected by the CHDI of its "neighboring" provinces. ③ Urbanization rate, per capita financial expenditure on education and the number of health professionals are the three main positive driving factors of China's CHDI and the per capita carbon emission is the main reverse driving factor. This study provides policy suggestions for improving the level of human development in China and realizing regional balanced development.

3.
Clin Otolaryngol ; 2021 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-33655689

RESUMO

OBJECTIVES: To identify genes that are related to delayed endolymphatic hydrops (DEH) in patients by RNA-Seq analysis. DESIGN: Observational study. SETTING: Eye & ENT Hospital, Fudan University (Shanghai, China). PARTICIPANTS: We collected the entire vestibular system from four patients with DEH who underwent labyrinthectomy. Three control samples were collected from patients with acoustic neuroma or facial neuroma treated via the translabyrinthine approach. High-throughput RNA-Seq analysis was performed to investigate gene expression in the pathological vestibular system. MAIN OUTCOME MEASURES: Our bioinformatic analysis identified 17 genes that were upregulated and eight genes that were downregulated in patients with DEH compared with the controls. RESULTS: The altered gene expression profile suggested that DEH is closely related to neuropathy and autoimmune disease. In addition, many of the differentially regulated genes were involved in cell adhesion, suggesting a role of cell adhesion in DEH. Immunofluorescence analysis confirmed the expression of PMP2 and CLDN19 in the cytoplasm of hair cells and scattered expression of MPZ at cell junctions. The protein expression levels were higher in specimens from patients with Ménière's disease and DEH compared with controls. CONCLUSIONS: The protein expression profile of vestibular organs in patients with endolymphatic hydrops exhibited a degree of similarity to that of Ménière's disease. Endolymphatic hydrops is characterised by autoimmune abnormalities. DEH and Ménière's disease are likely to be different manifestations of the same disease, with disparate clinical symptoms. RNA-Seq is a useful analytical tool to characterise the vestibular pathology based on its transcriptome.

4.
J Orthop Surg Res ; 16(1): 158, 2021 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-33632253

RESUMO

BACKGROUND: This study was done to observe the incidence of Osteo-line on the femur neck and to explore the clinical application of Osteo-line in osteotomy. METHODS: Eighty-nine adult femur specimens were selected to observe the incidence of Osteo-line on the femur neck. From August 2015 to January 2019, a total of 278 patients who completed unilateral hip arthroplasty at the Third Hospital of Hebei Medical University were retrospectively included. Patients who accepted osteotomy via Osteo-line on the femur neck were defined as the experimental group (n = 139), and patients who accepted osteotomy via traditional method (The femoral distance 1.5 cm above the trochanter was retained for osteotomy by visual inspection.) were defined as the control group (n = 139). According to the postoperative pelvic X-ray, Photoshop was used to evaluate the leg length discrepancy (LLD) by the CFR-T-LT method. RESULTS: Among the 89 specimens, the incidence of anterior Osteo-line was 75.28%, and the incidence of posterior Osteo-line was 100%. According to the clinical application results, the incidence of anterior Osteo-line on the femur neck was 80%, and the incidence of posterior Osteo-line was 100%. The Osteo-line was clearer than those on the femoral specimens. Twenty-six cases had LLD greater than 1 cm (9.29%), including 2 cases in the experimental group and 24 cases in the control group. The average postoperative LLD in the experimental group (0.19 ± 0.38 mm) was significantly shorter than in the control group (0.54 ± 0.51 mm)(P = 0.005). CONCLUSION: The incidence of Osteo-line on the femur neck was high, and patients who accepted osteotomy via Osteo-line on the femur neck can achieve shorter postoperative LLD than the control group.

