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1.
Inorg Chem ; 2020 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-32452688

RESUMO

Novel bimetallic zinc acetate complexes supported by heteroscorpionate ligands have been developed for the ring-opening copolymerization of cyclohexene oxide and CO2 and the terpolymerization of cyclohexene oxide, phthalic anhydride, and CO2. Heteroscorpionate ligands precursors L1-L3 were reacted with two equivalents of zinc acetate to afford the dinuclear zinc complexes [{Zn(κ3-bpzappe)}(µ-O2CCH3)3-{Zn(HO2CCH3)}] (1), [{Zn(κ3-bpzbdmape)}(µ-O2CCH3)3-{Zn(HO2CCH3)}] (2), and [{Zn(κ3-bpzbdeape)}(µ-O2CCH3)3{Zn(HO2CCH3)}] (3) in excellent yields. The molecular structure of these compounds was determined spectroscopically and confirmed by X-ray diffraction analysis. Zinc acetate complexes 1-3 were screened as catalysts for the copolymerization of cyclohexene oxide and CO2 to produce poly(cyclohexene)carbonate, and complex 3 was found to be the most active catalyst for this process in the absence of a cocatalyst. Furthermore, the terpolymerization of cyclohexene oxide, phthalic anhydride, and CO2 was studied using the combination of complex 3 and 4-dimethylaminopyridine as catalyst system yielding the corresponding polyester-polycarbonate materials.

2.
Cancer ; 126(8): 1656-1667, 2020 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-32037524

RESUMO

BACKGROUND: Human papillomavirus (HPV)-related disease remains a significant source of morbidity and mortality, and this underscores the need to increase HPV vaccination to reduce the burden of the disease. The objective of this study was to examine the association between the number of HPV vaccine doses and the risk of histologically confirmed preinvasive cervical disease and high-grade cytology. METHODS: This retrospective matched cohort study used administrative data from Optum's Clinformatics DataMart Database to identify females aged 9 to 26 years who received 1 or more quadrivalent HPV vaccine doses between January 2006 and June 2015. Cases and controls were matched on region, age, sexually transmitted disease history, and pregnancy. All had a Papanicolaou test ≥1 year after the date of the matched case's final dose. Cox proportional hazards models were used to examine the association between the number of HPV vaccine doses and the incidence of preinvasive cervical disease and high-grade cytology. The Kaplan-Meier method was used to estimate the cumulative incidence rate at the 5-year follow-up. RESULTS: The study included 133,082 females (66,541 vaccinated and 66,541 unvaccinated) stratified by the number of HPV vaccine doses and the vaccine initiation age. Among those aged 15 to 19 years, the hazard ratio (HR) for high-grade cytology for the 3-dose group was 0.84 (95% confidence interval [CI], 0.73-0.97), whereas the HRs for histologically confirmed preinvasive cervical disease for 1, 2, and 3 doses were 0.64 (95% CI, 0.47-0.88), 0.72 (95% CI, 0.54-0.95), and 0.66 (95% CI, 0.55-0.80), respectively. CONCLUSIONS: The receipt of 1, 2, or 3 doses of an HPV vaccine by females aged 15 to 19 years was associated with a lower incidence of preinvasive cervical disease in comparison with unvaccinated females, and this supports the use of any HPV vaccination in reducing the burden of the disease.

4.
Rev. Asoc. Esp. Espec. Med. Trab ; 28(4): 278-287, dic. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-187675

RESUMO

Objetivo: comprobar las modificaciones en capacidad funcional en músicos de viento (IV). Estudio: observacional transversal de 45 IV. Metodología: Somatometría, ECG y ergoespirometría con estadísticos correspondientes, T de Student y Chi cuadrado. Resultados y discusión: Consumo máximo de O2 y en el umbral anaeróbico (UA) superan los teóricos esperados, medias 108 y 70.8% (p < 0,001; r = 3,1 y r = 2.32). El pulso máximo y en el UA con respecto al teórico esperado, medias 108.3 y 85.7 % (p < 0.001, r = 3.01 y r = 2.86), expresan una buena respuesta cardiorrespiratoria. Los Equivalentes deCO2 en el UA , media 26.24 (DT 2.95) IC ( 25.31-27.16), se distancia del valor de referencia (32) de modo significativo (p = 0.0001). La edad influye (p = 0.0253) de forma que por cada 5 años se produce un incremento en 0.57 unidades. Conclusiones: Existe una probable adaptación morfofuncional en IV por tipo de actividad laboral


