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1.
Appl Environ Microbiol ; 87(6)2021 02 26.
Artigo em Inglês | MEDLINE | ID: mdl-33397693

RESUMO

Freshwater can support the survival of the enteric pathogen Salmonella, though temporal Salmonella diversity in a large watershed has not been assessed. At 28 locations within the Susquehanna River basin, 10-liter samples were assessed in spring and summer over 2 years. Salmonella prevalence was 49%, and increased river discharge was the main driver of Salmonella presence. The amplicon-based sequencing tool, CRISPR-SeroSeq, was used to determine serovar population diversity and detected 25 different Salmonella serovars, including up to 10 serovars from a single water sample. On average, there were three serovars per sample, and 80% of Salmonella-positive samples contained more than one serovar. Serovars Give, Typhimurium, Thompson, and Infantis were identified throughout the watershed and over multiple collections. Seasonal differences were evident: serovar Give was abundant in the spring, whereas serovar Infantis was more frequently identified in the summer. Eight of the ten serovars most commonly associated with human illness were detected in this study. Crucially, six of these serovars often existed in the background, where they were masked by a more abundant serovar(s) in a sample. Serovars Enteritidis and Typhimurium, especially, were masked in 71 and 78% of samples where they were detected, respectively. Whole-genome sequencing-based phylogeny demonstrated that strains within the same serovar collected throughout the watershed were also very diverse. The Susquehanna River basin is the largest system where Salmonella prevalence and serovar diversity have been temporally and spatially investigated, and this study reveals an extraordinary level of inter- and intraserovar diversity.IMPORTANCE Salmonella is a leading cause of bacterial foodborne illness in the United States, and outbreaks linked to fresh produce are increasing. Understanding Salmonella ecology in freshwater is of importance, especially where irrigation practices or recreational use occur. As the third largest river in the United States east of the Mississippi, the Susquehanna River is the largest freshwater contributor to the Chesapeake Bay, and it is the largest river system where Salmonella diversity has been studied. Rainfall and subsequent high river discharge rates were the greatest indicators of Salmonella presence in the Susquehanna and its tributaries. Several Salmonella serovars were identified, including eight commonly associated with foodborne illness. Many clinically important serovars were present at a low frequency within individual samples and so could not be detected by conventional culture methods. The technologies employed here reveal an average of three serovars in a 10-liter sample of water and up to 10 serovars in a single sample.


Assuntos
Rios/microbiologia , Salmonella/isolamento & purificação , Genômica , Filogenia , Salmonella/genética , Estações do Ano , Sorogrupo , Microbiologia da Água , Sequenciamento Completo do Genoma
2.
Cancer Epidemiol ; 68: 101797, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32882568

RESUMO

BACKGROUND: Few studies have assessed the relation between maternal prenatal pesticides use and childhood lymphoma risk, some reporting a positive association with non-Hodgkin lymphoma (NHL). We investigated the association between maternal exposure to pesticides during pregnancy and childhood Hodgkin (HL) and non-Hodgkin lymphoma. METHODS: We pooled data from the two French national population-based case-control studies ESCALE (2003-2004) and ESTELLE (2010-2011). Data on domestic and occupational exposures to pesticides during pregnancy were obtained through standardised maternal interviews. Logistic regression models were used to compute odds ratios (OR) and 95% confidence intervals (CI) for HL and NHL, by pesticide category adjusted for potential confounders. Analyses by histological subtypes were also performed. RESULTS: We included 328 H L, 305 non-Hodgkin NHL and 2,415 controls. Around 40% of control mothers reported having used pesticides during index pregnancy, of whom 95% reported insecticides use. Maternal use of herbicides and fungicides occurred mostly in combination with insecticides. Insecticides use was more frequently reported in cases than controls (ORNHL = 1.6 [95%CI 1.3-2.1], p = 0.0001; ORHL = 1.3 [95%CI 1.0-1.7], p = 0.03). This association appeared more marked for Burkitt lymphoma and mixed cellularity classical HL. No obvious association was observed with occupational pesticides exposure during pregnancy. CONCLUSION: These results suggest that maternal domestic use of insecticides during pregnancy might be related to both childhood NHL and HL. Further larger studies are urgently needed.

3.
Cancer Epidemiol ; 66: 101706, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32247207

RESUMO

INTRODUCTION: Wilms' tumor is the most frequently diagnosed renal tumor in children. Little is known about its etiology. The aim of this study was to investigate the potential role of specific exposures related to parental habits such as parental smoking, maternal alcohol consumption and the use of household pesticides during pregnancy. METHODS: The ESTELLE study was a nationwide case-control study that included 117 Wilms' tumor cases and 1100 control children from the general French population, frequency-matched by age and gender. Unconditional logistic regression was used to estimate odds ratios and 95 % confidence intervals. RESULTS: After controlling for matching variables and potential confounders, the maternal use of any type of pesticide during pregnancy was associated with the risk of Wilms' tumor in children (OR 1.6 [95 % CI 1.1-2.3]). Insecticides were the most commonly reported type of pesticide and there was a positive association with their use (OR 1.7 [95 % CI 1.1-2.6]. The association was stronger when they were used more often than once a month (OR 1.9 [95 % CI 1.2-3.0]. Neither maternal smoking during pregnancy nor paternal smoking during preconception/pregnancy was associated with a risk of Wilms' tumor (ORs 1.1[95 % CI 0.7-1.8] and 1.1 [95 % CI 0.7-1.7], respectively). No association was observed with maternal alcohol intake during pregnancy (OR 1.2 [95 % CI 0.8-2.0]). CONCLUSION: Our findings suggest an association between the maternal use of household pesticides during pregnancy and the risk of Wilms' tumor.