5.
Mol Med ; 27(1): 19, 2021 02 26.
Artigo em Inglês | MEDLINE | ID: mdl-33637048

RESUMO

BACKGROUND: Osteoporosis is a common phenomenon in HIV patients on tenofovir treatment, but its underlying mechanisms remain to be explored. METHODS: Quantitative real-time PCR was performed to analyze the expression of miR-302, miR-101, miR-145 and osteoclast-specific genes in the serum of HIV patients treated with tenofovir and ZOL. ELISA was used to evaluate the expression of RANKL, SMAD3 and PRKACB in the serum of these patients. Luciferase assay was carried out to explore the inhibitory effects of miR-302, miR-101 and miR-145 on the expression of PRKACB, RANKL and SMAD3, respectively. Western blot was used to examine the expression of genes involved in NF­κB and JNK signaling pathways. RESULTS: ZOL treatment significantly suppressed the expression of CTx and osteocalcin in HIV patients treated with tenofovir. The BMD loss of HIV patients treated with tenofovir was effectively hindered by ZOL treatment. Mechanistically, the expression of miR-302, miR-101, miR-145, RANKL, SMAD3 and PRKACB in the serum was remarkably activated by ZOL treatment. Luciferase assays showed that miR-302, miR-101 and miR-145 effectively suppressed the expression of PRKACB, RANKL and SMAD3, respectively, through binding to their 3' UTR. Furthermore, ZOL treatment notably restored the normal expression of osteoclast­specific genes while activating NF­κB and JNK signaling pathways. CONCLUSION: The findings of this study demonstrated that administration of ZOL suppressed the expression of RANKL via modulating signaling pathways of miR-101-3p/RANKL, miR-302/PRKACB/RANKL and miR-145/SMAD3/RANKL. Furthermore, down-regulated expression of RANKL by ZOL treatment alleviated osteoporosis in HIV-positive subjects treated with tenofovir.

6.
J Hazard Mater ; 401: 123434, 2021 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-32763715

RESUMO

Rice straw returning causes a considerable amount of dissolved organic matter (DOM) release into aquatic croplands in a relatively short-term. The presence of rice straw-derived DOM in cropland waters may alter the photochemical behaviors of organic pollutants. However, the photochemical activity and photosensitization role of the DOMs are poorly understood. Here, eight DOM samples were extracted from decomposing rice straw at different times in 49 days to explore their photosensitizing capacities toward diuron (DIU), 17ß-estradiol (E2), and sulfamethoxazole (SMX). All of the DOMs were photosensitive and mainly composed of tryptophan-, tyrosine- and fulvic-like substances. Over the decomposition period, the amount of photochemically produced reactive intermediates (PPRIs) by the DOMs peaked on days 7 and 14. The evolution of the DOM photosensitizing capacity towards DIU and E2 was consistent with the variations of PPRIs, and HO· was confirmed as a critical factor. However, the influence of the DOMs on SMX photodegradation was opposite to that on DIU and E2. The positive role of the DOMs in SMX photodegradation was attributed to the tryptophan-like components. The results suggest that straw-derived DOM is an important photosensitizer and that its photosensitization towards organic pollutants is dependent on straw decomposing time and pollutant type.

7.
Medicine (Baltimore) ; 99(49): e23260, 2020 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-33285701

RESUMO

This retrospective study assessed the feasible effect of Yiqihuoxue Formula (YQHXF) for the treatment of patients with ischemic stroke (IS).A total of 66 patients with IS were included in this retrospective study. All patients received routine treatment, and were divided into two groups: a treatment group (n = 33) and a control group (n = 33). In addition to the routine treatment, all patients in the treatment group also underwent YQHXF treatment. All patients in both groups were treated for a total of 8 weeks. The outcomes were assessed by National Institute of Health Stroke Scale (NIHSS), modified Rankin scale (mRS), Barthel index scale (BIS), stroke-specific quality of life (SS-QOL) scale, and adverse events. All outcomes were measured before and after the treatment.After treatment, patients in the treatment group showed better improvements in NIHSS scale (P = .01), mRS (P < .01), BIS (P = .04), and SS-QOL scale (P = .04), than patients in the control group. No treatment-associated adverse events were recorded in this study.The results of this study indicated that YQHXF may benefit for patients with IS.