Objetive: To check all the modifications in pneumofunctional capabilities in wind musicians. Study: Observational and transvesal study in 45 wind musicians. Method: somatometry , ECG and ergospirometry with proper statistics , t-student and chi -square. Results and discussions: Maximun intake of O2 and in the anaerobic threshold(UA) overcome expected theorics means 108 and 70.8%(p < 0,001; r = 3,1 and r = 2.32). Maximun pulse and in the UA respect to expected reference values ,means 108,3% and 85,7%(p < 0.001, r = 3.01 and r = 2.86) show a Good cardiorespiratoryanswer. The CO2 equivalents inthe UA, mean 26.24 (DT 2.95) IC (25.31-27.16), distances from reference values significantly (p = 0.0001). Age influences(p = 0.0253) so that for every 5 years there is an increase in 0.57 units. Conclusions: Probably morphofunctional adaptation in wind musicians because occupational activity


Assuntos
Humanos , Masculino , Feminino , Música , Saúde do Trabalhador , Consumo de Oxigênio/fisiologia , Estudos Transversais , Eletrocardiografia , Teste de Esforço , Espirometria
5.
Papillomavirus Res ; 8: 100189, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31654772

RESUMO

OBJECTIVE: Compare the effectiveness of community-based HPV-related education and onsite school-based vaccination versus community-based education only for increasing HPV vaccine uptake in a rural, medically underserved area. METHODS: Our cohort included 2307 Rio Grande City Consolidated Independent School District (RGCISD) middle school students from 3 schools enrolled in August 2016 and followed until April 2018. Using a quasi-experimental design, this study implemented an onsite school-based vaccination program and physician-led education on HPV and HPV vaccines for parents/guardians, school nurses/staff, and pediatric/family providers in the surrounding community (15-mile radius of RGCCISD) at 1 middle school ("intervention school"), and education-only for the remaining 2 schools ("comparison schools"). The Centers for Disease Control and Prevention's HPV-related educational materials supplemented the education. HPV vaccine status was obtained from school immunization records and the project's contracted vaccine vendor. HPV vaccine initiation and completion rates were compared pre and post intervention and between the intervention and comparison schools. Logistic regression was used to compare the odds of newly initiating/completing vaccination between the intervention and comparison schools. RESULTS: At baseline, the intervention school had lower HPV vaccine initiation and completion rates than the comparison schools (20.00% and 8.70% vs 28.97% and 14.56%). Post intervention, the intervention school had higher initiation and completion rates than the comparison schools (53.67% and 28.36% vs 41.56% and 20.53%). Students from the intervention school were over 3.6-times more likely to newly initiate/complete the HPV vaccinations than students from the comparison schools. CONCLUSION: The school with on-site vaccination events and community-based education had a higher adolescent HPV vaccination rate compared to schools that received community-based education only.

6.
Int J Mol Sci ; 20(17)2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31480694

RESUMO

A comparative study on potential risks was carried out in a collection of 50 enterococci isolated from faeces of mice fed a standard or a high-fat diet enriched with extra virgin olive oil, refined olive oil or butter, at the beginning, after six weeks and after twelve weeks of experiments. Strains were biochemically assessed and genetically characterized. E. faecalis and E. casseliflavus were the most frequently isolated species in any diet and time points. Apart from the fact of not having isolated any strain from the virgin olive oil group during the last balance, we found statistically significant differences p < 0 . 05 among the diets in the percentage of antibiotic resistance and in the presence of the enterococcal surface protein gene (esp), as well as a tendency p < 0 . 1 for the presence of the tyrosine decarboxylase gene (tdc) to increase over time in the group of isolates from the standard diet. When the resistance of the strains to virgin or refined olive oil was studied, only the group of enterococci from high fat diets showed a significantly higher percentage of resistance to refined olive oil p < 0 . 05 , while both types of oil equally inhibited those isolated from the standard diet p > 0 . 05 .