Assuntos
Consumo de Bebidas Alcoólicas/efeitos adversos , Exposição Ambiental/efeitos adversos , Hábitos , Neoplasias Renais/epidemiologia , Pais/psicologia , Assistência Perinatal/métodos , Praguicidas/efeitos adversos , Fumar/efeitos adversos , Tumor de Wilms/epidemiologia , Adulto , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Gravidez , Fatores de Risco
4.
Cancer Causes Control ; 31(5): 491-501, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32144681

RESUMO

PURPOSE: Wilms tumor (WT), or nephroblastoma, is an embryonic tumor that constitutes the most common renal tumor in children. Little is known about the etiology of WT. The aim of this study was to investigate whether maternal or perinatal characteristics were associated with the risk of WT. METHODS: The ESTELLE study is a national-based case-control study that included 117 cases of WT and 1,100 controls younger than 11 years old. The cases were children diagnosed in France in 2010-2011 and the controls were frequency matched with cases by age and gender. The mothers of case and control children responded to a telephone questionnaire addressing sociodemographic and perinatal characteristics, childhood environment, and lifestyle. Unconditional logistic regression models adjusted on potential cofounders were used to estimate the odds ratios (OR) and their confidence intervals (95% CI). RESULTS: High birth weight and the presence of congenital malformation were associated with WT (OR 1.9 [95% CI 1.0-3.7] and OR 2.5 [95% CI 1.1-5.8], respectively). No association with breastfeeding or folic acid supplementation was observed. CONCLUSIONS: Although potential recall bias cannot be excluded, our findings reinforce the hypothesis that high birth weight and the presence of congenital malformation may be associated with an increased risk of WT. Further investigations are needed to further elucidate the possible role of maternal characteristics in the etiology of WT.


Assuntos
Neoplasias Renais/patologia , Tumor de Wilms/patologia , Adulto , Peso ao Nascer , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , França , Humanos , Lactente , Recém-Nascido , Masculino , Mães , Gravidez , Fatores de Risco , Inquéritos e Questionários , Adulto Jovem
5.
Rev Colomb Psiquiatr ; 2020 Jun 11.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33735023

RESUMO

Bipolar disorder (BD) has a large hereditary component. It is a disorder that begins in early adulthood, but about which it has been described a premorbid period preceding the onset of BD. During this herald expression psychiatric disorders and symptoms, such as depressive, manic, psychotic, anxious and others, may appear. OBJECTIVE: To determine the psychopathological profile of a Bipolar Offspring (BO) group compared with the Community Control Offspring (CCO) group, and its evolution over time, including subthreshold symptoms and mental disorders. METHODS: We conducted an observational mixed cohort study, with a prospective design. We included subjects from six to 30 years of age, from the region of Antioquia, Colombia. A total of 131 subjects from the risk group BO and 150 subjects from the CCO group were evaluated through validated psychiatric diagnostic interviews (K-SADS-PL and DIGS) at baseline and at 4 years follow up. All interviews were carried out by a staff blind to parent diagnoses. Follow-up assessment were complete in 72% of the offspring. Forty-two subjects were excluded as they surpassed the age of 30 years, and only 46 subjects were not followed (change of address or did not consent to participate). RESULTS: Compared with the CCO group, the BO group had a higher frequency of affective disorder, psychotic disorder, externalizing disorders and use of the psychoactive substances during both assessments at time 1 and 2. The magnitude of the differences between the groups increased when they reach time 2. The BO group had a greater risk for presenting subthreshold symptoms and definitive psychiatric disorders, such as affective disorders, psychotic disorders and externalizing disorders. In addition, the BO group had a younger age of onset for psychoactive substances consumption. CONCLUSION: During the follow-up period, the BO group had a higher risk of presenting mental disorders compared with the CCO group. The most relevant symptoms and disorders that could precede the onset of BD were depressive, bipolar not otherwise specified, psychotic and substance use.

6.
Rev. neurol. (Ed. impr.) ; 69(3): 94-98, 1 ago., 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-184021

RESUMO

Introducción. La neuropatía periférica inducida por quimioterapia es una reacción común a una variedad de medicamentos usados en el tratamiento del cáncer, que consiste principalmente en síntomas sensitivos, con componentes motores y cambios autonómicos. La prevalencia es del 30-68% después de terminar la quimioterapia en países no latinoamericanos. Objetivo. Determinar la prevalencia de la neuropatía periférica inducida por quimioterapia en la población colombiana. Pacientes y métodos. Estudio retrospectivo con evidencia del mundo real en la totalidad de pacientes atendidos en cuatro centros oncológicos de Colombia, quienes recibieron terapia farmacológica para algún tipo de cáncer entre enero de 2015 y diciembre de 2016 con taxanos (paclitaxel, docetaxel), agentes alquilantes (oxaliplatino), inhibidores de proteasoma (bortezomib) y análogos de epotilona B (ixabepilona). Resultados. Se siguió a un total de 1.551 pacientes en cuatro ciudades a quienes se les aplicaron 11.280 dosis, con predominio femenino (n = 1.094; 70,5%) y una edad media de 57 ± 13 años. El paclitaxel fue el fármaco más prescrito (n = 788; 50,8%). La neuropatía inducida por quimioterapia se presentó en el 48,9% de los pacientes con paclitaxel, el 58,5% de los pacientes con oxaliplatino, el 50,5% de los pacientes con docetaxel, el 43,7% de los pacientes con bortezomib y el 95,2% de los pacientes con ixabepilona. Se trató a 33 pacientes con dos de estos medicamentos simultáneamente. Conclusiones. La neuropatía periférica inducida por quimioterapia es una reacción adversa frecuente en pacientes con cáncer en Colombia tratados con taxanos, alquilantes, inhibidores de proteasoma e ixabepilona. Es necesario establecer métodos diagnósticos efectivos e incorporar escalas validadas en la evaluación rutinaria de los pacientes que reciben estas medicaciones


