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1.
Neurochem Res ; 44(1): 228-233, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29299811

RESUMO

Impaired interactions between Calcineurin (Cn) and (Cu/Zn) superoxide dismutase (SOD1) are suspected to be responsible for the formation of hyperphosphorylated protein aggregation in amyotrophic lateral sclerosis (ALS). Serine (Ser)- enriched phosphorylated TDP-43 protein aggregation appears in the spinal cord of ALS animal models, and may be linked to the reduced phosphatase activity of Cn. The mutant overexpressed SOD1G93A protein does not properly bind zinc (Zn) in animal models; hence, mutant SOD1G93A-Cn interaction weakens. Consequently, unstable Cn fails to dephosphorylate TDP-43 that yields hyperphosphorylated TDP-43 aggregates. Our previous studies had suggested that Cn and SOD1 interaction was necessary to keep Cn enzyme functional. We have observed low Cn level, increased Zn concentrations, and increased TDP-43 protein levels in cervical, thoracic, lumbar, and sacral regions of the spinal cord tissue homogenates. This study further supports our previously published work indicating that Cn stability depends on functional Cn-SOD1 interaction because Zn is crucial for maintaining the Cn stability. Less active Cn did not efficiently dephosphorylate TDP-43; hence TDP-43 aggregations appeared in the spinal cord tissue.


Assuntos
Esclerose Amiotrófica Lateral/metabolismo , Calcineurina/metabolismo , Proteínas de Ligação a DNA/metabolismo , Medula Espinal/metabolismo , Superóxido Dismutase/metabolismo , Zinco/metabolismo , Esclerose Amiotrófica Lateral/genética , Animais , Calcineurina/genética , Proteínas de Ligação a DNA/genética , Ratos , Ratos Transgênicos , Superóxido Dismutase/genética
2.
Rev. Col. Méd. Cir. Guatem ; 156(2): 75-78, nov. 2017. graf, tab
Artigo em Espanhol | LILACS | ID: biblio-995468

RESUMO

Determinar niveles de ruido mediante técnicas de sonometría, que resultan propicios parala contaminación acústica en el ambiente quirúrgico de los servicios de Sala de Operaciones de Adultos, Sala de Operaciones de la Emergencia de Adultos, Sala de Operaciones de Pediatría, Sala de Operaciones de Ginecología y Sala de Labor y Partos del Hospital Roosevelt, durante abril ­ mayo de 2017. Material y método: Estudio descriptivo transversal realizado en quirófanos del Hospital Roosevelt donde se utilizó la tercera estrategia de la NTG ­ ISO 9612 para determinar exposición al ruido ocupacional con la participación de 26 médicos residentes de anestesiología a quienes se les aplicó diversos test para identificar efectos cognitivos, trastornos del sueño y de la conducta relacionados a niveles altos de ruido. Resultados: Existe una media energética del sonido en quirófanos de entre 69.8 y 95.4 decibelios. El departamento quirúrgico con más ruido es Labor y Partos con 95.4 decibelios, el tipo de procedimiento con mayor contaminación acústica es la cirugía abdominal. El 53.85% de médicos presenta resultado anormal en pruebas cognitivas, 61.54% posee dificultad media para dormir. No existe evidencia de trastornos conductuales. Conclusiones: Los niveles de ruido en quirófanos sobrepasan al doble de lo recomendado por OMS provocando efectos cognitivos y trastornos del sueño en residentes de anestesiología. El horario fijo de labores es la jornada con mayor polución sonora en quirófanos. La fuente con mayor emisión de ruido dentro del área quirúrgica es el sistema de aspiración (AU)


Purpose: To determine noise levels using sonometric techniques, which are conducive to acoustic contamination in the surgical environment of the Adult Operating Room, Adult Emergency Operating Room, Pediatric Operating Room, Operating Room of Gynecology and Labor and Delivery Room of the Hospital Roosevelt in Guatemala, during the months of April and May, 2017. Population and methods: A cross - sectional descriptive study performed in operating rooms of the Hospital Roosevelt where the third strategy of NTG - ISO 9612 was used to determine exposure to occupational noise with the participation of 26 resident physicians of anesthesiology who were given different tests to identify cognitive effects, sleep disorders and behavior related to high noise levels. Results: There is an energetic mean of the sound in operating rooms between 69.8 and 95.4 decibels. The surgical department with the most noise is Labor and Delivery Room with 95.4 decibels, the procedure with the highest noise emission is abdominal surgery. 53.85% of physicians present abnormal results in cognitive tests, 61.54% have medium difficulty sleeping. There is no evidence of behavioral disorders. Conclusion: Noise levels in operating rooms are more than twice that recommended by whom, causing cognitive effects and sleep disorders in residents of anesthesiology. The fixed work schedule is the day with the greatest sound pollution in operating theaters. The source with the highest noise emission within the surgical area is the aspiration system (AU)


Assuntos
Humanos , Masculino , Feminino , Efeitos do Ruído/efeitos adversos , Transtornos do Sono do Ritmo Circadiano/prevenção & controle , Audiômetros/métodos , Hospitais , Ruído/efeitos adversos , Salas Cirúrgicas
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