Assuntos
Dieta Hiperlipídica , Resistência Microbiana a Medicamentos , Enterococcus/isolamento & purificação , Fezes/microbiologia , Animais , Aminas Biogênicas/metabolismo , Resistência Microbiana a Medicamentos/efeitos dos fármacos , Enterococcus/patogenicidade , Masculino , Camundongos Endogâmicos ICR , Azeite de Oliva/farmacologia , Filogenia , Técnica de Amplificação ao Acaso de DNA Polimórfico , Fatores de Virulência/metabolismo
8.
Gynecol Oncol ; 154(3): 558-564, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31288949

RESUMO

OBJECTIVE: Cervical cancer rates in the United States have declined since the 1940's, however, cervical cancer incidence remains elevated in medically-underserved areas, especially in the Rio Grande Valley (RGV) along the Texas-Mexico border. High-resolution microendoscopy (HRME) is a low-cost, in vivo imaging technique that can identify high-grade precancerous cervical lesions (CIN2+) at the point-of-care. The goal of this study was to evaluate the performance of HRME in medically-underserved areas in Texas, comparing results to a tertiary academic medical center. METHODS: HRME was evaluated in five different outpatient clinical settings, two in Houston and three in the RGV, with medical providers of varying skill and training. Colposcopy, followed by HRME imaging, was performed on eligible women. The sensitivity and specificity of traditional colposcopy and colposcopy followed by HRME to detect CIN2+ were compared and HRME image quality was evaluated. RESULTS: 174 women (227 cervical sites) were included in the final analysis, with 12% (11% of cervical sites) diagnosed with CIN2+ on histopathology. On a per-site basis, a colposcopic impression of low-grade precancer or greater had a sensitivity of 84% and a specificity of 45% to detect CIN2+. While there was no significant difference in sensitivity (76%, p = 0.62), the specificity when using HRME was significantly higher than that of traditional colposcopy (56%, p = 0.01). There was no significant difference in HRME image quality between clinical sites (p = 0.77) or medical providers (p = 0.33). CONCLUSIONS: HRME imaging increased the specificity for detecting CIN2+ when compared to traditional colposcopy. HRME image quality remained consistent across different clinical settings.


Assuntos
Colonoscopia/economia , Colonoscopia/métodos , Área Carente de Assistência Médica , Lesões Pré-Cancerosas/diagnóstico por imagem , Neoplasias do Colo do Útero/diagnóstico por imagem , Neoplasia Intraepitelial Cervical/diagnóstico por imagem , Neoplasia Intraepitelial Cervical/economia , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Gradação de Tumores , Lesões Pré-Cancerosas/economia , Estudos Prospectivos , Sensibilidade e Especificidade , Texas , Estados Unidos , Neoplasias do Colo do Útero/patologia
9.
Chem Commun (Camb) ; 55(61): 8947-8950, 2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31289801

RESUMO

A novel nucleophilic addition of an organolithium to a ketenimine to prepare an enantiopure NNN-heteroscorpionate ligand is described. We verified its potential utility as a valuable scaffold for chirality induction through the preparation of enantiopure zinc complexes, which behave as highly efficient initiators to produce highly-enriched isotactic poly(lactide)s (Pi up to 0.88).