Introduction. Chemotherapy-induced peripheral neuropathy is a common adverse reaction in a variety of medications frequently used for a great number of cancer treatments. This condition consists of mainly sensory-type symptoms, motor components and autonomic changes. Reported prevalence ranges from 30-68%, after the completion of chemotherapy in non-Latin American people with different populations and socioeconomic levels. Aim. To determine the prevalence of chemotherapy-induced peripheral neuropathy in a Colombian population. Patients and methods. A real-world evidence cross-sectional retrospective study was performed in all patients from oncological clinical centers in Colombia, which received pharmacological therapy for any cancer between January 2015 and December 2016, with taxanes (paclitaxel, docetaxel), alkylators (oxaliplatin), proteasome inhibitors (bortezomib), and epothilone B analogs (ixabepilone). Results. A total of 1,551 patients in four cities were included, and 11,280 doses were applied; predominantly females (n = 1,094; 70.5%), with a mean age of 57 ± 13 years old. Paclitaxel was the most commonly prescribed drug (n = 788; 50.8%). Chemotherapy-induced peripheral neuropathy was developed in 48.9% of paclitaxel, 58.5% of oxaliplatin, 50.5% of docetaxel, 43.7% of bortezomib and 95.2% of ixabepilone patients. Thirty-three patients were treated with two of these medications simultaneously. Conclusions. Chemotherapy-induced peripheral neuropathy is a frequent adverse reaction to daily cancer therapy in Colombian patients managed with taxanes, alkylators, proteasome inhibitors, and epothilone B analogs. Hence, it is necessary to establish more successful diagnostic methods and incorporate validated scales in the routine evaluation of all patients receiving these medications in our environment


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Antineoplásicos/efeitos adversos , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Prevalência , Antineoplásicos/uso terapêutico , Colômbia , Estudos Retrospectivos , Estudos Transversais , Fatores Socioeconômicos , Neoplasias/tratamento farmacológico
7.
Food Chem ; 288: 262-267, 2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-30902291

RESUMO

The objective of this study was to evaluate the ability of Raman spectroscopy to identify the genotype of green coffee beans. Four genotypes of Arabic coffee: one Mundo Novo line (G1) and three Bourbon lines (G2, G3, and G4). The harvest was selected using a wet processing method. Raman spectra of the samples were obtained using a FT-Raman RFS/100 spectrometer in the spectral range of 3500-400 cm-1. The data were treated using chemometric unsupervised classification tools and supervised analysis. Using the unsupervised analysis (PCA), the apparent tendency of agglomeration between samples G1 and G3 was verified. These differences were present in the spectral bands that are characteristic of fatty acids and kahweol. Based on this information, a classification model to discriminate (PLS-DA) the Mundo Novo and Bourbon samples was utilized. Raman spectroscopy allowed the building of an adequate model to differentiate between coffee genotypes.


Assuntos
Coffea/genética , Análise Espectral Raman , Coffea/química , Coffea/crescimento & desenvolvimento , Análise Discriminante , Diterpenos/química , Genótipo , Análise dos Mínimos Quadrados , Análise de Componente Principal , Sementes/genética
8.
Int J Cancer ; 145(11): 2907-2916, 2019 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-30697705

RESUMO

Neuroblastoma (NB) is the most common extra-cranial tumour in children. Little is known about the aetiology of NB. The early age at onset and the embryonic nature suggest a role for perinatal exposures. We conducted a pooled analysis of two French national population-based case-control studies to explore whether there was an association between parental smoking and alcohol consumption and the risk of NB. The mothers of 357 NB cases and 1,783 controls from general population, frequency matched by age and sex, were interviewed on demographic, socioeconomic and perinatal characteristics, maternal reproductive story, and life-style and childhood environment. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. A meta-analysis of our findings with those of previous studies was also conducted. Maternal smoking during pregnancy was slightly more often reported for the cases (24.1%) than for the controls (19.7%) (OR 1.3 [95% CI 0.9-1.7]; summary OR from meta-analysis 1.1 [95% CI 1.0-1.3]. Paternal smoking in the year before child's birth were not associated with NB as independent exposure (OR 1.1 [95% CI 0.9-1.4] but the association was stronger when both parents reported having smoked during pregnancy (OR 1.5 [95% CI 1.1-2.1]. No association was observed with maternal alcohol intake during pregnancy (OR 1.0 [95% CI 0.8-1.4], summary OR from meta-analysis 1.0 [95% CI 0.9-1.2]. Our findings provide some evidence of an association between maternal smoking during pregnancy and NB and add another reason to recommend that women refrain from smoking during pregnancy.


Assuntos
Consumo de Bebidas Alcoólicas/epidemiologia , Neuroblastoma/epidemiologia , Fumar Tabaco/epidemiologia , Consumo de Bebidas Alcoólicas/efeitos adversos , Estudos de Casos e Controles , Pré-Escolar , Feminino , Humanos , Lactente , Modelos Logísticos , Masculino , Exposição Materna/efeitos adversos , Razão de Chances , Exposição Paterna/efeitos adversos , Gravidez , Sistema de Registros , Fumar Tabaco/efeitos adversos
9.
Psicol. (Univ. Brasília, Online) ; 35: e35443, 2019. tab, graf
Artigo em Inglês | LILACS-Express | LILACS, Index Psicologia - Periódicos técnico-científicos | ID: biblio-1135742

RESUMO

Abstract Depression and stress have been related with poor Health Related Quality of Life (HRQoL) prognosis. However, it is not clear when these depressive symptoms should be measured. A sample of 177 Coronary Heart Disease patients were followed for 15 months aimed to compare the effect of depression and stress measure at time of hospitalization and three months later on the physical HRQoL trajectory. Linear growth models' results showed that depression and stress after discharge are negatively correlated with the physical HRQoL and depressive symptoms negatively affect the prognosis of these patients.


