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1.
Medicine (Baltimore) ; 98(52): e18353, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31876709

RESUMO

BACKGROUND: To determine the effectiveness of text message reminders (TMR) on medication adherence (MA) and to investigate the effects of TMR on clinical outcomes. METHODS: The PubMed, Cochrane library, EMbase, and China Biology Medicine databases were searched for randomized-controlled trials with TMR as the intervention for patients with coronary heart disease. Two reviewers independently extracted data and assessed the risk of bias. Meta-analysis was conducted using Stata 15.0 software. RESULTS: In total, 1678 patients in 6 trials were included. Compared with the control group, the MA was 2.85 times greater among the intervention group (RR [relative risk] 2.85; 95% confidence interval [CI] 1.07-7.58). TMR reduced systolic blood pressure (BP) (weighted mean difference) = -6.51; 95% CI -9.79 to -3.23), cholesterol (standard mean difference = -0.26; 95% CI -0.4 to -0.12) and increased the number of patients with BP <140/90 mm Hg (RR 1.39; 95% CI 1.26-1.54). CONCLUSION: TMR significantly promoted MA and reduced systolic BP, cholesterol level, and body mass index, but had no effect on mortality, diastolic BP, or lipoproteins. However, substantial heterogeneity existed in our analyses.


Assuntos
Doença das Coronárias/tratamento farmacológico , Adesão à Medicação , Sistemas de Alerta , Mensagem de Texto , Humanos
2.
Int J Infect Dis ; 87: 154-165, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31442627

RESUMO

OBJECTIVES: It remains uncertain which catheter lock solution (CLS) to prevent catheter-related bloodstream infections (CRBSI) works best and is safest for patients. This study was performed to compare the efficacy of different CLSs for the prevention of CRBSI and ranked these CLSs for practical consideration. METHODS: The PubMed, Web of Science, Embase, and MEDLINE databases, earlier relevant meta-analyses, and the reference lists of included studies were searched. The primary outcome was CRBSI; secondary outcomes were catheter-related thrombosis and exit-site infections. A network meta-analysis was performed to estimate odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: A total of 52 randomized controlled trials involving 9099 patients and evaluating 13 CLSs (single and combinations) were included. With regard to the quality of the evidence, the risk of bias was typically low or unclear (45 out of 52 trials, 86.5%). In the network meta-analysis, saline (OR 8.44, 95% CI 2.19-32.46), gentamicin+citrate (OR 2.92, 95% CI 1.32-6.42), ethanol (OR 5.33, 95% CI 1.22-23.32), and cloxacillin+heparin (OR 2.07, 95% CI 1.19-5.49) were associated with a greater effect on CRBSI than heparin. CONCLUSIONS: This network meta-analysis showed that minocycline-ethylenediaminetetraacetic acid (EDTA) seemed to be the most effective for the prevention of CRBSI and exit-site infection, and cefotaxime+heparin seemed to be the most effective for catheter-related thrombosis.


Assuntos
Antibacterianos/administração & dosagem , Bacteriemia/prevenção & controle , Infecções Relacionadas a Cateter/prevenção & controle , Humanos , Meta-Análise em Rede , Ensaios Clínicos Controlados Aleatórios como Assunto
3.
BMJ Open ; 9(6): e030019, 2019 06 28.
Artigo em Inglês | MEDLINE | ID: mdl-31256039