10.
Hum Vaccin Immunother ; 15(7-8): 1678-1687, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31170031

RESUMO

Purpose: Despite its availability for more than a decade, the human papillomavirus (HPV) vaccine has low uptake in Texas (49%). The objective of this study was to understand parental knowledge and attitudes about HPV and the HPV vaccine as well as child experience with the HPV vaccine among a medically underserved, economically disadvantaged population. Methods: As part of a Cancer Prevention Research Institute of Texas-funded project to improve HPV vaccination rates, we surveyed parents / guardians of 4th-12th graders (ages 9-17) in the Rio Grande City Consolidated Independent School District (RGCCISD). Descriptive statistics were used to describe parents' knowledge and attitude and children's vaccine experience. Results: Of the 7,055 surveys distributed, 622 (8.8%) were returned. About 84% of the respondents were female. About 57.1% of the parents /guardians had female RGCCISD students with a mean age of 11.7 ± 1.8 years. Overall, 43.9% reported receiving a healthcare provider recommendation and 32.5% had their child vaccinated. Higher percentages were reported if the respondent was female and had a female child aged ≥15 years old. Among survey respondents, 28.2% reported their child initiated the HPV vaccine and 18.8% completed the series. Barriers of uptake included work / school schedule conflicts and no healthcare provider recommendation. Conclusions: There are still prominent gaps in parents' and students' complete understanding of HPV vaccination, gender preferences for vaccination, and provider recommendations. Future interventions must target men and minority populations in order to increase knowledge and awareness about HPV, the HPV vaccine, and HPV-associated cancers.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus/administração & dosagem , Pais/educação , Adolescente , Adulto , Criança , Tomada de Decisões , Feminino , Humanos , Tutores Legais/educação , Tutores Legais/psicologia , Masculino , Pais/psicologia , Aceitação pelo Paciente de Cuidados de Saúde , Pobreza , Pesquisa Qualitativa , Instituições Acadêmicas , Estudantes , Inquéritos e Questionários , Texas , Cobertura Vacinal/estatística & dados numéricos
11.
Phys Chem Chem Phys ; 21(21): 11214-11225, 2019 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-31099372

RESUMO

This work reports the experimental study of the ozonolysis of indene in the presence of SO2 and the reaction conditions leading to the formation of secondary aerosols. The reactions have been carried out in a Teflon chamber filled with synthetic air mixtures at atmospheric pressure and room temperature. As in the case of styrene, SO2 plays a key role in the oxidation of the Criegee intermediates and enhances the formation of particulate matter. Thus, for the ozonolysis of indene, nucleation was observed for reacted indene concentrations above (4.5 ± 0.8) × 1011 molecule cm-3 in the absence of SO2 while new particle formation was observed for concentrations one order of magnitude lower, (3 ± 1) × 1010 molecule cm-3, in the presence of SO2. Within the detection limit of the system, SO2 concentrations remained constant during the experiments. The formation of secondary aerosols in the smog chamber was inhibited by H2O and so the potential formation of secondary aerosols under atmospheric conditions depends on the concentration of SO2 and relative humidity. Computational calculations have been performed for the ozonolysis of both indene and styrene in the presence of SO2 and water to identify the reaction channels and species responsible for new particle formation. The release of SO3 and its subsequent conversion into H2SO4 from the reaction of the Criegee intermediate H2COO in the ozonolysis of styrene makes this aromatic have a high potential of aerosol formation in the atmosphere. On the other hand, quantitative conversion of SO2 into SO3 does not occur following the ozonolysis of indene.

12.
Neuroscience ; 410: 264-273, 2019 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-31128159

RESUMO

Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection.


Assuntos
Barreira Hematoencefálica/imunologia , Brucelose/imunologia , Sistema Nervoso Central/imunologia , Imunidade Inata/fisiologia , Fatores Imunológicos/imunologia , Animais , Barreira Hematoencefálica/metabolismo , Brucelose/metabolismo , Sistema Nervoso Central/metabolismo , Humanos , Fatores Imunológicos/metabolismo
13.
Biophys J ; 116(9): 1579-1585, 2019 05 07.
Artigo em Inglês | MEDLINE | ID: mdl-30975453

RESUMO

Flow at the molecular level induces shear-induced unfolding of single proteins and can drive their assembly, the mechanisms of which are not completely understood. To be able to analyze the role of flow on molecules, we present uniform-flow molecular dynamics simulations at atomic level. The pull module of the GRoningen MAchine for Chemical Simulations package was extended to be able to force-group atoms within a defined layer of the simulation box. Application of this external enforcement to explicit water molecules, together with the coupling to a thermostat, led to a uniform terminal velocity of the solvent water molecules. We monitored the density of the whole system to establish the conditions under which the simulated flow is well-behaved. A maximal velocity of 1.3 m/s can be generated if a pull slice of 8 nm is used, and high velocities would require larger pull slices to still maintain a stable density. As expected, the target velocity increases linearly with the total external force applied. Finally, we suggest an appropriate setup to stretch a protein by uniform flow, in which protein extensions depend on the flow conditions. Our implementation provides an efficient computational tool to investigate the effect of the flow at the molecular level.