Resumo Depressão e estresse têm sido associados ao prognóstico da Qualidade de Vida Relacionada à Saúde (QVRS). Contudo, não há clareza sobre quando os sintomas de depressão devem ser mensurados. Uma amostra de 177 pacientes com cardiopatia isquêmica foi acompanhada por 15 meses, para comparar o efeito do estresse e a depressão durante a internação e, três meses depois, avaliou-se a trajetória do componente físico da QVRS. Os resultados da comparação de duas curvas de crescimento latente mostraram que a depressão e o estresse pós-alta estão negativamente correlacionados com o componente físico da QVRS, e que os sintomas depressivos afetam negativamente o prognóstico desses pacientes.

10.
Rev. baiana saúde pública ; 42(1): https://doi.org/10.22278/2318-2660.2018.v42.n1.a2406, 12,Out 2018.
Artigo em Português | LILACS | ID: biblio-948020

RESUMO

As peças publicitárias de campanhas midiáticas relacionadas à prevenção foram utilizadas como produção textual e se configuraram como ferramenta-chave na construção das representações sociais. O objetivo da pesquisa foi analisar a relação intertextual entre as publicações científicas sobre cuidado às pessoas com Vírus da Imunodeficiência Humana/Síndrome da Imunodeficiência Adquirida, no período de 10 anos (2002-2011), e as campanhas midiáticas para o Dia Mundial de Luta Contra a Síndrome da Imunodeficiência Adquirida, nesse mesmo período. Trata-se de uma pesquisa documental e descritiva em bases de dados e em documentação oficial. Os resultados permitiram perceber a existência de quatro categorias: gênero, geração, preconceito/discriminação e raça, sendo que houve predomínio no foco das campanhas para o tema preconceito, demonstrando intenção governamental em interferir na representação social negativa, discriminatória e historicamente associada à Síndrome da Imunodeficiência Adquirida. A intertextualidade na categoria gênero identificou conteúdos que destacam o protagonismo feminino na prevenção/tratamento ou no estabelecimento das estratégias de enfrentamento. E, na categoria geração, independente do pertencimento geracional, a experiência com o Vírus da Imunodeficiência Humana/Síndrome da Imunodeficiência Adquirida é difícil, complexa e limitante. Concluiu-se que a relação intertextual apresenta-se como forma de apreender a dinâmica dessa epidemia e pode trazer contribuição à forma de agir frente às suas diversas facetas. A intertextualidade constitui-se em um recurso eficaz para apreender a construção do sentido, conferindo-lhe coerência e credibilidade. Utilizá-la com propriedade, como apoio argumentativo ou simplesmente como um jogo linguístico, contribui para a compreensão das representações sociais sobre a Síndrome da Imunodeficiência Adquirida ao longo da epidemia.


Publicity pieces of media campaigns related to prevention were used as textual production and are configurated as a key tool in the construction of social representations. The objective of this study was to analyze the intertextual relation between scientific publications on the care for persons with Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome in the period of 10 years (2002-2011) and the media campaigns for the World Day against Acquired Immunodeficiency Syndrome, in this same period. It is a documentary and descriptive research in databases in official documentation. The results allowed to perceive the existence of four categories: gender, generation, prejudice/discrimination and race, prejudice being the predominant in the focus of the campaigns, demonstrating governmental intention to interfere in the negative social representation, discriminatory and historically associated to Acquired Immunodeficiency Syndrome. Intertextuality in the gender category has identified content that highlights female protagonism in prevention / treatment or in the establishment of coping strategies. And in the generation category, regardless of generational belonging, the experience with Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome is difficult, complex and limiting. It was possible to conclude that the intertextual relation presents itself as a way of apprehending the dynamics of this epidemy and can contribute to the way of acting in face of its various facets. Intertextuality is an effective resource for understanding the construction of meaning, giving it coherence and credibility. To use it properly, as argumentative support or simply as a linguistic game, contributes to the understanding of social representations about Acquired Immunodeficiency Syndrome throughout the epidemic.


Las piezas publicitarias de campañas mediáticas relacionadas a la prevención fueron utilizadas como producción textual y configuraron como herramienta clave en la construcción de las representaciones sociales. El objetivo de la investigación fue analizar la relación intertextual entre las publicaciones científicas sobre cuidado a las personas con Virus de la Inmunodeficiencia Humana / Síndrome de Inmunodeficiencia Adquirida en el período de 10 años (2002-2011), y las campañas mediáticas para el Día Mundial de Lucha contra el Síndrome de Inmunodeficiencia Adquirida en este mismo período. Tratase de una investigación documental y descriptiva en bases de datos en documentación oficial. Los resultados permitieron percibir la existencia de cuatro categorías: género, generación, preconcepto / discriminación y raza, siendo que hubo predominio en el foco de las campañas para el tema preconcepto, demostrando intención gubernamental en interferir en la representación social negativa, discriminatoria e históricamente asociada al Síndrome de Inmunodeficiencia Adquirida. La intertextualidad en la categoría género identificó contenidos que destacan el protagonismo femenino en la prevención / tratamiento o en el establecimiento de las estrategias de enfrentamiento. Y, en la categoría generación, independientemente de la pertenencia generacional, la experiencia con el Virus de la Inmunodeficiencia Humana / Síndrome de Inmunodeficiencia Adquirida es difícil, compleja y limitante. Concluyese que la relación intertextual presentase como forma de aprehender la dinámica de esa epidemia y, puede aportar contribución a la forma de actuar frente a sus diversas facetas. La intertextualidad, constituyese en un recurso eficaz para aprehender la construcción del sentido, confiriéndole coherencia y credibilidad. La utilización con propiedad, como apoyo argumentativo o simplemente como un juego lingüístico, contribuye a la comprensión de las representaciones sociales sobre el Síndrome de Inmunodeficiencia Adquirida a lo largo de la epidemia.