8.
J Appl Biomater Funct Mater ; 18: 2280800020975172, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33307948

RESUMO

BACKGROUND: Poly Ether Ether Ketone (PEEK) has been considered as a potential alternative material for endosseous dental implants, for its low elastic modulus, biocompatibility, and low cost in customized device manufacture. Hydroxyapatite-incorporation is supposed to improve the poor osseointegration of PEEK. METHODS: In the present study we analyzed the in vivo response of hydroxyapatite-incorporated PEEK (PEEK-HA) implants in canine tibia. PEEK-HA and PEEK implants were implanted and were examined 4 weeks and 12 weeks after implantation with radiology and histology. Commercial titanium dental implants served as controls. RESULTS: The ratio of bone volume to tissue volume of PEEK-HA implants was higher than that of PEEK implants 4 weeks after implantation in the µ-CT analysis. The bone implant contact of PEEK and PEEK-HA implants showed no statistical difference in the histological examination, but newly-formed bone around PEEK-HA implants showed more signs of mineralization than that around PEEK implants. CONCLUSION: The study suggested that bone formation was improved with hydroxyapatite-incorporation in PEEK. Hydroxyapatite-incorporated PEEK implants may represent a potential material for endosseous dental implant.

9.
Med Sci Monit ; 26: e928788, 2020 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-33338031

RESUMO

BACKGROUND Diabetic wound (DW) treatment is a serious challenge for clinicians, and the underlying mechanisms of DWs remain elusive. We sought to identify the critical genes in the development of DWs and provide potential targets for DW therapies. MATERIAL AND METHODS Datasets of GSE38396 from the Gene Expression Omnibus (GEO) database were reviewed. Pathway analysis was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology term analyses were carried out, and Cytoscape software (Cytoscape 3.7.2) was used to construct the protein interaction network. Serum samples from patients with diabetes and control participants were collected, and the expression of estrogen receptor 1 (ESR1) was measured by quantitative reverse-transcription polymerase chain reaction. In addition, the function of ESR1 in human skin fibroblasts was investigated in vitro. RESULTS Eight samples were analyzed using the Morpheus online tool, which identified 637 upregulated and 448 downregulated differentially expressed genes. The top 5 KEGG pathways of upregulated differentially expressed genes were associated with sphingolipid metabolism, estrogen signaling, ECM-receptor interaction, MAPK signaling, and PI3K-Akt signaling. The hub genes for DWs were JUN, ESR1, CD44, SMARCA4, MMP2, BMP4, GSK3B, WDR5, PTK2, and PTGS2. JUN, MMP2, and ESR1 were the upregulated hub genes, and ESR1 was found to be consistently enriched in DW patients. Inhibition of ESR1 had a stimulative role in human skin fibroblasts. CONCLUSIONS ESR1 was identified as a crucial gene in the development of DWs, which suggests potential therapeutic targets for DW healing.


Assuntos
Complicações do Diabetes/genética , Receptor alfa de Estrogênio/genética , Fibroblastos/metabolismo , Úlcera Cutânea , Células Cultivadas , Bases de Dados Genéticas , Regulação da Expressão Gênica , Ontologia Genética , Humanos , Transdução de Sinais , Úlcera Cutânea/etiologia , Úlcera Cutânea/genética , Úlcera Cutânea/metabolismo , Cicatrização/genética
10.
J Nat Prod ; 83(10): 2817-2830, 2020 10 23.
Artigo em Inglês | MEDLINE | ID: mdl-33001650

RESUMO

A pair of enantiomeric 15-nordolabellane diterpenoids, (-)- and (+)-caseadolabellols A (1a and 1b), three dolabellane diterpenoids, caseadolabellols B-D (2-4), two dolastane diterpenoids, caseadolastols A and B (5 and 6), 10 clerodane diterpenoids, caseakurzins A-J (7-16), and nine known diterpenoids (17-25) were isolated from the twigs and leaves of Casearia kurzii. The structures of the new compounds were established on the basis of extensive spectroscopic data, and those of compounds 1a, 1b, and 2 were verified by single-crystal X-ray crystallographic analysis. The enantiomers 1a and 1b were separated by chiral-phase HPLC. The absolute configurations were determined by experimental and calculated ECD data, the modified Mosher's method, or literature comparison. Compounds 1a and 5 showed significant quinone reductase-inducing activity in Hepa 1c1c7 cells, while 1b showed moderate activity. Molecular docking studies showed that 1a had greater binding affinity with Nrf2 protein (5FNQ) than 1b. The cytotoxic activity of compounds 1a, 1b, 2-12, 15, and 16 was evaluated, among which compounds 8 and 16 exhibited significant inhibitory activity against the A549 cell line. Compounds 8 and 16 induced the A549 cells to arrest at G2/M and S phases, respectively, and both compounds induced apoptosis in A549 cells.