14.
Dalton Trans ; 48(13): 4218-4227, 2019 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-30843571

RESUMO

Helical aluminium complexes [Al2X4(µ-nbptam)] (X = Me 1, Et 2), [Al2X4(µ-fbpam)] (R = Me 3, Et 4), [Al3X7(µ-nbptam)] (X = Me 5, Et 6) and [Al3X7(µ-fbpam)] (X = Me 7, Et 8) have been prepared by treatment of scorpionate ligand precursors with two or three equivalents of the corresponding trialkylaluminium derivative. The structures of these complexes have been determined by spectroscopic methods and the X-ray crystal structure of complex 1 has also been established. These complexes have been studied as catalysts for the chemical fixation of carbon dioxide into cyclic carbonates displaying good catalytic activity. When cyclohexene oxide was used as a substrate, polyether-polycarbonate was obtained in a ratio which is highly dependent on the cocatalyst and the catalyst to cocatalyst ratio used.

15.
Microorganisms ; 7(2)2019 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-30813410

RESUMO

Extra virgin olive oil (EVOO) has been reported to have a distinct influence on gut microbiota in comparison to other fats, with its physiological benefits widely studied. However, a large proportion of the population consumes olive oil after a depurative process that not only mellows its taste, but also deprives it of polyphenols and other minority components. In this study, we compare the influence on the intestinal microbiota of a diet high in this refined olive oil (ROO) with other fat-enriched diets. Swiss Webster mice were fed standard or a high-fat diet enriched with EVOO, ROO, or butter (BT). Physiological parameters were also evaluated. At the end of the feeding period, DNA was extracted from feces and the 16S rRNA was pyrosequenced. The group fed ROO behaved differently to the EVOO group in half the families with statistically significant differences among the diets, with higher comparative levels in three families-Desulfovibrionaceae, Spiroplasmataceae, and Helicobacteraceae-correlating with total cholesterol. These results are again indicative of a link between specific diets, certain physiological parameters and the prevalence of some taxa, but also support the possibility that polyphenols and minor components of EVOO are involved in some of the proposed effects of this fat through the modulation of the intestinal microbiota.

16.
Am J Prev Med ; 56(4): 591-602, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30773231

RESUMO

CONTEXT: Despite current recommendations, human papillomavirus vaccine uptake remains low. A systematic review and meta-analysis assessed the effectiveness of interventions targeting human papillomavirus vaccine initiation and completion among children, adolescents, and young adults aged 9-26 years. EVIDENCE ACQUISITION: Three electronic databases (CINAHL, OVID, and Web of Science) were searched for articles published in English peer-reviewed journals between January 2006 and January 2017 of U.S. studies that evaluated intervention strategies and reported post-intervention human papillomavirus vaccine initiation or completion rates among individuals aged 9-26 years. Study characteristics and outcomes were extracted. Data were collected in 2016 and analyzed in 2017. EVIDENCE SYNTHESIS: Reviewers screened 983 unique titles and abstracts, read 241 full-text articles, and extracted data from 30 articles meeting the inclusion criteria (12 behavioral, ten environmental, four informational, and four combination strategies). Published EQUATOR (Enhancing the Quality and Transparency of Health Research) guidelines were used to assess study quality. Random effects meta-analyses were conducted. The meta-analyses included 17 RCTs and quasi-experiments involving 68,623 children, adolescents, and young adults. The pooled relative incidence estimates were 1.84 (95% CI=1.36, 2.48) for human papillomavirus vaccine initiation and 1.50 (95% CI=1.23, 1.83) for completion. Behavioral and informational interventions doubled human papillomavirus vaccine initiation (relative incidence estimate=2.04, 95% CI=1.36, 3.06 and relative incidence estimate=1.92, 95% CI=1.27, 2.91, respectively). Behavioral interventions increased completion by 68% (relative incidence estimate=1.68, 95% CI=1.25, 2.27). CONCLUSIONS: Evidence supports behavioral interventions for increasing human papillomavirus vaccine initiation and completion. Future studies are needed to assess the effectiveness of interventions in reaching diverse populations and reducing missed opportunities for human papillomavirus vaccination.