Assuntos
Humanos , Síndrome de Imunodeficiência Adquirida , HIV , Mídias Sociais , Promoção da Saúde
11.
Pesqui. vet. bras ; 38(8): 1631-1637, Aug. 2018. tab, graf
Artigo em Português | LILACS, VETINDEX | ID: biblio-976479

RESUMO

O objetivo deste estudo foi descrever os resultados a longo prazo do uso da técnica extracapsular TightRope (TR) modificada no tratamento da doença do ligamento cruzado cranial (LCCr) em oito cães (10 articulações) com peso corporal variando entre 4kg e 28kg. Todos os animais selecionados foram submetidos aos exames ortopédicos específicos, sendo diagnosticada ruptura completa do LCCr pelos testes de gaveta e de compressão tibial. Realizaram-se exames radiográficos convencionais e em posição de estresse das articulações. A técnica TR foi modificada utilizando-se o fio de náilon substituindo o fio de fibra empregado na técnica original, facilitando a disponibilidade de obtenção do material. Houve também modificação na origem da perfuração do túnel tibial, sendo realizada imediatamente cranial ao sulco do tendão extensor digital longo. Todos os cães foram submetidos ao exame radiográfico tanto no pós-operatório imediato como no tardio. Aos 30 dias após a intervenção cirúrgica, os pacientes apresentavam claudicação nos membros pélvicos operados de grau discreto a moderado. Foi observado discreto movimento de gaveta cranial em 60% das articulações acometidas. Aos três meses após o procedimento cirúrgico, os animais apresentaram ausência de dor e discreta redução na amplitude dos movimentos articulares. Em duas articulações (20%) observou-se discreto deslocamento cranial da tíbia no teste de gaveta. Nesta fase, 80% dos membros avaliados apresentavam apoio normal. Um ano após a intervenção cirúrgica, observou-se ao exame radiográfico discreta progressão da doença articular degenerativa em 50% das articulações operadas. Das oito articulações avaliadas a longo prazo, em apenas um membro operado observou-se discreta claudicação com reduzida transferência de peso para o membro contralateral. Os demais membros pélvicos avaliados (87,5%) demonstraram ausência de claudicação e adequada recuperação da função articular. Concluiu-se que a técnica cirúrgica extracapsular TR modificada mostrou-se efetiva como opção de tratamento para doença do LCCr em cães de porte pequeno e médio, não apresentando complicações. As modificações do fio cirúrgico e da perfuração da tíbia na técnica TR parecem ter efeitos positivos na estabilização da articulação do joelho.(AU)


The aim of the study was to describe the long term outcomes of the modified extracapsular TightRope (TR) technique in the treatment of the cranial cruciate ligament (CCL) disease in eight dogs (10 joints) with a body weight ranging from 4kg to 28kg. The animals were submitted to specific orthopedic examinations and were diagnosed with total CCL rupture by drawer and tibial compression tests. Conventional and stress positional radiographic examinations of the affected joints were performed. The TR technique was modified using the nylon suture thread replacing the fiber suture used in the original technique, which facilitated the availability of obtaining the material. There was also modification in the origin of the tibial tunnel perforation that was performed immediately cranial to the groove of the long digital extensor tendon. The dogs underwent radiographic examination in the immediate postoperative and in later periods. At one month after surgical procedure, the animals showed mild or moderate lameness in the affected pelvic limbs. Mild cranial tibial drawer was observed in 60% of the operated joints. At three months after the procedure, the animals have mild decrease in the range of joint motion, but without signs of pain. Two stifle joints (20%) showed a slight cranial displacement of the tibia in the drawer test. In this period, 80% of the affected joints showed normal limb support. At one year after the procedure, radiographic examination showed a discrete progression of the degenerative joint disease in 50% of the operated joints. The long term outcomes were obtained from eight joints and in only one pelvic limb was observed mild lameness with slight weight transfer to the normal contralateral limb. All other evaluated pelvic limbs (87.5%) showed no lameness and proper recovery of joint function. In conclusion, the modified TR extracapsular surgical technique proved to be effective as a treatment option for CCL disease in small and medium dogs, with no complications. Modifications of the surgical suture thread and the tibial site perforation of the TR technique seem to have positive effects on stabilization of the stifle joint.(AU)


Assuntos
Animais , Cães , Cães/cirurgia , Cães/lesões , Lesões do Ligamento Cruzado Anterior/veterinária , Traumatismos do Joelho/cirurgia
12.
Pesqui. vet. bras ; 38(7): 1293-1299, July 2018. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-976453

