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1.
Prehosp Emerg Care ; 25(4): 588-592, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32776812

RESUMO

The American College of Surgeons Committee on Trauma (ACS-COT), the American College of Emergency Physicians (ACEP), the National Association of State EMS Officials (NASEMSO), the National Association of EMS Physicians (NAEMSP) and the National Association of EMTs (NAEMT) have previously offered varied guidance on the use of ketamine in trauma patients. The following consensus statement represents the collective positions of the ACS-COT, ACEP, NASEMSO, NAEMSP and NAEMT. This updated uniform guidance is intended for use by emergency medical services (EMS) personnel, EMS medical directors, emergency physicians, trauma surgeons, nurses and pharmacists in their treatment of the trauma patient in both the prehospital and hospital setting.


Assuntos
Serviços Médicos de Emergência , Ketamina , Consenso , Serviço Hospitalar de Emergência , Hospitais , Humanos
2.
Trauma Surg Acute Care Open ; 4(1): e000376, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31673635

RESUMO

This is a joint statement from the American College of Surgeons Committee on Trauma, the American College of Emergency Physicians, the National Association of Emergency Medical Services Physicians and the National Association of Emergency Medical Technicians regarding the clinical use of resuscitative endovascular balloon occlusion of the aorta (REBOA) in civilian trauma systems in the USA. This statement addresses the system of care needed to manage trauma patients requiring the use of REBOA, in light of the current evidence available in this patient population. This statement was developed by an expert panel following a comprehensive review of the literature with representation from all sponsoring organizations and the US Military. This is an update to the previous statement published in 2018. It has been formally endorsed by the four sponsoring organizations.

5.
Reprod Fertil Dev ; 2015 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-25896743

RESUMO

Decreasing mammalian fertility and sperm quality have created an urgent need to find effective methods to distinguish non-viable from viable fertilising spermatozoa. The aims of the present study were to evaluate expression levels of ?-tubulin 2C (TUBB2C), heat shock protein 10 (HSP10), hexokinase 1 (HXK1) and superoxide dismutase 1 (SOD1) in spermatozoa from Holstein bulls with varying fertility using western blotting and to analyse the biological networks of these key sperm proteins using a bioinformatics software (Metacore; Thomson-Reuters, Philadelphia, PA, USA). The rationales behind this study were that the sperm proteins play crucial roles in fertilisation and early embryonic development in mammals and ascertaining the biological networks of the proteins helps us better understand sperm physiology and early mammalian development. The results showed that expression of SOD1 was higher in spermatozoa from high fertility bulls (PPin vivo bull fertility. The findings are important because they illuminate molecular and cellular determinants of sperm viability and the identified protein markers can be used to determine bull fertility.

6.
Can Vet J ; 54(4): 353-8, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24082161

RESUMO

This study evaluated the biomechanical characteristics of a single self-locking knot (sSLK) and a double self-locking knot (dSLK) compared with the square knot (SQ) for stabilization of cranial cruciate ligament rupture. Each knot underwent monotonic tensile and cyclical loading. Starting tension, elongation, stiffness, and load to failure were all evaluated. A value of P < 0.05 was considered significant. Starting tension, overall stiffness, and load to failure were all significantly greater in both the sSLK and dSLK compared with the SQ. There was no difference in elongation among the knots. There were no significant differences in starting tension, elongation, stiffness, and load to failure between the sSLK and the dSLK. The self-locking knots were stronger and stiffer than the SQ; there is no biomechanical advantage in using the dSLK compared with the sSLK.


Assuntos
Técnicas de Sutura/veterinária , Animais , Ligamento Cruzado Anterior/cirurgia , Artroscopia/métodos , Fenômenos Biomecânicos , Teste de Materiais , Suturas
7.
J Am Anim Hosp Assoc ; 49(2): 108-14, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23325596

RESUMO

Cranial cruciate ligament rupture (CCLR) is the most common cause of degenerative joint disease (DJD) in the stifle of adult dogs. Over the last several years, a new generation of nonabsorbable, multifilament, polyblend polyethylene orthopedic suture materials have been evaluated for use in the lateral fabellar suture (LFS) technique for surgical treatment of CCLR. This retrospective study compared the short-term outcome of 16 dogs that were treated using the LFS technique using either a proprietary polyblend polyethylene orthopedic suture material (FW) or monofilament nylon leader line (NLL). The FW was significantly more likely to fail compared with the NLL (P = 0.0379). Specifically, the FW was 14.667 times likelier to fail than the NLL. When one and two strands of NLL were compared with FW, the FW was 6 times more likely to fail than one strand of NLL and 32 times more likely to fail than two strands of NLL. To the authors' knowledge, this is the first study comparing the two materials used in the LFS procedure performed in clinical cases.