RESUMO

INTRODUCTION: Catheter-related bloodstream infection (CRBSI) is a major complication after central venous catheter insertion, which is associated with significant morbidity, mortality and additional medical costs. Many lock solutions for CRBSI have been evaluated. However, using traditional pairwise meta-analyses to summarise the evidence does not allow the inclusion of data from treatments that have not been compared head to head, which could impact the precision of pooled estimates in a meta-analysis. Therefore, we evaluated the efficacy and safety of the different lock solutions for CRBSI through a network meta-analysis. METHODS AND ANALYSIS: The primary outcome of this network meta-analysis is the CRBSI. The secondary outcomes are exit-site infection and catheter-related thrombosis. We will search the PubMed, Embase, Web of Science and the Cochrane Library databases for recent relevant meta-analysis and their reference lists to include randomised controlled trials (RCTs) that compared lock solutions for CRBSI prevention. Two individuals will independently extract data from each included RCT according to a predesigned Excel spreadsheet and will assess the methodological quality using the Cochrane risk of bias tool. We will analyse the data using WinBUGS (V.1.4.3) and Stata (V.15.0). We will also estimate the pooled direct and indirect effects for all lock solutions using the network meta-analysis. ETHICS AND DISSEMINATION: As the present meta-analysis is performed based on previous published studies, no ethical approval and patient safety considerations are required. This study commenced on 18 January 2019, and its expected completion date is 1 December 2019. We will disseminate the results of our network meta-analysis through an international peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42019121089.

4.
Medicine (Baltimore) ; 98(30): e16517, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31348264

RESUMO

BACKGROUND: Prostate cancer (PCa) is common, with it being the 2nd most prevalent cancer in men worldwide and the 6th leading cause of death in men. Screening for any type of cancer aims to increase the chances of successful treatment through early detection of the disease. There were some systematic reviews (SRs) evaluated the diagnostic value of biomarkers for the diagnosis of PCa and no studies have been conducted to analyze the quality of these SRs. We are not clear which kind of marker is the best choice. Thus, this study aims to assess the methodologic quality of the SRs and reanalyze the published data based on SRs for the biomarkers to find the optimal biomarker for the early diagnosis of PCa. METHODS: We performed a systematic literature search of PubMed, Embase, Web of Science, and Cochrane Library and to identify relevant SRs from inception to April 2019. Diagnostic accuracy studies included any type of single biomarker or combined biomarkers aimed at evaluating the diagnostic value is considered eligible for this overview. The Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) instrument will be used to evaluate the risk of bias of the included SRs. Standard pairwise meta-analysis and adjusted indirect comparison will be used to compare the diagnostic value of different biomarkers. RESULTS: The results of this study will be submitted to a peer-reviewed journal for publication. CONCLUSION: This study will reanalyze the published data based on SRs. We hope that the results will help find a biomarker with the superior diagnostic performance for the diagnosis of PCa. PROSPERO REGISTRATION NUMBER: CRD42019125880.


Assuntos
Detecção Precoce de Câncer/métodos , Neoplasias da Próstata/diagnóstico , Biomarcadores Tumorais , Humanos , Masculino , Meta-Análise em Rede , Projetos de Pesquisa , Literatura de Revisão como Assunto , Sensibilidade e Especificidade
5.
J Hazard Mater ; 368: 613-620, 2019 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-30721856

RESUMO

The suppression effects of pure ultrafine water mist and 5% mass fraction alkali metal (NaCl, Na2CO3, KHCO3, KCl and K2CO3) solutions ultrafine water mist on methane explosion were conducted under five mist concentrations in a sealed visual vessel. Mist diameters of different additive solutions were measured by a phase doppler particle analyzer. Pressure data and dynamic flame pictures were recorded respectively by a high-frequency pressure sensor and a high-speed camera. Results indicate that alkali metal compound can enhance the suppression effect of ultrafine water mist and it was related to the additive type. The suppression order of alkali metal compound for methane explosion was K2CO3>KCl > KHCO3>Na2CO3>NaCl. Meanwhile, additive radicals can obviously affect explosion intensity and it mainly reflected in the reduction of explosion pressure under different mist conditions (K+>Na+, Cl- >HCO3-). The pressure generated from combustion wave accelerating propagation underwent two accelerating rises and was affected by additive type and mist amount. The effect of additive type on explosion intensity (maximum explosion overpressure (ΔPmax), two peak values of pressure rising rate) was similar with flame propagation velocity and were decreased evidently with increasing mist concentration. The enhancement in explosion suppression was due to the combination of improved physical and chemical effects.