17.
Inorg Chem ; 58(5): 3396-3408, 2019 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-30735040

RESUMO

New bifunctional aluminum complexes have been prepared with the aim of studying the effect of a counterion on the synthesis of cyclic carbonates from epoxides and carbon dioxide (CO2). Neutral ligand 1 was used as a precursor to obtain four novel mesylate, chloride, bromide, and iodide zwitterionic NNO ligands (2-5). The reaction of these ligands with 1 or 2 equiv of AlR3 (R = Me, Et) allowed the synthesis of mono- and bimetallic bifunctional aluminum complexes [AlR2(κ2-mbpzappe)]X [X = Cl, R = Me (6), Et (7); X = Br, R = Me (8), Et (9); X = I, R = Me (10), Et (11)] and [{AlR2(κ2-mbpzappe)}(µ-O){AlR3}]X [X = MeSO3, R = Me (12), Et (13); X = Cl, R = Me (14), Et (15); X = Br, R = Me (16), Et (17); X = I, R = Me (18), Et (19)] via alkane elimination. These complexes were studied as catalysts for the synthesis of cyclic carbonates from epoxides and CO2. Iodide complex 11 showed to be the most active catalyst for terminal epoxides, whereas bromide complex 9 was found to be the optimal catalyst when internal epoxides were used, showing the importance of the nucleophile cocatalyst on the catalytic activity.

18.
Front Physiol ; 10: 83, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30800077

RESUMO

Nutritional programming of the thermogenic and fuel oxidation capacity of white adipose tissue (WAT) through dietary interventions in early life is a potential strategy to enhance future metabolic health. We previously showed that mild neonatal supplementations with the polyphenol resveratrol (RSV) and the vitamin B3 form nicotinamide riboside (NR) have sex-dependent, long-term effects on the thermogenic/oxidative phenotype of WAT of mice in adulthood, enhancing this phenotype selectively in male animals. Here, we tested the hypothesis that these dietary interventions may impact the commitment of progenitor cells resident in the developing WAT toward brown-like (beige) adipogenesis. NMRI mice received orally from postnatal day 2-20 (P2-20) a mild dose of RSV or NR, in independent experiments; control littermates received the vehicle. Sex-separated primary cultures were established at P35 from the stromovascular fraction of inguinal WAT (iWAT) and of brown adipose tissue (BAT). Expression of genes related to thermogenesis and oxidative metabolism was assessed in the differentiated cultures, and in vivo in the iWAT depot of young (P35) animals. Neonatal RSV and NR treatments had little impact on the animals' growth during early postnatal life and the expression of thermogenesis- and oxidative metabolism-related genes in the iWAT depot of young mice. However, the expression of brown/beige adipocyte marker genes was upregulated in the iWAT primary cultures from RSV supplemented and NR supplemented male mice, and downregulated in those from supplemented female mice, as compared to cultures derived from sex-matched control littermates. RSV supplementation had similar sex-dependent effects on the expression of thermogenesis-related genes in the BAT primary cultures. A link between the sex-dependent short-term effects of neonatal RSV and NR supplementations on primary iWAT preadipocyte differentiation observed herein and their previously reported sex-dependent long-term effects on the thermogenic/oxidative capacity of adult iWAT is suggested. The results provide proof-of-concept that the fate of preadipocytes resident in WAT of young animals toward the beige adipogenesis transcriptional program can be modulated by specific food bioactives/micronutrients received in early postnatal life.