Assuntos
Ligamento Cruzado Anterior/cirurgia , Doenças do Cão/cirurgia , Joelho de Quadrúpedes/cirurgia , Técnicas de Sutura/veterinária , Suturas/veterinária , Animais , Ligamento Cruzado Anterior/patologia , Lesões do Ligamento Cruzado Anterior , Cães , Feminino , Masculino , Nylons/normas , Poliésteres/normas , Estudos Retrospectivos , Ruptura/veterinária , Joelho de Quadrúpedes/fisiologia , Técnicas de Sutura/instrumentação
8.
Open J Vet Med ; 3(1): 1-5, 2013 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-25938006

RESUMO

Obesity has not been linked to causing intervertebral disc degeneration, but has been shown to influence time to ambulation, a strong long-term prognostic indicator in dogs with intervertebral disc disease. However, monitoring obesity to date is imprecise and subjective in the clinical setting. Having an objective formula based on morphometric measurements would potentially be more precise to track our patients' weights. Dogs have been shown to gain weight along their lumbar spine more rapidly than other areas. Varying body conformations make extrapolation from nonchondrodystrophic dogs to Dachshunds difficult. This study aimed to establish the region of fat accumulation along the thoracolumbar spine in Dachshunds. Retrospective computed tomographic (CT) analysis was performed on healthy Dachshunds that presented for intervertebral disc disease (IVDD). Fat area measured at L3 and L5 using attenuation ranges -135/-105 Hounsfield units (HU) was the most dependent on body weight (p = 0.05). There appeared to be no difference between subcutaneous, visceral or total percent body fat with weight agreement. T13, L3 and L5 all had linear relationships with patient weight and will likely be helpful for body mass index (BMI) formula creation (p < 0.01). This study indicates that any consistent location between L3 and L5 will give an accurate representation of the abdominal circumference and most obese area of the Dachshund with the umbilicus used as a landmark.

9.
J Reprod Dev ; 59(1): 18-26, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-22986927

RESUMO

Male fertility, the ability of sperm to fertilize and activate the egg and support early embryogenesis, is vital for mammalian reproduction. Despite producing adequate numbers of sperm with normal motility and morphology, some males suffer from low fertility whose molecular mechanisms are not known. The objective was to determine apoptosis in sperm from high and low fertility bulls and its relationship with male fertility. DNA damage, phosphatidylserine (PS) translocation, and expression of pro- and anti-apoptotic proteins (BAX and BCL-2) in the sperm were determined using TUNEL, Annexin V, and immunoblotting approaches, respectively. Amounts of apoptotic spermatozoa were 2.86 (± 1.31) and 3.00 (± 0.96) in high and low fertility bulls, respectively (P=0.548), and were not correlated with fertility. There was a negative correlation between early necrotic spermatozoa and viable spermatozoa (r = -0.99, P<0.0001). Fertility scores were correlated with live spermatozoa detected by eosin-nigrosin test and necrotic spermatozoa determined via flow cytometry (r = -0.49, P<0.006 and r = -0.266, P<0.0113, respectively). BAX level was higher in low fertile group than high fertile group; however, this difference was not statistically significant due to the variations of bull samples (Bull 1-3 vs. Bull 4-5) in low fertile group (P<0.283). BCL-2 was not detectable in any of the sperm samples. The results shed light onto molecular and cellular underpinnings of male fertility.


