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1.
Neurosurgery ; 86(3): 383-390, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31215635

RESUMO

BACKGROUND: Intraneural ganglion cysts are joint-connected, with the primary pathology residing in the associated joint. For peroneal intraneural ganglion cysts, the surgical strategy can include resection of the synovial surface of the superior tibiofibular joint (STFJ). However, the rate of instability postoperatively is unclear. OBJECTIVE: To evaluate the rate of STFJ instability, following surgery for peroneal intraneural ganglion cysts. The second goal of the study was to assess the relationship between volume of resection of the STFJ and risk of extraneural recurrence. METHODS: We performed a retrospective analysis of a cohort of patients with peroneal intraneural ganglion cysts. We analyzed clinical factors, including recurrence, and assessed the rate of postoperative STFJ instability. We created 3-dimensional models of the STFJ pre- and postoperatively to compare the volume of resection in recurrent cases and nonrecurrent cases using a case-control design. RESULTS: The total cohort consisted of 65 subjects. No patient had evidence of radiological or clinical instability of the STFJ postoperatively. Extraneural radiological recurrence occurred in 6 (9%) patients. No intraneural recurrences were observed. The average volume of resection for patients with recurrence was 1349 mm3 (SD = 1027 mm3) vs 3018 mm3 (SD = 1433 mm3) in controls that did not have a recurrence (P = .018). CONCLUSION: This study supports performing an aggressive STFJ resection to minimize the risk of extraneural recurrence. Superior tibiofibular joint resection is not associated with postoperative joint instability. A smaller volume resection is correlated with recurrence risk.

2.
Acta Neurochir (Wien) ; 160(3): 651-654, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29372402

RESUMO

The intraoperative use of intravenous fluorescein is presented in a case of peroneal intraneural ganglion cyst. When illuminated with the operative microscope and yellow filter, this fluorophore provided excellent visualization of the abnormal cystic peroneal nerve and its articular branch connection. The articular (synovial) theory for the pathogenesis of intraneural cysts is further supported by this pattern of fluorescence. Further, our report presents a novel use of fluorescein in peripheral nerve surgery.


Assuntos
Cistos Glanglionares/cirurgia , Articulação do Joelho/cirurgia , Nervo Fibular/cirurgia , Fluoresceína , Corantes Fluorescentes , Cistos Glanglionares/patologia , Humanos , Cuidados Intraoperatórios , Articulação do Joelho/patologia , Masculino , Microscopia de Fluorescência , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos , Nervo Fibular/patologia
3.
Muscle Nerve ; 57(6): 989-993, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29315664

RESUMO

INTRODUCTION: The objective of this study was to answer the typical questions from patients regarding the likely neurologic outcome and likelihood of recurrence when discussing peroneal intraneural ganglion cysts preoperatively. METHODS: Retrospective analysis of all patients who underwent surgery for a peroneal intraneural ganglion cyst between January 1, 2000, and April 1, 2017, was performed. Postoperative neurologic outcomes and radiologic recurrences are reported. RESULTS: There were 65 patients. Average clinical follow-up was 14 months. Median dorsiflexion and eversion preoperatively were 2/5 and 4/5, respectively. Median dorsiflexion and eversion at last follow-up postoperatively were 5/5. Radiologic recurrence occurred in 6 (9%) patients, all extraneural. DISCUSSION: The data support excellent postoperative motor outcomes, despite frequent dense weakness of peroneal-innervated musculature preoperatively. The surgical approach appears to eliminate risk of intraneural recurrence and minimizes risk of extraneural recurrence. Muscle Nerve 57: 989-993, 2018.


Assuntos
Cistos Glanglionares/cirurgia , Articulação do Joelho/cirurgia , Nervo Fibular/cirurgia , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Adulto Jovem
6.
Trustee ; 69(3): 23, 1, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27125121

RESUMO

This Hospitals in Pursuit of Excellence column considers innovative care and payment models to help hospitals and health systems achieve the Triple Aim.