RESUMO

The objective of this study was to evaluate the adherence to and invasion of HeLa cells by Campylobacter spp. strains (total n=63) isolated from chickens (n=4), dogs (n=4), non-human primates (n=16), pigs (n=9), calf feces (n=18), and bovine genital tracts (n=12). Thirty-two strains adhered to and 13 invaded HeLa cells. Invasive strains included 1 of 4 dog isolates, 4 of 16 non-human primate isolates (2 C. jejuni and 2 C. coli), 1 of 9 C. coli strains isolated from pigs, and 7 of 18 C. fetus subsp. fetus isolated from calf feces. Only 25% of chicken and dog isolates and 23% of pig isolates were able to adhere to HeLa cells, a property of 65% of strains obtained from calf feces and 83% of bovine genital tract-isolated strains. The adherent phenotype was observed in 5 of 19, 6 of 15, and 21 of 29 strains of C. jejuni, C. coli, and C. fetus subsp. fetus, respectively, whereas 3 of 19, 3 of 15, and 7 of 29 strains were additionally able to invade HeLa cells, respectively. C. jejuni, C. coli, and C. fetus subsp. fetus strains isolated from animal feces are able to adhere and invade HeLa cells, whereas C. fetus subsp. fetus strains isolated from the bovine genital tract were not invasive in HeLa cells. The present study showed that C. jejuni isolated from primates and dogs, C. coli isolated from non-human primates and pigs, and C. fetus subsp. fetus isolated from calf feces have the ability to adhere to and to invade HeLa cells. Moreover, the lack of invasive ability by C. fetus subsp. fetus strains isolated from the bovine genital tract could be important in the pathogenesis of the genital tract diseases caused by this bacterium.(AU)


O objetivo deste estudo foi avaliar a adesão e invasão de células HeLa por amotras de Campylobacter spp. (total n=63) isoladas de frangos (n=4), cães (n=4), primatas não-humanos (n=16), porcos (n=9), fezes de bezerros (n=18), e trato genital de bovinos (n=12). Trinta e duas amostras foram capazes de aderir e 13 invadiram células HeLa. As amostras invasivas incluíram 1 de 4 isolados de cão, 4 de 16 isolados de primatas não-humano (2 C. jejuni e 2 C. coli), 1 de 9 C. coli isoladas de porcos e 7 de 18 C. fetus subsp. fetus isoladas de fezes de bezerros. Apenas 25% dos isolados de frango e de cão e 23% dos isolados de suínos foram capazes de aderir a células HeLa, propriedade exibida por 65% das cepas obtidas a partir de fezes de bezerros e por 83% das amostras isoladas de trato genital bovino. O fenótipo aderente foi observado em 5 de 19, 6 de 15 e 21 de 29 amostras de C. jejuni, C. coli e C. fetus subsp. fetus, respectivamente, enquanto que 3 de 19, 3 de 15 e 7 de 29 amostras foram adicionalmente capazes de invadir as células HeLa, respectivamente. Amostras de C. jejuni, C. coli e C. fetus subsp. fetus isoladas de fezes de animais foram capazes de aderir e invadir as células HeLa, enquanto amostras de C. fetus subsp. fetus isoladas a partir de amostras de trato genital bovino não foram invasivas, em células HeLa. O presente estudo mostrou que amostras de C. jejuni isoladas de primatas não-humanos e cães, C. coli isoladas de primatas não-humanos e porcos, e C. fetus subsp. fetus isolados a partir de fezes de bezerros foram capazes de aderir e invadir células HeLa. Além disso, a falta de capacidade invasiva de amostras de C. fetus subsp. fetus isoladas de trato genital bovino pode ser importante na patogênese das doenças das vias genitais causadas por esta bactéria.(AU)


Assuntos
Animais , Suínos/microbiologia , Campylobacter/isolamento & purificação , Bovinos/microbiologia , Galinhas/microbiologia
13.
Cancer Causes Control ; 28(10): 1125-1132, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28840389

RESUMO

PURPOSE: Neuroblastoma (NB) is an embryonic tumor that occurs almost exclusively in infancy and early childhood. While considerable evidence suggests that it may be initiated during embryonic development, the etiology of NB is still unknown. The aim of this study was to explore whether there is an association between maternal use of household pesticides during pregnancy and the risk of NB in the offspring. METHODS: We conducted a pooled analysis of two French national-based case-control studies. The mothers of 357 NB cases and 1,783 controls younger than 6 years, frequency-matched by age and gender, responded to a telephone interview that focused on sociodemographic and perinatal characteristics, childhood environment, and life-style. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. RESULTS: After controlling for matching variables, study of origin, and potential confounders, the maternal use of any type of pesticide during pregnancy was associated with NB (OR 1.5 [95% CI 1.2-1.9]). The most commonly used type of pesticides were insecticides and there was a positive association with their use alone (OR 1.4 [95% CI 1.1-1.9]) or with other pesticides (OR 2.0 [95% CI 1.1-3.4]). CONCLUSIONS: Although there is the potential for recall bias due to the study design, our findings add to the evidence of an association between the household use of pesticides and NB. Until a better study design can be found, our findings add yet another reason why to advise pregnant women to limit pesticide exposure during the periconceptional period.


Assuntos
Exposição Materna , Troca Materno-Fetal , Neuroblastoma/epidemiologia , Praguicidas , Adulto , Estudos de Casos e Controles , Pré-Escolar , Feminino , França/epidemiologia , Humanos , Lactente , Modelos Logísticos , Masculino , Razão de Chances , Gravidez , Fatores de Risco
14.
Int J Cancer ; 140(8): 1757-1769, 2017 04 15.
Artigo em Inglês | MEDLINE | ID: mdl-28054353

RESUMO

Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal preconceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender did a telephone interview, which focussed on demographic and perinatal characteristics, and maternal life style habits and reproductive history. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex, study of origin and relevant confounders. No association was found between CBT and birth weight or fetal growth. The use of preconceptional folic acid supplementation was rare (5.3% in cases and 7.8% in controls) and the OR was 0.8 (95% CI 0.5, 1.4). There was no association with breastfeeding, even prolonged (six months or more; OR 1.0, 95% CI 0.8, 1.4). Neither was there any association between CBT and other investigated factors (maternal body mass index, gestational weight gain, congenital abnormality, maternal reproductive history or use of fertility treatments. Although large, this study was underpowered for subtype analyses. Pooling data with other population-based studies may provide further insight into findings by CBT subtypes.