11.
Fitoterapia ; 147: 104758, 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33069833

RESUMO

Three new isopimarane-type diterpenoids, botrysphins G-I (1-3), a new muurolane-type sesquiterpenoid, 11,12-dihydroxylentideusether (4), and two new triketides, 4-dechlorobotrysphone C (5) and 4,5-dihydroxy-3-methoxy-6-undecanoyloxy-2-cyclohexen-1-one (6), together with one known diterpenoid, sphaeropsidin A (7), one sesquiterpenoid, lentideusether (8), and one triketide sphaeropsidone (9), were isolated from culture of the fungus Botrysphaeria laricina associated with the moss Rhodobryum umgiganteum. The structures of the new compounds were established on the basis of extensive spectroscopic techniques including HRMS and 1D and 2D NMR data. Compounds 1 and 2 exhibited NO inhibitory activity with IC50 values of 13.9 µM and 41.9 µM, respectively. At the same time, these two compounds showed quinone reductase inducing activity with 2.7-fold of induction for 1 at 12.5 µM and 1.6-fold for 2 at 25.0 µM.

12.
Otolaryngol Head Neck Surg ; : 194599820965940, 2020 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-33048615

RESUMO

OBJECTIVE: To compare endoscopic myringoplasty using the cartilage-perichondrium complex as a graft (test group) with temporalis fascia microscopic myringoplasty (control group). STUDY DESIGN: A retrospective cohort study. SETTING: Department of Otorhinolaryngology in a tertiary Chinese hospital. METHODS: Data were collected on patients between 2017 and 2019. To balance the baseline characteristics between groups, we performed a propensity score-matched analysis, and 44 patients were included in each group. Hearing improvement and eardrum closure rates were compared, and risk factors affecting them were analyzed. RESULTS: In the control and test groups, 90.90% and 86.36% of patients had a mean air-bone gap ≤20 dB after the surgery, respectively (P = .843). The air conduction (AC) threshold gain at each frequency was similar in the 2 groups (P > .05). The closure rates were 95.45% and 93.18%, respectively (P = .645). The air-bone gap improved significantly after surgery, F(1, 61) = 6.729, P = .012. Age, group, middle ear mucosal status, and location of the perforation did not affect the change in air-bone gap or the drum closure rate (P > .05). However, there was an interaction between the change in air-bone gap and the size of the perforation, F(1, 61) = 11.067, P = 0001. CONCLUSION: Endoscopic myringoplasty using a cartilage-perichondrium complex graft is comparable with traditional surgery. Age, location of the perforation, and middle ear mucosal status did not significantly affect the change in air-bone gap or the drum closure rate. A perforation size ≥50% was always associated with a better air-bone gap improvement.

13.
Zootaxa ; 4822(1): zootaxa.4822.1.4, 2020 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-33056301

RESUMO

Contrary to the typical southern distribution of the extant Kempyninae, a subfamily of Osmylidae, its fossil group shows the high diversification in the northern hemisphere during the Mesozoic. Herein a new genus with a new species, Mirokempynus profundobifurcus gen. et sp. nov., and a new species, Jurakempynus loculosus sp. nov., of Kempyninae, are described from the Middle Jurassic Jiulongshan Formation of Daohugou Village, Inner Mongolia, China. The new species share the characteristic synapomorphies of Kempyninae, e.g. subcostal veinlets mostly irregularly forked in the forewing and the distinctly expanded intramedial area with multiple rows of cells in the hind wing. The new genus distinctly shows a particular condition of intramedial area and MP branching in the hind wing. However, the condition of the region between MA and MP significantly broadened in the hind wing appear distinctively different to other known kempynine genera. A key is provided for all the genera of documented kempynines, both fossil and extant.


