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1.
Rev Gastroenterol Peru ; 37(2): 142-145, 2017.
Artigo em Espanhol | MEDLINE | ID: mdl-28731994

RESUMO

OBJECTIVES: To describe the frequency and clinical profile of gallbladder cancer in patients undergoing cholecystectomy in 3 reference hospitals in Chiclayo between 2011-2015. MATERIALS AND METHODS: A retrospective cross-sectional study. The study is divided into 2 phases, the first was to count the total number of reports of gallbladder pathology and select positive cases for cancer; the second phase was to collect data from the medical records of patients positive for cancer. RESULTS: From 5720 pathology reports gallbladder, 58 (1.01%) were positive for vesicular neoplasia. 42 cases (72.4%) were women and only 16 (27.6%) were men. The most common symptom was abdominal pain in 41 cases (70.7%). 18 patients (31%) reported other symptoms, the hyporexia was the most frequent with 8 cases (13.8%). 41 cases (70.7%) had gallstone. The predominant type of cancer was adenocarcinoma in 48 cases (82.8%) followed by mucinous carcinoma in 3 cases (5.2%). CONCLUSIONS: In the department of Lambayeque frequency of gallbladder cancer was 1.01% with predominance in females and sixth decade of life, being Adenocarcinoma, the most common type. Likewise, patients had more frequent abdominal pain and jaundice.


Assuntos
Adenocarcinoma/epidemiologia , Colecistectomia , Neoplasias da Vesícula Biliar/epidemiologia , Adenocarcinoma/complicações , Adenocarcinoma/diagnóstico , Adenocarcinoma/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Neoplasias da Vesícula Biliar/complicações , Neoplasias da Vesícula Biliar/diagnóstico , Neoplasias da Vesícula Biliar/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Peru/epidemiologia , Estudos Retrospectivos , Centros de Atenção Terciária
2.
Rev. gastroenterol. Perú ; 37(2): 142-145, abr.-jun. 2017. ilus, tab
Artigo em Espanhol | LILACS-Express | ID: biblio-991241

RESUMO

Objetivos: Describir la frecuencia y perfil clínico de cáncer de vesícula biliar en pacientes colecistectomizados en 3 hospitales referenciales en Chiclayo entre 2011-2015. Materiales y métodos: Estudio descriptivo transversal retrospectivo. El estudio está dividido en 2 fases, la primera consistió en contabilizar el número total de informes de patología de vesícula biliar y seleccionar los casos positivos para cáncer; la segunda fase consistió en recolectar datos de las historias clínicas de los pacientes positivos para cáncer. Resultados: De 5720 reportes de anatomía patológica de vesícula biliar, 58 (1,01%) fueron positivas para neoplasia vesicular. 42 casos (72,4%) fueron mujeres y solo 16 (27,6%) fueron hombres. El síntoma más frecuente fue el dolor abdominal con 41 casos (70,7%). 18 pacientes (31%) refirieron otra sintomatología, la hiporexia fue la más frecuente con 8 casos (13,8%). 41 casos (70,7%) presentaron cálculos vesiculares. El tipo de cáncer que predomino fue el adenocarcinoma con 48 casos (82,8%) seguido por el carcinoma mucinoso con 3 casos (5,2%). Conclusiones: En el departamento de Lambayeque la frecuencia de cáncer de vesícula biliar fue de 1,01% con predominancia en el sexo femenino y sexta década de la vida, siendo el Adenocarcinoma, el tipo más común. Así mismo, los pacientes presentaron con mayor frecuencia dolor abdominal e ictericia


ABSTRACT Objectives: To describe the frequency and clinical profile of gallbladder cancer in patients undergoing cholecystectomy in 3 reference hospitals in Chiclayo between 2011-2015. Materials and methods: A retrospective cross-sectional study. The study is divided into 2 phases, the first was to count the total number of reports of gallbladder pathology and select positive cases for cancer; the second phase was to collect data from the medical records of patients positive for cancer. Results: From 5720 pathology reports gallbladder, 58 (1.01%) were positive for vesicular neoplasia. 42 cases (72.4%) were women and only 16 (27.6%) were men. The most common symptom was abdominal pain in 41 cases (70.7%). 18 patients (31%) reported other symptoms, the hyporexia was the most frequent with 8 cases (13.8%). 41 cases (70.7%) had gallstone. The predominant type of cancer was adenocarcinoma in 48 cases (82.8%) followed by mucinous carcinoma in 3 cases (5.2%). Conclusions: In the department of Lambayeque frequency of gallbladder cancer was 1.01% with predominance in females and sixth decade of life, being Adenocarcinoma, the most common type. Likewise, patients had more frequent abdominal pain and jaundice