6.
J Hazard Mater ; 338: 502-507, 2017 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-28618372

RESUMO

In order to study the coupling response process of the liquid tank under the external thermal attack, experiments were carried out on a vertical cylindrical storage tank by electric heating. The response processes of the tank pressure, the medium temperatures, and the wet and dry tank wall temperatures were monitored in the experiments. The coupling responding process between the evolving characters of the medium temperature and the tank wall temperature, as well as the resulting rising features of the tank pressure were analyzed comprehensively. The results indicated that, on the one side the heat transfers process across and through the tank wall were influenced obviously by the thermal-flow fields of the two phase mediums which differ a lot in the thermal physical properties. On the other side, affected by the temperature rise in the wall, the vapor medium became thermal stratified and overheated with respect to the tank pressure, and the flow regime in the liquid medium would transform from causing stratification to promoting de-stratification affected by the wall boiling phenomenon.

7.
J Hazard Mater ; 324(Pt B): 489-497, 2017 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-27843023

RESUMO

The inhibition effects of ultrafine water mists on 6.5%, 8%, 9.5%, 11%, and 13.5% methane explosions were experimentally studied in a sealed visual vessel. The mist (10µm) produced by a mist generation system in the vessel was measured by a phase doppler particle analyzer. A high-speed camera was used to record the explosion flame affected by spraying concentration and a high frequency pressure sensor was used to acquire the explosion pressure. Meanwhile, the relationship between flame propagation and pressure rising with time was analyzed. The appearance height of "tulip" flame was increased and appearance moment was delayed obviously with the mist amount increased. The variation trend was illustrated from the viewpoint of the interactions among the flame front, the flame-induced reverse flow and the vortices. Moreover, cellular structure appeared in the burned zone and experienced four developing stages, and its formation indicates that water vapor can cause the intrinsic flame instability and absorb heat on the burned zone further. The pressure underwent two accelerating rises, which was affected by mist amount. The accelerating rise processes were related to the accelerating propagation of combustion wave. Furthermore, methane explosion can be absolutely suppressed by the mist.

8.
J Hazard Mater ; 285: 311-8, 2015 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-25528229

RESUMO

The suppression effect of ultrafine mists on methane/air explosions with methane concentrations of 6.5%, 8%, 9.5%, 11%, and 13.5% were experimentally studied in a closed visual vessel. Ultrafine water/NaCl solution mist as well as pure water mist was adopted and the droplet sizes of mists were measured by phase doppler particle analyzer (PDPA). A high speed camera was used to record the flame evolution processes. In contrast to pure water mist, the flame propagation speed, the maximum explosion overpressure (ΔP(max)), and the maximum pressure rising rate ((dP/dt)max) decreased significantly, with the "tulip" flame disappearing and the flame getting brighter. The results show that the suppressing effect on methane explosion by ultrafine water/NaCl solution mist is influenced by the mist amount and methane concentration. With the increase of the mist amount, the pressure, and the flame speed both descended significantly. And when the mist amount reached 74.08 g/m(3) and 37.04 g/m(3), the flames of 6.5% and 13.5% methane explosions can be absolutely suppressed, respectively. All of results indicate that addition of NaCl can improve the suppression effect of ultrafine pure water mist on the methane explosions, and the suppression effect is considered due to the combination effect of physical and chemical inhibitions.


Assuntos
Ar , Explosões/prevenção & controle , Metano/química , Cloreto de Sódio/química , Água/química , Pressão
9.
J Hazard Mater ; 192(2): 874-9, 2011 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-21723662

RESUMO

A model has been developed to predict the thermal response of liquefied-pressure gases (LPG) tanks under fire, and three-dimensional numerical simulations were carried out on a horizontal LPG tank which was 60% filled. Comparison between numerical predictions and published experimental data shows close agreement. The attention is focused on the influence of different fire conditions (different fire scenarios, various engulfing degrees and flame temperatures) on thermal response of LPG tanks. Potential hazard probabilities under different fire conditions were discussed by analyzing the maximum wall temperature and media energy after the internal pressure rose to the same value. It is found that the less severe fire scenario and lower engulfing case may lead to a greater probability of burst hazard because of the higher maximum wall temperature and media energy before the pressure relief valve (PRV) opens.


Assuntos
Fogo , Modelos Teóricos
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