19.
Inorg Chem ; 58(1): 900-908, 2019 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-30540186

RESUMO

A new coordination mode for the hybrid scorpionate/cyclopentadienyl ligand bpzcp, [bpzcp = 2,2-bis(3,5-dimethylpyrazol-1-yl)-1,1-diphenylethylcyclopentadienyl] is observed in iridium complexes. The reaction of the lithium precursor, [Li(bpzcp)(THF)], with a range of [IrCl(diene)]2 compounds leads to an unprecedented binding mode of the hybrid scorpionate/cyclopentadienyl ligand as η5-Cp-coordinated and the formation of Ir(I) derivatives [Ir(η5-Cp-bpzcp)(η4-cod)] (1), [Ir(η5-Cp-bpzcp){η4-CH2═C(Me)C(Me)═CH2}] (2), [Ir(η5-Cp-bpzcp)(η2-coe)2] (3), and [Ir(η5-Cp-bpzcp)(η2-CH2═CH2)2] (4). The Ir(I) complex 4 reacts with CO or bromine to afford the compound [Ir(η5-Cp-bpzcp)(CO)2] (5) and the 18e- Ir(III) complex [Ir(κ-N-η5-Cp-bpzcpBr2)Br2] (6), respectively. Reaction of the iridium compounds (2-4) with CuI or [PdCl2(CH3CN)2] yields the heterobimetallic iridium-copper or iridium-palladium complexes [Ir(η5-Cp-bpzcp){η4-CH2═C(Me)C(Me)═CH2}(µ-bpzcp){CuI(κ2-NN-bpzcp)}] (7), [Ir(η5-Cp-bpzcp)(η2-coe)2}(µ-bpzcp){CuI(κ2-NN-bpzcp)}] (8), [Ir(η5-Cp-bpzcp)(η2-CH2═CH2)2}(µ-bpzcp){CuI(κ2-NN-bpzcp)}] (9), [Ir(η5-Cp-bpzcp)(coe)2}(µ-bpzcp){PdCl2(κ2-NN-bpzcp)}] (10), and [Ir(η5-Cp-bpzcp)(η2-CH2═CH2)2(µ-bpzcp){PdCl2(κ2-NN-bpzcp)}] (11). All products were characterized by spectroscopic methods and the X-ray crystal structures of 1, 2, 3, 4, and 6 were also established.

20.
Int Forum Allergy Rhinol ; 9(5): 556-561, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30576084

RESUMO

BACKGROUND: The medial and inferior recti encompass the ideal surgical corridor to approach the intraconal space endonasally. Here, we describe 3 different maneuvers to achieve greater access to orbital contents through an expanded endonasal approach (EEA). METHODS: Four human cadaver heads were dissected bilaterally (n = 8). EEA to the medial intraconal orbit was executed. The following 3 maneuvers were performed: (1) anterior: extraocular muscles control (EOM); (2) posterior: annulus of Zinn (AZ) release; and (3) anterior/posterior combined. Measurements of the inferior and medial rectus corridor at the level of anterior ethmoidal artery (AEA) and posterior ethmoidal artery (PEA) and extent of optic nerve and medial rectus visualization was performed before and after each maneuver. RESULTS: Medial rectus length (MRL) and optic nerve length (ONL) achieved were 1.72 ± 0.28 cm and 0.85 ± 0.2 cm, respectively. Mean caudal-rostral distances between the rectus muscles at the level of the AEA and PEA were 3.45 ± 0.7 mm and 1.30 ± 0.3 mm, respectively. After EOM control, mean caudal-rostral distances at the same level were as follows: AEA 4.90 ± 1.15 mm (p = 0.009) and PEA 1.70 ± 0.20 mm (p = 0.016). With AZ release, MRL was 2.20 ± 0.7 cm (p = 0.002) and ONL was 1.30 ± 0.2 cm (p = 0.003), with mean rostral-caudal distance at the level of AEA at 4.03 ± 0.8 mm (p = 0.16) and PEA at 1.71 ± 0.36 mm (p = 0.039). Mean caudal-rostral distances achieved with AZ release and EOM control were as follows: AEA 5.6 ± 1.2 mm (p = 0.001) and PEA 2.15 ± 0.4 mm (p = 0.001). CONCLUSION: Progressive access to the orbital contents is afforded with the 3 delineated maneuvers. The magnitude of access is optimized with the combined maneuver. The actual anterior/posterior location of the target will determine which maneuvers are required.

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