Assuntos
Peso ao Nascer , Neoplasias Encefálicas/epidemiologia , Neoplasias Encefálicas/fisiopatologia , Adolescente , Adulto , Índice de Massa Corporal , Neoplasias Encefálicas/diagnóstico , Aleitamento Materno , Estudos de Casos e Controles , Criança , Feminino , França , Humanos , Modelos Logísticos , Masculino , Mães , Gravidez , Fatores de Risco
15.
Int J Cancer ; 139(9): 1936-48, 2016 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-27342419

RESUMO

Neuroblastoma (NB), an embryonic tumour arising from neural crest cells, is the most common malignancy among infants. The aetiology of NB is largely unknown. We conducted a pooled analysis to explore whether there is an association between NB and preconception and perinatal factors using data from two French national population-based case-control studies. The mothers of 357 NB cases and 1783 controls younger than 6 years, frequency-matched by age and gender, responded to a telephone interview that focused on demographic, socioeconomic and perinatal characteristics, childhood environment, life-style and maternal reproductive history. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. After controlling for matching variables, study of origin and potential confounders, being born either small (OR 1.4 95% CI 1.0-2.0) or large (OR 1.5 95% CI 1.1-2.2) for gestational age and, among children younger than 18 months, having congenital malformations (OR 3.6 95% CI 1.3-8.9), were significantly associated with NB. Inverse associations were observed with breastfeeding (OR 0.7 95% CI 0.5-1.0) and maternal use of any supplements containing folic acid, vitamins or minerals (OR 0.5 95% CI 0.3-0.9) during the preconception period. Our findings reinforce the hypothesis that fetal growth anomalies and congenital malformations may be associated with an increased risk of NB. Further investigations are needed in order to clarify the role of folic acid supplementation and breastfeeding, given their potential importance in NB prevention.


Assuntos
Anormalidades Congênitas/epidemiologia , Suplementos Nutricionais/estatística & dados numéricos , Neuroblastoma/epidemiologia , Complicações na Gravidez/epidemiologia , Adolescente , Adulto , Peso ao Nascer , Aleitamento Materno , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , França/epidemiologia , Humanos , Lactente , Recém-Nascido , Entrevistas como Assunto , Modelos Logísticos , Masculino , Gravidez , Complicações na Gravidez/etiologia , Adulto Jovem
16.
Rev Colomb Psiquiatr ; 44(3): 150-8, 2015.
Artigo em Espanhol | MEDLINE | ID: mdl-26578415

RESUMO

INTRODUCTION: Offspring of bipolar parents are a high risk population for the develop of mental diseases, their study allow determining the genetic risk, early symptoms, prodromes and psychopathology of bipolar disorder. OBJECTIVE: To describe the psychopathological characteristics and neurocognitives profiles of the offspring of bipolar type I parents. And to identify the presence of sub-syndromal symptoms in all the symptom domains. METHODS: A descriptive and cross-sectional study was conducted on 110 offspring between 6 and 30 years old. Semi-structured diagnostic interviews were performed. The intelectual coeficient was determined and a neuropsychological assessment was performed on 89 offspring. RESULTS: The most prevalent disorder in the offspring was ADHD (27.6%), with major depression (15.5%) and separation anxiety (14.1%) also being prevalent. Seven patients of the sample were diagnosed with bipolar disorder. There was a statistically significant difference between the age groups for ADHD prevalence. The most frequent sub-syndromal symptoms were observed in the disruptive group. Alterations in the cognitive domains: attention, verbal fluency, work memory, and speed of information processing, were observed in the group younger than 18 years. CONCLUSIONS: The offspring of bipolar parents have an elevated rate of psychopathology and cognitive alterations. They are a high risk population for the development of mental disease. These subjects also require close longitudinal observation and early and preventive therapeuthic interventions.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia , Transtorno Bipolar/epidemiologia , Filho de Pais Incapacitados/psicologia , Transtorno Depressivo Maior/epidemiologia , Adolescente , Adulto , Ansiedade de Separação/epidemiologia , Criança , Transtornos Cognitivos/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Prevalência , Adulto Jovem
17.
Water Sci Technol ; 72(7): 1226-33, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26398039

RESUMO

This study offers the opportunity to utilize Undaria pinnatifida and Phragmites australis to remove lead from water in permeable reactive barrier (PRB) technology. Its efficacy was tested using batch experiments and PRB column systems. From the batch experiment results, a higher adsorption capacity was observed for Undaria pinnatifida. Nevertheless, Phragmites australis in the column system efficiently removed lead and the breakthrough occurred at the same time for both biomaterials. To dissipate this difference, a sequential extraction for metal speciation analysis was used for both columns. The results have shown that each biomaterial has a dominant mechanism. Phragmites australis removed lead by physical adsorption, whereas Undaria pinnatifida showed a higher tendency to bind lead due to organic matter, primary and secondary minerals.