Assuntos
Holometábolos , Insetos , Animais , China , Fósseis , Asas de Animais
14.
Annu Rev Entomol ; 2020 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-32916066

RESUMO

During the past 20 years, more than 1,600 species of well-preserved fossil insects, including members of over 270 families within 24 orders, have been described from the Middle Jurassic Yanliao Entomofauna and Early Cretaceous Jehol Entomofauna in Northeastern China. Diversified fossil insects not only document the origin, systematics, and early evolution of many lineages, but also reveal these lineages' behaviors and interactions with coexisting plants, vertebrates, and other insects in their ecosystems. For example, fossil evidence has been documented, for example, regarding insects' feeding and pollination mutualism with gymnosperms; ectoparasitic feeding on blood of vertebrates; camouflage, mimicry of gymnosperm plants, and eyespot warning; sound stridulation for attracting potential mates; and sexual display, mating, egg-laying, and parental care. In this article, we review the diverse taxonomy of mid-Mesozoic insects of Northeastern China and elucidate their behaviors and interactions within their ecosystems, which have impacted their early evolution and development into extant insects. Expected final online publication date for the Annual Review of Entomology, Volume 66 is January 11, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

15.
Ecotoxicol Environ Saf ; 203: 110990, 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-32888601

RESUMO

The presence of sulfamethoxazole (SMX) in croplands has become an international concern. The environmental behavior and fate of SMX in agricultural soils are not well understood, especially when the adsorption behavior is disturbed by the dissolved organic matter (DOM) released by crop straw. As canola straw is one of the biomasses widely returned to farmlands, we characterized DOM derived from pristine and decomposed canola straw, and explored the effects and mechanisms of the DOMs on regulating SMX adsorption to purple paddy soils. The spectral analysis showed that the molecular weight, aromaticity, and hydrophobicity of canola straw-derived DOM increased as decomposition proceeded. These physicochemical properties collectively determined the effects of the DOM on SMX adsorption. The DOM derived from pristine canola straw increased SMX maximum adsorption capacity of the soils by approximately 2.6 times, but this positive effect gradually decreased to a steady state by day 90 in the straw decomposition period. Nevertheless, the SMX adsorption behavior in the soils was invariably determined by the DOM extracts. These adsorption processes of SMX were well fitted by the double-chamber kinetics model and the Langmuir and Freundlich thermodynamic models. Thermodynamic parameters indicated that SMX adsorption onto the soils was spontaneous and endothermic, and this adsorption characteristics was not significantly (p > 0.05) changed by the DOM extracts. However, the adsorption kinetics were altered by those DOMs, i.e., the fast and slow adsorption processes were both diminished. Correspondingly, co-adsorption and cumulative adsorption were identified as the main mechanisms determining SMX adsorption to the purple paddy soils in the presence of the straw-derived DOMs. These results collectively indicated that the DOMs released by straw in croplands may decrease the ecological risks of organic pollutants by inhibiting their migration processes.


Assuntos
Brassica/química , Poluentes do Solo/química , Solo/química , Sulfametoxazol/química , Adsorção , Agricultura , Oryza/crescimento & desenvolvimento , Silagem
16.
Zookeys ; 965: 73-84, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32973381

RESUMO

A new genus and species of fossil moth, Miogeometrida chunjenshihi Zhang, Shih & Shih, gen. et sp. nov., assigned to Geometridae, is described from Miocene Dominican amber dating from 15-20 Mya. The new genus is characterized by the forewing without a fovea, R1 not anastomosing with Sc, no areole formed by veins R1 and Rs, R1 and Rs1 completely coincident, M2 arising midway between M1 and M3, anal veins 1A and 2A fused for their entire lengths; and the hind wing with Rs running close to Sc + R1 and M2 absent.