Assuntos
Apoptose , Fertilidade , Espermatozoides/patologia , Espermatozoides/fisiologia , Animais , Bovinos , Dano ao DNA , Citometria de Fluxo , Masculino , Fosfatidilserinas/metabolismo , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Reprodução , Motilidade Espermática , Proteína X Associada a bcl-2/metabolismo
10.
Plant Sci ; 199-200: 103-12, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23265323

RESUMO

Many studies have documented the induction of belowground defenses in plants in response to aboveground herbivory and vice versa, but the genes and signaling molecules mediating systemic induction are not well understood. We performed comparative microarray analysis on maize whorl and root tissues from the insect resistant inbred Mp708 in response to foliar feeding by fall armyworm (Spodoptera frugiperda) caterpillars. Although Mp708 has elevated jasmonic acid (JA) levels prior to herbivory, genes involved in JA biosynthesis were up-regulated in whorls in response to fall armyworm feeding. Alternatively, genes possibly involved in regulating ethylene (ET) perception and signaling were up-regulated in roots following foliar herbivory. Transcript levels of genes encoding proteins involved in direct defenses against herbivores were enhanced both in roots and leaves, but transcriptional factors and genes involved in various biosynthetic pathways were selectively down-regulated in the whorl. The results indicate that foliar herbivory by fall armyworm changes root gene expression pathways suggesting profound long distance signaling. Tissue specific induction and suppression of JA and ET signaling pathway genes provides a clue to their possible roles in signaling between the two distant tissue types that eventually triggers defense responses in the roots in response to foliar herbivory.


Assuntos
Regulação da Expressão Gênica de Plantas/genética , Genes de Plantas/genética , Doenças das Plantas/imunologia , Spodoptera/fisiologia , Zea mays/imunologia , Animais , Vias Biossintéticas/genética , Ciclopentanos/metabolismo , Etilenos/metabolismo , Comportamento Alimentar , Perfilação da Expressão Gênica , Genótipo , Herbivoria , Interações Hospedeiro-Parasita , Análise de Sequência com Séries de Oligonucleotídeos , Especificidade de Órgãos , Oxilipinas/metabolismo , Doenças das Plantas/parasitologia , Folhas de Planta/genética , Folhas de Planta/imunologia , Folhas de Planta/parasitologia , Folhas de Planta/fisiologia , Raízes de Plantas/genética , Raízes de Plantas/imunologia , Raízes de Plantas/parasitologia , Raízes de Plantas/fisiologia , Brotos de Planta/genética , Brotos de Planta/imunologia , Brotos de Planta/parasitologia , Brotos de Planta/fisiologia , Transdução de Sinais/genética , Transcriptoma , Zea mays/genética , Zea mays/parasitologia , Zea mays/fisiologia
11.
Cardiovasc Dis ; 8(3): 333-343, 1981 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15216190

RESUMO

To determine the usefulness of R-wave amplitude changes during exercise testing for the diagnosis of coronary artery disease (CAD) and to understand the discrepancies that have been described in the literature regarding their value, we studied two groups of patients by means of electrocardiographic (EKG) treadmill testing and coronary arteriography. Group I was composed of 149 patients who were studied prospectively. The specificity of R-wave changes measured from preexercise to immediately postexercise (SRV(5)) was 81%, but that of R-wave changes measured from preexercise to peak exercise (URV(5)) was 46%. A group of 156 patients (Group II) evaluated retrospectively showed a high specificity for the SRV(5) (84%) and poor specificity for the URV(5) (39%). The sensitivity of the SRV(5) was 38% in Group I and 42% in Group II. Therefore, if measured during the immediate postexercise period and not at peak exercise, changes in R-wave amplitude may be of value in the diagnosis of coronary artery disease by electrocardiographic exercise testing.

12.
Cardiovasc Dis ; 8(3): 344-354, 1981 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15216191

RESUMO

Two-dimensional echocardiographic data in orthogonal apical projections were used to calculate left ventricular ejection fraction and volumes in 18 patients, 10 of whom had asynergy. The left ventricular chamber was modeled as a stack of 20 elliptical discs in order to minimize errors associated with assumptions of regular geometry. Calculations were compared to data from biplane angiography and yielded correlation coefficients of 0.91 for ejection fraction and 0.90 for volumes. The technique significantly underestimated volumes; the average ventricular volume was 161 +/- 23 ml from cineangiography and 104 +/- 25 ml from echocardiography (p < 0.001). Since this technique utilizes the most readily obtained echocardiographic views and allows for variations in ventricular architecture, its potential utility in long-term, serial evaluation of cardiac function appears promising.

13.
Cardiovasc Dis ; 8(1): 39-47, 1981 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15216224

RESUMO

A technique of modelling the left ventricle for the purpose of volume determination has been devised. Two-dimensional echocardiographic data from the apical four chamber and two chamber views are used to pattern the ventricle as a stack of elliptical discs. The method has been validated for an array of regular geometric shapes commonly associated with ventricular architecture. The relative advantages of this model are discussed.

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