3.
Archiv. med. fam. gen. (En línea) ; 13(1): 6-13, nov. 2016. tab, ilus
Artigo em Espanhol | LILACS | ID: biblio-907413

RESUMO

Introducción: el estado nutricional (EN) infantil requiere adecuada evaluación. Objetivos: Describir el EN de niños de 1-5 años que asistieron a tres centros de atención primaria de una obra social en 2014 y su método de evaluación. Conocer el impacto del diagnóstico en sus familias. Materiales y métodos: Estudio multicéntrico cuali-cuantitativo, n=891. Se revisaron historias clínicas y se entrevistó a padres de niños con diagnóstico de obesidad o bajo peso. Resultados: El 52% de los niños fueron evaluados con percentilos Peso/Edad, hallándose 71% eutrófico, 6% con obesidad, y 4% bajo peso. Utilizando percentilos IMC/Edad, 60% resulto eutrófico, 14 % con obesidad y 1% con bajo peso. En el análisis cualitativo se observaron: naturalización diagnóstico, dificultad de los padres para poner límites, sentimientos de culpa y frustración y déficit en la comunicación médico-familia. Conclusión: El 60% de los niños de 1-5 años que consultaron en tres centros de atención primaria de un obra social en el 2014 resultaron eutróficos, 14% con obesidad y 1% bajo peso. La mayoría de los niños fueron evaluados utilizando percentilos incorrectos. La subestimación del diagnóstico por parte de los padres fue favorecida por el uso de eufemismos y lenguaje diminutivo por parte de los médicos.


Introduction: childhood nutritional status (NS) requires adequate assessment. Objectives: To describe NS of children aged 1-5 that attended three primary care centers of a social security organisation during 2014 and its method of assessment. To know the impact the diagnosis had on their families. Materials and methods: Quali-quantitative multicenter study, n=891. Charts were reviewed and parents of children diagnosed with obesity or low weight were interviewed. Results: 52% of children were assessed using Weight/Age percentiles, being 71% eutrophic, 6% with obesity, and 4% low weight. Using BMI/Age percentiles, 60% were eutrophic, 14% with obesity and 1% with low weight. In the qualitative analysis were observed: naturalization of the diagnosis, parental difficulties in setting limits, feelings of the quilt and frustration, anddeficits in physician-family communication. Conclusion: Using the BMI/Age curve, 60% of the 1-5 year olds who were attended at three primary care centers of a social security organisation in 2014 were eutrophic, 14% were obese and 1% had low weight. Most children were assessed using wrong percentiles. Underestimation of the diagnosis by parents was favored by the use of euphemisms and diminutive language by physicians.


Assuntos
Humanos , Lactente , Pré-Escolar , Recém-Nascido de Baixo Peso , Obesidade , Transtornos do Crescimento , Relações Profissional-Família
6.
Rev Argent Microbiol ; 48(1): 27-37, 2016.
Artigo em Espanhol | MEDLINE | ID: mdl-26895996

RESUMO

The epidemiological and clinical management of cystic fibrosis (CF) patients suffering from acute pulmonary exacerbations or chronic lung infections demands continuous updating of medical and microbiological processes associated with the constant evolution of pathogens during host colonization. In order to monitor the dynamics of these processes, it is essential to have expert systems capable of storing and subsequently extracting the information generated from different studies of the patients and microorganisms isolated from them. In this work we have designed and developed an on-line database based on an information system that allows to store, manage and visualize data from clinical studies and microbiological analysis of bacteria obtained from the respiratory tract of patients suffering from cystic fibrosis. The information system, named Cystic Fibrosis Cloud database is available on the http://servoy.infocomsa.com/cfc_database site and is composed of a main database and a web-based interface, which uses Servoy's product architecture based on Java technology. Although the CFC database system can be implemented as a local program for private use in CF centers, it can also be used, updated and shared by different users who can access the stored information in a systematic, practical and safe manner. The implementation of the CFC database could have a significant impact on the monitoring of respiratory infections, the prevention of exacerbations, the detection of emerging organisms, and the adequacy of control strategies for lung infections in CF patients.