17.
Sci China Life Sci ; 2020 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-32915406

RESUMO

Neuroblastoma (NB) is one of the most common malignant tumors in children, with variable clinical behaviors and a 15% death rate of all malignancies in childhood. However, genetic susceptibility to sporadic NB in Han Chinese patients is largely unknown. To identify genetic risk factors for NB, we performed an association study on 357 NB patients and 738 control subjects among Han Chinese children. We focused on DEAD box 1 (DDX1), a putative RNA helicase, which is involved in NB carcinogenesis. The potential association of DDX1 polymorphisms with NB has not been discovered. Our results demonstrate that rs72780850 (NM_004939.2:c.-1555T>C) located in the DDX1 promoter region is significantly associated with higher expression of DDX1 transcript and increased NB risk (odds ratio=1.64, 95% confidence interval=1.03%-2.60%, P=0.004), especially in aggressive NB compared with ganglioneuroma and ganglioneuroblastoma in a dominant model (TC+CC vs. TT). Furthermore, the MYC-associated protein X (MAX) transcription factor showed stronger binding affinity to the DDX1 rs 72780850 CC allele compared with the TT allele, explaining the molecular mechanism of the increased NB risk caused by the rs72780850 polymorphism. Our results highlight the involvement of regulatory genetic variants of DDX1 in NB.

18.
Int Immunopharmacol ; 88: 106904, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32866785

RESUMO

Intervertebral disc degeneration (IDD) is the major pathogenesis of lower back pain. Tyrosol is a polyphenolic compound that exhibits anti-oxidant, anti-apoptotic, and anti-inflammatory effects. Herein, we explored the effects and mechanisms of tyrosol on IDD progression in interleukin (IL)-1ß-stimulated human nucleus pulposus cells (HNPCs). Cell viability and apoptosis were detected by CCK-8 and flow cytometry analysis, respectively. The production of tumor necrosis factor-α (TNF-α), IL-6, nitric oxide (NO), and prostaglandin E2 (PGE2) was examined to evaluate inflammation. The mRNA expression of matrix metalloproteinases (MMPs) (MMP-3/9/13), collagen type II, SRY-related high mobility group box 9 (SOX-9), and aggrecan was measured by qRT-PCR. Protein levels of silent information regulator 2 homolog 1 (Sirt1), phosphorylated protein kinase B (p-Akt), Akt, collagen type II, SOX-9, and aggrecan were determined by western blot. Results showed that tyrosol attenuated IL-1ß-induced viability reduction, apoptosis, and caspase-3/7 activity in HNPCs. The increase in the production of TNF-α, IL-6, NO, and PGE2 in IL-1ß-treated HNPCs was abolished by tyrosol treatment. Tyrosol treatment reversed IL-1ß-induced upregulation of MMP-3, MMP-9, and MMP-13, and downregulation of collagen II, SOX-9, and aggrecan in HNPCs. Additionally, tyrosol treatment activated the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in IL-1ß-stimulated HNPCs. Sirt1 was upregulated by tyrosol, and Sirt1 silencing inhibited Akt phosphorylation in HNPCs. Sirt1 knockdown attenuated the effects of tyrosol on IL-1ß-induced apoptosis, inflammation, and ECM remodeling in HNPCs. In summary, upregulation of Sirt1 by tyrosol suppressed apoptosis and inflammation and regulated ECM remodeling in IL-1ß-stimulated HNPCs through activation of PI3K/Akt pathway.

19.
Zookeys ; 954: 65-74, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32821205

RESUMO

A new fossil genus and species is described from the Middle Jurassic of China. The type of Sinoelcana minuta gen. et sp. nov. has body and legs preserved. It is distinguished from all other elcanids by the unique combination of wing venation and stout ovipositor. The sickle-shaped ovipositor suggests that the new species had a preference for oviposition on plant material. A world key to the genera of Elcanidae is provided based on the wing venation.

20.
Nat Prod Res ; : 1-5, 2020 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-32722947

RESUMO

Two new triterpenoids, 3ß-hydroxytirucall-7,25-dien-24-one (1) and 3ß-acetoxytirucall-7,23,25-triene (2), along with one new sesquiterpenoid, alloaromadendrane-12α,14ß-dioic acid (3), were isolated from the vines and leaves of Chonemorpha megacalyx Pierre. Their structures were established on the basis of extensive spectroscopic data.

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