Assuntos
Assistência à Saúde/organização & administração , Controle de Custos , Administração Hospitalar , Inovação Organizacional , Qualidade da Assistência à Saúde , Estados Unidos
7.
Clin Anat ; 28(8): 1058-69, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26296291

RESUMO

The etiology of intraneural ganglion cysts has been poorly understood. This has resulted in the development of multiple surgical treatment strategies and a high recurrence rate. We sought to analyze these recurrences in order to provide a pathoanatomic explanation and staging classification for intraneural cyst recurrence. An expanded literature search was performed to identify frequencies and patterns in cases of intraneural ganglion cyst recurrences following primary surgery. Two univariate analyses were completed to identify associations between the type of revision surgery and repeat cyst recurrences. The expanded literature search found an 11% recurrence rate following primary surgery, including 64 recurrences following isolated cyst decompression (Group 1); six after articular branch resection (Group 2); and none following surgical procedures that addressed the joint (Group 3). Eight cases did not specify the type of primary surgery. In group 1, forty-eight of the recurrences (75%) were in the parent nerve, three involved only the articular branch, and one travelled along the articular branch in a different distal direction without involving the main parent nerve. In group 2, only one case (17%) recurred/persisted within the parent nerve, one recurred within a persistent articular branch, and one formed within a persistent articular branch and travelled in a different distal direction. Intraneural recurrences most commonly occur following surgical procedures that only target the main parent nerve. We provide proven or theoretical explanations for all identified cases of intraneural recurrences for an occult or persistent articular branch pathway.


Assuntos
Cistos Glanglionares/patologia , Cistos Glanglionares/cirurgia , Articulações/inervação , Nervos Periféricos/cirurgia , Descompressão Cirúrgica , Cistos Glanglionares/etiologia , Humanos , Articulações/cirurgia , Recidiva , Reoperação
8.
Acta Neurochir (Wien) ; 157(5): 837-40, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25588748

RESUMO

BACKGROUND: Intraneural ganglia most commonly occur within the peroneal nerve near the fibular neck. Disconnection of the articular branch is required in their treatment. Surgical intervention can be challenging because of unfamiliarity with the region or scarring from previous surgery. METHOD: We present the layered "U" technique for peroneal intraneural ganglia with clinical examples. Dissection is carried down in parallel to the U-shaped course of the articular branch to provide optimal visualization and avoid injury to major branches of the nerve. CONCLUSION: This pathoanatomic approach provides direct and safe exposure of the articular branch of the common peroneal nerve.


Assuntos
Dissecação/métodos , Cistos Glanglionares/cirurgia , Articulação do Joelho/cirurgia , Procedimentos Neurocirúrgicos/métodos , Nervo Fibular/cirurgia , Neuropatias Fibulares/cirurgia , Humanos , Articulação do Joelho/patologia , Nervo Fibular/patologia
9.
Case Rep Radiol ; 2014: 101069, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24587935

RESUMO

Aneurysmal bone cysts (ABC) are rare, benign, expansile lesions of bone often found in the metaphyses of long bones in pediatric and young adult population. Multiple fluid levels are typically seen on imaging with magnetic resonance imaging (MRI) or computed tomography (CT). We describe a case of a primary ABC in the fibula of a 34-year-old man diagnosed on ultrasound with a mobile fluid level demonstrated sonographically.