Assuntos
Computação em Nuvem , Fibrose Cística , Bases de Dados Factuais , Fibrose Cística/complicações , Humanos , Infecções Respiratórias/etiologia
8.
Rev. gastroenterol. Perú ; 34(4): 299-303, oct. 2014. ilus
Artigo em Espanhol | LILACS | ID: lil-789674

RESUMO

Investigar molecularmente la deficiencia en los genes de reparo de DNA (MMR) asociados al síndrome de Lynch. Materiales y métodos: Realizar los análisis de inmunohistoquímica e inestabilidad de microsatélites (MSI) en 5 familias con sospecha de síndrome de Lynch de acuerdo a los criterios clínicos de Amsterdam y/o Bethesda, atendidos en el Hospital Nacional Almanzor Aguinaga Asenjo de la ciudad de Chiclayo (Lambayeque-Perú) durante 2007-2010. Resultados. La falta de expresión de las proteínas MLH1/PMS2 y una alta MSI (MSI-H) fueron observados en un paciente de sexo masculino de 60 años diagnosticado con adenocarcinoma de grado I. Adicionalmente, se realizó el análisis mutacional puntual en el gen BRAF (V600E) a fin de descartar que se trate de un caso esporádico de cáncer colorrectal. La ausencia de mutación en el gen analizado asociado a los resultados moleculares del tumor, sugiere la caracterización de este paciente como sospecha de síndrome de Lynch. Conclusiones: Es el primer estudio molecular reportado en la población peruana y demuestra la importancia del análisis molecular en familias con sospecha de cáncer colorrectal hereditario a fin de ofrecer posibilidades de vigilancia y seguimiento que han demostrado reducir la morbilidad y la mortalidad del cáncer colorrectal así como contribuir a la caracterización a nivel genética y clínica de este tipo de cáncer en la población peruana...


To investigate the molecular deficiency in MMR genes associated to Lynch syndrome. Material and methods: Immunohistochemical and microsatellite instability (MSI) analysis were performed in 5 families with suspected Lynch syndrome according to the clinical criteria, Amsterdam and/or Bethesda that had been treated at the Hospital Nacional Almanzor Aguinaga Asenjo (Lambayeque-Peru) during 2007-2010. Results: The absence of expression of MLH1/PMS2 and high MSI (MSI-H) were observed in a male patient aged 60 with adenocarcinoma grade I. In addition, the point mutational analysis was performed in BRAF (V600E) to rule that it is a sporadic case of colorectal cancer. The absence of mutation in BRAF together with the molecular analysis suggests the suspicion as a Lynch syndrome. Conclusions: It is the first molecular study reported in the Peruvian population and demonstrates the importance of molecular analysis in families with suspected hereditary colorectal cancer in order to provide possibilities of surveillance and monitoring that have been shown to reduce morbidity and mortality of colorectal cancer. The present study contributes to the genetic and clinical characterization of the Lynch syndrome in the Peruvian population...


Assuntos
Humanos , Masculino , Neoplasias Colorretais Hereditárias sem Polipose , Conformação Molecular
9.
Rev Gastroenterol Peru ; 34(4): 299-303, 2014.
Artigo em Espanhol | MEDLINE | ID: mdl-25594752

RESUMO

OBJECTIVE: To investigate the molecular deficiency in MMR genes associated to Lynch syndrome. MATERIAL AND METHODS: Immunohistochemical and microsatellite instability (MSI) analysis were performed in 5 families with suspected Lynch syndrome according to the clinical criteria, Amsterdam and/or Bethesda that had been treated at the Hospital Nacional Almanzor Aguinaga Asenjo (Lambayeque-Peru) during 2007-2010. RESULTS: The absence of expression of MLH1/PMS2 and high MSI (MSI-H) were observed in a male patient aged 60 with adenocarcinoma grade I. In addition, the point mutational analysis was performed in BRAF (V600E) to rule that it is a sporadic case of colorectal cancer. The absence of mutation in BRAF together with the molecular analysis suggests the suspicion as a Lynch syndrome. CONCLUSIONS: It is the first molecular study reported in the Peruvian population and demonstrates the importance of molecular analysis in families with suspected hereditary colorectal cancer in order to provide possibilities of surveillance and monitoring that have been shown to reduce morbidity and mortality of colorectal cancer in the Peruvian population.


Assuntos
Biomarcadores Tumorais/metabolismo , Neoplasias Colorretais Hereditárias sem Polipose/genética , Neoplasias Colorretais Hereditárias sem Polipose/metabolismo , Instabilidade de Microssatélites , Proteínas Adaptadoras de Transdução de Sinal/metabolismo , Adenosina Trifosfatases/metabolismo , Adulto , Idoso , Biomarcadores Tumorais/genética , Neoplasias Colorretais Hereditárias sem Polipose/diagnóstico , Enzimas Reparadoras do DNA/metabolismo , Proteínas de Ligação a DNA/metabolismo , Feminino , Marcadores Genéticos , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Endonuclease PMS2 de Reparo de Erro de Pareamento , Proteína 1 Homóloga a MutL , Proteínas Nucleares/metabolismo , Peru , Mutação Puntual , Proteínas Proto-Oncogênicas B-raf/genética
18.
Arch Argent Pediatr ; 107(5): 430-5, 2009 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-19809764