Assuntos
Chumbo/isolamento & purificação , Poaceae/química , Undaria/química , Poluentes Químicos da Água/isolamento & purificação , Purificação da Água/métodos , Adsorção , Biomassa , Modelos Teóricos , Poaceae/crescimento & desenvolvimento , Propriedades de Superfície , Undaria/crescimento & desenvolvimento
18.
Rev. colomb. psiquiatr ; 44(3): 150-158, jul.-dic. 2015. ilus, tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: lil-779617

RESUMO

Introducción: Los hijos de pacientes con trastorno bipolar (HPTB) son una población de alto riesgo de sufrir trastornos mentales; su observación permite apreciar el riesgo genético, los síntomas tempranos, los pródromos y la psicopatología del trastorno bipolar (TB). Objetivo: Describir las características psicopatológicas y los perfiles neurocognitivos de los HPTB tipo I. Métodos: Estudio descriptivo de corte transversal en el cual se incluyó a 110 HPTB de 6 a 30 arios de edad. Se hicieron entrevistas diagnósticas semiestructuradas, se determinó el coeficiente intelectual y se aplicó una valoración neuropsicológica a 49 de los HPTB. Resultados: Los diagnósticos más prevalentes entre los HPTB fueron: trastorno de déficit de atención e hiperactividad (27,6%), trastorno depresivo mayor (15,5%) y trastorno de ansiedad por separación (14,1%). A 7 HPTB se les diagnóstico TB. Los síntomas subumbrales más frecuentes, fueron los del grupo de los trastornos disruptivos. Además, en los HPTB menores de 18 años, se observaron alteraciones en los dominios cognitivos: atención, fluidez verbal, memoria de trabajo y velocidad de procesamiento de la información. Conclusiones: Los HPTB presentan una elevada tasa de psicopatologías y alteraciones cognitivas; son una población de alto riesgo de enfermedad mental que requiere estrecha observación longitudinal e intervenciones terapéuticas y preventivas tempranas.


Introduction: Offspring of bipolar parents are a high risk population for the develop of mental diseases, their study allow determining the genetic risk, early symptoms, prodromes and psychopathology of bipolar disorder. Objective: To describe the psychopathological characteristics and neurocognitives profiles of the offspring of bipolar type I parents. And to identify the presence of sub-syndromal symptoms in all the symptom domains. Methods: A descriptive and cross-sectional study was conducted on 110 offspring between 6 and 30 years old. Semi-structured diagnostic interviews were performed. The intelectual coeficient was determined and a neuropsychological assessment was performed on 89 offspring. Results:The most prevalent disorder in the offspring was ADHD (27.6%), with major depression (15.5%) and separation anxiety (14.1%) also being prevalent. Seven patients of the sample were diagnosed with bipolar disorder. There was a statistically significant difference between the age groups for ADHD prevalence. The most frequent sub-syndromal symptoms were observed in the disruptive group. Alterations in the cognitive domains: attention, verbal fluency, work memory, and speed of information processing, were observed in the group younger than 18 years. Conclusions: The offspring of bipolar parents have an elevated rate of psychopathology and cognitive alterations. They are a high risk population for the development of mental disease. These subjects also require close longitudinal observation and early and preventive therapeuthic interventions.

19.
Water Sci Technol ; 70(2): 307-14, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25051478

RESUMO

As alternative materials for heavy metal removal, this study investigated biosorbents to determine their suitability for permeable reactive barriers. The lead removal efficiencies of brown seaweed (Undaria pinnatifida) and reed (Phragmites australis) were determined under different conditions (batch and column system). The experimental results for these biomaterials fitted the Langmuir isotherm with high correlation values. It was verified that the influence of temperature on affinity was higher than that on adsorption capacity. While the lead removal efficiency of U. pinnatifida was higher than of P. australis in the batch experiments, lead removal efficiency decreased for both materials at approximately the same time in the column experiments. This indicates that the dominance of the chemical and physical adsorption mechanisms could result in differences in these systems.


Assuntos
Chumbo/química , Poaceae , Alga Marinha , Eliminação de Resíduos Líquidos/métodos , Águas Residuárias/química , Poluentes Químicos da Água/química , Adsorção , Reatores Biológicos
20.
Rev. med. Risaralda ; 18(2): 116-121, dic. 2012.
Artigo em Espanhol | LILACS | ID: lil-658196

RESUMO

Introducción: Se describe una serie casos de cáncer en el periodo 2001-2011 de usuarios atendidos en Oncólogos del Occidente que permite establecer una tendencia de la notificación de los casos a través del tiempo. Métodos: Se diseñó un sistema de información de cáncer en Oncólogos del Occidente tomando como fuente la historia clínica digital de la institución. Resultados: En el periodo de observación, los cánceres que más generan consulta en las diferentes sedes de Oncólogos del Occidente están localizados en próstata, mama, cérvix, gástrico, bronquios y pulmón, linfomas, colon, recto, tiroides, ovario y leucemias linfoides. Discusión: Casi todos los cánceres aquí definidos como importantes por su frecuencia pueden ser intervenidos de una manera precoz, con adecuados programas de promoción de la salud y tamizajes que son costo-efectivos.


Introduction: The document establishes the tendencies of cancer cases through time. It describes the series of cancer cases for patients who attended the Oncologos del Occidente during the period of 2001-2011. Methods: To accomplish this, Oncologos del Occidente designed an information system that used as a main source the digital clinical history of the institution. Results: During the period of observation, the most prevalent cancers requiring medical consultation throughout the centers of Oncologos del Occidente were: prostate, breast, cervical, stomach, bronchial tubes and lung, lymphoma, colon, rectum, thyroid, ovarian, and lymphoid leukemia. Discussion: Most of the cancers defined as important by their frequency in this document, can be early intervened through appropriate cost-effective health and screening promotional programs.


Assuntos
Humanos , Epidemiologia , Neoplasias , Vigilância , Colômbia
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