10.
BMC Health Serv Res ; 12: 464, 2012 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-23244445

RESUMO

BACKGROUND: Medicare hospital Value-based purchasing (VBP) program that links Medicare payments to quality of care will become effective from 2013. It is unclear whether specific hospital characteristics are associated with a hospital's VBP score, and consequently incentive payments.The objective of the study was to assess the association of hospital characteristics with (i) the mean VBP score, and (ii) specific percentiles of the VBP score distribution. The secondary objective was to quantify the associations of hospital characteristics with the VBP score components: clinical process of care (CPC) score and patient satisfaction score. METHODS: Observational analysis that used data from three sources: Medicare Hospital Compare Database, American Hospital Association 2010 Annual Survey and Medicare Impact File. The final study sample included 2,491 U.S. acute care hospitals eligible for the VBP program. The association of hospital characteristics with the mean VBP score and specific VBP score percentiles were assessed by ordinary least square (OLS) regression and quantile regression (QR), respectively. RESULTS: VBP score had substantial variations, with mean score of 30 and 60 in the first and fourth quartiles of the VBP score distribution. For-profit status (vs. non-profit), smaller bed size (vs. 100-199 beds), East South Central region (vs. New England region) and the report of specific CPC measures (discharge instructions, timely provision of antibiotics and beta blockers, and serum glucose controls in cardiac surgery patients) were positively associated with mean VBP scores (p<0.01 in all). Total number of CPC measures reported, bed size of 400-499 (vs. 100-199 beds), a few geographic regions (Mid-Atlantic, West North Central, Mountain and Pacific) compared to the New England region were negatively associated with mean VBP score (p<0.01 in all). Disproportionate share index, proportion of Medicare and Medicaid days to total inpatient days had significant (p<0.01) but small effects. QR results indicate evidence of differential effects of some of the hospital characteristics across low-, medium- and high-quality providers. CONCLUSIONS: Although hospitals serving the poor and the elderly are more likely to score lower under the VBP program, the correlation appears small. Profit status, geographic regions, number and type of CPC measures reported explain the most variation among scores.


Assuntos
Hospitais/classificação , Aquisição Baseada em Valor , Benchmarking , Intervalos de Confiança , Bases de Dados Factuais , Número de Leitos em Hospital , Hospitalização , Medicaid , Medicare , Análise Multivariada , Patient Protection and Affordable Care Act , Análise de Regressão , Estados Unidos , Aquisição Baseada em Valor/estatística & dados numéricos
11.
J Neurosurg ; 114(1): 217-24, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20486896

RESUMO

OBJECT: The mechanism responsible for exceptional examples of intraneural ganglia with extensive longitudinal involvement has not been understood. Such cases of intraneural cysts, seemingly remote from a joint, have been thought not to have articular connections. Decompression and attempted resection of the cyst has led to intraneural recurrence and poor neurological recovery. The purpose of this report is not only to clarify the pathogenesis of these cysts, but also to discuss their treatment based on modern concepts of intraneural ganglia. METHODS: Two examples of extreme longitudinal propagation of intraneural ganglia are presented. RESULTS: A patient with a moderate tibial neuropathy was found to have a tibial intraneural ganglion. Prospective interpretation of the MR imaging study demonstrated the cyst's origin from the posterior portion of the superior tibiofibular joint (STFJ), with proximal extension within the sciatic nerve to the lower buttock region. Communication between the STFJ and the cyst was confirmed with direct knee MR arthrography. The tibial intraneural cyst was treated successfully by a relatively limited exposure in the distal popliteal fossa: the cyst was decompressed, the articular branch disconnected, and the STFJ resected. Postoperatively, the patient improved neurologically and there was no evidence of recurrent cyst on postoperative MR imaging. A second patient, previously reported by another group, was reexamined 22 years after surgery. This patient had an extensive peroneal intraneural ganglion that extended into the sciatic nerve from the knee to the buttock; no joint connection or recurrent cyst had initially been described. In this patient, the authors hypothesized and established with MR imaging the presence of both: a joint connection to the anterior portion of the STFJ from the peroneal articular branch as well as recurrent cyst within the peroneal and tibial nerves. CONCLUSIONS: This paper demonstrates that extreme intraneural cysts are not clinical outliers but represent extreme examples of other more typical intraneural cysts. They logically obey the same principles, previously described in the unified articular (synovial) theory. The degree of longitudinal extension is probably due to high intraarticular pressures within the degenerative joint of origin. The generalizability of the mechanistic principles is highlighted by the fact that these 2 cases, involving the tibial and the peroneal nerve respectively, both extended well distant (that is, to the buttock) from the STFJ via their respective articular branch of origin. These extensive intraneural cysts can be treated successfully by disconnecting the affected articular branch and by resection of the joint of origin, rather than by a more aggressive operation resecting the cyst and cyst wall.