RESUMO

INTRODUCTION: Newborn Screening for Cystic Fibrosis (CF) has demonstrated better clinical and functional results in patients diagnosed and treated prematurely. OBJECTIVE: To compare clinical and functional state in children with CF detected by newborn screening or by symptoms. PATIENTS AND METHODS: Cross-sectional study. We compared two groups paired by age, sex and genotype. A group detected by newborn screening (Group N) and other by symptoms (Group S), both confirmed with sweat test. We evaluated: age at diagnosis and enter to the center, z score weight/age (z W/A) at first visit and z score for body mass index (BMI) and height/age (z H/A) in last control, score of Shwachman-Brasfield (S/B), forced expiratory volume in one second (FEV1), first isolation of Pseudomonas aeruginosa (Pa) and number of hospitalizations. RESULTS: We included 21 patients in each of the groups from an universe of 250 patients treated in our center. The mean of both groups was 4.4 years. The age at diagnosis was lower in the group N than in the group S (p= 0.002, IC95%:-1.11/- 0.32). z W/A at diagnosis; z IMC; z H/A, score S/B and FEV(1) were better in group N (p< 0.001, 0.3, 0.01, 0.02, 0.1, respectively). The average age of first isolation of Pa and the average of hospitalizations was lower in group N (p= 0.34, IC95%: -1.45/0.51, p= 0.04, IC95%: -3.16/-0.07). CONCLUSIONS: Children with CF detected by neonatal screening programs had better clinical and functional outcome.


Assuntos
Fibrose Cística/diagnóstico , Fibrose Cística/fisiopatologia , Triagem Neonatal , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Recém-Nascido , Masculino
19.
Arch. argent. pediatr ; 107(5): 430-435, oct. 2009. graf, tab
Artigo em Espanhol | LILACS | ID: lil-534884

RESUMO

Introducción. La pesquisa neonatal para fibrosis quística (FQ) ha demostrado que en los pacientes diagnosticados y tratados precozmente se asocia con mejores resultados clínicos y funcionales. Objetivo. Comparar el estado clínico-funcional en niños con FQ detectados por pesquisa neonatalo por síntomas clínicos. Población, material y métodos. Estudio transversal. Se compararon dos grupos apareados por edad, sexo y genotipo. Un grupo detectado por pesquisa neonatal (Grupo P) y otro por síntomas (Grupo S), confirmados con prueba del sudor. Se evaluaron: edades al diagnóstico y al ingreso al centro, puntaje z peso/edad (z P/E) en la primer visita y z de índice de masa corporal (z IMC) y de talla/edad (z T/E) al último control, puntaje de Shwachman-Brasfield (S/B), volumen espiratorio forzado en el 1er segundo (VEF1), primer aislamiento de Pseudomonas aeruginosa (Pa) y número de hospitalizaciones. Resultados. De 250 pacientes en seguimiento, se incluyeron 21 pacientes en cada grupo. La edad (media) de ambos fue 4,4 años. La edad al diagnóstico fue más temprana en el grupo P que en el grupo S (p= 0,002, IC 95 por ciento: -1,11/-0,32). El z P/E diagnóstico, z IMC, z T/E, puntaje S/B y VEF1 fueron mejores en el grupo P (p< 0,001; 0,3; 0,01; 0,02; 0,1 respectivamente). La edad promedio del primer aislamiento de Pa y la media de hospitalizaciones fue menor en el grupo P (p= 0,34,IC95 por ciento: -1,45/0,51, p= 0,04, IC95 por ciento: -3,16/-0,07; respectivamente). Conclusiones. Los niños con FQ detectados a través de programas de pesquisa neonatal presentan un mejor estado clínico y funcional.


Introduction. Newborn Screening for Cystic Fibrosis(CF) has demonstrated better clinical and functional results in patients diagnosed and treated prematurely. Objective. To compare clinical and functional state in children with CF detected by newborn screening or by symptoms. Patients and methods. Cross-sectional study. We compared two groups paired by age, sex and genotype. A group detected by newborn screening (Group N) and other by symptoms (Group S), both confirmed with sweat test. We evaluated: age at diagnosis and enter to the center, z score weight/age (z W/A) at first visit and z score for body mass index (BMI) and height/age (z H/A) in last control, score of Shwachman-Brasfield (S/B), forced expiratory volume in one second (FEV1), first isolation of Pseudomonas aeruginosa (Pa) and number of hospitalizations. Results. We included 21 patients in each of the groups from an universe of 250 patients treated in our center. The mean of both groups was 4.4 years. The age at diagnosis was lower in the group N than in the group S (p= 0.002, IC95 por ciento:-1.11/-0.32); z W/A at diagnosis; z IMC; z H/A, score S/B and FEV1 were better in group N (p< 0.001, 0.3, 0.01, 0.02, 0.1, respectively). The average age of first isolation of Pa and the average of hospitalizations was lower in group N (p= 0.34, IC95 por ciento: -1.45/0.51, p= 0.04, IC95 por ciento: -3.16/-0.07). Conclusions. Children with CF detected by neonatal screening programs had better clinical and functional outcome.