Assuntos
Cistos Glanglionares/diagnóstico , Cistos Glanglionares/cirurgia , Nervo Fibular/cirurgia , Índice de Gravidade de Doença , Nervo Tibial/cirurgia , Adolescente , Descompressão Cirúrgica/métodos , Feminino , Cistos Glanglionares/patologia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Nervo Fibular/patologia , Reoperação/métodos , Nervo Tibial/patologia , Resultado do Tratamento
12.
Neurosurgery ; 67(3 Suppl Operative): ons71-8; discussion ons78, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20679946

RESUMO

BACKGROUND: Recent research has resulted in an improved understanding of the pathogenesis and treatment of intraneural ganglia, particularly with respect to the most common form, the peroneal nerve at the fibular neck region. OBJECTIVE: To outline the mechanism for the development and propagation of intraneural ganglia located in the knee region, along with their treatment, as well as highlight how shared principles can be exploited for successful treatment of the more commonly occurring peroneal intraneural ganglia. METHODS: A surgical approach has been developed for peroneal intraneural cysts based on the pathogenesis. The treatment of the less common tibial intraneural cysts is designed along the same principles. RESULTS: A strategy consisting of (1) disarticulation (resection) of the superior tibiofibular joint (ie, the source), (2) disconnection of the articular branch connection (ie, the conduit), and (3) decompression (rather than resection) of the cyst has improved outcomes and eliminated intraneural recurrences in peroneal intraneural cysts. These same principles and techniques can be applied to the rarer tibial intraneural ganglia derived from the same joint. The mechanism of development and propagation for intraneural cysts in the knee region as well as a surgical technique and its rational are described and illustrated. CONCLUSION: Understanding the joint-related basis of intraneural cysts leads to simple targeted surgery that addresses the joint, its articular branch, and the cyst. The success of the shared surgical strategy for both peroneal and tibial intraneural ganglia confirms the principles of the unifying articular theory.


Assuntos
Cistos Glanglionares/cirurgia , Articulação do Joelho , Neurocirurgia/métodos , Neoplasias do Sistema Nervoso Periférico/cirurgia , Neuropatias Fibulares/cirurgia , Neuropatia Tibial/cirurgia , Descompressão Cirúrgica/métodos , Desarticulação/métodos , Cistos Glanglionares/complicações , Cistos Glanglionares/diagnóstico , Humanos , Articulação do Joelho/inervação , Articulação do Joelho/cirurgia , Imagem por Ressonância Magnética/métodos , Neoplasias do Sistema Nervoso Periférico/complicações , Neoplasias do Sistema Nervoso Periférico/diagnóstico , Neuropatias Fibulares/complicações , Neuropatias Fibulares/diagnóstico , Cuidados Pós-Operatórios , Neuropatia Tibial/complicações , Neuropatia Tibial/diagnóstico
13.
J Arthroplasty ; 24(5): 806-14, 2009 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18639433

RESUMO

Secure fixation of acetabular components in total hip arthroplasty can be challenging. The purpose of this study was to perform biomechanical analysis of cup fixation strength using fixed-angle vs standard screw fixation. Multihole, porous-backed acetabular prostheses were implanted in both acetabuli of 8 cadaveric pelves using standard press-fit techniques. Fixed-angle screws were used on the left side, and standard cancellous screws were used in the right. The use of fixed-angle screws enhanced acetabular fixation substantially under subfailure cyclic loading conditions and load-to-failure. The triradiate screw configuration increases the bending moment required to fail the specimens as well. Fixed-angle screws may be useful for achieving rigid fixation of acetabular prostheses in challenging clinical scenarios.


Assuntos
Acetábulo/cirurgia , Artroplastia de Quadril/instrumentação , Parafusos Ósseos , Prótese de Quadril , Fenômenos Biomecânicos , Cadáver , Humanos
14.
J Neurosurg ; 107(2): 296-307, 2007 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-17695383

RESUMO

OBJECT: The pathogenesis of intraneural ganglia has been a controversial issue for longer than a century. Recently the authors identified a stereotypical pattern of occurrence of peroneal and tibial intraneural ganglia, and based on an understanding of their pathogenesis provided a unifying articular explanation. Atypical features, which occasionally are observed, have offered an opportunity to verify further and expand on the authors' proposed theory. METHODS: Three unusual cases are presented to exemplify the dynamic features of peroneal and tibial intraneural ganglia formation. RESULTS: Two patients with a predominant deep peroneal nerve deficit shared essential anatomical findings common to peroneal intraneural ganglia: namely, 1) joint connections to the anterior portion of the superior tibiofibular joint, and 2) dissection of the cyst along the articular branch of the peroneal nerve and proximally. Magnetic resonance (MR) images obtained in these patients demonstrated some unusual findings, including the presence of a cyst within the tibial and sural nerves in the popliteal fossa region, and spontaneous regression of the cysts, which was observed on serial images obtained weeks apart. The authors identified a clinical outlier, a case that could not be understood within the context of their previously reported theory of intraneural ganglion cyst formation. Described 32 years ago, this patient had a tibial neuropathy and was found at surgery to have tibial, peroneal, and sciatic intraneural cysts without a joint connection. The authors' hypothesis about this case, based on their unified theory, was twofold: 1) the lesion was a primary tibial intraneural ganglion with proximal extension followed by sciatic cross-over and distal descent; and 2) a joint connection to the posterior aspect of the superior tibiofibular joint with a remnant cyst within the articular branch would be present, a finding that would help explain the formation of different cysts by a single mechanism. The authors proved their hypothesis by careful inspection of a recently obtained postoperative MR image. CONCLUSIONS: These three cases together with data obtained from a retrospective review of the authors' clinical material and findings reported in the literature provide firm evidence for mechanisms underlying intraneural ganglia formation. Thus, expansion of the authors' unified articular theory permits understanding and elucidation of unusual presentations of intraneural cysts. Whereas an articular connection and fluid following the path of least resistance was pivotal, the authors now incorporate dynamic aspects of cyst formation due to pressure fluxes. These basic principles explain patterns of ascent, cross-over, and descent down terminal nerve branches based on articular connections, paths of diminished resistance to fluid flow within recognized anatomical compartments, and the effects of fluctuating pressure gradients.


Assuntos
Cistos Glanglionares/etiologia , Neuropatias Fibulares/etiologia , Neuropatia Tibial/etiologia , Adolescente , Adulto , Cistos Glanglionares/diagnóstico , Cistos Glanglionares/fisiopatologia , Humanos , Masculino , Neuropatias Fibulares/diagnóstico , Neuropatias Fibulares/fisiopatologia , Neuropatia Tibial/diagnóstico , Neuropatia Tibial/fisiopatologia
15.
Neurosurg Focus ; 22(6): E16, 2007 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-17613207

RESUMO

The common peroneal nerve is the peripheral nerve most often affected by intraneural ganglion cysts. Although the pathogenesis of these cysts has been the subject of controversy in the literature, it is becoming increasingly evident that they are of articular origin. Recent recognition of this fact has proven to be significant in reducing recurrences and improving treatment outcomes for patients. The authors present a stepwise method of assessing and treating peroneal intraneural ganglion cysts.