Assuntos
Humanos , Masculino , Pré-Escolar , Feminino , Estudo Comparativo , Fibrose Cística , Diagnóstico Precoce , Nível de Saúde , Sinais e Sintomas , Triagem Neonatal , Estudos Transversais
20.
Arch. argent. pediatr ; 107(5): 430-435, oct. 2009. graf, tab
Artigo em Espanhol | BINACIS | ID: bin-124897

RESUMO

Introducción. La pesquisa neonatal para fibrosis quística (FQ) ha demostrado que en los pacientes diagnosticados y tratados precozmente se asocia con mejores resultados clínicos y funcionales. Objetivo. Comparar el estado clínico-funcional en niños con FQ detectados por pesquisa neonatalo por síntomas clínicos. Población, material y métodos. Estudio transversal. Se compararon dos grupos apareados por edad, sexo y genotipo. Un grupo detectado por pesquisa neonatal (Grupo P) y otro por síntomas (Grupo S), confirmados con prueba del sudor. Se evaluaron: edades al diagnóstico y al ingreso al centro, puntaje z peso/edad (z P/E) en la primer visita y z de índice de masa corporal (z IMC) y de talla/edad (z T/E) al último control, puntaje de Shwachman-Brasfield (S/B), volumen espiratorio forzado en el 1er segundo (VEF1), primer aislamiento de Pseudomonas aeruginosa (Pa) y número de hospitalizaciones. Resultados. De 250 pacientes en seguimiento, se incluyeron 21 pacientes en cada grupo. La edad (media) de ambos fue 4,4 años. La edad al diagnóstico fue más temprana en el grupo P que en el grupo S (p= 0,002, IC 95 por ciento: -1,11/-0,32). El z P/E diagnóstico, z IMC, z T/E, puntaje S/B y VEF1 fueron mejores en el grupo P (p< 0,001; 0,3; 0,01; 0,02; 0,1 respectivamente). La edad promedio del primer aislamiento de Pa y la media de hospitalizaciones fue menor en el grupo P (p= 0,34,IC95 por ciento: -1,45/0,51, p= 0,04, IC95 por ciento: -3,16/-0,07; respectivamente). Conclusiones. Los niños con FQ detectados a través de programas de pesquisa neonatal presentan un mejor estado clínico y funcional.(AU)


Introduction. Newborn Screening for Cystic Fibrosis(CF) has demonstrated better clinical and functional results in patients diagnosed and treated prematurely. Objective. To compare clinical and functional state in children with CF detected by newborn screening or by symptoms. Patients and methods. Cross-sectional study. We compared two groups paired by age, sex and genotype. A group detected by newborn screening (Group N) and other by symptoms (Group S), both confirmed with sweat test. We evaluated: age at diagnosis and enter to the center, z score weight/age (z W/A) at first visit and z score for body mass index (BMI) and height/age (z H/A) in last control, score of Shwachman-Brasfield (S/B), forced expiratory volume in one second (FEV1), first isolation of Pseudomonas aeruginosa (Pa) and number of hospitalizations. Results. We included 21 patients in each of the groups from an universe of 250 patients treated in our center. The mean of both groups was 4.4 years. The age at diagnosis was lower in the group N than in the group S (p= 0.002, IC95 por ciento:-1.11/-0.32); z W/A at diagnosis; z IMC; z H/A, score S/B and FEV1 were better in group N (p< 0.001, 0.3, 0.01, 0.02, 0.1, respectively). The average age of first isolation of Pa and the average of hospitalizations was lower in group N (p= 0.34, IC95 por ciento: -1.45/0.51, p= 0.04, IC95 por ciento: -3.16/-0.07). Conclusions. Children with CF detected by neonatal screening programs had better clinical and functional outcome.(AU)


Assuntos
Humanos , Masculino , Pré-Escolar , Feminino , Fibrose Cística , Triagem Neonatal/22074 , Sinais e Sintomas , Diagnóstico Precoce , Estudo Comparativo , Nível de Saúde , Estudos Transversais
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