Assuntos
Cistos Glanglionares/diagnóstico , Cistos Glanglionares/cirurgia , Neuropatias Fibulares/diagnóstico , Neuropatias Fibulares/cirurgia , Adulto , Feminino , Cistos Glanglionares/fisiopatologia , Humanos , Nervo Fibular/patologia , Nervo Fibular/cirurgia , Neuropatias Fibulares/fisiopatologia , Recuperação de Função Fisiológica/fisiologia
16.
Neurosurg Focus ; 22(6): E27, 2007 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-17613219

RESUMO

The authors describe common modes of failure in the diagnosis and treatment of patients with peroneal intraneural ganglia. Illustrated examples correlate the modes of failure and the diagnostic or surgical errors. Understanding these pitfalls reinforces the rationale behind current treatment recommendations as outlined in the companion article. Avoiding these pitfalls will ultimately improve outcomes.


Assuntos
Cistos Glanglionares/diagnóstico , Cistos Glanglionares/cirurgia , Neuropatias Fibulares/diagnóstico , Neuropatias Fibulares/cirurgia , Humanos , Procedimentos Neurocirúrgicos/métodos , Procedimentos Neurocirúrgicos/tendências , Nervo Fibular/patologia , Nervo Fibular/cirurgia
17.
Skeletal Radiol ; 35(10): 734-44, 2006 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16799784

RESUMO

OBJECTIVE: To introduce the clinical entity of an intraneural ganglion cyst coexisting with a vascular adventitial cyst arising from the same joint. DESIGN: Retrospective review. PATIENTS: Two patients presented with predominantly deep peroneal neuropathy due to complex superior tibiofibular joint-related cysts. In addition to having peroneal intraneural ganglion cysts, these patients had vascular adventitial cysts: one involving a capsular arterial branch, the other a capsular vein [as well as a large, recurrent, intramuscular (extraneural) ganglion]. We then reviewed MRIs of 12 other consecutive cases of intraneural ganglia (10 peroneal and 2 tibial) arising from the superior tibiofibular joint that we treated, as well as other reported cases in the literature to determine if there were other (unrecognized) examples supporting the combination of clinical findings and radiographic patterns. RESULTS: Retrospective analysis of MRIs in the two surgically proven cases of peroneal intraneural ganglia with vascular adventitial cyst extension showed a common imaging pattern that we have termed "the wishbone sign," consisting of the connection of the ascending limb of the peroneal intraneural ganglion and the longitudinal limb of the vascular adventitial cyst in the axial plane. Our review suggests that vascular adventitial cyst extension occurs in a large proportion of cases of peroneal intraneural ganglia. A similar growth pattern was noted in a case of a tibial intraneural ganglion. CONCLUSIONS: The combination of intraneural and vascular adventitial cysts is understandable given our knowledge of normal and pathologic anatomy of para-articular cysts. The combination of intraneural ganglia and vascular adventitial cysts broadens the spectrum of clinical presentations of these cysts and suggests that cysts and their content can dissect from a joint along neurovascular bundles. These cases provide important evidence to support the articular theory for the pathogenesis of not only neural but vascular adventitial cysts as well.


Assuntos
Fíbula , Cistos Glanglionares/complicações , Cistos Glanglionares/diagnóstico , Articulação do Joelho/inervação , Neuropatias Fibulares/diagnóstico , Neuropatias Fibulares/etiologia , Tíbia , Diagnóstico Diferencial , Eletromiografia , Feminino , Fíbula/lesões , Cistos Glanglionares/patologia , Humanos , Articulação do Joelho/patologia , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Neuropatias Fibulares/patologia , Estudos Retrospectivos
18.
Skeletal Radiol ; 35(3): 172-9, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16333654

RESUMO

The pathogenesis of intraneural ganglia remains controversial. Only half of the reported cases of the most common type, the peroneal nerve at the fibular neck, have been found to have pedicles connecting the cysts to neighboring joints detected with preoperative imaging or intraoperatively. We believe that all intraneural ganglia arise from joints, and that radiologists and surgeons need to look closely preoperatively and intraoperatively for connections. Not identifying these connections with imaging and surgical exploration has led not only to skepticism about an articular origin of the cyst, but also to a high recurrence rate after surgery. We present a patient who had two recurrences of a peroneal intraneural ganglion in whom a joint connection was not detected on previous MRIs and operations. Reinterpretation of the original films and high-resolution MRI demonstrated an "occult" joint connection to the superior tibiofibular joint. MR arthrography performed after exercise and 1 h delay, however, clearly showed the connection and communication. The joint connection was then confirmed at surgery through an articular branch. Postoperatively the patient regained nearly normal neurologic function, and follow-up MRI showed no cyst recurrence. MR arthrography with delayed imaging should be considered in cases of intraneural ganglia when a joint connection is not obvious on MRI.


Assuntos
Cistos Glanglionares/diagnóstico , Imagem por Ressonância Magnética , Nervo Fibular , Adulto , Diagnóstico Diferencial , Cistos Glanglionares/patologia , Cistos Glanglionares/cirurgia , Humanos , Imageamento Tridimensional , Masculino , Reoperação
19.
Clin Orthop Relat Res ; (431): 187-92, 2005 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-15685074

RESUMO

To define the importance of the type of surgical treatment, we retrospectively analyzed the survival rate of 60 patients with solitary bony metastasis from renal cell carcinoma. Thirteen patients had wide resection, 20 had local stabilization, and 27 patients had no surgical treatment, but had adjuvant treatment alone. The 1-, 3-, and 5-year survival rates were 83%, 45%, and 23%, respectively. Patients with surgical treatment (wide or intralesional resection) survived longer compared with patients who had no surgical treatment but had adjuvant treatment modalities. However, there was no survival advantage for patients who had a wide resection of the lesion compared with patients who had intralesional resection or intramedullary stabilization alone. Our results indicate that wide surgical excision of a solitary bony metastasis from renal cell carcinoma is not mandatory to improve survival. However, because three of 20 patients (15%) treated with stabilization alone had local disease progression, wide resection of metastatic lesions and stabilization may be necessary to prevent local disease progression and complications.


Assuntos
Neoplasias Ósseas/secundário , Carcinoma de Células Renais/secundário , Neoplasias Renais/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Ósseas/mortalidade , Neoplasias Ósseas/cirurgia , Carcinoma de Células Renais/mortalidade , Carcinoma de Células Renais/cirurgia , Feminino , Humanos , Neoplasias Renais/cirurgia , Masculino , Pessoa de Meia-Idade , Nefrectomia , Estudos Retrospectivos , Fatores Sexuais , Análise de Sobrevida
20.
J Surg Orthop Adv ; 14(4): 168-74, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16442014

RESUMO

Malignant peripheral nerve sheath tumors (MPNSTs) are highly malignant cancers that account for approximately 5-10% of all soft tissue sarcomas. They occur either sporadically, in association with neurofibromatosis type 1 (NF1), or subsequent to radiation therapy. Histologically, MPNSTs resemble fibrosarcomas in their basic organization. Immunohistochemistry, particularly S100, plays an important role in the diagnosis. At the molecular level, loss of the NF1 gene and high levels of Ras-activity are hallmarks. Magnetic resonance imaging (MRI) is the most helpful imaging technique to clearly identify tumoral extent and to suggest neurogenic origin. The presence of heterogeneity with evidence of necrosis and hemorrhage on MRI and increased uptake on positron emission tomography scan may prove helpful in detecting malignant changes. MPNSTs need to be approached by a multidisciplinary team, assuring the complete surgical removal of the lesion. Disease-free and overall survival statistics reinforce the aggressive nature of this unique soft tissue tumor.


Assuntos
Neoplasias da Bainha Neural/diagnóstico , Animais , Expressão Gênica , Genes da Neurofibromatose 1/fisiologia , Genes ras/fisiologia , Humanos , Imuno-Histoquímica , Imagem por Ressonância Magnética , Neoplasias da Bainha Neural/genética , Neoplasias da Bainha Neural/metabolismo , Neoplasias da Bainha Neural/terapia , Neurofibromatose 1/diagnóstico , Neurofibromatose 1/genética
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